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Found 237 Enz. Inhib. hit(s) with Target = 'Ephrin type-B receptor 2'
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50341519((S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl...)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of EPHB2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50463483(CHEMBL4245242)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of EphB2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50463479(CHEMBL4249925)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of EphB2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50299218(8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-5'-hydro...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of EphB2 by [gamma33-P]ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50536679(CHEMBL4568087)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of recombinant human GST-tagged cytoplasmic EPHB2 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of EPHB2More data for this Ligand-Target Pair
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM4552(4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-...)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of EPHB2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50: <10nMAssay Description:Inhibition of recombinant human GST-tagged cytoplasmic EPHB2 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50:  10nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50331095(CHEMBL1289494 | Tivozanib | US10464902, Tivozanib)
Affinity DataIC50:  18nMAssay Description:Inhibition of recombinant EphB2 (unknown origin) by cell-free assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50:  26nMAssay Description:Inhibition of human EphB2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50:  26nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50331095(CHEMBL1289494 | Tivozanib | US10464902, Tivozanib)
Affinity DataIC50:  27nMAssay Description:Inhibition of recombinant EphB2 (unknown origin) by cell-free assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM378885(US10266537, Compound 93)
Affinity DataIC50:  33nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50536678(CHEMBL4550702)
Affinity DataIC50:  36nMAssay Description:Inhibition of recombinant human GST-tagged cytoplasmic EPHB2 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  42.4nMAssay Description:Inhibition of human EPHB2 using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50538442(CHEMBL4638981)
Affinity DataIC50:  71nMAssay Description:Inhibition of EPHB2 (unknown origin) assessed as residual activity incubated for 5 mins in presence of [gamma-33ATP] by scintillation counting based ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50328755(2-(3-(3-tert-butyl-5-(3-(2,3-dichlorophenyl)ureido...)
Affinity DataIC50:  82nMAssay Description:Inhibition of EPHB2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50538438(CHEMBL4640297)
Affinity DataIC50:  93nMAssay Description:Inhibition of EPHB2 (unknown origin) assessed as residual activity incubated for 5 mins in presence of [gamma-33ATP] by scintillation counting based ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  115nMAssay Description:Inhibition of human EPHB2 using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataIC50:  160nMAssay Description:Inhibition of EPHB2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  199nMAssay Description:Inhibition of EPHB2 (unknown origin) incubated for 1 hr by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50498455(CHEMBL3596879)
Affinity DataIC50:  880nMAssay Description:Inhibition of EphB2 (unknown origin) using ATP and 5FAM tagged TrkA peptide substrate incubated for 60 mins by microfluidics assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50462709(CHEMBL4245507)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of EPH-B2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataIC50: <1.00E+3nMAssay Description:Concentration required to inhibit the phosphorylation of a 14-residue fragment of phospholipase C gamma 1 by Epidermal growth factor receptor from A4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50563891(CHEMBL4793380)
Affinity DataIC50:  1.09E+3nMAssay Description:Inhibition of recombinant human EphB2 (560 to end residues) using poly(Glu, Tyr) 4:1 as substrate incubated for 40 mins in presence of [gamma-33ATP] ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM4622(3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol | An...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of EPH receptor B2 using ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50592745(CHEMBL5188373)
Affinity DataIC50:  1.23E+3nMAssay Description:Inhibition of EphB2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEphrin type-B receptor 2(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50384721(CHEMBL2037224)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of Tel-fused EPHB2 in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50498452(CHEMBL3596873)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of EphB2 (unknown origin) using ATP and 5FAM tagged TrkA peptide substrate incubated for 60 mins by microfluidics assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50498449(CHEMBL3596889)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of EphB2 (unknown origin) using ATP and 5FAM tagged TrkA peptide substrate incubated for 60 mins by microfluidics assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50498453(CHEMBL3596862)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of EphB2 (unknown origin) using ATP and 5FAM tagged TrkA peptide substrate incubated for 60 mins by microfluidics assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50498458(CHEMBL3596868)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of EphB2 (unknown origin) using ATP and 5FAM tagged TrkA peptide substrate incubated for 60 mins by microfluidics assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50:  2.16E+3nMAssay Description:Inhibition of human recombinant GST-tagged EPHB2 cytoplasmic domain (616 to 884 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50498457(CHEMBL3596893)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of EphB2 (unknown origin) using ATP and 5FAM tagged TrkA peptide substrate incubated for 60 mins by microfluidics assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50384720(CHEMBL2037220)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of Tel-fused EPHB2 in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50384726(CHEMBL2037208)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of Tel-fused EPHB2 in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50498459(CHEMBL3596892)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of EphB2 (unknown origin) using ATP and 5FAM tagged TrkA peptide substrate incubated for 60 mins by microfluidics assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50428059(CHEMBL2322989)
Affinity DataIC50:  3.80E+3nMAssay Description:Displacement of ephrin-B1-Fc from EphB2 receptor Fc ectodomain (unknown origin) after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of recombinant human GST-tagged cytoplasmic EPHB2 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50384725(CHEMBL2037209)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of Tel-fused EPHB2 in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM39299(3-imidazol-1-ylpropyl(7H-purin-6-yl)amine | CHEMBL...)
Affinity DataIC50:  5.20E+3nMAssay Description:Inhibition of EPH receptor B2 using ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50384727(CHEMBL2037226)
Affinity DataIC50:  5.80E+3nMAssay Description:Inhibition of Tel-fused EPHB2 in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50:  7.20E+3nMAssay Description:Inhibition of EPHB2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM13336(4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-...)
Affinity DataIC50:  7.80E+3nMAssay Description:Inhibition of EPH receptor B2 using ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM4621(Anilinoquinazoline deriv. 4 | CHEMBL150315 | N-(4-...)
Affinity DataIC50:  8.50E+3nMAssay Description:Inhibition of EPH receptor B2 using ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50401152(CHEMBL2205766)
Affinity DataIC50: <1.00E+4nMAssay Description:Inhibition of EPHB2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50341628(3-(4-Acetylpiperazin-1-yl)-5-(3-nitrobenzylamino)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EPH-B2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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