4DFL: Crystal structure of spleen tyrosine kinase complexed with a sulfonamidopyrazine piperidine inhibitor

PDB ID: 4DFLDownload
MMDB ID: 99071
PDB Deposition Date: 2012/1/24
Updated in MMDB: 2018/04
Experimental Method:
x-ray diffraction
Resolution: 1.98  Å
Source Organism:
Similar Structures:
Biological Unit for 4DFL: monomeric; determined by author and by software (PISA)
Molecular Components in 4DFL
Label Count Molecule
Protein (1 molecule)
1
Tyrosine-protein Kinase SYK
(Gene symbol: SYK)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
1
3-amino-6-{3-[(methylsulfonyl)amino]phenyl}-N-(piperidin-4-ylmethyl)pyrazine-2-carboxamide3-amino-6-{3-[(methylsulfonyl)amino]phenyl}-N-(piperidin-4-ylmethyl)pyrazine-2-carboxamide
2
1
1,2-ETHANEDIOL1,2-ETHANEDIOL
3
1
SULFATE IONSULFATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303