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Found 59 with Last Name = 'alexandre' and Initial = 'f'
TargetGenome polyprotein(Hepatitis C virus)
Idenix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142916((1S,4R,6S,14S,18R)-14-Cyclopentyloxycarbonylamino-...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of full length Hepatitis C virus genotype 1b Con1 NS3/4A by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Idenix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50023510(CHEMBL3326826)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of full length Hepatitis C virus genotype 1b Con1 NS3/4A by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Idenix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50023579(CHEMBL3326830)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of full length Hepatitis C virus genotype 1b Con1 NS3/4A by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Idenix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50023508(CHEMBL3326539)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of full length Hepatitis C virus genotype 1b Con1 NS3/4A by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Idenix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50023578(CHEMBL3326829)
Affinity DataIC50:  6.60nMAssay Description:Inhibition of full length Hepatitis C virus genotype 1b Con1 NS3/4A by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Idenix An Msd

Curated by ChEMBL
LigandPNGBDBM50138406(3TC Triphosphate | CHEMBL1230 | LAMIVUDINE | Lamiv...)
Affinity DataIC50:  15nMAssay Description:Inhibition of full-length wild-type HIV1 reverse transcriptase expressed in Escherichia coli BL21(DE3) pre-incubated for 30 mins before addition of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Idenix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50023509(CHEMBL3326540)
Affinity DataIC50:  17nMAssay Description:Inhibition of full length Hepatitis C virus genotype 1b Con1 NS3/4A by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Idenix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50023507(CHEMBL3326538)
Affinity DataIC50:  45nMAssay Description:Inhibition of full length Hepatitis C virus genotype 1b Con1 NS3/4A by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Idenix An Msd

Curated by ChEMBL
LigandPNGBDBM50459813(CHEMBL4205384)
Affinity DataIC50:  114nMAssay Description:Inhibition of full-length wild-type HIV1 reverse transcriptase expressed in Escherichia coli BL21(DE3) pre-incubated for 30 mins before addition of t...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C Virus (Virus))
Idenix Pharmaceuticals

US Patent
LigandPNGBDBM347259(US10202411, Compound 302)
Affinity DataIC50: <250nMAssay Description:Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C Virus (Virus))
Idenix Pharmaceuticals

US Patent
LigandPNGBDBM426319(US10513534, Compound 407)
Affinity DataIC50: <250nMMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C Virus (Virus))
Idenix Pharmaceuticals

US Patent
LigandPNGBDBM426312(US10513534, Compound 401)
Affinity DataIC50: <250nMAssay Description:Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein [S283T](Hepatitis C virus genotype 1b (isolate Japanese) (...)
Idenix Pharmaceuticals

US Patent
LigandPNGBDBM347266(US10202411, Compound 330)
Affinity DataIC50: <250nMAssay Description:Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein [S283T](Hepatitis C virus genotype 1b (isolate Japanese) (...)
Idenix Pharmaceuticals

US Patent
LigandPNGBDBM347259(US10202411, Compound 302)
Affinity DataIC50: <250nMAssay Description:Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C Virus (Virus))
Idenix Pharmaceuticals

US Patent
LigandPNGBDBM347260(US10202411, Compound 305)
Affinity DataIC50: <250nMAssay Description:Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein [S283T](Hepatitis C virus genotype 1b (isolate Japanese) (...)
Idenix Pharmaceuticals

US Patent
LigandPNGBDBM347260(US10202411, Compound 305)
Affinity DataIC50: <250nMAssay Description:Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C Virus (Virus))
Idenix Pharmaceuticals

US Patent
LigandPNGBDBM426315(US10513534, Compound 403)
Affinity DataIC50: <250nMMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C Virus (Virus))
Idenix Pharmaceuticals

US Patent
LigandPNGBDBM347262(US10202411, Compound 308)
Affinity DataIC50: <250nMAssay Description:Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein [S283T](Hepatitis C virus genotype 1b (isolate Japanese) (...)
Idenix Pharmaceuticals

US Patent
LigandPNGBDBM347262(US10202411, Compound 308)
Affinity DataIC50: <250nMAssay Description:Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C Virus (Virus))
Idenix Pharmaceuticals

US Patent
LigandPNGBDBM426317(US10513534, Compound 405)
Affinity DataIC50: <250nMMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C Virus (Virus))
Idenix Pharmaceuticals

US Patent
LigandPNGBDBM426318(US10513534, Compound 406)
Affinity DataIC50: <250nMAssay Description:Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C Virus (Virus))
Idenix Pharmaceuticals

US Patent
LigandPNGBDBM347265(US10202411, Compound 327)
Affinity DataIC50: <250nMAssay Description:Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein [S283T](Hepatitis C virus genotype 1b (isolate Japanese) (...)
Idenix Pharmaceuticals

US Patent
LigandPNGBDBM347265(US10202411, Compound 327)
Affinity DataIC50: <250nMAssay Description:Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetReverse transcriptase(Human immunodeficiency virus 1)
Idenix An Msd

Curated by ChEMBL
LigandPNGBDBM50459816(CHEMBL518606)
Affinity DataIC50:  263nMAssay Description:Inhibition of full-length wild-type HIV1 reverse transcriptase expressed in Escherichia coli BL21(DE3) pre-incubated for 30 mins before addition of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Idenix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50023581(CHEMBL3326537)
Affinity DataIC50:  278nMAssay Description:Inhibition of full length Hepatitis C virus genotype 1b Con1 NS3/4A by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Idenix An Msd

