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Found 1934 with Last Name = 'ahn' and Initial = 'b'
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM50095296(CHEMBL3589082 | US9278953, 1)
Affinity DataKi:  2nM ΔG°:  -49.7kJ/molepH: 7.4 T: 2°CAssay Description:Test compounds were half log serially diluted in 100% DMSO (J. T. Baker #922401). 1 uL of each compound was added to appropriate wells of a 384-well ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Julius-Maximilians-UniversitäT WüRzburg

Curated by ChEMBL
LigandPNGBDBM50051672(2-Phenyl-9-((R)-1-phenyl-ethyl)-9H-pyrimido[4,5-b]...)
Affinity DataKi:  2.60nMAssay Description:Radioligand binding assay for [3H]-PIA affinity towards Adenosine A1 receptor of rat cerebral cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM50095295(CHEMBL3589083 | US9278953, 2)
Affinity DataKi:  3.60nM ΔG°:  -48.2kJ/molepH: 7.4 T: 2°CAssay Description:Test compounds were half log serially diluted in 100% DMSO (J. T. Baker #922401). 1 uL of each compound was added to appropriate wells of a 384-well ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Julius-Maximilians-UniversitäT WüRzburg

Curated by ChEMBL
LigandPNGBDBM50014280(5,6-Dimethyl-2-phenyl-7-((S)-1-phenyl-ethyl)-7H-py...)
Affinity DataKi:  4.70nMAssay Description:Radioligand binding assay for [3H]-PIA affinity towards Adenosine A1 receptor of rat cerebral cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Julius-Maximilians-UniversitäT WüRzburg

Curated by ChEMBL
LigandPNGBDBM50051653((5,6-Dimethyl-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-...)
Affinity DataKi:  6.70nMAssay Description:Radioligand binding assay for [3H]-PIA affinity towards Adenosine A1 receptor of rat cerebral cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50424575(CHEMBL2312159)
Affinity DataKi:  7nMAssay Description:Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50393088(CHEMBL2152903)
Affinity DataKi:  7.5nMAssay Description:Inhibition of human recombinant BACE2 using (europium)CEVNLDAEFK(Qsy7) as substrate incubated for 10 mins prior to substrate addition measured after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Julius-Maximilians-UniversitäT WüRzburg

Curated by ChEMBL
LigandPNGBDBM50051657(2-(3-Chloro-phenyl)-5,6-dimethyl-7-((R)-1-phenyl-e...)
Affinity DataKi:  7.60nMAssay Description:Radioligand binding assay for [3H]-PIA affinity towards Adenosine A1 receptor of rat cerebral cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM50095294(CHEMBL3589084 | US9278953, 7)
Affinity DataKi:  7.80nM ΔG°:  -46.3kJ/molepH: 7.4 T: 2°CAssay Description:Test compounds were half log serially diluted in 100% DMSO (J. T. Baker #922401). 1 uL of each compound was added to appropriate wells of a 384-well ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM212596(US9278953, 3)
Affinity DataKi:  9.5nM ΔG°:  -45.8kJ/molepH: 7.4 T: 2°CAssay Description:Test compounds were half log serially diluted in 100% DMSO (J. T. Baker #922401). 1 uL of each compound was added to appropriate wells of a 384-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Julius-Maximilians-UniversitäT WüRzburg

Curated by ChEMBL
LigandPNGBDBM50051660(2-(2-Chloro-phenyl)-5,6-dimethyl-7-((R)-1-phenyl-e...)
Affinity DataKi:  9.60nMAssay Description:Radioligand binding assay for [3H]-PIA affinity towards Adenosine A1 receptor of rat cerebral cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Julius-Maximilians-UniversitäT WüRzburg

Curated by ChEMBL
LigandPNGBDBM82025(1,3-Dipropyl-8-phenylxanthine | 8-Phenyl-1,3-dipro...)
Affinity DataKi:  10nMAssay Description:Binding affinity to A1 adenosine receptor from rat cortical membrane in presence of [3H]-R-(phenylisopropyl)-adenosineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM212598(US9278953, 4)
Affinity DataKi:  11.2nM ΔG°:  -45.4kJ/molepH: 7.4 T: 2°CAssay Description:Test compounds were half log serially diluted in 100% DMSO (J. T. Baker #922401). 1 uL of each compound was added to appropriate wells of a 384-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM212605(US9278953, 9)
Affinity DataKi:  11.9nM ΔG°:  -45.2kJ/molepH: 7.4 T: 2°CAssay Description:Test compounds were half log serially diluted in 100% DMSO (J. T. Baker #922401). 1 uL of each compound was added to appropriate wells of a 384-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM212600(US9278953, 5)
Affinity DataKi:  12.2nM ΔG°:  -45.2kJ/molepH: 7.4 T: 2°CAssay Description:Test compounds were half log serially diluted in 100% DMSO (J. T. Baker #922401). 1 uL of each compound was added to appropriate wells of a 384-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Julius-Maximilians-UniversitäT WüRzburg

