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Found 77 with Last Name = 'alonso' and Initial = 'd'
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50345695(5-(Dimethylamino)-N-{4-[2-{4-[4-(1-naphthyl)pipera...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in EBNA gene-positive HEK293 cells after 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50345703(8-{4-[4-(1,3-Dioxotetrahydro-1H-pyrrolo[1,2-c]imid...)
Affinity DataKi:  2.40nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in EBNA gene-positive HEK293 cells after 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50126474(2-[4-(4-Naphthalen-1-yl-piperazin-1-yl)-butyl]-tet...)
Affinity DataKi:  2.40nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in EBNA gene-positive HEK293 cells after 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50345697(5-(Dimethylamino)-N-{7-[2-{4-[4-(1-naphthyl)pipera...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in EBNA gene-positive HEK293 cells after 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50054395(2-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butyl}-...)
Affinity DataKi:  5.5nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in EBNA gene-positive HEK293 cells after 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50345698(5-(Dimethylamino)-N-[5-({2-[2-{4-[4-(2-methoxyphen...)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in EBNA gene-positive HEK293 cells after 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50345699(5-(Dimethylamino)-N-[5-({4-[2-{4-[4-(2-methoxyphen...)
Affinity DataKi:  9nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in EBNA gene-positive HEK293 cells after 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50345694(5-(Dimethylamino)-N-{4-[2-{4-[4-(2-methoxyphenyl)p...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in EBNA gene-positive HEK293 cells after 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50345696(5-(Dimethylamino)-N-{7-[2-{4-[4-(2-methoxyphenyl)p...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in EBNA gene-positive HEK293 cells after 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50345695(5-(Dimethylamino)-N-{4-[2-{4-[4-(1-naphthyl)pipera...)
Affinity DataKi:  38nMAssay Description:Binding affinity to human 5HT1A receptor expressed in CHO cells after 10 mins by confocal microscopyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50345702(5-{4-[4-(1,3-Dioxotetrahydro-1H-pyrrolo[1,2-c]imid...)
Affinity DataKi:  98nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in EBNA gene-positive HEK293 cells after 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50345701(5-{4-[4-(1,3-Dioxotetrahydro-1H-pyrrolo[1,2-c]imid...)
Affinity DataKi:  350nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in EBNA gene-positive HEK293 cells after 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50345700(2-[4-(4-{5-(Dimethylamino)-1-naphthylsulfonyl}pipe...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in EBNA gene-positive HEK293 cells after 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Neuropharma

LigandPNGBDBM9063(5,6-Dimethoxy-2-{[7-(1,2,3,4-tetrahydro-acridin-9-...)
Affinity DataIC50:  0.600nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Neuropharma

LigandPNGBDBM9073(2-[9-(Acridin-9-ylamino)-nonyl]-isoindole-1,3-dion...)
Affinity DataIC50:  2.40nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Neuropharma

LigandPNGBDBM9067(Donepezil-tacrine hybrid 12 | N-[4-({2-[(6-chloro-...)
Affinity DataIC50:  2.80nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Neuropharma

LigandPNGBDBM9070(2-[6-(Acridin-9-ylamino)-hexyl]-isoindole-1,3-dion...)
Affinity DataIC50:  7.80nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Neuropharma

LigandPNGBDBM9068(2-[7-(1,2,3,4-Tetrahydro-acridin-9-ylamino)-heptyl...)
Affinity DataIC50:  10nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Neuropharma

LigandPNGBDBM9065(Donepezil-tacrine hybrid 10 | N-[6-(6-Chloro-1,2,3...)
Affinity DataIC50:  10nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Neuropharma

LigandPNGBDBM8960((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)
Affinity DataIC50:  19nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Bos taurus (bovine))
Neuropharma

LigandPNGBDBM9066(Donepezil-tacrine hybrid 11 | N-[7-(6-Chloro-1,2,3...)
Affinity DataIC50:  20nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Neuropharma

LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  24nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Bos taurus (bovine))
Neuropharma

LigandPNGBDBM9063(5,6-Dimethoxy-2-{[7-(1,2,3,4-tetrahydro-acridin-9-...)
Affinity DataIC50:  25nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Neuropharma

LigandPNGBDBM9069(2-[8-(1,2,3,4-Tetrahydro-acridin-9-ylamino)-octyl]...)
Affinity DataIC50:  29nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Neuropharma

LigandPNGBDBM9062(5,6-Dimethoxy-2-{[6-(1,2,3,4-tetrahydro-acridin-9-...)
Affinity DataIC50:  50nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Neuropharma

LigandPNGBDBM9067(Donepezil-tacrine hybrid 12 | N-[4-({2-[(6-chloro-...)
Affinity DataIC50:  75nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Neuropharma

