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Found 150 with Last Name = 'almo' and Initial = 'sc'
Target5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase(Escherichia coli (strain K12))
Albert Einstein College Of Medicine

LigandPNGBDBM36435((3R,4S)-1-[(9-Deaza-adenin-9-yl)methyl]-4-ethylthi...)
Affinity DataKi:  0.0700nM ΔG°:  -58.0kJ/molepH: 7.5 T: 2°CAssay Description:Purified MTAN activity in MTAN enzyme inhibition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase(Escherichia coli (strain K12))
Albert Einstein College Of Medicine

LigandPNGBDBM22113((3R,4S)-1-({4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-y...)
Affinity DataKi:  0.0730nM ΔG°:  -57.9kJ/molepH: 7.5 T: 2°CAssay Description:Purified MTAN activity in MTAN enzyme inhibition assayMore data for this Ligand-Target Pair
Target5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase(Escherichia coli (strain K12))
Albert Einstein College Of Medicine

LigandPNGBDBM36436((3R,4S)-1-[(9-Deaza-adenin-9-yl)methyl]-4-ethylthi...)
Affinity DataKi:  0.208nM ΔG°:  -55.3kJ/molepH: 7.5 T: 2°CAssay Description:Purified MTAN activity in MTAN enzyme inhibition assayMore data for this Ligand-Target Pair
TargetHypoxanthine-guanine-xanthine phosphoribosyltransferase(Plasmodium falciparum)
Albert Einstein College Of Medicine

LigandPNGBDBM92358(HGXPRT Inhibitor, 3)
Affinity DataKi:  0.650nM ΔG°:  -54.5kJ/molepH: 7.6 T: 2°CAssay Description:PfHGXPRT activity was measured using spectrophotometric assay observing the conversion of xanthine and 5-phospho-alpha-D-ribose-1-pyrophosphate to xa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxanthine-guanine-xanthine phosphoribosyltransferase(Plasmodium falciparum)
Albert Einstein College Of Medicine

LigandPNGBDBM92357(HGXPRT Inhibitor, 2)
Affinity DataKi:  10.6nM ΔG°:  -47.3kJ/molepH: 7.6 T: 2°CAssay Description:PfHGXPRT activity was measured using spectrophotometric assay observing the conversion of xanthine and 5-phospho-alpha-D-ribose-1-pyrophosphate to xa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxanthine-guanine phosphoribosyltransferase(Homo sapiens (Human))
Albert Einstein College Of Medicine

LigandPNGBDBM92358(HGXPRT Inhibitor, 3)
Affinity DataKi:  385nM ΔG°:  -38.1kJ/molepH: 7.6 T: 2°CAssay Description:PfHGXPRT activity was measured using spectrophotometric assay observing the conversion of xanthine and 5-phospho-alpha-D-ribose-1-pyrophosphate to xa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxanthine-guanine phosphoribosyltransferase(Homo sapiens (Human))
Albert Einstein College Of Medicine

LigandPNGBDBM92357(HGXPRT Inhibitor, 2)
Affinity DataKi:  4.94E+3nM ΔG°:  -31.5kJ/molepH: 7.6 T: 2°CAssay Description:PfHGXPRT activity was measured using spectrophotometric assay observing the conversion of xanthine and 5-phospho-alpha-D-ribose-1-pyrophosphate to xa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318946(CHEMBL1085293 | rac-9-(2-hydroxyethyl)-5-methyl-12...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318959(CHEMBL1084337 | rac-9-isobutyl-5-methyl-12-(tetrah...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant TIE-2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318963(CHEMBL1084061 | rac-5-methyl-9-propyl-12-(tetrahyd...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant TIE-2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318960(CHEMBL1082503 | rac-5-methyl-12-(tetrahydro-2H-pyr...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318958(CHEMBL1082829 | rac-9-butyl-5-methyl-12-(tetrahydr...)
Affinity DataIC50:  5nMAssay Description:Inhibition of VEGFR3 at 3 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318962(CHEMBL1083757 | rac-9-ethyl-5-methyl-12-(tetrahydr...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318957(9-(2-hydroxyethyl)-6-methyl-12-(tetrahydro-2H-pyra...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318963(CHEMBL1084061 | rac-5-methyl-9-propyl-12-(tetrahyd...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318949(6-methyl-12-(tetrahydro-2H-pyran-2-yl)-6,7,8,9-tet...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318959(CHEMBL1084337 | rac-9-isobutyl-5-methyl-12-(tetrah...)
Affinity DataIC50:  9nMAssay Description:Inhibition of VEGFR3 at 3 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318970(CHEMBL1082755 | rac-9-allyl-5-methyl-12-(tetrahydr...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human recombinant TIE-2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318951(9-ethyl-6-methyl-12-(tetrahydro-2H-pyran-2-yl)-6,7...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318960(CHEMBL1082503 | rac-5-methyl-12-(tetrahydro-2H-pyr...)
Affinity DataIC50: <10nMAssay Description:Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318961(CHEMBL1082826 | rac-5,9-dimethyl-12-(tetrahydro-2H...)
Affinity DataIC50: <10nMAssay Description:Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318964(CHEMBL1084062 | rac-9-isopropyl-5-methyl-12-(tetra...)
Affinity DataIC50: <10nMAssay Description:Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318959(CHEMBL1084337 | rac-9-isobutyl-5-methyl-12-(tetrah...)
Affinity DataIC50:  10nMAssay Description:Inhibition of VEGF-stimulated VEGFR2 autophosphorylation in HUVECMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318963(CHEMBL1084061 | rac-5-methyl-9-propyl-12-(tetrahyd...)
Affinity DataIC50: <10nMAssay Description:Inhibition of VEGF-stimulated VEGFR2 autophosphorylation in HUVECMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318962(CHEMBL1083757 | rac-9-ethyl-5-methyl-12-(tetrahydr...)
Affinity DataIC50: <10nMAssay Description:Inhibition of VEGF-stimulated VEGFR2 autophosphorylation in HUVECMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318958(CHEMBL1082829 | rac-9-butyl-5-methyl-12-(tetrahydr...)
Affinity DataIC50:  10nMAssay Description:Inhibition of VEGF-stimulated VEGFR2 autophosphorylation in HUVECMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318964(CHEMBL1084062 | rac-9-isopropyl-5-methyl-12-(tetra...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant TIE-2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318958(CHEMBL1082829 | rac-9-butyl-5-methyl-12-(tetrahydr...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant TIE-2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318959(CHEMBL1084337 | rac-9-isobutyl-5-methyl-12-(tetrah...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318962(CHEMBL1083757 | rac-9-ethyl-5-methyl-12-(tetrahydr...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human recombinant TIE-2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Global Blood Therapeutics