Curated by ChEMBL
LigandPNGBDBM50041584(6-Phenyl-1,3-dipropyl-1,5-dihydro-pyrrolo[3,2-d]py...)
Affinity DataKi:  13nMAssay Description:Binding affinity to A1 adenosine receptor from rat cortical membrane in presence of [3H]-R-(phenylisopropyl)-adenosineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM212607(US9278953, 11)
Affinity DataKi:  13.9nM ΔG°:  -44.8kJ/molepH: 7.4 T: 2°CAssay Description:Test compounds were half log serially diluted in 100% DMSO (J. T. Baker #922401). 1 uL of each compound was added to appropriate wells of a 384-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Julius-Maximilians-UniversitäT WüRzburg

Curated by ChEMBL
LigandPNGBDBM50051648(2-Phenyl-9-((R)-1-p-tolyl-ethyl)-9H-pyrimido[4,5-b...)
Affinity DataKi:  14nMAssay Description:Radioligand binding assay for [3H]-PIA affinity towards Adenosine A1 receptor of rat cerebral cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM212604(US9278953, 8)
Affinity DataKi:  14.2nM ΔG°:  -44.8kJ/molepH: 7.4 T: 2°CAssay Description:Test compounds were half log serially diluted in 100% DMSO (J. T. Baker #922401). 1 uL of each compound was added to appropriate wells of a 384-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50424576(CHEMBL2312158)
Affinity DataKi:  15nMAssay Description:Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50424564(CHEMBL2312506)
Affinity DataKi:  18nMAssay Description:Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50424577(CHEMBL2312157)
Affinity DataKi:  18nMAssay Description:Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM212606(US9278953, 10)
Affinity DataKi:  19.9nM ΔG°:  -44.0kJ/molepH: 7.4 T: 2°CAssay Description:Test compounds were half log serially diluted in 100% DMSO (J. T. Baker #922401). 1 uL of each compound was added to appropriate wells of a 384-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50424579(CHEMBL2312156)
Affinity DataKi:  21nMAssay Description:Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Julius-Maximilians-UniversitäT WüRzburg

Curated by ChEMBL
LigandPNGBDBM50051655(2,9-Diphenyl-9H-pyrimido[4,5-b]indol-4-ylamine | C...)
Affinity DataKi:  22nMAssay Description:Radioligand binding assay for [3H]-PIA affinity towards Adenosine A1 receptor of rat cerebral cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM212608(US9278953, 12)
Affinity DataKi:  25nM ΔG°:  -43.4kJ/molepH: 7.4 T: 2°CAssay Description:Test compounds were half log serially diluted in 100% DMSO (J. T. Baker #922401). 1 uL of each compound was added to appropriate wells of a 384-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Julius-Maximilians-UniversitäT WüRzburg

Curated by ChEMBL
LigandPNGBDBM50041579(1,3-Dimethyl-6-naphthalen-2-yl-1,5-dihydro-pyrrolo...)
Affinity DataKi:  26nMAssay Description:Binding affinity to A1 adenosine receptor from rat cortical membrane in presence of [3H]-R-(phenylisopropyl)-adenosineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM212609(US9278953, 14)
Affinity DataKi:  29.2nM ΔG°:  -43.0kJ/molepH: 7.4 T: 2°CAssay Description:Test compounds were half log serially diluted in 100% DMSO (J. T. Baker #922401). 1 uL of each compound was added to appropriate wells of a 384-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM50095293(CHEMBL3589085 | US9278953, 13)
Affinity DataKi:  31.6nM ΔG°:  -42.8kJ/molepH: 7.4 T: 2°CAssay Description:Test compounds were half log serially diluted in 100% DMSO (J. T. Baker #922401). 1 uL of each compound was added to appropriate wells of a 384-well ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50424573(CHEMBL2312161)
Affinity DataKi:  33nMAssay Description:Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Julius-Maximilians-UniversitäT WüRzburg

Curated by ChEMBL
LigandPNGBDBM50041590(6-Phenyl-3-propyl-1,5-dihydro-pyrrolo[3,2-d]pyrimi...)
Affinity DataKi:  39nMAssay Description:Binding affinity to A1 adenosine receptor from rat cortical membrane in presence of [3H]-R-(phenylisopropyl)-adenosineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50424548(CHEMBL2312517)
Affinity DataKi:  41nMAssay Description:Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM212602(US9278953, 6)
Affinity DataKi:  46nM ΔG°:  -41.9kJ/molepH: 7.4 T: 2°CAssay Description:Test compounds were half log serially diluted in 100% DMSO (J. T. Baker #922401). 1 uL of each compound was added to appropriate wells of a 384-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Julius-Maximilians-UniversitäT WüRzburg

