2. Apoptosis
  3. Necroptosis
  4. AG311

AG311 is an anticancer and antimetastatic agent. AG311 induces rapid necrosis in numerous cancer cell lines.

For research use only. We do not sell to patients.

AG311 Chemical Structure

AG311 Chemical Structure

CAS No. : 1126602-42-3

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AG311 Related Antibodies

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Description

AG311 is an anticancer and antimetastatic agent. AG311 induces rapid necrosis in numerous cancer cell lines[1].

In Vitro

AG311 (0-30 μM; 48 h) shows cytotoxicity against cancer cells[1].
AG311 (10-40 μM; 0-150 min) selectively induces membrane permeabilization in breast cancer cells (compared to HUVECs)[1].
AG311 (25 μM; 20 min) induces necrosis and lacks molecular markers of apoptosis in MDA-MB-435 cells[1].
AG311 (15-25 μM) affects calcium homeostasis and induces plasma membrane depolarization in MDA-MB-435 cells[1].
AG311 (5-20 μM) induces rapid mitochondrial membrane changes and mitochondrial dysfunction in MDA-MB-435 cells[1].
AG311 (0-14 μM; 30 h) inhibits breast cancer cell migration[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AG311 Related Antibodies

Cell Viability Assay[1]

Cell Line: MDA-MB-435, MDA-MB-468, MDA-MB-231, MCF7, PANC-1, A375, U251, SH-SY5Y, A431, B16F10, COLO-205, DU145, HUVEC and HDF
Concentration:
Incubation Time: 48 h
Result: The IC50 value for MDA-MB-435 (BLBC) was 13.9 μM. In other breast cancer cell lines, had similar (MDA-MB-468 and MCF7) or lower (MDA-MB-231) IC50 values compared with MDAMB-435. was least potent on noncancerous human dermal fibroblasts HDF (IC50 29.3 μM), suggesting a level of selectivity.

Cell Migration Assay [1]

Cell Line: 4T1-luc2-GFP TNBC cells
Concentration: 0, 8, 10, 12, 14 μM
Incubation Time: 30 h
Result: Significantly inhibited cell migration at multiple subtoxic doses in 4T1-luc2-GFP cells.
In Vivo

AG311 (23 mM; intratumoral; once daily for 2 days) increases necrosis in mice[1].
AG311 (45 mg/kg; i.p.; twice weekly for 30 days) inhibits tumor growth and lung metastases in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/cJ mice, 4T1 Triple Negative Orthotopic Allograft[1]
Dosage: 23 mM, 1/15 of tumor volume
Administration: Intratumoral injection, once daily for 2 days
Result: Injected tumors had a significantly higher percentage of necrosis compared with their control-treated counterparts.
Animal Model: 7-week-old female NCr nu/nu athymic mice, MDA-MB-435 Orthotopic Xenograft[1]
Dosage: 45 mg/kg
Administration: Intraperitoneal injection, twice weekly for 30 days
Result: Significantly reduced primary tumor growth. Animals had fewer lung metastases at the end of the experiment compared with control-treated animals.
Molecular Weight

321.40

Formula

C17H15N5S
CAS No.
SMILES

NC1=NC(N)=C2C(NC3=C2C(SC4=CC=C(C=C4)C)=CC=C3)=N1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AG311 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AG3111126602-42-3AG 311AG-311NecroptosisMDA-MB-435MDA-MB-468MDA-MB-231MCF7PANC-1A375U251SH-SY5YA431B16F10COLO-205DU145Inhibitorinhibitorinhibit

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