Abstract
A series of indanotriazine C-ribosides were prepared as SAH mimics, and tested for their ability to inhibit erythromycin resistance methylases Erm AM and Erm C'. A carbocyclic analogue derived from quinic acid was also synthesized and tested.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Enzyme Inhibitors / chemical synthesis*
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Indans / chemical synthesis*
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Indans / pharmacology
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Methyltransferases / antagonists & inhibitors*
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Ribonucleosides / chemical synthesis*
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Ribonucleosides / pharmacology
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S-Adenosylhomocysteine / analogs & derivatives
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S-Adenosylhomocysteine / chemistry*
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S-Adenosylhomocysteine / pharmacology
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Triazines / chemical synthesis*
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Triazines / pharmacology
Substances
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Enzyme Inhibitors
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Indans
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Ribonucleosides
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Triazines
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S-Adenosylhomocysteine
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Methyltransferases
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S-adenosylmethionine-erythromycin O-methyltransferase