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Found 5091 with Last Name = 'an' and Initial = 'jy'
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50334730(3-(Naphthalen-1-ylsulfonyl)-5-(piperazin-1-ylmethy...)
Affinity DataKi:  0.240nMAssay Description:Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50528793(CHEMBL4471708)
Affinity DataKi:  0.460nMAssay Description:Displacement of [3H]RTX from recombinant human TRPV1 expressed in CHO cells incubated for 60 mins by liquid scintillation counterMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM28574(1-sulfonylindazole, 6c | 3-amino-N-[1-(naphthalene...)
Affinity DataKi:  0.5nM ΔG°:  -52.6kJ/molepH: 7.4 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50334734(3-(Naphthalen-2-ylsulfonyl)-N-(piperidin-4-yl)-1H-...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50528804(CHEMBL4553702)
Affinity DataKi:  0.670nMAssay Description:Displacement of [3H]RTX from recombinant human TRPV1 expressed in CHO cells incubated for 60 mins by liquid scintillation counterMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50334731(CHEMBL1642851 | [3-(Naphthalen-1-sulfonyl)-1H-inda...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50334754(CHEMBL1642883 | N-(Piperidin-4-yl)-3-(m-tolylsulfo...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50448144(CHEMBL3122212)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]-MPEPy from human mGluR5 expressed in HEK293FT cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50330507(5-(4-Methylpiperazin-1-yl)-3-(m-tolylsulfonyl)-1H-...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50528797(CHEMBL4438643)
Affinity DataKi:  0.950nMAssay Description:Displacement of [3H]RTX from recombinant human TRPV1 expressed in CHO cells incubated for 60 mins by liquid scintillation counterMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240887(CHEMBL4066731)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]MPEPy from human mGlu5 expressed in HEK293FT cell membranes after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50330538(3-(3-Chlorophenylsulfonyl)-5-(4-methylpiperazin-1-...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50334732(3-(3-Chlorophenylsulfonyl)-N-(piperidin-4-yl)-1H-i...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50334733(3-(4-Isopropylphenylsulfonyl)-N-(piperidin-4-yl)-1...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50334725(CHEMBL1642866 | N-(3-(Naphthalen-1-ylsulfonyl)-1H-...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50330505(3-(3-Methoxyphenylsulfonyl)-5-(4-methylpiperazin-1...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50330512(3-(Naphthalen-1-ylsulfonyl)-5-(piperazin-1-yl)-1H-...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM28575(1-sulfonylindazole, 6d | 3-(methylamino)-N-[1-(nap...)
Affinity DataKi:  1.20nM ΔG°:  -50.4kJ/molepH: 7.4 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM28580(1-sulfonylindazole, 7b | N-[1-(naphthalene-1-sulfo...)
Affinity DataKi:  1.30nM ΔG°:  -50.2kJ/molepH: 7.4 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50448157(CHEMBL3122215)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]-MPEPy from human mGluR5 expressed in HEK293FT cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM28583(5-chloro-N-[4-methoxy-3-(piperazin-1-yl)phenyl]-3-...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]LSD from human 5HT6 receptor expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50330523(1-isobutyl-5-(4-methylpiperazin-1-yl)-3-(naphthale...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50334747(CHEMBL1642849 | N1-(3-(Naphthalen-1-ylsulfonyl)-1H...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240900(CHEMBL4091620)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]MPEPy from human mGlu5 expressed in HEK293FT cell membranes after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50334720(3-Amino-N-[3-(naphthalen-1-sulfonyl)-1H-indazol-5-...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50334757(CHEMBL1642887 | N-(Piperidin-4-yl)-3-(4-(trifluoro...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50330511(5-(4-Methylpiperazin-1-yl)-3-(1-naphthalenesulfony...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50330516(1-methyl-3-(naphthalen-1-ylsulfonyl)-5-(piperazin-...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50330515(1-methyl-5-(4-methylpiperazin-1-yl)-3-(naphthalen-...)
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50334716(3-(Naphthalen-1-ylsulfonyl)-N-(piperidin-5-yl)-1H-...)
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50330535(3-(3-Fluorophenylsulfonyl)-5-(4-methylpiperazin-1-...)
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50528802(CHEMBL4562769)
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]RTX from recombinant human TRPV1 expressed in CHO cells incubated for 60 mins by liquid scintillation counterMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50330517(1-ethyl-5-(4-methylpiperazin-1-yl)-3-(naphthalen-1...)
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50330519(5-(4-methylpiperazin-1-yl)-3-(naphthalen-1-ylsulfo...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM28576(1-sulfonylindazole, 6e | 3-(dimethylamino)-N-[1-(n...)
Affinity DataKi:  1.80nM ΔG°:  -49.4kJ/molepH: 7.4 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50330521(1-isopropyl-5-(4-methylpiperazin-1-yl)-3-(naphthal...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50330533(5-(4-methylpiperazin-1-yl)-3-(phenylsulfonyl)-1H-i...)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50330518(1-ethyl-3-(naphthalen-1-ylsulfonyl)-5-(piperazin-1...)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
In DepthDetails ArticlePubMedDrugBank

TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50330525(1-benzyl-5-(4-methylpiperazin-1-yl)-3-(naphthalen-...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM28577(1-sulfonylindazole, 6f | 3-(diethylamino)-N-[1-(na...)
Affinity DataKi:  2.10nM ΔG°:  -49.0kJ/molepH: 7.4 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50330520(3-(naphthalen-1-ylsulfonyl)-5-(piperazin-1-yl)-1-p...)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM34141(CHEMBL76237 | MS-245)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]LSD from human 5HT6 receptor expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM28579(1-sulfonylindazole, 7a | N-[1-(naphthalene-1-sulfo...)
Affinity DataKi:  2.30nM ΔG°:  -48.8kJ/molepH: 7.4 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50334756(3-(4-Chlorophenylsulfonyl)-N-(piperidin-4-yl)-1H-i...)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50448161(CHEMBL3122210)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]-MPEPy from human mGluR5 expressed in HEK293FT cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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