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4FLH:
Crystal structure of human PI3K-gamma in complex with AMG511
PDB ID:
4FLH
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MMDB ID:
102484
PDB Deposition Date:
2012/6/14
Updated in MMDB:
2017/11
Experimental Method:
x-ray diffraction
Resolution:
2.6 Å
Source Organism:
Homo sapiens
Similar Structures:
VAST+
Download sequence data
Biological Unit for 4FLH: monomeric; determined by author and by software (PISA)
Molecular Components in 4FLH
Label
Count
Molecule
Protein (1 molecule)
A
1
Phosphatidylinositol 4,5-bisphosphate 3-kinase Catalytic Subunit Gamma Isoform
(Gene symbol:
PIK3CG
)
Chemicals and Non-standard biopolymers (5 molecules)
1
4
SULFATE ION
2
1
4-(2-[(5-fluoro-6-methoxypyridin-3-yl)amino]-5-{(1R)-1-[4-(methylsulfonyl)piperazin-1-yl]ethyl}pyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303