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Found 471 with Last Name = 'acher' and Initial = 'fc'
TargetMetabotropic glutamate receptor 1(RAT)
Parc Club Orsay Universit£

Curated by ChEMBL
LigandPNGBDBM17660((2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl...)
Affinity DataKi:  10nMAssay Description:Binding affinity at Metabotropic glutamate receptor 1More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Parc Club Orsay Universit£

Curated by ChEMBL
LigandPNGBDBM50056272((1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dic...)
Affinity DataKi:  13nMAssay Description:Binding affinity at Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Parc Club Orsay Universit£

Curated by ChEMBL
LigandPNGBDBM50034503((1R,2R)-3-((S)-Amino-carboxy-methyl)-cyclopropane-...)
Affinity DataKi:  110nMAssay Description:Binding affinity at Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Parc Club Orsay Universit£

Curated by ChEMBL
LigandPNGBDBM26431((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)
Affinity DataKi:  340nMAssay Description:Binding affinity at Metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Parc Club Orsay Universit£

Curated by ChEMBL
LigandPNGBDBM50007548((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Affinity DataKi:  470nMAssay Description:Binding affinity at Metabotropic glutamate receptor 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Parc Club Orsay Universit£

Curated by ChEMBL
LigandPNGBDBM50079183((2S)-amino(3,5-dihydroxyphenyl)ethanoic acid | (S)...)
Affinity DataKi:  900nMAssay Description:Binding affinity at Metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Parc Club Orsay Universit£

Curated by ChEMBL
LigandPNGBDBM26431((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)
Affinity DataKi:  1.20E+3nMAssay Description:Binding affinity at Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Parc Club Orsay Universit£

Curated by ChEMBL
LigandPNGBDBM26431((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)
Affinity DataKi:  1.60E+3nMAssay Description:Binding affinity at Metabotropic glutamate receptor 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Parc Club Orsay Universit£

Curated by ChEMBL
LigandPNGBDBM50053588((S)-4-(amino(carboxy)methyl)benzoic acid | (S)-4-c...)
Affinity DataKi:  3.70E+3nMAssay Description:Binding affinity at Metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSialin(Homo sapiens)
Universit£

Curated by ChEMBL
LigandPNGBDBM50545752(CHEMBL4646356)
Affinity DataKi:  7.80E+3nMAssay Description:Non-competitive inhibition of human recombinant-Sialin expressed in HEK293 cells assessed as reduction in [3H]Neu5Ac uptake incubated for 15 mins by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSialin(Homo sapiens)
Universit£

Curated by ChEMBL
LigandPNGBDBM115093((2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-met...)
Affinity DataKi:  1.02E+4nMAssay Description:Non-competitive inhibition of human recombinant-Sialin expressed in HEK293 cells assessed as reduction in [3H]Neu5Ac uptake incubated for 15 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSialin(Homo sapiens)
Universit£

Curated by ChEMBL
LigandPNGBDBM50286804((R)-2-[(R)-2-{(S)-2-[(Azepane-1-carbonyl)-amino]-4...)
Affinity DataKi:  2.00E+4nMAssay Description:Inhibition of human recombinant-Sialin expressed in HEK293 cells assessed as reduction in [3H]Neu5Ac uptake at 30 to 300 uM incubated for 15 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Parc Club Orsay Universit£

Curated by ChEMBL
LigandPNGBDBM50174519((3aR,5R,6aR)-5-Amino-4,5,6,6a-tetrahydro-3aH-cyclo...)
Affinity DataKi:  3.30E+4nMAssay Description:Binding affinity for mGluR1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Parc Club Orsay Universit£

Curated by ChEMBL
LigandPNGBDBM50174516(5-Amino-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxa...)
Affinity DataKi:  9.40E+4nMAssay Description:Binding affinity for mGluR1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Parc Club Orsay Universit£

Curated by ChEMBL
LigandPNGBDBM50174516(5-Amino-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxa...)
Affinity DataKi:  9.40E+4nMAssay Description:Binding affinity for mGluR1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Parc Club Orsay Universit£

Curated by ChEMBL
LigandPNGBDBM50130516((+/-)-(3aS*,5R*,6aS*)-5-amino-4,5,6,6a-tetrahydro-...)
Affinity DataKi:  9.50E+4nMAssay Description:Binding affinity for mGluR1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Parc Club Orsay Universit£

