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Found 106 with Last Name = 'aly' and Initial = 'om'
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Minia University

Curated by ChEMBL
LigandPNGBDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Affinity DataKi:  140nMAssay Description:Inhibition of [3H] colchicine binding to bovine brain tubulin incubated for 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Minia University

Curated by ChEMBL
LigandPNGBDBM50504214(CHEMBL4530425)
Affinity DataKi:  150nMAssay Description:Inhibition of [3H] colchicine binding to bovine brain tubulin incubated for 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Minia University

Curated by ChEMBL
LigandPNGBDBM50504215(CHEMBL4463939)
Affinity DataKi:  260nMAssay Description:Inhibition of [3H] colchicine binding to bovine brain tubulin incubated for 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50603507(CHEMBL5169560)
Affinity DataIC50:  16nMAssay Description:Inhibition of human plasma BuChE using butyrylthiocholine as substrate preincubated for 5 mins followed by substrate addition by Ellman's methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Minia University

Curated by ChEMBL
LigandPNGBDBM50292317(CHEMBL4172557)
Affinity DataIC50:  27nMAssay Description:Inhibition of HDAC1 in human HeLa cells after 72 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Minia University

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  31nMAssay Description:Inhibition of HDAC1 in human HeLa cells after 72 hrs by ELISAMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Minia University

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  33nMAssay Description:Inhibition of HDAC6 in human HeLa cells after 72 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAcetylcholinesterase(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50603482(CHEMBL5199487)
Affinity DataIC50:  34nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant AChE (32 to 614 residues) expressed in HEK293 cells using acetylthiocholine iodide as substrat...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Minia University

Curated by ChEMBL
LigandPNGBDBM50292331(CHEMBL4168150)
Affinity DataIC50:  38nMAssay Description:Inhibition of HDAC1 in human HeLa cells after 72 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM8960((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)
Affinity DataIC50:  54nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant AChE (32 to 614 residues) expressed in HEK293 cells using acetylthiocholine iodide as substrat...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50603488(CHEMBL5205489)
Affinity DataIC50:  56nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant AChE (32 to 614 residues) expressed in HEK293 cells using acetylthiocholine iodide as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Minia University

Curated by ChEMBL
LigandPNGBDBM50292318(CHEMBL4174925)
Affinity DataIC50:  58nMAssay Description:Inhibition of HDAC1 in human HeLa cells after 72 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50603485(CHEMBL5172647)
Affinity DataIC50:  62nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant AChE (32 to 614 residues) expressed in HEK293 cells using acetylthiocholine iodide as substrat...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Minia University

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  81nMAssay Description:Inhibition of VLA-4 from HL60 lysate in a protein-based ligand binding assay.More data for this Ligand-Target Pair
TargetCholinesterase(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  82nMAssay Description:Inhibition of human plasma BuChE using butyrylthiocholine as substrate preincubated for 5 mins followed by substrate addition by Ellman's methodMore data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Minia University

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  91nMAssay Description:Inhibition of HDAC4 in human HeLa cells after 72 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50603507(CHEMBL5169560)
Affinity DataIC50:  93nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine as substrate preincubated for 5 mins followed by substrate addition by Ellman's methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Minia University

Curated by ChEMBL
LigandPNGBDBM50292317(CHEMBL4172557)
Affinity DataIC50:  99nMAssay Description:Inhibition of HDAC4 in human HeLa cells after 72 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  99nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine as substrate preincubated for 5 mins followed by substrate addition by Ellman's methodMore data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Minia University

Curated by ChEMBL
LigandPNGBDBM50292317(CHEMBL4172557)
Affinity DataIC50:  114nMAssay Description:Inhibition of HDAC2 in human HeLa cells after 72 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50603484(CHEMBL5197114)
Affinity DataIC50:  118nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant AChE (32 to 614 residues) expressed in HEK293 cells using acetylthiocholine iodide as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50603490(CHEMBL5199187)
Affinity DataIC50:  131nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant AChE (32 to 614 residues) expressed in HEK293 cells using acetylthiocholine iodide as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlyceraldehyde-3-phosphate dehydrogenase(Oryctolagus cuniculus)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50439262(CHEMBL2419244)
Affinity DataIC50:  150nMAssay Description:Inhibition of rabbit muscle GAPDH assessed as residual enzyme activity after 60 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50603486(CHEMBL5199361)
Affinity DataIC50:  166nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant BuChE (29 to 602 residues) using butyrylthiocholine iodide as substrate preincubated for 5 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Minia University

Curated by ChEMBL
LigandPNGBDBM50292331(CHEMBL4168150)
Affinity DataIC50:  180nMAssay Description:Inhibition of HDAC4 in human HeLa cells after 72 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50603489(CHEMBL5190530)
Affinity DataIC50:  180nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant AChE (32 to 614 residues) expressed in HEK293 cells using acetylthiocholine iodide as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Minia University

