Abstract
A Pseudomonas aeruginosa isolate recovered in Belgium produced a novel extended-spectrum ss-lactamase, BEL-2, differing from BEL-1 by a single Leu162Phe substitution. That modification significantly altered the kinetic properties of the enzyme, increasing its affinity for expanded-spectrum cephalosporins. The bla(BEL-2) gene was identified from a P. aeruginosa isolate clonally related to another bla(BEL-1)-positive isolate.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Belgium
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Cephalosporinase / genetics
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Cephalosporinase / metabolism*
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Cephalosporins / pharmacology*
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Cross Infection / microbiology
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Escherichia coli / genetics
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Genes, Bacterial / genetics
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Humans
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Kinetics
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Microbial Sensitivity Tests
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Pseudomonas Infections / microbiology
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Pseudomonas aeruginosa / drug effects*
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Pseudomonas aeruginosa / enzymology*
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Pseudomonas aeruginosa / genetics
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beta-Lactamases / genetics*
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beta-Lactamases / metabolism*
Substances
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Cephalosporins
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Cephalosporinase
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beta-Lactamases
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beta-lactamase BEL-2, Pseudomonas aeruginosa