A new series of C3-aza carbocyclic influenza neuraminidase inhibitors: synthesis and inhibitory activity

W Lew; H Wu; D B Mendel; P A Escarpe; X Chen; W G Laver; B J Graves; C U Kim

doi:10.1016/s0960-894x(98)00587-3

A new series of C3-aza carbocyclic influenza neuraminidase inhibitors: synthesis and inhibitory activity

Bioorg Med Chem Lett. 1998 Dec 1;8(23):3321-4. doi: 10.1016/s0960-894x(98)00587-3.

Authors

W Lew¹, H Wu, D B Mendel, P A Escarpe, X Chen, W G Laver, B J Graves, C U Kim

Affiliation

¹ Gilead Sciences Inc., Foster City, CA 94404, USA.

PMID: 9873727
DOI: 10.1016/s0960-894x(98)00587-3

Abstract

The synthesis and influenza neuraminidase inhibitory activity of a new series of C3-aza carbocyclic neuraminidase inhibitors are described. Analogues 3c and 3j, bearing a 3-pentyl group, exhibit influenza A inhibitory activities comparable to that of 1.

MeSH terms

Antiviral Agents / chemical synthesis*
Antiviral Agents / pharmacology
Aza Compounds / chemical synthesis*
Aza Compounds / pharmacology
Enzyme Inhibitors / chemical synthesis*
Enzyme Inhibitors / pharmacology
Neuraminidase / antagonists & inhibitors*
Neuraminidase / chemistry
Orthomyxoviridae / drug effects*
Orthomyxoviridae / enzymology
Structure-Activity Relationship

Substances

Antiviral Agents
Aza Compounds
Enzyme Inhibitors
Neuraminidase