Curated by ChEMBL
LigandPNGBDBM17660((2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl...)
Affinity DataKi:  1.12E+5nMAssay Description:Binding affinity at Metabotropic glutamate receptor 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Parc Club Orsay Universit£

Curated by ChEMBL
LigandPNGBDBM17660((2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl...)
Affinity DataKi:  1.13E+5nMAssay Description:Binding affinity at Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Parc Club Orsay Universit£

Curated by ChEMBL
LigandPNGBDBM50007548((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Affinity DataKi:  1.29E+5nMAssay Description:Binding affinity at Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Parc Club Orsay Universit£

Curated by ChEMBL
LigandPNGBDBM50053588((S)-4-(amino(carboxy)methyl)benzoic acid | (S)-4-c...)
Affinity DataKi:  8.38E+5nMAssay Description:Binding affinity at Metabotropic glutamate receptor 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
Università

Curated by ChEMBL
LigandPNGBDBM50130515((3aS,5S,6aS)-5-Amino-4,5,6,6a-tetrahydro-3aH-cyclo...)
Affinity DataKi: >1.00E+6nMAssay Description:Binding affinity for mGluR4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
Università

Curated by ChEMBL
LigandPNGBDBM50130516((+/-)-(3aS*,5R*,6aS*)-5-amino-4,5,6,6a-tetrahydro-...)
Affinity DataKi: >1.00E+6nMAssay Description:Binding affinity for mGluR4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Parc Club Orsay Universit£

Curated by ChEMBL
LigandPNGBDBM50130515((3aS,5S,6aS)-5-Amino-4,5,6,6a-tetrahydro-3aH-cyclo...)
Affinity DataKi: >1.00E+6nMAssay Description:Binding affinity for mGluR2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
Università

Curated by ChEMBL
LigandPNGBDBM50174519((3aR,5R,6aR)-5-Amino-4,5,6,6a-tetrahydro-3aH-cyclo...)
Affinity DataKi: >1.00E+6nMAssay Description:Binding affinity for mGluR4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Parc Club Orsay Universit£

Curated by ChEMBL
LigandPNGBDBM50174517(5-(2-Amino-2-carboxy-ethyl)-4,5-dihydro-isoxazole-...)
Affinity DataKi: >1.00E+6nMAssay Description:Binding affinity for mGluR1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Parc Club Orsay Universit£

Curated by ChEMBL
LigandPNGBDBM50174517(5-(2-Amino-2-carboxy-ethyl)-4,5-dihydro-isoxazole-...)
Affinity DataKi: >1.00E+6nMAssay Description:Binding affinity for mGluR2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Parc Club Orsay Universit£

Curated by ChEMBL
LigandPNGBDBM50174515((3aR,5S,6aR)-5-Amino-4,5,6,6a-tetrahydro-3aH-cyclo...)
Affinity DataKi: >1.00E+6nMAssay Description:Binding affinity for mGluR2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Parc Club Orsay Universit£

Curated by ChEMBL
LigandPNGBDBM50174515((3aR,5S,6aR)-5-Amino-4,5,6,6a-tetrahydro-3aH-cyclo...)
Affinity DataKi: >1.00E+6nMAssay Description:Binding affinity for mGluR1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
Università

Curated by ChEMBL
LigandPNGBDBM50174517(5-(2-Amino-2-carboxy-ethyl)-4,5-dihydro-isoxazole-...)
Affinity DataKi: >1.00E+6nMAssay Description:Binding affinity for mGluR4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
Università

Curated by ChEMBL
LigandPNGBDBM50174516(5-Amino-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxa...)
Affinity DataKi: >1.00E+6nMAssay Description:Binding affinity for mGluR4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Parc Club Orsay Universit£

Curated by ChEMBL
LigandPNGBDBM50130515((3aS,5S,6aS)-5-Amino-4,5,6,6a-tetrahydro-3aH-cyclo...)
Affinity DataKi: >1.00E+6nMAssay Description:Binding affinity for mGluR1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
Università

Curated by ChEMBL
LigandPNGBDBM50174515((3aR,5S,6aR)-5-Amino-4,5,6,6a-tetrahydro-3aH-cyclo...)
Affinity DataKi: >1.00E+6nMAssay Description:Binding affinity for mGluR4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Parc Club Orsay Universit£

