2. Metabolic Enzyme/Protease
  3. SGK
  4. SI-113

SI-113 is a SGK1 inhibitor, with an IC50 of 600 nM. SI113 induces autophagy.

For research use only. We do not sell to patients.

SI-113 Chemical Structure

SI-113 Chemical Structure

CAS No. : 1392816-46-4

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10 mg USD 175 In-stock
25 mg USD 320 In-stock
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Based on 1 publication(s) in Google Scholar

SI-113 Related Antibodies

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Description

SI-113 is a SGK1 inhibitor, with an IC50 of 600 nM. SI113 induces autophagy[1][2].

In Vitro

SI-113 exhibits IC50 values of 10.5, 14.4 and 10.7 μM in GIN8, GIN28 and GCE28 GBM cells[1].
SI-113 induces significant increases in caspase-3/7 activation in all GBM cell lines[1].
SI-113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SI-113 Related Antibodies
Molecular Weight

400.48

Formula

C23H24N6O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OCCNC1=NC(NCCC2=CC=CC=C2)=C3C(N(/C=C/C4=CC=CC=C4)N=C3)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (624.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4970 mL 12.4850 mL 24.9700 mL
5 mM 0.4994 mL 2.4970 mL 4.9940 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4970 mL 12.4850 mL 24.9700 mL 62.4251 mL
5 mM 0.4994 mL 2.4970 mL 4.9940 mL 12.4850 mL
10 mM 0.2497 mL 1.2485 mL 2.4970 mL 6.2425 mL
15 mM 0.1665 mL 0.8323 mL 1.6647 mL 4.1617 mL
20 mM 0.1249 mL 0.6243 mL 1.2485 mL 3.1213 mL
25 mM 0.0999 mL 0.4994 mL 0.9988 mL 2.4970 mL
30 mM 0.0832 mL 0.4162 mL 0.8323 mL 2.0808 mL
40 mM 0.0624 mL 0.3121 mL 0.6243 mL 1.5606 mL
50 mM 0.0499 mL 0.2497 mL 0.4994 mL 1.2485 mL
60 mM 0.0416 mL 0.2081 mL 0.4162 mL 1.0404 mL
80 mM 0.0312 mL 0.1561 mL 0.3121 mL 0.7803 mL
100 mM 0.0250 mL 0.1249 mL 0.2497 mL 0.6243 mL
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SI-113 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SI-1131392816-46-4SI113SI 113SGKSerum-glucocorticoid regulated kinaseSerum and glucocorticoid-regulated kinaseSGK1GIN8GIN28GBM cellcaspase-3caspase-7autophagyglioblastomaInhibitorinhibitorinhibit

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