Curated by ChEMBL
LigandPNGBDBM50041591(1,3-Dimethyl-6-phenyl-1,5-dihydro-pyrrolo[3,2-d]py...)
Affinity DataKi:  47nMAssay Description:Binding affinity to A1 adenosine receptor from rat cortical membrane in presence of [3H]-R-(phenylisopropyl)-adenosineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50424580(CHEMBL2312516)
Affinity DataKi:  48nMAssay Description:Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Julius-Maximilians-UniversitäT WüRzburg

Curated by ChEMBL
LigandPNGBDBM50051679(2-(4-Chloro-phenyl)-5,6-dimethyl-7-((R)-1-phenyl-e...)
Affinity DataKi:  50nMAssay Description:Radioligand binding assay for [3H]-PIA affinity towards Adenosine A1 receptor of rat cerebral cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50364541(CHEMBL1951011)
Affinity DataKi:  53nMAssay Description:Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Julius-Maximilians-UniversitäT WüRzburg

Curated by ChEMBL
LigandPNGBDBM50051669(2-Phenyl-9-((S)-1-phenyl-ethyl)-9H-pyrimido[4,5-b]...)
Affinity DataKi:  64nMAssay Description:Radioligand binding assay for [3H]-PIA affinity towards Adenosine A1 receptor of rat cerebral cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Julius-Maximilians-UniversitäT WüRzburg

Curated by ChEMBL
LigandPNGBDBM50018152(8-Phenyl-1-propyl-3,7-dihydro-purine-2,6-dione | C...)
Affinity DataKi:  67nMAssay Description:Binding affinity to A1 adenosine receptor from rat cortical membrane in presence of [3H]-R-(phenylisopropyl)-adenosineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50398267(CHEMBL2177304)
Affinity DataKi:  78nMAssay Description:Inhibition of human recombinant BACE2 using (europium)CEVNLDAEFK(Qsy7) as substrate incubated for 10 mins prior to substrate addition measured after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Julius-Maximilians-UniversitäT WüRzburg

Curated by ChEMBL
LigandPNGBDBM50051667(2-(3-Methoxy-phenyl)-5,6-dimethyl-7-((R)-1-phenyl-...)
Affinity DataKi:  83nMAssay Description:Radioligand binding assay for [3H]-PIA affinity towards Adenosine A1 receptor of rat cerebral cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Julius-Maximilians-UniversitäT WüRzburg

Curated by ChEMBL
LigandPNGBDBM82015(1,3-Dimethyl-8-phenyl-3,9-dihydro-purine-2,6-dione...)
Affinity DataKi:  89nMAssay Description:Binding affinity to A1 adenosine receptor from rat cortical membrane in presence of [3H]-R-(phenylisopropyl)-adenosineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50424581(CHEMBL2312515)
Affinity DataKi:  94nMAssay Description:Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Julius-Maximilians-UniversitäT WüRzburg

Curated by ChEMBL
LigandPNGBDBM50041599(3-Methyl-6-phenyl-1,5-dihydro-pyrrolo[3,2-d]pyrimi...)
Affinity DataKi:  97nMAssay Description:Binding affinity to A1 adenosine receptor from rat cortical membrane in presence of [3H]-R-(phenylisopropyl)-adenosineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Julius-Maximilians-UniversitäT WüRzburg

Curated by ChEMBL
LigandPNGBDBM50051651(2-(4-Methoxy-phenyl)-5,6-dimethyl-7-((R)-1-phenyl-...)
Affinity DataKi:  101nMAssay Description:Radioligand binding assay for [3H]-PIA affinity towards Adenosine A1 receptor of rat cerebral cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Julius-Maximilians-UniversitäT WüRzburg

Curated by ChEMBL
LigandPNGBDBM50041593(5-Methyl-6-phenyl-1,3-dipropyl-1,5-dihydro-pyrrolo...)
Affinity DataKi:  110nMAssay Description:Binding affinity to A1 adenosine receptor from rat cortical membrane in presence of [3H]-R-(phenylisopropyl)-adenosineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50424563(CHEMBL2312505)
Affinity DataKi:  123nMAssay Description:Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50424578(CHEMBL2311545)
Affinity DataKi:  125nMAssay Description:Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Julius-Maximilians-UniversitäT WüRzburg

Curated by ChEMBL
LigandPNGBDBM50041577(6-Dimethylamino-1,3-dipropyl-1,5-dihydro-pyrrolo[3...)
Affinity DataKi:  130nMAssay Description:Binding affinity to A1 adenosine receptor from rat cortical membrane in presence of [3H]-R-(phenylisopropyl)-adenosineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50424550(CHEMBL2312519)
Affinity DataKi:  131nMAssay Description:Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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