Curated by ChEMBL
LigandPNGBDBM50459815(CHEMBL4216055)
Affinity DataIC50:  324nMAssay Description:Inhibition of full-length wild-type HIV1 reverse transcriptase expressed in Escherichia coli BL21(DE3) pre-incubated for 30 mins before addition of t...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Idenix An Msd

Curated by ChEMBL
LigandPNGBDBM50459812(CHEMBL4214561)
Affinity DataIC50:  444nMAssay Description:Inhibition of full-length wild-type HIV1 reverse transcriptase expressed in Escherichia coli BL21(DE3) pre-incubated for 30 mins before addition of t...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Idenix An Msd

Curated by ChEMBL
LigandPNGBDBM50459817(CHEMBL4211088)
Affinity DataIC50:  523nMAssay Description:Inhibition of full-length wild-type HIV1 reverse transcriptase expressed in Escherichia coli BL21(DE3) pre-incubated for 30 mins before addition of t...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C Virus (Virus))
Idenix Pharmaceuticals

US Patent
LigandPNGBDBM347268(US10202411, Compound 332)
Affinity DataIC50:  625nMAssay Description:Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C Virus (Virus))
Idenix Pharmaceuticals

US Patent
LigandPNGBDBM347266(US10202411, Compound 330)
Affinity DataIC50:  625nMAssay Description:Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C Virus (Virus))
Idenix Pharmaceuticals

US Patent
LigandPNGBDBM347261(US10202411, Compound 307)
Affinity DataIC50:  625nMAssay Description:Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus)
Idenix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50023576(CHEMBL3326827)
Affinity DataIC50: <1.00E+3nMAssay Description:Inhibition of full length Hepatitis C virus genotype 1b Con1 NS3/4A by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Idenix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50023577(CHEMBL3326828)
Affinity DataIC50: <1.00E+3nMAssay Description:Inhibition of full length Hepatitis C virus genotype 1b Con1 NS3/4A by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Idenix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50023580(CHEMBL3326536)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of full length Hepatitis C virus genotype 1b Con1 NS3/4A by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Idenix An Msd

Curated by ChEMBL
LigandPNGBDBM50459814(CHEMBL4211602)
Affinity DataIC50:  3.46E+3nMAssay Description:Inhibition of full-length wild-type HIV1 reverse transcriptase expressed in Escherichia coli BL21(DE3) pre-incubated for 30 mins before addition of t...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C Virus (Virus))
Idenix Pharmaceuticals

US Patent
LigandPNGBDBM426314(US10513534, Compound 402)
Affinity DataIC50:  5.50E+3nMAssay Description:Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C Virus (Virus))
Idenix Pharmaceuticals

US Patent
LigandPNGBDBM347272(US10202411, Compound 402)
Affinity DataIC50:  5.50E+3nMAssay Description:Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C Virus (Virus))
Idenix Pharmaceuticals

US Patent
LigandPNGBDBM347263(US10202411, Compound 325)
Affinity DataIC50:  5.50E+3nMAssay Description:Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C Virus (Virus))
Idenix Pharmaceuticals

US Patent
LigandPNGBDBM347264(US10202411, Compound 326)
Affinity DataIC50:  5.50E+3nMAssay Description:Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C Virus (Virus))
Idenix Pharmaceuticals

US Patent
LigandPNGBDBM347258(US10202411, Compound 301)
Affinity DataIC50:  5.50E+3nMAssay Description:Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C Virus (Virus))
Idenix Pharmaceuticals

US Patent
LigandPNGBDBM426322(US10513534, Compound 410)
Affinity DataIC50:  6.25E+3nMAssay Description:Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C Virus (Virus))
Idenix Pharmaceuticals

US Patent
LigandPNGBDBM426323(US10513534, Compound 411)
Affinity DataIC50:  6.25E+3nMAssay Description:Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C Virus (Virus))
Idenix Pharmaceuticals

US Patent
LigandPNGBDBM426321(US10513534, Compound 409)
Affinity DataIC50:  6.25E+3nMAssay Description:Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C Virus (Virus))
Idenix Pharmaceuticals

US Patent
LigandPNGBDBM426320(US10513534, Compound 408)
Affinity DataIC50:  6.25E+3nMAssay Description:Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C Virus (Virus))
Idenix Pharmaceuticals

US Patent
LigandPNGBDBM426319(US10513534, Compound 407)
Affinity DataIC50:  6.25E+3nMAssay Description:Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C Virus (Virus))
Idenix Pharmaceuticals

US Patent
LigandPNGBDBM426318(US10513534, Compound 406)
Affinity DataIC50:  6.25E+3nMMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C Virus (Virus))
Idenix Pharmaceuticals

US Patent
LigandPNGBDBM426317(US10513534, Compound 405)
Affinity DataIC50:  6.25E+3nMAssay Description:Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C Virus (Virus))
Idenix Pharmaceuticals

US Patent
LigandPNGBDBM426315(US10513534, Compound 403)
Affinity DataIC50:  6.25E+3nMAssay Description:Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C Virus (Virus))
Idenix Pharmaceuticals

US Patent
LigandPNGBDBM426312(US10513534, Compound 401)
Affinity DataIC50:  6.25E+3nMMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C Virus (Virus))
Idenix Pharmaceuticals

US Patent
LigandPNGBDBM347267(US10202411, Compound 331)
Affinity DataIC50: >1.00E+4nMAssay Description:Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
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