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Found 47 with Last Name = 'abbate' and Initial = 's'
TargetAromatase(Homo sapiens (Human))
University Of Bath

LigandPNGBDBM24317(4-[(R)-(3-bromo-4-hydroxyphenyl)(1H-1,2,4-triazol-...)
Affinity DataIC50:  0.600nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bath

LigandPNGBDBM13061(4,4 -(1H-1,2,4-triazol-1-ylmethanediyl)dibenzonitr...)
Affinity DataIC50:  0.890nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSteryl-sulfatase(Homo sapiens (Human))
University Of Bath

LigandPNGBDBM13058(6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-...)
Affinity DataIC50:  1.5nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of sulfatase activities was assessed using intact monolayers of JEG-3 cells. Sulfatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bath

LigandPNGBDBM24316(4-[(3-bromo-4-hydroxyphenyl)(1H-1,2,4-triazol-1-yl...)
Affinity DataIC50:  1.80nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bath

LigandPNGBDBM24306(Letrozole derivative, 40 | {2-bromo-4-[(4-cyanophe...)
Affinity DataIC50:  3nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bath

LigandPNGBDBM24307(Letrozole derivative, 40a R-(+) | {2-bromo-4-[(R)-...)
Affinity DataIC50:  3.20nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bath

LigandPNGBDBM24318(4-[(S)-(3-bromo-4-hydroxyphenyl)(1H-1,2,4-triazol-...)
Affinity DataIC50:  3.40nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bath

LigandPNGBDBM24315(4-[(3-chloro-4-hydroxyphenyl)(1H-1,2,4-triazol-1-y...)
Affinity DataIC50:  5.5nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bath

LigandPNGBDBM24314(4-[(4-hydroxyphenyl)(1H-1,2,4-triazol-1-yl)methyl]...)
Affinity DataIC50:  7.20nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bath

LigandPNGBDBM24311(2-bromo-4-[(3-bromo-4-hydroxyphenyl)(1H-1,2,4-tria...)
Affinity DataIC50:  10nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bath

LigandPNGBDBM24305(Letrozole derivative, 34 | {2-chloro-4-[(4-cyanoph...)
Affinity DataIC50:  12nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bath

LigandPNGBDBM24304(Letrozole derivative, 28 | {4-[(4-cyanophenyl)(1H-...)
Affinity DataIC50:  13nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bath

LigandPNGBDBM24308(Letrozole derivative, 40b S-(-) | {2-bromo-4-[(S)-...)
Affinity DataIC50:  14.3nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bath

LigandPNGBDBM24301((2-bromo-4-{[3-bromo-4-(sulfamoyloxy)phenyl](1H-1,...)
Affinity DataIC50:  43nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bath

LigandPNGBDBM24300((3-{[3-(sulfamoyloxy)phenyl](1H-1,2,4-triazol-1-yl...)
Affinity DataIC50:  99nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Genova

Curated by ChEMBL
LigandPNGBDBM50577800(CHEMBL4853419)
Affinity DataIC50:  160nMAssay Description:Inhibition of C-terminal 6His-tagged human PDE4D3 expressed in baculovirus infected Sf9 insect cells assessed as reduction in 5'-AMP formation using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bath

LigandPNGBDBM24312(5-[(3-hydroxy-4-methoxyphenyl)(1H-1,2,4-triazol-1-...)
Affinity DataIC50:  169nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bath

LigandPNGBDBM24310(4-[(4-hydroxyphenyl)(1H-1,2,4-triazol-1-yl)methyl]...)
Affinity DataIC50:  178nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bath

LigandPNGBDBM24313(4-[(4-hydroxy-3-methoxyphenyl)(1H-1,2,4-triazol-1-...)
Affinity DataIC50:  215nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bath

LigandPNGBDBM13058(6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-...)
Affinity DataIC50:  300nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Genova

Curated by ChEMBL
LigandPNGBDBM50577801(CHEMBL4862157)
Affinity DataIC50:  470nMAssay Description:Inhibition of C-terminal 6His-tagged human PDE4D3 expressed in baculovirus infected Sf9 insect cells assessed as reduction in 5'-AMP formation using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
University Of Bath

LigandPNGBDBM24301((2-bromo-4-{[3-bromo-4-(sulfamoyloxy)phenyl](1H-1,...)
Affinity DataIC50:  476nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of sulfatase activities was assessed using intact monolayers of JEG-3 cells. Sulfatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
University Of Bath

LigandPNGBDBM24308(Letrozole derivative, 40b S-(-) | {2-bromo-4-[(S)-...)
Affinity DataIC50:  553nMAssay Description:The extent of in vitro inhibition of sulfatase activities was assessed using intact monolayers of JEG-3 cells. Sulfatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Genova

Curated by ChEMBL
LigandPNGBDBM50577804(CHEMBL4852484)
Affinity DataIC50:  720nMAssay Description:Inhibition of C-terminal 6His-tagged human PDE4D3 expressed in baculovirus infected Sf9 insect cells assessed as reduction in 5'-AMP formation using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
University Of Bath

LigandPNGBDBM24305(Letrozole derivative, 34 | {2-chloro-4-[(4-cyanoph...)
Affinity DataIC50:  920nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of sulfatase activities was assessed using intact monolayers of JEG-3 cells. Sulfatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Genova

Curated by ChEMBL
LigandPNGBDBM50577805(CHEMBL4876286)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of C-terminal 6His-tagged human PDE4D3 expressed in baculovirus infected Sf9 insect cells assessed as reduction in 5'-AMP formation using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bath

