BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design

J Med Chem. 2000 Sep 21;43(19):3482-6. doi: 10.1021/jm0002679.
No abstract available

MeSH terms

  • Acids, Carbocyclic
  • Administration, Oral
  • Animals
  • Antiviral Agents / chemical synthesis*
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology
  • Catalytic Domain
  • Crystallography, X-Ray
  • Cyclopentanes / chemical synthesis*
  • Cyclopentanes / chemistry
  • Cyclopentanes / pharmacology
  • Drug Design
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology
  • Guanidines
  • Influenza A virus / enzymology*
  • Influenza B virus / enzymology*
  • Mice
  • Models, Molecular
  • Neuraminidase / antagonists & inhibitors*
  • Orthomyxoviridae Infections / drug therapy*
  • Protein Binding
  • Stereoisomerism
  • Structure-Activity Relationship

Substances

  • Acids, Carbocyclic
  • Antiviral Agents
  • Cyclopentanes
  • Enzyme Inhibitors
  • Guanidines
  • Neuraminidase
  • peramivir