2MD 

2MD is an orally active vitamin D analog. 2MD stimulates periosteal bone formation and decreases trabecular bone resorption. Thus 2MD restores trabecular and cortical bone mass and strength. 2MD also regulates intraocular pressure (IOP)-relative genes and reduces IOP in non-human primates^[1][2].

2MD (5 μg/eye; instillation; single dose) decreases the IOP gradually by 20% in the ipsilateral eye and 15% or less in the contralateral eye after 7-8 h in cynomolgus monkey eyes in vivo^[1].
2MD (0.5-10 ng/kg, 0,1 mL/day; p.o.; once daily for 16 weeks) not only restores both trabecular and cortical bone mass, but also increases bone mass and strength in osteopenic ovariectomized (OVX) rats by stimulating bone formation on the periosteal surface and decreasing bone resorption on the trabecular surface in rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

416.64

C₂₇H₄₄O₃

213250-70-5

C[C@@]12[C@](CC[C@]2([H])[C@@H](C)CCCC(C)(O)C)([H])/C(CCC1)=C/C=C3C[C@H](C([C@@H](C\3)O)=C)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kutuzova GD, et al. 1α,25-Dihydroxyvitamin D(3) and its analog, 2-methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D(3) (2MD), suppress intraocular pressure in non-human primates. Arch Biochem Biophys. 2012 Feb 1;518(1):53-60.  [Content Brief]

  [2]. Ke HZ, et al. A new vitamin D analog, 2MD, restores trabecular and cortical bone mass and strength in ovariectomized rats with established osteopenia. J Bone Miner Res. 2005 Oct;20(10):1742-55.  [Content Brief]