Abstract
Amidino-phenoxy quinoline derivatives represent a new class of potent thrombin inhibitors with good selectivity and remarkably low molecular weight (M(W): 335-391). X-ray analyses of thrombin-bound inhibitors revealed that enzyme inhibition is mainly based on hydrophobic interactions.
MeSH terms
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Amidines / chemical synthesis*
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Amidines / pharmacology
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Chemical Phenomena
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Chemistry, Physical
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Crystallography, X-Ray
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Drug Design
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Fibrinolysin / antagonists & inhibitors
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Fibrinolytic Agents / chemical synthesis*
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Fibrinolytic Agents / pharmacology*
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Heterocyclic Compounds / chemical synthesis*
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Heterocyclic Compounds / pharmacology*
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Humans
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In Vitro Techniques
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Indicators and Reagents
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Models, Molecular
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Molecular Weight
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Partial Thromboplastin Time
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Quinolines / chemical synthesis*
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Quinolines / pharmacology
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Thrombin / antagonists & inhibitors*
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Trypsin Inhibitors / chemical synthesis
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Trypsin Inhibitors / pharmacology
Substances
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Amidines
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Fibrinolytic Agents
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Heterocyclic Compounds
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Indicators and Reagents
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Quinolines
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Trypsin Inhibitors
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amidino-phenoxy quinoline
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Thrombin
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Fibrinolysin