Curated by ChEMBL
LigandPNGBDBM50292318(CHEMBL4174925)
Affinity DataIC50:  198nMAssay Description:Inhibition of HDAC4 in human HeLa cells after 72 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlyceraldehyde-3-phosphate dehydrogenase(Oryctolagus cuniculus)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50439263(1-NITROSOCYCLOHEXYL ACETATE)
Affinity DataIC50:  200nMAssay Description:Inhibition of rabbit muscle GAPDH assessed as residual enzyme activity after 60 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50603483(CHEMBL5183077)
Affinity DataIC50:  230nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant AChE (32 to 614 residues) expressed in HEK293 cells using acetylthiocholine iodide as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Minia University

Curated by ChEMBL
LigandPNGBDBM50292331(CHEMBL4168150)
Affinity DataIC50:  232nMAssay Description:Inhibition of HDAC2 in human HeLa cells after 72 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50603486(CHEMBL5199361)
Affinity DataIC50:  245nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant AChE (32 to 614 residues) expressed in HEK293 cells using acetylthiocholine iodide as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Minia University

Curated by ChEMBL
LigandPNGBDBM50292317(CHEMBL4172557)
Affinity DataIC50:  261nMAssay Description:Inhibition of HDAC6 in human HeLa cells after 72 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Minia University

Curated by ChEMBL
LigandPNGBDBM50292318(CHEMBL4174925)
Affinity DataIC50:  263nMAssay Description:Inhibition of HDAC2 in human HeLa cells after 72 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50603481(CHEMBL5194732)
Affinity DataIC50:  275nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant AChE (32 to 614 residues) expressed in HEK293 cells using acetylthiocholine iodide as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Minia University

Curated by ChEMBL
LigandPNGBDBM50292331(CHEMBL4168150)
Affinity DataIC50:  276nMAssay Description:Inhibition of HDAC6 in human HeLa cells after 72 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Minia University

Curated by ChEMBL
LigandPNGBDBM50292318(CHEMBL4174925)
Affinity DataIC50:  290nMAssay Description:Inhibition of HDAC6 in human HeLa cells after 72 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50603487(CHEMBL5174252)
Affinity DataIC50:  299nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant AChE (32 to 614 residues) expressed in HEK293 cells using acetylthiocholine iodide as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50603480(CHEMBL5174183)
Affinity DataIC50:  301nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant AChE (32 to 614 residues) expressed in HEK293 cells using acetylthiocholine iodide as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50603491(CHEMBL5185354)
Affinity DataIC50:  301nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant AChE (32 to 614 residues) expressed in HEK293 cells using acetylthiocholine iodide as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlyceraldehyde-3-phosphate dehydrogenase(Oryctolagus cuniculus)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50439264(ANGELI'S SALT | Angeli''s Salt)
Affinity DataIC50:  400nMAssay Description:Inhibition of rabbit muscle GAPDH assessed as residual enzyme activity after 60 mins by spectrophotometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50603487(CHEMBL5174252)
Affinity DataIC50:  429nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant BuChE (29 to 602 residues) using butyrylthiocholine iodide as substrate preincubated for 5 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50603497(CHEMBL5203109)
Affinity DataIC50:  440nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant AChE (32 to 614 residues) expressed in HEK293 cells using acetylthiocholine iodide as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCholinesterase(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50603491(CHEMBL5185354)
Affinity DataIC50:  459nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant BuChE (29 to 602 residues) using butyrylthiocholine iodide as substrate preincubated for 5 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCholinesterase(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50603481(CHEMBL5194732)
Affinity DataIC50:  473nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant BuChE (29 to 602 residues) using butyrylthiocholine iodide as substrate preincubated for 5 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTubulin beta chain(Sus scrofa)
Minia University

Curated by ChEMBL
LigandPNGBDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Affinity DataIC50:  520nMAssay Description:Inhibition of porcine brain tubulin polymerization assessed as decrease in fluorescence intensity measured every 60 sec for 90 mins in presence of GT...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50603505(CHEMBL5184869)
Affinity DataIC50:  521nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant AChE (32 to 614 residues) expressed in HEK293 cells using acetylthiocholine iodide as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Minia University

Curated by ChEMBL
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50:  600nMAssay Description:Inhibition of ovine COX1 assessed as prostaglandin F2alpha levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50603494(CHEMBL5185422)
Affinity DataIC50:  658nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant AChE (32 to 614 residues) expressed in HEK293 cells using acetylthiocholine iodide as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlyceraldehyde-3-phosphate dehydrogenase(Oryctolagus cuniculus)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50439261(1-NITROSOCYCLOHEXYL TRIFLUOROACETATE)
Affinity DataIC50:  670nMAssay Description:Inhibition of rabbit muscle GAPDH assessed as residual enzyme activity after 60 mins by spectrophotometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTubulin beta chain(Sus scrofa)
Minia University

Curated by ChEMBL
LigandPNGBDBM50504214(CHEMBL4530425)
Affinity DataIC50:  700nMAssay Description:Inhibition of porcine brain tubulin polymerization assessed as decrease in fluorescence intensity measured every 60 sec for 90 mins in presence of GT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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