TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: <1nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: <1nMAssay Description:Displacement of [33P]S1P from S1P1 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Displacement of [33P]S1P from S1P1 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Agonist activity at S1P5 receptor (unknown origin) expressed in CHO cell membranes after 30 mins by GTPgammaS binding based MFB methodMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Displacement of [33P]S1P from S1P1 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
TargetPhenylalanine--tRNA ligase alpha/beta subunit(Escherichia coli (Enterobacteria))
Astrazeneca R&D Boston
Astrazeneca R&D Boston
Affinity DataIC50: 2.20nMpH: 8.0Assay Description:Compounds were solubilized in DMSO. Serial 2-fold dilutions covering two concentration ranges, 10 mM to 19.5 μM and 100 μM to 195 nM, were ...More data for this Ligand-Target Pair
TargetPhenylalanine--tRNA ligase alpha/beta subunit(Escherichia coli (Enterobacteria))
Astrazeneca R&D Boston
Astrazeneca R&D Boston
Affinity DataIC50: 2.70nMpH: 8.0Assay Description:Compounds were solubilized in DMSO. Serial 2-fold dilutions covering two concentration ranges, 10 mM to 19.5 μM and 100 μM to 195 nM, were ...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Displacement of [33P]S1P from S1P3 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
TargetG protein-coupled receptor kinase 6(Homo sapiens (Human))
Ontario Institute For Cancer Research
Curated by ChEMBL
Ontario Institute For Cancer Research
Curated by ChEMBL
Affinity DataIC50: 3.5nMAssay Description:Inhibition of recombinant full-length human GRK6 using casein as substrate measured after 80 mins in presence of [gamma33P]ATP by radiometric scintil...More data for this Ligand-Target Pair
TargetG protein-coupled receptor kinase 6(Homo sapiens (Human))
Ontario Institute For Cancer Research
Curated by ChEMBL
Ontario Institute For Cancer Research
Curated by ChEMBL
Affinity DataIC50: 3.80nMAssay Description:Inhibition of human GRK6 using casein as substrate in presence of [gamma33P]ATP by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Agonist activity at S1P5 receptor (unknown origin) expressed in CHO cell membranes after 30 mins by GTPgammaS binding based MFB methodMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Displacement of [33P]S1P from S1P1 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
TargetG protein-coupled receptor kinase 6(Homo sapiens (Human))
Ontario Institute For Cancer Research
Curated by ChEMBL
Ontario Institute For Cancer Research
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant full-length human GRK6 using casein as substrate measured after 80 mins in presence of [gamma33P]ATP by radiometric scintil...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
TargetRhodopsin kinase GRK7(Homo sapiens (Human))
Ontario Institute For Cancer Research
Curated by ChEMBL
Ontario Institute For Cancer Research
Curated by ChEMBL
Affinity DataIC50: 6.40nMAssay Description:Inhibition of recombinant full length human GRK7 using casein as substrate incubated for 40 mins in presence of [gamma-33ATP] by scintillation counti...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Agonist activity at S1P5 receptor (unknown origin) expressed in CHO cell membranes after 30 mins by GTPgammaS binding based MFB methodMore data for this Ligand-Target Pair
TargetG protein-coupled receptor kinase 6(Homo sapiens (Human))
Ontario Institute For Cancer Research
Curated by ChEMBL
Ontario Institute For Cancer Research
Curated by ChEMBL
Affinity DataIC50: 7.20nMAssay Description:Inhibition of recombinant full-length human GRK6 using casein as substrate measured after 80 mins in presence of [gamma33P]ATP by radiometric scintil...More data for this Ligand-Target Pair
TargetG protein-coupled receptor kinase 6(Homo sapiens (Human))
Ontario Institute For Cancer Research
Curated by ChEMBL
Ontario Institute For Cancer Research
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant full-length human GRK6 using casein as substrate measured after 80 mins in presence of [gamma33P]ATP by radiometric scintil...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Agonist activity at S1P5 receptor (unknown origin) expressed in CHO cell membranes after 30 mins by GTPgammaS binding based MFB methodMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Agonist activity at S1P5 receptor (unknown origin) expressed in CHO cell membranes after 30 mins by GTPgammaS binding based MFB methodMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
TargetG protein-coupled receptor kinase 6(Homo sapiens (Human))
Ontario Institute For Cancer Research
Curated by ChEMBL
Ontario Institute For Cancer Research
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant full-length human GRK6 using casein as substrate measured after 80 mins in presence of [gamma33P]ATP by radiometric scintil...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB ...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]PGD2 from human CRTH2 receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant full length human Aurora A using LRRASLG as substrate incubated for 40 mins in presence of [gamma-33ATP] by radiometric sci...More data for this Ligand-Target Pair
TargetG protein-coupled receptor kinase 6(Homo sapiens (Human))
Ontario Institute For Cancer Research
Curated by ChEMBL
Ontario Institute For Cancer Research
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant full-length human GRK6 using casein as substrate measured after 80 mins in presence of [gamma33P]ATP by radiometric scintil...More data for this Ligand-Target Pair
TargetG protein-coupled receptor kinase 5(Homo sapiens (Human))
Ontario Institute For Cancer Research
Curated by ChEMBL
Ontario Institute For Cancer Research
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant full length human GRK5 using casein as substrate incubated for 40 mins in presence of [gamma-33ATP] by scintillation counti...More data for this Ligand-Target Pair