2IEH: Crystal structure of human kinesin Eg5 in complex with (R)-mon97, a new monastrol-based inhibitor that binds as (R)-enantiomer

PDB ID: 2IEHDownload
MMDB ID: 234967
PDB Deposition Date: 2006/9/19
Updated in MMDB: 2023/09
Experimental Method:
x-ray diffraction
Resolution: 2.7  Å
Source Organism:
Similar Structures:
Biological Unit for 2IEH: monomeric; determined by author
Molecular Components in 2IEH
Label Count Molecule
Protein (1 molecule)
1
Kinesin-like Protein Kif11
(Gene symbol: KIF11)
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
1
MAGNESIUM IONMAGNESIUM ION
2
1
POTASSIUM IONPOTASSIUM ION
3
1
CHLORIDE IONCHLORIDE ION
4
1
ADENOSINE-5'-DIPHOSPHATEADENOSINE-5'-DIPHOSPHATE
5
1
[(4R)-4-(3-HYDROXYPHENYL)-1,6-DIMETHYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL](PHENYL)METHANONE[(4R)-4-(3-HYDROXYPHENYL)-1,6-DIMETHYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL](PHENYL)METHANONE
6
1
TETRAETHYLENE GLYCOLTETRAETHYLENE GLYCOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303