Curated by ChEMBL
LigandPNGBDBM151585(US11739089, Compound Ketoconazole | US8987315, Ket...)
Affinity DataIC50:  15nMAssay Description:Inhibition of CYP3A4 using in human liver microsomes using testosterone as substrate after 5 to 15 minsMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318961(CHEMBL1082826 | rac-5,9-dimethyl-12-(tetrahydro-2H...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318947(CHEMBL1085540 | rac-9-(3-hydroxypropyl)-5-methyl-1...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human recombinant TIE-2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318959(CHEMBL1084337 | rac-9-isobutyl-5-methyl-12-(tetrah...)
Affinity DataIC50:  16nMAssay Description:Inhibition of VEGFR1 at 3 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318948(CHEMBL1085541 | rac-9-(2-(diethylamino)ethyl)-5-me...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318947(CHEMBL1085540 | rac-9-(3-hydroxypropyl)-5-methyl-1...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318945(CHEMBL1082756 | rac-9-(2-ethoxyethyl)-5-methyl-12-...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human recombinant TIE-2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Global Blood Therapeutics

Curated by ChEMBL
LigandPNGBDBM151585(US11739089, Compound Ketoconazole | US8987315, Ket...)
Affinity DataIC50:  18nMAssay Description:Inhibition of CYP3A4 using in human liver microsomes using midazolam as substrate after 5 to 15 minsMore data for this Ligand-Target Pair
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318955(9-isobutyl-6-methyl-12-(tetrahydro-2H-pyran-2-yl)-...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human recombinant TIE-2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318970(CHEMBL1082755 | rac-9-allyl-5-methyl-12-(tetrahydr...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318952(6-methyl-9-propyl-12-(tetrahydro-2H-pyran-2-yl)-6,...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318964(CHEMBL1084062 | rac-9-isopropyl-5-methyl-12-(tetra...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318965(CHEMBL1084338 | rac-9-isopentyl-5-methyl-12-(tetra...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human recombinant TIE-2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318950(6,9-dimethyl-12-(tetrahydro-2H-pyran-2-yl)-6,7,8,9...)
Affinity DataIC50:  22nMAssay Description:Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318945(CHEMBL1082756 | rac-9-(2-ethoxyethyl)-5-methyl-12-...)
Affinity DataIC50:  22nMAssay Description:Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318952(6-methyl-9-propyl-12-(tetrahydro-2H-pyran-2-yl)-6,...)
Affinity DataIC50:  24nMAssay Description:Inhibition of human recombinant TIE-2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318958(CHEMBL1082829 | rac-9-butyl-5-methyl-12-(tetrahydr...)
Affinity DataIC50:  24nMAssay Description:Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Cephalon

LigandPNGBDBM24949(3-(2-hydroxyethyl)-20-(propan-2-yloxy)-3,13-diazah...)
Affinity DataIC50:  26nMpH: 7.2 T: 2°CAssay Description:The MLK kinase assays were performed by using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. The inhibition curves were genera...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318946(CHEMBL1085293 | rac-9-(2-hydroxyethyl)-5-methyl-12...)
Affinity DataIC50:  27nMAssay Description:Inhibition of human recombinant TIE-2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318958(CHEMBL1082829 | rac-9-butyl-5-methyl-12-(tetrahydr...)
Affinity DataIC50:  28nMAssay Description:Inhibition of VEGFR1 at 3 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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