Abstract
A series of alpha-amino acids were identified as ligands which compete with gabapentin for binding to the alpha(2)delta subunit of voltage-dependent Ca(2+) channels. Potent analogs were identified. Their activity in an in vivo pain assay is described.
MeSH terms
-
Amino Acids / chemistry*
-
Animals
-
Benzene / chemistry
-
Calcium Channel Blockers / chemistry*
-
Calcium Channel Blockers / pharmacology*
-
Calcium Channels / chemistry*
-
Calcium Channels / metabolism*
-
Ligands
-
Molecular Structure
-
Pain / drug therapy
-
Pain / metabolism
-
Protein Subunits / metabolism
-
Rats
-
Structure-Activity Relationship
Substances
-
Amino Acids
-
Calcium Channel Blockers
-
Calcium Channels
-
Ligands
-
Protein Subunits
-
Benzene