Direct renin inhibitors as a new therapy for hypertension

J Med Chem. 2010 Nov 11;53(21):7490-520. doi: 10.1021/jm901885s.
No abstract available

Publication types

  • Review

MeSH terms

  • Animals
  • Antihypertensive Agents / chemistry*
  • Antihypertensive Agents / pharmacology
  • Binding Sites
  • Crystallography, X-Ray
  • Drug Design
  • Drug Evaluation, Preclinical
  • Humans
  • Hypertension / drug therapy*
  • Models, Molecular
  • Molecular Structure
  • Peptidomimetics / chemistry*
  • Peptidomimetics / pharmacology
  • Piperidines / chemistry
  • Piperidines / pharmacology
  • Prorenin Receptor
  • Receptors, Cell Surface / agonists
  • Receptors, Cell Surface / metabolism
  • Renin / antagonists & inhibitors*
  • Renin / metabolism
  • Structure-Activity Relationship

Substances

  • Antihypertensive Agents
  • Peptidomimetics
  • Piperidines
  • Receptors, Cell Surface
  • Renin
  • Prorenin Receptor