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Found 374 with Last Name = 'ajani' and Initial = 'h'
TargetCoagulation factor X(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50392592(CHEMBL2153381)
Affinity DataKi:  1.10nMAssay Description:Inhibition of F10a assessed as S-2765 substrate hydrolysis by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50392589(CHEMBL2153377)
Affinity DataKi:  1.5nMAssay Description:Inhibition of F10a assessed as S-2765 substrate hydrolysis by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine racemase(Mus musculus)
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50038343(CHEMBL3360546)
Affinity DataKi:  1.90E+4nMAssay Description:Inhibition of mouse serine racemase by Lineweaver-Burk plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50392592(CHEMBL2153381)
Affinity DataKi: >2.00E+4nMAssay Description:Inhibition of thrombin assessed as S-2238 substrate hydrolysis by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50392589(CHEMBL2153377)
Affinity DataKi: >2.00E+4nMAssay Description:Inhibition of thrombin assessed as S-2238 substrate hydrolysis by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50392592(CHEMBL2153381)
Affinity DataKi: >2.00E+4nMAssay Description:Inhibition of activated protein C assessed as S-2366 substrate hydrolysis by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50392589(CHEMBL2153377)
Affinity DataKi: >2.00E+4nMAssay Description:Inhibition of plasmin assessed as S-2302 substrate hydrolysis by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50392592(CHEMBL2153381)
Affinity DataKi: >2.00E+4nMAssay Description:Inhibition of plasmin assessed as S-2302 substrate hydrolysis by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50392589(CHEMBL2153377)
Affinity DataKi: >2.00E+4nMAssay Description:Inhibition of tPA assessed as S-2288 substrate hydrolysis by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50392592(CHEMBL2153381)
Affinity DataKi: >2.00E+4nMAssay Description:Inhibition of tPA assessed as S-2288 substrate hydrolysis by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50392589(CHEMBL2153377)
Affinity DataKi: >2.00E+4nMAssay Description:Inhibition of activated protein C assessed as S-2366 substrate hydrolysis by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine racemase(Mus musculus)
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM14673(Fragment 3 | Malonic Acid | propanedioic acid)
Affinity DataKi:  2.70E+4nMAssay Description:Inhibition of mouse serine racemase by Lineweaver-Burk plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50576576(CHEMBL4869569)
Affinity DataIC50:  1nMAssay Description:Inhibition of human FLT3 ITD mutant using EAIYAAPFAKKK as substrate preincubated for 20 mins followed by 33P-ATP addition and measured after 2 hrs by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50453198(CHEMBL4212560)
Affinity DataIC50:  1nMAssay Description:Inhibition of N-terminal GST/His6-fused recombinant human FLT3 (R571 to S993 residues) ITD mutant expressed in Sf9 insect cells using poly (Ala,Glu,L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50453202(CHEMBL4207317)
Affinity DataIC50:  1nMAssay Description:Inhibition of N-terminal GST/His6-fused recombinant human FLT3 (R571 to S993 residues) ITD mutant expressed in Sf9 insect cells using poly (Ala,Glu,L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire

LigandPNGBDBM16314(2-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]-...)
Affinity DataIC50:  1nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B10(Homo sapiens (Human))
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire

LigandPNGBDBM16314(2-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]-...)
Affinity DataIC50:  1.20nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM7840(RIVAROXABAN | US8822458, 44 | US8822458, 97)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human F10a using S-2765 as substrate after 45 minsMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50453185(CHEMBL4203825)
Affinity DataIC50:  2nMAssay Description:Inhibition of N-terminal GST/His6-fused recombinant human FLT3 (R571 to S993 residues) D835Y mutant expressed in Sf9 insect cells using poly (Ala,Glu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50453197(CHEMBL4208701)
Affinity DataIC50:  2nMAssay Description:Inhibition of N-terminal GST/His6-fused recombinant human FLT3 (R571 to S993 residues) ITD mutant expressed in Sf9 insect cells using poly (Ala,Glu,L...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50392592(CHEMBL2153381)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human F10a using S-2765 as substrate after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50392595(CHEMBL2153392)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of human F10a using S-2765 as substrate after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50392589(CHEMBL2153377)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of human F10a using S-2765 as substrate after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50576569(CHEMBL4853855)
Affinity DataIC50:  3nMAssay Description:Inhibition of human FLT3 ITD mutant using EAIYAAPFAKKK as substrate preincubated for 20 mins followed by 33P-ATP addition and measured after 2 hrs by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50576570(CHEMBL4871182)
Affinity DataIC50:  3nMAssay Description:Inhibition of human FLT3 ITD mutant using EAIYAAPFAKKK as substrate preincubated for 20 mins followed by 33P-ATP addition and measured after 2 hrs by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-dependent kinase 2(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)
Affinity DataIC50:  3nMAssay Description:Inhibition of CDK2/Cyclin A1 (unknown origin) at 1 uM using histone H1 as substrate preincubated for 20 mins followed by 33P-ATP addition and measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50576545(CHEMBL4866768)
Affinity DataIC50:  3nMAssay Description:Inhibition of human FLT3 ITD mutant using EAIYAAPFAKKK as substrate preincubated for 20 mins followed by 33P-ATP addition and measured after 2 hrs by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50453200(CHEMBL4210745)
Affinity DataIC50:  3nMAssay Description:Inhibition of N-terminal GST/His6-fused recombinant human FLT3 (R571 to S993 residues) ITD mutant expressed in Sf9 insect cells using poly (Ala,Glu,L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire

LigandPNGBDBM16313(2-(2-{[(4-bromo-2-fluorophenyl)methyl]carbamothioy...)
Affinity DataIC50:  3nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50453185(CHEMBL4203825)
Affinity DataIC50:  3nMAssay Description:Inhibition of N-terminal GST/His6-fused recombinant human FLT3 (R571 to S993 residues) ITD mutant expressed in Sf9 insect cells using poly (Ala,Glu,L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50453194(CHEMBL4204373)
Affinity DataIC50:  3nMAssay Description:Inhibition of N-terminal GST/His6-fused recombinant human FLT3 (R571 to S993 residues) ITD mutant expressed in Sf9 insect cells using poly (Ala,Glu,L...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50453202(CHEMBL4207317)
Affinity DataIC50:  3nMAssay Description:Inhibition of N-terminal GST/His6-fused recombinant human FLT3 (R571 to S993 residues) D835Y mutant expressed in Sf9 insect cells using poly (Ala,Glu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50392593(CHEMBL2153383)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human F10a using S-2765 as substrate after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50392596(CHEMBL2153393)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of human F10a using S-2765 as substrate after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50576552(CHEMBL4869214)
Affinity DataIC50:  4nMAssay Description:Inhibition of human FLT3 ITD mutant using EAIYAAPFAKKK as substrate preincubated for 20 mins followed by 33P-ATP addition and measured after 2 hrs by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50453196(CHEMBL4216401)
Affinity DataIC50:  4nMAssay Description:Inhibition of N-terminal GST/His6-fused recombinant human FLT3 (R571 to S993 residues) ITD mutant expressed in Sf9 insect cells using poly (Ala,Glu,L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50453234(CHEMBL4213717)
Affinity DataIC50:  4nMAssay Description:Inhibition of N-terminal GST/His6-fused recombinant human FLT3 (R571 to S993 residues) ITD mutant expressed in Sf9 insect cells using poly (Ala,Glu,L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50453192(CHEMBL4216043)
Affinity DataIC50:  4nMAssay Description:Inhibition of N-terminal GST/His6-fused recombinant human FLT3 (R571 to S993 residues) ITD mutant expressed in Sf9 insect cells using poly (Ala,Glu,L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50392590(CHEMBL2153378)
Affinity DataIC50:  4nMAssay Description:Inhibition of human F10a using S-2765 as substrate after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50453195(CHEMBL4202430)
Affinity DataIC50:  4nMAssay Description:Inhibition of N-terminal GST/His6-fused recombinant human FLT3 (R571 to S993 residues) ITD mutant expressed in Sf9 insect cells using poly (Ala,Glu,L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50453196(CHEMBL4216401)
Affinity DataIC50:  4nMAssay Description:Inhibition of N-terminal GST/His6-fused recombinant human FLT3 (R571 to S993 residues) D835Y mutant expressed in Sf9 insect cells using poly (Ala,Glu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50515042(CHEMBL4593398)
Affinity DataIC50:  5nMAssay Description:Inhibition of human FLT3 ITD mutant using EAIYAAPFAKKK as substrate preincubated for 20 mins followed by 33P-ATP addition and measured after 2 hrs by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50453193(CHEMBL4213103)
Affinity DataIC50:  5nMAssay Description:Inhibition of N-terminal GST/His6-fused recombinant human FLT3 (R571 to S993 residues) ITD mutant expressed in Sf9 insect cells using poly (Ala,Glu,L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50453235(CHEMBL4207535)
Affinity DataIC50:  5nMAssay Description:Inhibition of N-terminal GST/His6-fused recombinant human FLT3 (R571 to S993 residues) ITD mutant expressed in Sf9 insect cells using poly (Ala,Glu,L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50453198(CHEMBL4212560)
Affinity DataIC50:  5nMAssay Description:Inhibition of N-terminal GST/His6-fused recombinant human FLT3 (R571 to S993 residues) D835Y mutant expressed in Sf9 insect cells using poly (Ala,Glu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Palack£

Curated by ChEMBL
LigandPNGBDBM50510914(CHEMBL4558664)
Affinity DataIC50:  5nMAssay Description:Inhibition of recombinant human 3C cleavage site/N-terminal GST-His6 fused PDGFR alpha C-terminal fragment (Q551 to L1089 residues) harboring V561D m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50392588(CHEMBL2153376)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of human F10a using S-2765 as substrate after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50392594(CHEMBL2153391)
Affinity DataIC50:  5.60nMAssay Description:Inhibition of human F10a using S-2765 as substrate after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50576572(CHEMBL4856135)
Affinity DataIC50:  6nMAssay Description:Inhibition of human FLT3 ITD mutant using EAIYAAPFAKKK as substrate preincubated for 20 mins followed by 33P-ATP addition and measured after 2 hrs by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50453230(CHEMBL4217517)
Affinity DataIC50:  6nMAssay Description:Inhibition of N-terminal GST/His6-fused recombinant human FLT3 (R571 to S993 residues) ITD mutant expressed in Sf9 insect cells using poly (Ala,Glu,L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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