RF 9
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RF 9

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RF 9 is a potent and selective Neuropeptide FF receptor antagonist, with Kis of 58±5 and 75±9 nM for hNPFF1R and hNPFF2R, respectively. It displays selectivity over several related receptors including NPY Y1 GPR10, GPR54, GPR103 and the opioid receptors.

Category
Peptide Inhibitors
Catalog number
BAT-010204
CAS number
876310-60-0
Molecular Formula
C26H38N6O3
Molecular Weight
482.62
RF 9
IUPAC Name
N-[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]adamantane-1-carboxamide
Synonyms
2-Adamantanecarbonyl-Arg-Phe-NH2
Purity
≥96%
Density
1.42±0.1 g/cm3(Predicted)
Sequence
Unk-Arg-Phe-NH2
Storage
Store at -20°C
Solubility
Soluble in DMSO, Water
InChI
InChI=1S/C26H38N6O3/c27-22(33)21(12-16-5-2-1-3-6-16)31-23(34)20(7-4-8-30-25(28)29)32-24(35)26-13-17-9-18(14-26)11-19(10-17)15-26/h1-3,5-6,17-21H,4,7-15H2,(H2,27,33)(H,31,34)(H,32,35)(H4,28,29,30)
InChI Key
UMKHUSRDQFQHAK-RNJMTYCLSA-N
Canonical SMILES
C1C2CC3CC1CC(C2)(C3)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC4=CC=CC=C4)C(=O)N
1.Trifluoroacetic acid catalyzed highly regioselective bromocyclization of styrene-type carboxylic acid.
Chen T1, Yeung YY2. Org Biomol Chem. 2016 Apr 29. [Epub ahead of print]
A trifluoroacetic acid catalyzed highly 6-endo regioselective bromocyclization of styrene-type carboxylic acid has been developed. The resulting 3,4-dihydroisocoumarines are valuable building blocks in organic synthesis.
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