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3TGE:
A novel series of potent and selective PDE5 inhibitor1
PDB ID:
3TGE
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MMDB ID:
94941
PDB Deposition Date:
2011/8/17
Updated in MMDB:
2011/11
Experimental Method:
x-ray diffraction
Resolution:
1.96 Å
Source Organism:
Homo sapiens
Similar Structures:
VAST+
Download sequence data
Biological Unit for 3TGE: monomeric; determined by author and by software (PISA)
Molecular Components in 3TGE
Label
Count
Molecule
Protein (1 molecule)
A
1
Cgmp-specific 3',5'-cyclic Phosphodiesterase
(Gene symbol:
PDE5A
)
Chemicals and Non-standard biopolymers (3 molecules)
1
1
ZINC ION
2
1
MAGNESIUM ION
3
1
7-(6-methoxypyridin-3-yl)-3-{[2-(morpholin-4-yl)ethyl]amino}-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303