Synthesis and discovery of novel hexacyclic cage compounds as inhibitors of acetylcholinesterase

Raju Suresh Kumar; Mohamed Ashraf Ali; Hasnah Osman; Rusli Ismail; Tan Soo Choon; Yeong Keng Yoon; Ang Chee Wei; Suresh Pandian; Elumalai Manogaran

doi:10.1016/j.bmcl.2011.05.003

Synthesis and discovery of novel hexacyclic cage compounds as inhibitors of acetylcholinesterase

Bioorg Med Chem Lett. 2011 Jul 1;21(13):3997-4000. doi: 10.1016/j.bmcl.2011.05.003. Epub 2011 May 8.

Authors

Raju Suresh Kumar¹, Mohamed Ashraf Ali, Hasnah Osman, Rusli Ismail, Tan Soo Choon, Yeong Keng Yoon, Ang Chee Wei, Suresh Pandian, Elumalai Manogaran

Affiliation

¹ School of Chemical Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia.

PMID: 21621414
DOI: 10.1016/j.bmcl.2011.05.003

Abstract

Hexacyclic derivatives share vital pharmacological properties, considered useful in Alzheimer's disease. The aim of this study was synthesis and its evaluation for acetyl cholinesterase inhibitory activity of novel hexacyclic analogues. Compound 4f, showed potent inhibitory activity against acetyl cholinesterase enzyme with IC(50) 0.72 μmol/L.

MeSH terms

Acetylcholinesterase / chemistry
Cholinesterase Inhibitors / chemical synthesis*
Cholinesterase Inhibitors / chemistry
Cholinesterase Inhibitors / pharmacology
Drug Discovery*
Heterocyclic Compounds, 4 or More Rings / chemical synthesis*
Heterocyclic Compounds, 4 or More Rings / chemistry
Heterocyclic Compounds, 4 or More Rings / pharmacology
Humans
Inhibitory Concentration 50
Molecular Structure

Substances

Cholinesterase Inhibitors
Heterocyclic Compounds, 4 or More Rings
Acetylcholinesterase