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Found 9 Enz. Inhib. hit(s) with Target = 'Histone H3.1'
TargetHistone H3.1 [22-45](Homo sapiens (Human))
Epizyme

US Patent
LigandPNGBDBM155253(US10098888, Compound 1 | US9006242, 1)
Affinity DataIC50: <5nMAssay Description:General Materials. S-adenosylmethionine (SAM), S-adenosylhomocyteine (SAH), bicine, KCI, Tween20, dimethylsulfoxide (DMSO) and bovine skin gelatin (B...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone H3.1 [22-45](Homo sapiens (Human))
Epizyme

US Patent
LigandPNGBDBM155255(US10098888, Compound 105 | US11642348, Compound 10...)
Affinity DataIC50:  8.40nMAssay Description:General Materials. S-adenosylmethionine (SAM), S-adenosylhomocyteine (SAH), bicine, KCI, Tween20, dimethylsulfoxide (DMSO) and bovine skin gelatin (B...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone H3.1 [22-45](Homo sapiens (Human))
Epizyme

US Patent
LigandPNGBDBM155254(US10098888, Compound 2 | US9006242, 2)
Affinity DataIC50:  15nMAssay Description:General Materials. S-adenosylmethionine (SAM), S-adenosylhomocyteine (SAH), bicine, KCI, Tween20, dimethylsulfoxide (DMSO) and bovine skin gelatin (B...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone H3.1 [22-45](Homo sapiens (Human))
Epizyme

US Patent
LigandPNGBDBM155253(US10098888, Compound 1 | US9006242, 1)
Affinity DataIC50:  77nMAssay Description:General Materials. S-adenosylmethionine (SAM), S-adenosylhomocyteine (SAH), bicine, KCI, Tween20, dimethylsulfoxide (DMSO) and bovine skin gelatin (B...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone H3.1 [22-45](Homo sapiens (Human))
Epizyme

US Patent
LigandPNGBDBM155255(US10098888, Compound 105 | US11642348, Compound 10...)
Affinity DataIC50:  104nMAssay Description:General Materials. S-adenosylmethionine (SAM), S-adenosylhomocyteine (SAH), bicine, KCI, Tween20, dimethylsulfoxide (DMSO) and bovine skin gelatin (B...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone H3.1 [22-45](Homo sapiens (Human))
Epizyme

US Patent
LigandPNGBDBM155254(US10098888, Compound 2 | US9006242, 2)
Affinity DataIC50:  110nMAssay Description:General Materials. S-adenosylmethionine (SAM), S-adenosylhomocyteine (SAH), bicine, KCI, Tween20, dimethylsulfoxide (DMSO) and bovine skin gelatin (B...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone H3.1(Homo sapiens (Human))
Mei Pharma

US Patent
LigandPNGBDBM50248522(CHEMBL489332 | N-hydroxy-3-(2-phenethyl-1-(2-(pipe...)
Affinity DataEC50:  500nMAssay Description:To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5×105 cells/well for 24 h. Colo20...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone H3.1(Homo sapiens (Human))
Mei Pharma

US Patent
LigandPNGBDBM50248375(CHEMBL491688 | N-hydroxy-3-(2-phenethyl-1-(3,4,5-t...)
Affinity DataEC50:  1.70E+3nMAssay Description:To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5×105 cells/well for 24 h. Colo20...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone H3.1(Homo sapiens (Human))
Mei Pharma

US Patent
LigandPNGBDBM50248570(3-(1-(3-(dimethylamino)-2,2-dimethylpropyl)-2-phen...)
Affinity DataEC50:  1.10E+3nMAssay Description:To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5×105 cells/well for 24 h. Colo20...More data for this Ligand-Target Pair
In DepthDetails US Patent