2. Protein Tyrosine Kinase/RTK
  3. Anaplastic lymphoma kinase (ALK)
  4. M4K2234

M4K2234 (compound 26b) is an ALK2 inhibitor. M4K2234 inhibits ALK2 and ALK5 with IC50s of 5 and 2144 nM, respectively. M4K2234 can be used as a chemical probe for ALK1 and ALK2 protein kinases. M4K2234 can be used for the research of cancer.

For research use only. We do not sell to patients.

M4K2234 Chemical Structure

M4K2234 Chemical Structure

CAS No. : 2421141-51-5

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 153 In-stock
Solution
10 mM * 1 mL in DMSO USD 153 In-stock
Solid
5 mg USD 150 In-stock
10 mg USD 240 In-stock
25 mg USD 480 In-stock
50 mg USD 770 In-stock
100 mg USD 1250 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

M4K2234 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

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Description

M4K2234 (compound 26b) is an ALK2 inhibitor. M4K2234 inhibits ALK2 and ALK5 with IC50s of 5 and 2144 nM, respectively. M4K2234 can be used as a chemical probe for ALK1 and ALK2 protein kinases. M4K2234 can be used for the research of cancer[1].

IC50 & Target

IC50: 5 nM (ALK2 WT), 3 nM (ALK2 G328V), 6 nM (ALK2 R206H), 6 nM (ALK2 R258G), 2144 nM (ALK5)[1]
In Vitro

M4K2234 (0-5 μM) shows inhibitory effects against WT and DIPG-linked mutant forms of ALK2 with IC50s of 5, 3, 6 and 6 nM for WT, G328V, R206H and R258G, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

M4K2234 Related Antibodies
In Vivo

1.19 Pharmacokinetic Properties of M4K2234 in Mice [1].

Mice
PO 3 mg/kg
Cmax(ng/mL) 1650
AUCinf(ng·h/mL) 4630
t1/2(h) 2.61

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

462.56

Formula

C27H31FN4O2
CAS No.
Appearance

Solid

Color

Light brown to brown

SMILES

O=C(C1=C(C=C(C2=CN=CC(C3=CC=C(N4CCN(C(C)C)CC4)C=C3)=C2C)C=C1OC)F)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (216.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1619 mL 10.8094 mL 21.6188 mL
5 mM 0.4324 mL 2.1619 mL 4.3238 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.71%

COA (245 KB) HNMR (277 KB) LCMS (95 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1619 mL 10.8094 mL 21.6188 mL 54.0470 mL
5 mM 0.4324 mL 2.1619 mL 4.3238 mL 10.8094 mL
10 mM 0.2162 mL 1.0809 mL 2.1619 mL 5.4047 mL
15 mM 0.1441 mL 0.7206 mL 1.4413 mL 3.6031 mL
20 mM 0.1081 mL 0.5405 mL 1.0809 mL 2.7024 mL
25 mM 0.0865 mL 0.4324 mL 0.8648 mL 2.1619 mL
30 mM 0.0721 mL 0.3603 mL 0.7206 mL 1.8016 mL
40 mM 0.0540 mL 0.2702 mL 0.5405 mL 1.3512 mL
50 mM 0.0432 mL 0.2162 mL 0.4324 mL 1.0809 mL
60 mM 0.0360 mL 0.1802 mL 0.3603 mL 0.9008 mL
80 mM 0.0270 mL 0.1351 mL 0.2702 mL 0.6756 mL
100 mM 0.0216 mL 0.1081 mL 0.2162 mL 0.5405 mL
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M4K2234 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

M4K22342421141-51-5Anaplastic lymphoma kinase (ALK)Anaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246cancerFOPDIPGchemical probeDIPG-linked mutantmiceInhibitorinhibitorinhibit

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