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Found 207 Enz. Inhib. hit(s) with Target = 'Dual specificity mitogen-activated protein kinase kinase 2'
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301967(CHEMBL583679 | N-(2-((S)-3-methyl-2,5-dioxo-1',3'-...)
Affinity DataKi:  670nMAssay Description:Displacement of [125I]adrenomedullin from human cloned AM2 receptor expressed in B6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301954((S)-N-benzyl-N-(2-(3-methyl-2,5-dioxo-1',3'-dihydr...)
Affinity DataKi:  710nMAssay Description:Displacement of [125I]adrenomedullin from human cloned AM2 receptor expressed in B6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301956((+/-)-N-(3-fluorobenzyl)-N-(2-(3-methyl-2,5-dioxo-...)
Affinity DataKi:  1.40E+3nMAssay Description:Displacement of [125I]adrenomedullin from human cloned AM2 receptor expressed in B6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301958((+/-)-N-(3-chlorobenzyl)-N-(2-(3-methyl-2,5-dioxo-...)
Affinity DataKi:  1.40E+3nMAssay Description:Displacement of [125I]adrenomedullin from human cloned AM2 receptor expressed in B6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301968(CHEMBL570474 | N-((R)-1-(3,5-difluorophenyl)ethyl)...)
Affinity DataKi:  1.40E+3nMAssay Description:Displacement of [125I]adrenomedullin from human cloned AM2 receptor expressed in B6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301964((S)-N-(3-chloro-5-fluorobenzyl)-N-(2-(3-methyl-2,5...)
Affinity DataKi:  1.80E+3nMAssay Description:Displacement of [125I]adrenomedullin from human cloned AM2 receptor expressed in B6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301959((+/-)-N-(2-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[...)
Affinity DataKi:  1.80E+3nMAssay Description:Displacement of [125I]adrenomedullin from human cloned AM2 receptor expressed in B6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301965((S)-N-(3,5-dichlorobenzyl)-N-(2-(3-methyl-2,5-diox...)
Affinity DataKi:  2.10E+3nMAssay Description:Displacement of [125I]adrenomedullin from human cloned AM2 receptor expressed in B6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301963((S)-N-(3,5-difluorobenzyl)-N-(2-(3-methyl-2,5-diox...)
Affinity DataKi:  2.40E+3nMAssay Description:Displacement of [125I]adrenomedullin from human cloned AM2 receptor expressed in B6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301957((+/-)-N-(4-fluorobenzyl)-N-(2-(3-methyl-2,5-dioxo-...)
Affinity DataKi:  3.70E+3nMAssay Description:Displacement of [125I]adrenomedullin from human cloned AM2 receptor expressed in B6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301962((+/-)-N-(2-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[...)
Affinity DataKi:  6.20E+3nMAssay Description:Displacement of [125I]adrenomedullin from human cloned AM2 receptor expressed in B6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301960((+/-)-N-(3-methoxybenzyl)-N-(2-(3-methyl-2,5-dioxo...)
Affinity DataKi:  9.70E+3nMAssay Description:Displacement of [125I]adrenomedullin from human cloned AM2 receptor expressed in B6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301961((+/-)-N-(3-cyanobenzyl)-N-(2-(3-methyl-2,5-dioxo-1...)
Affinity DataKi:  1.30E+4nMAssay Description:Displacement of [125I]adrenomedullin from human cloned AM2 receptor expressed in B6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301966(CHEMBL568880 | N-(2-((S)-3-methyl-2,5-dioxo-1',3'-...)
Affinity DataKi:  1.60E+4nMAssay Description:Displacement of [125I]adrenomedullin from human cloned AM2 receptor expressed in B6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50531540(CHEBI:75998 | GSK-1120212 | GSK1120212 | JTP 74057...)
Affinity DataIC50:  1.80nMAssay Description:Non competitive inhibition of MEK2 (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50531540(CHEBI:75998 | GSK-1120212 | GSK1120212 | JTP 74057...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of MEK2 (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM142744(US8937095, 6)
Affinity DataIC50:  4nMAssay Description:Inhibition of human MEK2More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50413752(CHEMBL2012519 | L-783277)
Affinity DataIC50:  8.20nMAssay Description:Inhibition of human MEK2 using ERK2 as substrate in presence of [gamma-33P]-ATP by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  14.6nMAssay Description:Inhibition of human MEK2 using ERK2 as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50531540(CHEBI:75998 | GSK-1120212 | GSK1120212 | JTP 74057...)
Affinity DataIC50:  15nMAssay Description:Inhibition of MEK2 (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50413752(CHEMBL2012519 | L-783277)
Affinity DataIC50:  15nMAssay Description:Inhibition of MEK2 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50132260(2-(2-Chloro-4-iodo-phenylamino)-N-cyclopropylmetho...)
Affinity DataIC50:  17nMAssay Description:Inhibition of MEK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  37.4nMAssay Description:Inhibition of human MEK2 using ERK2 as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM520650(US11147816, Refametinib (RDEA119, Bay | US11701360...)
Affinity DataIC50:  47nMAssay Description:The IC50 for MEK1 and 2 can be measured by methods in references such as [Yamaguchi et al. (2011) International Journal of Oncology 39:23-31].More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM520650(US11147816, Refametinib (RDEA119, Bay | US11701360...)
Affinity DataIC50:  47nMAssay Description:TBDMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM15458(4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidaz...)
Affinity DataIC50: >50nMAssay Description:Inhibition of ERK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50105742(4-[4-(4-Fluoro-phenyl)-5-(2-methoxy-pyrimidin-4-yl...)
Affinity DataIC50: >50nMAssay Description:Inhibition of ERK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  58nMAssay Description:Inhibition of MEK2Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  58nMAssay Description:Inhibition of MEK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMedMMDB

TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  58nMAssay Description:Inhibition of MEK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMedMMDB

TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  60nMAssay Description:Inhibition of the dual specificity kinase MEK-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetDual specificity mitogen-activated protein kinase kinase 2(Rattus norvegicus)
University Of Gothenburg

Curated by ChEMBL
LigandPNGBDBM50498024(CHEMBL3326332)
Affinity DataIC50:  73nMAssay Description:Inhibition of MEK1/2 in rat IEC6 cells assessed as reduction in ERK1/2 loop phosphorylation dosed 30 mins before to stimulation with 10% serum for 5 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50136226(CHEMBL3753341)
Affinity DataIC50:  82nMAssay Description:Inhibition of recombinant human MEK2 by radiometric assay in presence of [gamma-33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM104963(CHEMBL507361 | US11147816, PD0325901 | US11701360,...)
Affinity DataIC50:  110nMAssay Description:Inhibition of recombinant full length human His-tagged MEK2 expressed in baculovirus expression system using ERK K52R dead variant as substrate prein...More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50232968(CHEMBL4099337)
Affinity DataIC50:  187nMAssay Description:Inhibition of human MEK2 using ERK2 as substrate in presence of [gamma-33P]-ATP by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50375643(CHEMBL261237 | SL-327)
Affinity DataIC50:  220nMAssay Description:Inhibition of MEK2Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50:  391nMAssay Description:Inhibition of MEK2 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50506080(CHEMBL4470937)
Affinity DataIC50:  590nMAssay Description:Inhibition of recombinant full length human His-tagged MEK2 expressed in baculovirus expression system using ERK K52R dead variant as substrate prein...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Rattus norvegicus)
University Of Gothenburg

Curated by ChEMBL
LigandPNGBDBM50498026(CHEMBL3326319)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of MEK1/2 in rat IEC6 cells assessed as reduction in ERK1/2 loop phosphorylation dosed 30 mins before to stimulation with 10% serum for 5 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50387974(CHEMBL2057830)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of MEK2 using [gamma32P]ATP by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50506079(CHEMBL4446127)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of recombinant full length human His-tagged MEK2 expressed in baculovirus expression system using ERK K52R dead variant as substrate prein...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Rattus norvegicus)
University Of Gothenburg

Curated by ChEMBL
LigandPNGBDBM50498028(CHEMBL3326325)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of MEK1/2 in rat IEC6 cells assessed as reduction in ERK1/2 loop phosphorylation dosed 30 mins before to stimulation with 10% serum for 5 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Rattus norvegicus)
University Of Gothenburg

Curated by ChEMBL
LigandPNGBDBM50498030(CHEMBL3326326)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of MEK1/2 in rat IEC6 cells assessed as reduction in ERK1/2 loop phosphorylation dosed 30 mins before to stimulation with 10% serum for 5 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50574708(CHEMBL4866102)
Affinity DataIC50:  3.25E+3nMAssay Description:Inhibition of MEK2 (unknown origin) incubated for 40 mins in presence of Mg/ATP mix by [gamma p33]-ATP based scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Rattus norvegicus)
University Of Gothenburg

Curated by ChEMBL
LigandPNGBDBM50108771(2'-amino-3'-methoxyflavone | 2-(2-Amino-3-methoxy-...)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of MEK1/2 in rat IEC6 cells assessed as reduction in ERK1/2 loop phosphorylation dosed 30 mins before to stimulation with 10% serum for 5 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50335376((S)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-...)
Affinity DataIC50:  6.84E+3nMAssay Description:Inhibition of MEK2 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50519662(CHEMBL4438748)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant full length human MEK2 using MBP as substrate incubated for 40 mins in presence of [gamma-33ATP by radiometric scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50401152(CHEMBL2205766)
Affinity DataIC50: <1.00E+4nMAssay Description:Inhibition of MAP2K2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MEK2 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50235820(CHEMBL4066664)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MEK2 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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