3UI7: Discovery of orally active pyrazoloquinoline as a potent PDE10 inhibitor for the management of schizophrenia

PDB ID: 3UI7Download
MMDB ID: 95935
PDB Deposition Date: 2011/11/4
Updated in MMDB: 2011/12
Experimental Method:
x-ray diffraction
Resolution: 2.28  Å
Source Organism:
Similar Structures:
Biological Unit for 3UI7: monomeric; determined by author and by software (PISA)
Molecular Components in 3UI7
Label Count Molecule
Protein (1 molecule)
1
Camp and Camp-inhibited Cgmp 3',5'-cyclic Phosphodiesterase 10A
(Gene symbol: PDE10A)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
1
6-methoxy-3,8-dimethyl-4-(morpholin-4-ylmethyl)-1H-pyrazolo[3,4-b]quinoline6-methoxy-3,8-dimethyl-4-(morpholin-4-ylmethyl)-1H-pyrazolo[3,4-b]quinoline
2
1
MAGNESIUM IONMAGNESIUM ION
3
1
ZINC IONZINC ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303