2WQ5: Non-antibiotic properties of tetracyclines: structural basis for inhibition of secretory phospholipase A2

PDB ID: 2WQ5Download
MMDB ID: 80905
PDB Deposition Date: 2009/8/13
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 1.65  Å
Source Organism:
Similar Structures:
Biological Unit for 2WQ5: trimeric; determined by author and by software (PISA)
Molecular Components in 2WQ5
Label Count Molecule
Proteins (3 molecules)
3
Phospholipase A2, Acidic
Molecule annotation
Chemicals and Non-standard biopolymers (9 molecules)
1
3
CALCIUM IONCALCIUM ION
2
3
SULFATE IONSULFATE ION
3
3
(4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE(4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303