4I4E: Structure of Focal Adhesion Kinase catalytic domain in complex with hinge binding pyrazolobenzothiazine compound

PDB ID: 4I4EDownload
MMDB ID: 108194
PDB Deposition Date: 2012/11/27
Updated in MMDB: 2023/09
Experimental Method:
x-ray diffraction
Resolution: 1.55  Å
Source Organism:
Similar Structures:
Biological Unit for 4I4E: monomeric; determined by author and by software (PISA)
Molecular Components in 4I4E
Label Count Molecule
Protein (1 molecule)
1
Focal Adhesion Kinase 1
(Gene symbol: PTK2)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
[4-(2-hydroxyethyl)piperidin-1-yl][4-(5-methyl-4,4-dioxido-1,5-dihydropyrazolo[4,3-c][2,1]benzothiazin-8-yl)phenyl]methanone[4-(2-hydroxyethyl)piperidin-1-yl][4-(5-methyl-4,4-dioxido-1,5-dihydropyrazolo[4,3-c][2,1]benzothiazin-8-yl)phenyl]methanone
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303