Compile Data Set for Download or QSAR
maximum 50k data
Found 4 Enz. Inhib. hit(s) with Target = 'Bromodomain-containing protein 4 [44-166,D144A]'
TargetBromodomain-containing protein 4 [44-166,D144A](Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM227644(Histone H4 (1-25) | MSGRGKGGKGLGKGGAKRHRKVLRD)
Affinity DataKd:  6.90E+3nMpH: 7.5 T: 2°CAssay Description:The experiments were performed in 384-well black small volume microtiter plates(Greiner) in a buffer composed of 50mM Hepes, pH 7.5 (Applichem), 50 m...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4 [44-166,D144A](Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM50365262((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...)
Affinity DataKd:  44nMpH: 7.5 T: 2°CAssay Description:The experiments were performed in 384-well black small volume microtiter plates(Greiner) in a buffer composed of 50mM Hepes, pH 7.5 (Applichem), 50 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4 [44-166,D144A](Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM50365262((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...)
Affinity DataKd:  1nMpH: 7.5Assay Description:In a typical TSA, 0.4 μg of BRD4 BD1 protein were mixed with 5× Sypro Orange (Molecular Probe) and adjusted to a final volume of 5 μl with ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4 [44-166,D144A](Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM50365262((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...)
Affinity DataKd:  56.6nMpH: 7.5 T: 2°CAssay Description:For KD determinations, 10 nM JQ1-TAMRA probe was incubated in 384-well smallvolume black microtiter plates with serial (1:2) dilutions of each BRD4 v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed