6-aryl-pyrazolo[3,4-b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3)

Bioorg Med Chem Lett. 2003 Sep 15;13(18):3055-7. doi: 10.1016/s0960-894x(03)00645-0.

Abstract

A novel series of 6-aryl-pyrazolo[3,4-b]pyridines has been identified that are potent inhibitors of glycogen synthase kinase-3 (GSK-3).

MeSH terms

  • Animals
  • Binding Sites
  • Enzyme Inhibitors / chemical synthesis
  • Enzyme Inhibitors / pharmacology
  • Glycogen Synthase Kinase 3 / antagonists & inhibitors*
  • Humans
  • Inhibitory Concentration 50
  • Pyridines / chemical synthesis*
  • Pyridines / pharmacology
  • Structure-Activity Relationship
  • Water

Substances

  • Enzyme Inhibitors
  • Pyridines
  • Water
  • Glycogen Synthase Kinase 3