Galectin-3 antagonist 1

Name: Galectin-3 antagonist 1
Brand: MedChemExpress
SKU: HY-146808
Rating: 4.5 (1 reviews)

Cat. No.: HY-146808 Purity: 99.77%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Galectin-3 antagonist 1 (compound 15) is a potent and selective Galectin-3 (Gal-3) antagonist with K_d value of 5.3 μM. Meanwhile, Galectin-3 antagonist 1 binds to various Galectin with K_d values of 250 μM (Gal-4N), 18 μM (Gal-4C), 450 μM (Gal-8C), respectively.

For research use only. We do not sell to patients.

Galectin-3 antagonist 1 Chemical Structure

CAS No. : 2921603-03-2

Size	Price	Stock	Quantity
5 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 600	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1150	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1800	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2850	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Galectin-3

Molecular Weight

495.86

Formula

C₂₂H₂₂ClNO₁₀

CAS No.

2921603-03-2

Appearance

Solid

Color

White to off-white

SMILES

OC[C@H]1O[C@@H](OC)[C@@H](OC(C2=C([N+]([O-])=O)C=C(Cl)C=C2)=O)[C@@H](OC(C3=CC=C(C)C=C3)=O)[C@H]1O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (201.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0167 mL	10.0835 mL	20.1670 mL
5 mM	0.4033 mL	2.0167 mL	4.0334 mL
10 mM	0.2017 mL	1.0083 mL	2.0167 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (5.04 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (5.04 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.77%

Select Batch:

Data Sheet (275 KB) SDS (251 KB)

COA (254 KB) HNMR (283 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Bum-Erdene K, et al. Novel Selective Galectin-3 Antagonists Are Cytotoxic to Acute Lymphoblastic Leukemia. J Med Chem. 2022 Apr 28;65(8):5975-5989. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0167 mL	10.0835 mL	20.1670 mL	50.4175 mL
	5 mM	0.4033 mL	2.0167 mL	4.0334 mL	10.0835 mL
	10 mM	0.2017 mL	1.0083 mL	2.0167 mL	5.0417 mL
	15 mM	0.1344 mL	0.6722 mL	1.3445 mL	3.3612 mL
	20 mM	0.1008 mL	0.5042 mL	1.0083 mL	2.5209 mL
	25 mM	0.0807 mL	0.4033 mL	0.8067 mL	2.0167 mL
	30 mM	0.0672 mL	0.3361 mL	0.6722 mL	1.6806 mL
	40 mM	0.0504 mL	0.2521 mL	0.5042 mL	1.2604 mL
	50 mM	0.0403 mL	0.2017 mL	0.4033 mL	1.0083 mL
	60 mM	0.0336 mL	0.1681 mL	0.3361 mL	0.8403 mL
	80 mM	0.0252 mL	0.1260 mL	0.2521 mL	0.6302 mL
	100 mM	0.0202 mL	0.1008 mL	0.2017 mL	0.5042 mL