3ZO1: The Synthesis and Evaluation of Diazaspirocyclic Protein Kinase Inhibitors

PDB ID: 3ZO1Download
MMDB ID: 108082
PDB Deposition Date: 2013/2/20
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Similar Structures:
Biological Unit for 3ZO1: dimeric; determined by author and by software (PISA)
Molecular Components in 3ZO1
Label Count Molecule
Proteins (2 molecules)
1
Camp-dependent Protein Kinase Catalytic Subunit Alpha
(Gene symbol: PRKACA)
Molecule annotation
1
Camp-dependent Protein Kinase Inhibitor Alpha
(Gene symbol: PKIA)
Molecule annotation
Chemicals and Non-standard biopolymers (7 molecules)
1
1
6-(1,9-DIAZASPIRO[5.5]UNDECAN-9-YL)-9H-PURINE6-(1,9-DIAZASPIRO[5.5]UNDECAN-9-YL)-9H-PURINE
2
4
GLYCEROLGLYCEROL
3
2
METHANOLMETHANOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303