Curated by ChEMBL
LigandPNGBDBM50079183((2S)-amino(3,5-dihydroxyphenyl)ethanoic acid | (S)...)
Affinity DataKi: >1.00E+6nMAssay Description:Binding affinity at Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Parc Club Orsay Universit£

Curated by ChEMBL
LigandPNGBDBM50007548((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Affinity DataKi: >1.00E+6nMAssay Description:Binding affinity at Metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Parc Club Orsay Universit£

Curated by ChEMBL
LigandPNGBDBM50076389((1S,2S)-2-[(R)-Amino-carboxy-(9-methyl-9H-xanthen-...)
Affinity DataIC50:  34nMAssay Description:Inhibitory activity of the compound against human Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50083351((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)
Affinity DataIC50:  190nMAssay Description:Antagonist activity at wild type NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of agonist-induced current amplitude by two-el...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Parc Club Orsay Universit£

Curated by ChEMBL
LigandPNGBDBM50049748((2S,4S)-2-Amino-4-(4,4-diphenyl-butyl)-pentanedioi...)
Affinity DataIC50:  400nMAssay Description:Inhibitory activity of the compound against human Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50482632(CHEMBL1223786)
Affinity DataIC50:  1.65E+3nMAssay Description:Antagonist activity at wild type NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of agonist-induced current amplitude by two-el...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50482631(CHEMBL1223841)
Affinity DataIC50:  1.80E+3nMAssay Description:Antagonist activity at wild type NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of agonist-induced current amplitude by two-el...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSialin(Homo sapiens)
Universit£

Curated by ChEMBL
LigandPNGBDBM50545752(CHEMBL4646356)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of human recombinant-Sialin expressed in HEK293 cells assessed as reduction in [3H]Neu5Ac uptake at 30 to 300 uM incubated for 15 mins by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50482630(CHEMBL1223722)
Affinity DataIC50:  2.70E+3nMAssay Description:Antagonist activity at wild type NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of agonist-induced current amplitude by two-el...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Parc Club Orsay Universit£

Curated by ChEMBL
LigandPNGBDBM50069111((2S,4S)-2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioi...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibitory activity of the compound against human Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVesicular acetylcholine transporter(Rattus norvegicus)
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50111606(4,5,6,7-tetrachloro-2',4',5',7'-tetraiodo-3-oxospi...)
Affinity DataIC50:  9.70E+3nMAssay Description:Inhibition of VACHT in rat synaptic vesicles assessed as [3H]HT uptake pretreated for 30 mins measured after 10 mins by scintillation spectrophotomet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Parc Club Orsay Universit£

Curated by ChEMBL
LigandPNGBDBM50076393((1S,2S,3R)-2-((S)-Amino-carboxy-methyl)-3-phenyl-c...)
Affinity DataIC50:  9.90E+3nMAssay Description:Inhibitory activity of the compound against Metabotropic glutamate receptor 2 in the rat HEK 293 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50482628(CHEMBL1223842)
Affinity DataIC50:  1.10E+4nMAssay Description:Antagonist activity at wild type NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of agonist-induced current amplitude by two-el...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50482629(CHEMBL1223845)
Affinity DataIC50:  1.30E+4nMAssay Description:Antagonist activity at wild type NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of agonist-induced current amplitude by two-el...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSialin(Homo sapiens)
Universit£

Curated by ChEMBL
LigandPNGBDBM115093((2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-met...)
Affinity DataIC50:  2.33E+4nMAssay Description:Inhibition of human recombinant-Sialin expressed in HEK293 cells assessed as reduction in [3H]Neu5Ac uptake at 30 to 300 uM incubated for 15 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Parc Club Orsay Universit£

Curated by ChEMBL
LigandPNGBDBM50052256((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibitory activity of the compound against Metabotropic glutamate receptor 1 in the rat LLC-PK1/HEK 293 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Parc Club Orsay Universit£

Curated by ChEMBL
LigandPNGBDBM50053585((S)-4-(amino(carboxy)methyl)-2-hydroxybenzoic acid...)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibitory activity of the compound against Metabotropic glutamate receptor 1 in the rat LLC-PK1/HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Parc Club Orsay Universit£

Curated by ChEMBL
LigandPNGBDBM50076392((1S,2S)-2-((S)-1-Amino-1-carboxy-ethyl)-cyclopropa...)
Affinity DataIC50:  7.70E+4nMAssay Description:Inhibitory activity of the compound against Metabotropic glutamate receptor 2 in the rat HEK 293 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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