LigandPNGBDBM9073(2-[9-(Acridin-9-ylamino)-nonyl]-isoindole-1,3-dion...)
Affinity DataIC50:  90nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Neuropharma

LigandPNGBDBM9069(2-[8-(1,2,3,4-Tetrahydro-acridin-9-ylamino)-octyl]...)
Affinity DataIC50:  93nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Neuropharma

LigandPNGBDBM9064(2-({[6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyl]...)
Affinity DataIC50:  98nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Neuropharma

LigandPNGBDBM9062(5,6-Dimethoxy-2-{[6-(1,2,3,4-tetrahydro-acridin-9-...)
Affinity DataIC50:  100nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Neuropharma

LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  167nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair
TargetCholinesterase(Homo sapiens (Human))
Neuropharma

LigandPNGBDBM9065(Donepezil-tacrine hybrid 10 | N-[6-(6-Chloro-1,2,3...)
Affinity DataIC50:  220nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Neuropharma

LigandPNGBDBM9064(2-({[6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyl]...)
Affinity DataIC50:  504nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Neuropharma

LigandPNGBDBM9066(Donepezil-tacrine hybrid 11 | N-[7-(6-Chloro-1,2,3...)
Affinity DataIC50:  660nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Neuropharma

LigandPNGBDBM9071(2-[7-(Acridin-9-ylamino)-heptyl]-isoindole-1,3-dio...)
Affinity DataIC50:  711nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50426172(CHEMBL483841 | Ircinin 1)
Affinity DataIC50:  794nMAssay Description:Inhibition of human recombinant GSK-3beta using GS2 peptide as substrate and [gamma33P]-ATP after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50426172(CHEMBL483841 | Ircinin 1)
Affinity DataIC50:  794nMAssay Description:Inhibition of human recombinant GSK-3beta using GS2 peptide as substrate and [gamma33P]-ATP after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Neuropharma

LigandPNGBDBM9070(2-[6-(Acridin-9-ylamino)-hexyl]-isoindole-1,3-dion...)
Affinity DataIC50:  870nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Neuropharma

LigandPNGBDBM8960((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)
Affinity DataIC50:  930nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Neuropharma

LigandPNGBDBM9072(2-[8-(Acridin-9-ylamino)-octyl]-isoindole-1,3-dion...)
Affinity DataIC50:  1.01E+3nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Neuropharma

LigandPNGBDBM9072(2-[8-(Acridin-9-ylamino)-octyl]-isoindole-1,3-dion...)
Affinity DataIC50:  1.14E+3nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
University Of Mississippi

Curated by ChEMBL
LigandPNGBDBM50232478(CHEMBL403233)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human recombinant CDK5/p35More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Neuropharma

LigandPNGBDBM9071(2-[7-(Acridin-9-ylamino)-heptyl]-isoindole-1,3-dio...)
Affinity DataIC50:  1.55E+3nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50401965(PALINURIN)
Affinity DataIC50:  1.62E+3nMAssay Description:Inhibition of human recombinant GSK-3alpha using GS2 peptide as substrate and [gamma33P]-ATP after 12 mins by scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50401965(PALINURIN)
Affinity DataIC50:  1.62E+3nMAssay Description:Inhibition of human recombinant GSK-3alpha using GS2 peptide as substrate and [gamma33P]-ATP after 12 mins by scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50401965(PALINURIN)
Affinity DataIC50:  1.91E+3nMAssay Description:Inhibition of human recombinant GSK-3beta using GS2 peptide as substrate and [gamma33P]-ATP after 30 mins by scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50401965(PALINURIN)
Affinity DataIC50:  1.91E+3nMAssay Description:Inhibition of human recombinant GSK-3beta using GS2 peptide as substrate and [gamma33P]-ATP after 30 mins by scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTubulin beta-2B chain(Bos taurus)
Universidad De Salamanca

Curated by ChEMBL
LigandPNGBDBM50159568(1-Methyl-5-[(Z)-2-(3,4,5-trimethoxy-phenyl)-vinyl]...)
Affinity DataIC50:  2.00E+3nMAssay Description:In vitro inhibitory concentration value against bovine brain tubulin polymerizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50426171(CHEMBL483842 | Ircinin 2)
Affinity DataIC50:  2.34E+3nMAssay Description:Inhibition of human recombinant GSK-3beta using GS2 peptide as substrate and [gamma33P]-ATP after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50426171(CHEMBL483842 | Ircinin 2)
Affinity DataIC50:  2.34E+3nMAssay Description:Inhibition of human recombinant GSK-3beta using GS2 peptide as substrate and [gamma33P]-ATP after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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