LigandPNGBDBM24309(3-[(3-hydroxyphenyl)(1H-1,2,4-triazol-1-yl)methyl]...)
Affinity DataIC50:  2.46E+3nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Genova

Curated by ChEMBL
LigandPNGBDBM50577801(CHEMBL4862157)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of C-terminal 6His-tagged human PDE4D catalytic domain (244 to 578 residues) expressed in Escherichia coli BL21(DE3) pLysS cells assessed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
University Of Bath

LigandPNGBDBM24306(Letrozole derivative, 40 | {2-bromo-4-[(4-cyanophe...)
Affinity DataIC50:  2.60E+3nMAssay Description:The extent of in vitro inhibition of sulfatase activities was assessed using intact monolayers of JEG-3 cells. Sulfatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Genova

Curated by ChEMBL
LigandPNGBDBM50577800(CHEMBL4853419)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of C-terminal 6His-tagged human PDE4D catalytic domain (244 to 578 residues) expressed in Escherichia coli BL21(DE3) pLysS cells assessed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bath

LigandPNGBDBM13062((4-{[4-(sulfamoyloxy)phenyl](1H-1,2,4-triazol-1-yl...)
Affinity DataIC50:  3.04E+3nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Genova

Curated by ChEMBL
LigandPNGBDBM50577803(CHEMBL4868872)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of C-terminal 6His-tagged human PDE4D3 expressed in baculovirus infected Sf9 insect cells assessed as reduction in 5'-AMP formation using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Genova

Curated by ChEMBL
LigandPNGBDBM50577805(CHEMBL4876286)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibition of C-terminal 6His-tagged human PDE4D catalytic domain (244 to 578 residues) expressed in Escherichia coli BL21(DE3) pLysS cells assessed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Genova

Curated by ChEMBL
LigandPNGBDBM50577803(CHEMBL4868872)
Affinity DataIC50:  4.60E+3nMAssay Description:Inhibition of C-terminal 6His-tagged human PDE4D catalytic domain (244 to 578 residues) expressed in Escherichia coli BL21(DE3) pLysS cells assessed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
University Of Bath

LigandPNGBDBM24307(Letrozole derivative, 40a R-(+) | {2-bromo-4-[(R)-...)
Affinity DataIC50:  4.63E+3nMAssay Description:The extent of in vitro inhibition of sulfatase activities was assessed using intact monolayers of JEG-3 cells. Sulfatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Genova

Curated by ChEMBL
LigandPNGBDBM50577804(CHEMBL4852484)
Affinity DataIC50:  6.90E+3nMAssay Description:Inhibition of C-terminal 6His-tagged human PDE4D catalytic domain (244 to 578 residues) expressed in Escherichia coli BL21(DE3) pLysS cells assessed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
University Of Bath

LigandPNGBDBM13062((4-{[4-(sulfamoyloxy)phenyl](1H-1,2,4-triazol-1-yl...)
Affinity DataIC50: >1.00E+4nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of sulfatase activities was assessed using intact monolayers of JEG-3 cells. Sulfatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Genova

Curated by ChEMBL
LigandPNGBDBM50299569(3-(cyclopentyloxy)-4-methoxybenzaldehyde O-[2-(2,6...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of C-terminal 6His-tagged human PDE4D3 expressed in baculovirus infected Sf9 insect cells assessed as reduction in 5'-AMP formation using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Genova

Curated by ChEMBL
LigandPNGBDBM50577802(CHEMBL4862518)
Affinity DataIC50:  1.12E+4nMAssay Description:Inhibition of C-terminal 6His-tagged human PDE4D3 expressed in baculovirus infected Sf9 insect cells assessed as reduction in 5'-AMP formation using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Genova

Curated by ChEMBL
LigandPNGBDBM50299569(3-(cyclopentyloxy)-4-methoxybenzaldehyde O-[2-(2,6...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of C-terminal 6His-tagged human PDE4D catalytic domain (244 to 578 residues) expressed in Escherichia coli BL21(DE3) pLysS cells assessed ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Genova

Curated by ChEMBL
LigandPNGBDBM50577802(CHEMBL4862518)
Affinity DataIC50:  3.31E+4nMAssay Description:Inhibition of C-terminal 6His-tagged human PDE4D catalytic domain (244 to 578 residues) expressed in Escherichia coli BL21(DE3) pLysS cells assessed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bath

LigandPNGBDBM24303((2-methoxy-4-{[3-methoxy-4-(sulfamoyloxy)phenyl](1...)
Affinity DatapH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bath

LigandPNGBDBM24302((2-methoxy-5-{[4-methoxy-3-(sulfamoyloxy)phenyl](1...)
Affinity DatapH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
University Of Bath

LigandPNGBDBM24303((2-methoxy-4-{[3-methoxy-4-(sulfamoyloxy)phenyl](1...)
Affinity DatapH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of sulfatase activities was assessed using intact monolayers of JEG-3 cells. Sulfatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
University Of Bath

LigandPNGBDBM24302((2-methoxy-5-{[4-methoxy-3-(sulfamoyloxy)phenyl](1...)
Affinity DatapH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of sulfatase activities was assessed using intact monolayers of JEG-3 cells. Sulfatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
University Of Bath

LigandPNGBDBM24300((3-{[3-(sulfamoyloxy)phenyl](1H-1,2,4-triazol-1-yl...)
Affinity DatapH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of sulfatase activities was assessed using intact monolayers of JEG-3 cells. Sulfatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
University Of Bath

LigandPNGBDBM24304(Letrozole derivative, 28 | {4-[(4-cyanophenyl)(1H-...)
Affinity DatapH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of sulfatase activities was assessed using intact monolayers of JEG-3 cells. Sulfatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed