TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Ain Shams University
Curated by ChEMBL
Ain Shams University
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of ROS1 (unknown origin)More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Ain Shams University
Curated by ChEMBL
Ain Shams University
Curated by ChEMBL
Affinity DataIC50: 0.254nMAssay Description:Inhibition of recombinant His-tagged human FLT3 D835Y mutant (564 to 958 residues) expressed in baculovirus expression system by LanthaScreen assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Ain Shams University
Curated by ChEMBL
Ain Shams University
Curated by ChEMBL
Affinity DataIC50: 0.259nMAssay Description:Inhibition of recombinant N-terminal GST/His6-tagged human FLT3 ITD mutant (571 to 993 residues) expressed in insect cells by LanthaScreen assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Ain Shams University
Curated by ChEMBL
Ain Shams University
Curated by ChEMBL
Affinity DataIC50: 0.290nMAssay Description:Inhibition of FLT3 autophosphorylation in human RS4-11 cells measured after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of GST-tagged human EGFR catalytic domain expressed in insect cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.370nMAssay Description:Inhibition of ABL (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human EGFR L858R mutant expressed in mouse Ba/F3 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human EGFR L858R mutant expressed in mouse Ba/F3 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of GST-tagged human EGFR catalytic domain expressed in insect cellsMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Ain Shams University
Curated by ChEMBL
Ain Shams University
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.510nMAssay Description:Inhibition of human EGFR L858R mutant expressed in mouse Ba/F3 cellsMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Ain Shams University
Curated by ChEMBL
Ain Shams University
Curated by ChEMBL
Affinity DataIC50: 0.700nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.75nMAssay Description:Inhibition of ABL (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.790nMAssay Description:Inhibition of human EGFR T790M mutant expressed in mouse Ba/F3 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of TrkC (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of TrkB (unknown origin)More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Ain Shams University
Curated by ChEMBL
Ain Shams University
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of TrkA (unknown origin)More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Ain Shams University
Curated by ChEMBL
Ain Shams University
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of FLT3-ITD autophosphorylation in human MV4-11 cells measured after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Ain Shams University
Curated by ChEMBL
Ain Shams University
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Inhibition of FLT3-ITD autophosphorylation in human MV4-11 cells measured after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Inhibition of GST-tagged human EGFR catalytic domain expressed in insect cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Ain Shams University
Curated by ChEMBL
Ain Shams University
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of FLT3-D835Y autophosphorylation in human MV4-11 cells measured after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Ain Shams University
Curated by ChEMBL
Ain Shams University
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of FLT3-ITD autophosphorylation in human MV4-11 cells measured after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Ain Shams University
Curated by ChEMBL
Ain Shams University
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Ain Shams University
Curated by ChEMBL
Ain Shams University
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of FLT3 autophosphorylation in human RS4-11 cells measured after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human EGFR T790M/L858R mutant expressed in mouse Ba/F3 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human EGFR T790M/L858R mutant expressed in mouse Ba/F3 cellsMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Ain Shams University
Curated by ChEMBL
Ain Shams University
Curated by ChEMBL
Affinity DataIC50: 2.80nMAssay Description:Inhibition of FLT3-ITD (unknown origin)More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Ain Shams University
Curated by ChEMBL
Ain Shams University
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of FLT3-WT (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Ain Shams University
Curated by ChEMBL
Ain Shams University
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Ain Shams University
Curated by ChEMBL
Ain Shams University
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3.20nMAssay Description:Inhibition of GST-tagged human EGFR catalytic domain expressed in insect cellsMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Ain Shams University
Curated by ChEMBL
Ain Shams University
Curated by ChEMBL
Affinity DataIC50: 3.70nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Ain Shams University
Curated by ChEMBL
Ain Shams University
Curated by ChEMBL
Affinity DataIC50: 4.20nMAssay Description:Inhibition of FLT3 autophosphorylation in human RS4-11 cells measured after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 4.20nMAssay Description:Inhibition of human EGFR T790M mutant expressed in mouse Ba/F3 cellsMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Ain Shams University
Curated by ChEMBL
Ain Shams University
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of FLT3 (unknown origin) autophosphorylation measured after 3 hrs by multi-mode microplate readerMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Ain Shams University
Curated by ChEMBL
Ain Shams University
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of TrkA (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of TrkB (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Ain Shams University
Curated by ChEMBL
Ain Shams University
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Competitive inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of TrkC (unknown origin)More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Ain Shams University
Curated by ChEMBL
Ain Shams University
Curated by ChEMBL
Affinity DataIC50: 5.30nMAssay Description:Inhibition of GST-tagged human HER2 catalytic domain expressed in insect cellsMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Ain Shams University
Curated by ChEMBL
Ain Shams University
Curated by ChEMBL
Affinity DataIC50: 5.5nMAssay Description:Inhibition of TrkA (unknown origin)More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Ain Shams University
Curated by ChEMBL
Ain Shams University
Curated by ChEMBL
Affinity DataIC50: 5.80nMAssay Description:Inhibition of recombinant His-tagged human TrKA expressed in baculovirus expression system by LanthaScreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of GST-tagged human EGFR catalytic domain expressed in insect cellsMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Ain Shams University
Curated by ChEMBL
Ain Shams University
Curated by ChEMBL
Affinity DataIC50: 6.40nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Ain Shams University
Curated by ChEMBL
Ain Shams University
Curated by ChEMBL
Affinity DataIC50: 6.90nMAssay Description:Inhibition of FLT3-D835Y autophosphorylation in human MV4-11 cells measured after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Ain Shams University
Curated by ChEMBL
Ain Shams University
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of PI3K p110gamma (unknown origin)More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Ain Shams University
Curated by ChEMBL
Ain Shams University
Curated by ChEMBL
Affinity DataIC50: 9.20nMAssay Description:Inhibition of HER2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 9.80nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of human EGFR T790M/L858R mutant expressed in mouse Ba/F3 cellsMore data for this Ligand-Target Pair