Conformationally restricted tricyclic antidepressants. 1. Octahydrodibenzazepinonaphthyridines as rigid imipramine analogues

J Med Chem. 1980 Aug;23(8):865-73. doi: 10.1021/jm00182a011.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antidepressive Agents, Tricyclic / chemical synthesis*
  • Brain / metabolism
  • Dibenzazepines / chemical synthesis*
  • Dibenzazepines / pharmacology
  • Imipramine / analogs & derivatives
  • Imipramine / chemical synthesis
  • In Vitro Techniques
  • Male
  • Mice
  • Models, Molecular
  • Naphthyridines / chemical synthesis*
  • Naphthyridines / pharmacology
  • Norepinephrine / metabolism
  • Rats
  • Receptors, Adrenergic, alpha / drug effects
  • Receptors, Dopamine / drug effects
  • Receptors, Muscarinic / drug effects
  • Serotonin / metabolism
  • Stereoisomerism
  • Structure-Activity Relationship
  • Synaptosomes / metabolism

Substances

  • Antidepressive Agents, Tricyclic
  • Dibenzazepines
  • Naphthyridines
  • Receptors, Adrenergic, alpha
  • Receptors, Dopamine
  • Receptors, Muscarinic
  • Serotonin
  • Imipramine
  • Norepinephrine