2. Cell Cycle/DNA Damage Epigenetics
  3. PARP
  4. PARP10/15-IN-1

PARP10/15-IN-1 (compound 8l) is a potent inhibitor of dual inhibitor of PARP10 and PARP15, with IC50s of 160 nM and 370 nM, respectively. PARP10/15-IN-1 can be used for cancer.

For research use only. We do not sell to patients.

PARP10/15-IN-1 Chemical Structure

PARP10/15-IN-1 Chemical Structure

CAS No. : 2892065-01-7

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Based on 1 publication(s) in Google Scholar

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Description

PARP10/15-IN-1 (compound 8l) is a potent inhibitor of dual inhibitor of PARP10 and PARP15, with IC50s of 160 nM and 370 nM, respectively. PARP10/15-IN-1 can be used for cancer[1].

IC50 & Target[1]

PARP10

160 nM (IC50)

PARP15

370 nM (IC50)

Molecular Weight

274.30

Formula

C13H10N2O3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1NNC(C2=C1C=CC(OCC3=CSC=C3)=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (91.14 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6456 mL 18.2282 mL 36.4564 mL
5 mM 0.7291 mL 3.6456 mL 7.2913 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6456 mL 18.2282 mL 36.4564 mL 91.1411 mL
5 mM 0.7291 mL 3.6456 mL 7.2913 mL 18.2282 mL
10 mM 0.3646 mL 1.8228 mL 3.6456 mL 9.1141 mL
15 mM 0.2430 mL 1.2152 mL 2.4304 mL 6.0761 mL
20 mM 0.1823 mL 0.9114 mL 1.8228 mL 4.5571 mL
25 mM 0.1458 mL 0.7291 mL 1.4583 mL 3.6456 mL
30 mM 0.1215 mL 0.6076 mL 1.2152 mL 3.0380 mL
40 mM 0.0911 mL 0.4557 mL 0.9114 mL 2.2785 mL
50 mM 0.0729 mL 0.3646 mL 0.7291 mL 1.8228 mL
60 mM 0.0608 mL 0.3038 mL 0.6076 mL 1.5190 mL
80 mM 0.0456 mL 0.2279 mL 0.4557 mL 1.1393 mL
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PARP10/15-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PARP10/15-IN-12892065-01-7PARPpoly ADP ribose polymerasePARP10PARP15cancerInhibitorinhibitorinhibit

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