Abstract
Four new phorbol derivatives, 12-O-[(2R)-N,N-dimethyl-3-methylbutanoyl]-4-deoxyphorbol 13-acetate (1), 12-O-[(2S)-N,N-dimethyl-3-methylbutanoyl]-4-deoxyphorbol 13-acetate (2), 12-O-[3-methyl-2-butenoyl]-4-deoxyphorbol 13-acetate (3), and 12-O-[(2R)-N,N-dimethyl-3-methylbutanoyl]phorbol 13-acetate (4), along with six known compounds, were isolated from the aerial parts of Croton ciliatoglandulifer. An anti-inflammatory activity of a hexane extract of this plant was demonstrated against ear edema in mice produced by 12-O-tetradecanoylphorbol 13-acetate, and compounds 1, 4, and 3beta-O-acetyloleanolic acid (5) were active when evaluated against cyclooxygenases-1 and -2.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Anti-Inflammatory Agents, Non-Steroidal / chemistry
-
Anti-Inflammatory Agents, Non-Steroidal / isolation & purification*
-
Anti-Inflammatory Agents, Non-Steroidal / pharmacology
-
Croton / chemistry*
-
Cyclooxygenase 1 / drug effects
-
Cyclooxygenase 2 / drug effects
-
Cyclooxygenase 2 Inhibitors / chemistry
-
Cyclooxygenase 2 Inhibitors / isolation & purification*
-
Cyclooxygenase 2 Inhibitors / pharmacology
-
Disease Models, Animal
-
Ear
-
Edema / chemically induced
-
Edema / drug therapy
-
Mexico
-
Mice
-
Nitrogen / chemistry*
-
Phorbol Esters / chemistry
-
Phorbol Esters / isolation & purification*
-
Phorbol Esters / pharmacology
-
Plants, Medicinal / chemistry*
-
Tetradecanoylphorbol Acetate / pharmacology
Substances
-
Anti-Inflammatory Agents, Non-Steroidal
-
Cyclooxygenase 2 Inhibitors
-
Phorbol Esters
-
Cyclooxygenase 1
-
Cyclooxygenase 2
-
Nitrogen
-
Tetradecanoylphorbol Acetate