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Found 128 with Last Name = 'abouzid' and Initial = 'kam'
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of ROS1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  0.254nMAssay Description:Inhibition of recombinant His-tagged human FLT3 D835Y mutant (564 to 958 residues) expressed in baculovirus expression system by LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  0.259nMAssay Description:Inhibition of recombinant N-terminal GST/His6-tagged human FLT3 ITD mutant (571 to 993 residues) expressed in insect cells by LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50596396(CHEMBL5201174)
Affinity DataIC50:  0.290nMAssay Description:Inhibition of FLT3 autophosphorylation in human RS4-11 cells measured after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM4779(CHEMBL31965 | CHEMBL545315 | CI-1033 | Canertinib ...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of GST-tagged human EGFR catalytic domain expressed in insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Affinity DataIC50:  0.370nMAssay Description:Inhibition of ABL (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50406868(BIBW2992 | CHEMBL2347958)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human EGFR L858R mutant expressed in mouse Ba/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM4779(CHEMBL31965 | CHEMBL545315 | CI-1033 | Canertinib ...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human EGFR L858R mutant expressed in mouse Ba/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50406868(BIBW2992 | CHEMBL2347958)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of GST-tagged human EGFR catalytic domain expressed in insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50204093(BAY 80-6946 | BAY-80-6946 | Copanlisib)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50468245(AV-412 | CHEMBL2138625 | MP-412)
Affinity DataIC50:  0.510nMAssay Description:Inhibition of human EGFR L858R mutant expressed in mouse Ba/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50204093(BAY 80-6946 | BAY-80-6946 | Copanlisib)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM185674(4-[4-[(5-tert-butyl-2-quinolin-6-ylpyrazol-3-yl)ca...)
Affinity DataIC50:  0.75nMAssay Description:Inhibition of ABL (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50468245(AV-412 | CHEMBL2138625 | MP-412)
Affinity DataIC50:  0.790nMAssay Description:Inhibition of human EGFR T790M mutant expressed in mouse Ba/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  1nMAssay Description:Inhibition of TrkC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  1nMAssay Description:Inhibition of TrkB (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  1nMAssay Description:Inhibition of TrkA (unknown origin)More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of FLT3-ITD autophosphorylation in human MV4-11 cells measured after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM185149(1-[2-[5-[(3-methyloxetan-3-yl)methoxy]benzimidazol...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of FLT3-ITD autophosphorylation in human MV4-11 cells measured after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50468245(AV-412 | CHEMBL2138625 | MP-412)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of GST-tagged human EGFR catalytic domain expressed in insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50596396(CHEMBL5201174)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of FLT3-D835Y autophosphorylation in human MV4-11 cells measured after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50596396(CHEMBL5201174)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of FLT3-ITD autophosphorylation in human MV4-11 cells measured after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM185674(4-[4-[(5-tert-butyl-2-quinolin-6-ylpyrazol-3-yl)ca...)
Affinity DataIC50:  2nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM185149(1-[2-[5-[(3-methyloxetan-3-yl)methoxy]benzimidazol...)
Affinity DataIC50:  2nMAssay Description:Inhibition of FLT3 autophosphorylation in human RS4-11 cells measured after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50468247(HM 781-36B | HM-781-36B | NOV-120101 | Poziotinib ...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of human EGFR T790M/L858R mutant expressed in mouse Ba/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50468245(AV-412 | CHEMBL2138625 | MP-412)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human EGFR T790M/L858R mutant expressed in mouse Ba/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of FLT3-ITD (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataIC50:  3nMAssay Description:Inhibition of FLT3-WT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataIC50:  3nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataIC50:  3nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50468247(HM 781-36B | HM-781-36B | NOV-120101 | Poziotinib ...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of GST-tagged human EGFR catalytic domain expressed in insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50204093(BAY 80-6946 | BAY-80-6946 | Copanlisib)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of FLT3 autophosphorylation in human RS4-11 cells measured after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50468247(HM 781-36B | HM-781-36B | NOV-120101 | Poziotinib ...)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of human EGFR T790M mutant expressed in mouse Ba/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50515042(CHEMBL4593398)
Affinity DataIC50:  5nMAssay Description:Inhibition of FLT3 (unknown origin) autophosphorylation measured after 3 hrs by multi-mode microplate readerMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM136597(US10005783, 14 | US10047097, 14 | US10774085, Exam...)
Affinity DataIC50:  5nMAssay Description:Inhibition of TrkA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM136597(US10005783, 14 | US10047097, 14 | US10774085, Exam...)
Affinity DataIC50:  5nMAssay Description:Inhibition of TrkB (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50315213(2-(difluoromethyl)-1-(4,6-dimorpholin-4-yl-1,3,5-t...)
Affinity DataIC50:  5nMAssay Description:Competitive inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM136597(US10005783, 14 | US10047097, 14 | US10774085, Exam...)
Affinity DataIC50:  5nMAssay Description:Inhibition of TrkC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50468247(HM 781-36B | HM-781-36B | NOV-120101 | Poziotinib ...)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of GST-tagged human HER2 catalytic domain expressed in insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM185674(4-[4-[(5-tert-butyl-2-quinolin-6-ylpyrazol-3-yl)ca...)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of TrkA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  5.80nMAssay Description:Inhibition of recombinant His-tagged human TrKA expressed in baculovirus expression system by LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM112499(DACOMITINIB | US8623883, No. 2 | WO2022090481, Exa...)
Affinity DataIC50:  6nMAssay Description:Inhibition of GST-tagged human EGFR catalytic domain expressed in insect cellsMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50204093(BAY 80-6946 | BAY-80-6946 | Copanlisib)
Affinity DataIC50:  6.40nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM185149(1-[2-[5-[(3-methyloxetan-3-yl)methoxy]benzimidazol...)
Affinity DataIC50:  6.90nMAssay Description:Inhibition of FLT3-D835Y autophosphorylation in human MV4-11 cells measured after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50519385(SAR-245409 | SAR245409 | Voxtalisib | XL-765 | XL7...)
Affinity DataIC50:  9nMAssay Description:Inhibition of PI3K p110gamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM5445(CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapa...)
Affinity DataIC50:  9.20nMAssay Description:Inhibition of HER2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50468248(CHEMBL4290869)
Affinity DataIC50:  9.80nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50406868(BIBW2992 | CHEMBL2347958)
Affinity DataIC50:  10nMAssay Description:Inhibition of human EGFR T790M/L858R mutant expressed in mouse Ba/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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