Affinity DataKi: 170nM ΔG°: -38.2kJ/mole IC50: 390nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...More data for this Ligand-Target Pair
Affinity DataKi: 400nM ΔG°: -36.2kJ/mole IC50: 500nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...More data for this Ligand-Target Pair
Affinity DataKi: 740nM ΔG°: -34.6kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...More data for this Ligand-Target Pair
Affinity DataKi: 1.18E+3nM ΔG°: -33.5kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...More data for this Ligand-Target Pair
Affinity DataKi: 1.85E+3nM ΔG°: -32.4kJ/mole IC50: 890nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...More data for this Ligand-Target Pair
Affinity DataKi: 4.50E+3nM ΔG°: -30.2kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Università
Curated by ChEMBL
Università
Curated by ChEMBL
TargetHistone deacetylase 1(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Inhibition of HDAC 1 in human HeLa nuclear extract using HDAC substrate-3 measured after 60 mins by fluorometric analysisMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Affinity DataIC50: 211nMAssay Description:Inhibition of HDAC 8 in human HeLa nuclear extract using fluorogenic HDAC class 2A substrate measured after 60 mins by fluorometric analysisMore data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Affinity DataIC50: 261nMAssay Description:Inhibition of HDAC 3 in human HeLa nuclear extract using HDAC substrate-3 measured after 60 mins by fluorometric analysisMore data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Affinity DataIC50: 268nMAssay Description:Inhibition of HDAC 2 in human HeLa nuclear extract using HDAC substrate-3 measured after 60 mins by fluorometric analysisMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of HDAC 8 in human HeLa nuclear extract using fluorogenic HDAC class 2A substrate measured after 60 mins by fluorometric analysisMore data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Affinity DataIC50: 368nMAssay Description:Inhibition of HDAC 3 in human HeLa nuclear extract using HDAC substrate-3 measured after 60 mins by fluorometric analysisMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Affinity DataIC50: 415nMAssay Description:Inhibition of HDAC 1 in human HeLa nuclear extract using HDAC substrate-3 measured after 60 mins by fluorometric analysisMore data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Affinity DataIC50: 454nMAssay Description:Inhibition of HDAC 2 in human HeLa nuclear extract using HDAC substrate-3 measured after 60 mins by fluorometric analysisMore data for this Ligand-Target Pair
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Affinity DataIC50: 982nMAssay Description:Inhibition of HDAC 10 in human HeLa nuclear extract measured after 60 mins by fluorometric analysisMore data for this Ligand-Target Pair
TargetHistone deacetylase 5(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Affinity DataIC50: 2.18E+3nMAssay Description:Inhibition of HDAC 5 in human HeLa nuclear extract using fluorogenic HDAC class 2A substrate measured after 60 mins by fluorometric analysisMore data for this Ligand-Target Pair
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Università
Curated by ChEMBL
Università
Curated by ChEMBL
Affinity DataIC50: 2.38E+3nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of rat spleen LynMore data for this Ligand-Target Pair
Affinity DataIC50: 3.20E+3nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha/beta/gamma(Homo sapiens (Human))
Università
Curated by ChEMBL
Università
Curated by ChEMBL
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of PKAMore data for this Ligand-Target Pair
Affinity DataIC50: 3.57E+3nMAssay Description:Inhibition of SGKMore data for this Ligand-Target Pair
Affinity DataIC50: 3.60E+3nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...More data for this Ligand-Target Pair
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of rat spleen SYKMore data for this Ligand-Target Pair
TargetHistone deacetylase 5(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Affinity DataIC50: 5.39E+3nMAssay Description:Inhibition of HDAC 5 in human HeLa nuclear extract using fluorogenic HDAC class 2A substrate measured after 60 mins by fluorometric analysisMore data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Affinity DataIC50: 7.12E+3nMAssay Description:Inhibition of HDAC 4 in human HeLa nuclear extract using fluorogenic HDAC class 2A substrate measured after 60 mins by fluorometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of human recombinant GSK3-betaMore data for this Ligand-Target Pair
Affinity DataIC50: 9.40E+3nMAssay Description:Inhibition of rat spleen FGRMore data for this Ligand-Target Pair
Affinity DataIC50: 9.60E+3nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...More data for this Ligand-Target Pair
TargetHistone deacetylase 11(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of HDAC 11 in human HeLa nuclear extract using fluorogenic HDAC class 2A substrate measured after 60 mins by fluorometric analysisMore data for this Ligand-Target Pair
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of HDAC 10 in human HeLa nuclear extract measured after 60 mins by fluorometric analysisMore data for this Ligand-Target Pair
TargetHistone deacetylase 9(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of HDAC 9 in human HeLa nuclear extract using fluorogenic HDAC class 2A substrate measured after 60 mins by fluorometric analysisMore data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of HDAC 4 in human HeLa nuclear extract using fluorogenic HDAC class 2A substrate measured after 60 mins by fluorometric analysisMore data for this Ligand-Target Pair
TargetHistone deacetylase 11(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of HDAC 11 in human HeLa nuclear extract using fluorogenic HDAC class 2A substrate measured after 60 mins by fluorometric analysisMore data for this Ligand-Target Pair
TargetHistone deacetylase 9(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of HDAC 9 in human HeLa nuclear extract using fluorogenic HDAC class 2A substrate measured after 60 mins by fluorometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.03E+4nMAssay Description:Inhibition of MAPKAPK1aMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Università
Curated by ChEMBL
Università
Curated by ChEMBL
Affinity DataIC50: 1.05E+4nMAssay Description:Inhibition of MKK1More data for this Ligand-Target Pair
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of NPM-ALKMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Università
Curated by ChEMBL
Università
Curated by ChEMBL
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of human recombinant DYRK1aMore data for this Ligand-Target Pair
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of rat spleen CSKMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Università
Curated by ChEMBL
Università
Curated by ChEMBL
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of RETMore data for this Ligand-Target Pair
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of FLT3More data for this Ligand-Target Pair