Compile Data Set for Download or QSAR
maximum 50k data
Found 53 Enz. Inhib. hit(s) with Target = 'Inhibitor of nuclear factor kappa-B kinase subunit alpha/Inhibitor of nuclear factor kappa-B kinase subunit beta/NF-kappa-B essential modulator'
LigandPNGBDBM50175690((4-(4-(5-(3-amino-3-ethylpentyl)thiophen-2-yl)pyri...)
Affinity DataIC50:  30nMAssay Description:Inhibitory activity against IKK complex isolated from HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175701((4-(4-(5-(3-amino-3-methylbutyl)thiophen-2-yl)pyri...)
Affinity DataIC50:  40nMAssay Description:Inhibitory activity against IKK complex isolated from HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175686((4-(4-(5-(4-hydroxybutyl)thiophen-2-yl)pyrimidin-2...)
Affinity DataIC50:  40nMAssay Description:Inhibitory activity against IKK complex isolated from HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175687((4-(4-(5-(3-hydroxy-3-methylbutyl)thiophen-2-yl)py...)
Affinity DataIC50:  50nMAssay Description:Inhibitory activity against IKK complex isolated from HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175688((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)p...)
Affinity DataIC50:  70nMAssay Description:Inhibitory activity against IKK complex isolated from HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175689((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)p...)
Affinity DataIC50:  80nMAssay Description:Inhibitory activity against IKK complex isolated from HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175695((4-(4-(5-(3-methoxypropyl)thiophen-2-yl)pyrimidin-...)
Affinity DataIC50:  100nMAssay Description:Inhibitory activity against IKK complex isolated from HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175700((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)-...)
Affinity DataIC50:  150nMAssay Description:Inhibitory activity against IKK complex isolated from HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175686((4-(4-(5-(4-hydroxybutyl)thiophen-2-yl)pyrimidin-2...)
Affinity DataIC50:  200nMAssay Description:Inhibition of TNF-alpha-stimulated expression of VCAM1 in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175686((4-(4-(5-(4-hydroxybutyl)thiophen-2-yl)pyrimidin-2...)
Affinity DataIC50:  200nMAssay Description:Inhibition of TNF-alpha-stimulated expression of E-selectin in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175686((4-(4-(5-(4-hydroxybutyl)thiophen-2-yl)pyrimidin-2...)
Affinity DataIC50:  200nMAssay Description:Inhibition of TNF-alpha-stimulated expression of ICAM1 in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175697((4-(4-(5-(3-amino-3-methylbut-1-ynyl)thiophen-2-yl...)
Affinity DataIC50:  200nMAssay Description:Inhibitory activity against IKK complex isolated from HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175698((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)-...)
Affinity DataIC50:  250nMAssay Description:Inhibitory activity against IKK complex isolated from HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175688((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)p...)
Affinity DataIC50:  300nMAssay Description:Inhibition of LPS-induced TNFalpha release from human PBMCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175685(4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)-N...)
Affinity DataIC50:  300nMAssay Description:Inhibitory activity against IKK complex isolated from HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175688((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)p...)
Affinity DataIC50:  300nMAssay Description:Inhibition of TNF-alpha-stimulated expression of ICAM1 in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175688((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)p...)
Affinity DataIC50:  300nMAssay Description:Inhibition of TNF-alpha-stimulated expression of VCAM1 in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175689((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)p...)
Affinity DataIC50:  300nMAssay Description:Inhibition of TNF-alpha-stimulated expression of E-selectin in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175695((4-(4-(5-(3-methoxypropyl)thiophen-2-yl)pyrimidin-...)
Affinity DataIC50:  400nMAssay Description:Inhibition of TNF-alpha-stimulated expression of E-selectin in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175689((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)p...)
Affinity DataIC50:  400nMAssay Description:Inhibition of TNF-alpha-stimulated expression of ICAM1 in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175689((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)p...)
Affinity DataIC50:  400nMAssay Description:Inhibition of TNF-alpha-stimulated expression of VCAM1 in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175687((4-(4-(5-(3-hydroxy-3-methylbutyl)thiophen-2-yl)py...)
Affinity DataIC50:  450nMAssay Description:Inhibition of TNF-alpha-stimulated expression of E-selectin in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175685(4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)-N...)
Affinity DataIC50:  500nMAssay Description:Inhibition of TNF-alpha-stimulated expression of VCAM1 in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175688((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)p...)
Affinity DataIC50:  500nMAssay Description:Inhibition of TNF-alpha-stimulated expression of E-selectin in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175687((4-(4-(5-(3-hydroxy-3-methylbutyl)thiophen-2-yl)py...)
Affinity DataIC50:  500nMAssay Description:Inhibition of TNF-alpha-stimulated expression of ICAM1 in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175685(4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)-N...)
Affinity DataIC50:  500nMAssay Description:Inhibition of TNF-alpha-stimulated expression of ICAM1 in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175695((4-(4-(5-(3-methoxypropyl)thiophen-2-yl)pyrimidin-...)
Affinity DataIC50:  500nMAssay Description:Inhibition of TNF-alpha-stimulated expression of VCAM1 in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175693(4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)-N...)
Affinity DataIC50:  500nMAssay Description:Inhibitory activity against IKK complex isolated from HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175685(4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)-N...)
Affinity DataIC50:  500nMAssay Description:Inhibition of TNF-alpha-stimulated expression of E-selectin in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175695((4-(4-(5-(3-methoxypropyl)thiophen-2-yl)pyrimidin-...)
Affinity DataIC50:  600nMAssay Description:Inhibition of TNF-alpha-stimulated expression of ICAM1 in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175687((4-(4-(5-(3-hydroxy-3-methylbutyl)thiophen-2-yl)py...)
Affinity DataIC50:  600nMAssay Description:Inhibition of TNF-alpha-stimulated expression of VCAM1 in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175699(CHEMBL372160 | N-(2-methyl-4-(5-(2-(4-(4-(pyrrolid...)
Affinity DataIC50:  800nMAssay Description:Inhibitory activity against IKK complex isolated from HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175695((4-(4-(5-(3-methoxypropyl)thiophen-2-yl)pyrimidin-...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of TNF-alpha-stimulated IkappaBalpha degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175688((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)p...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of TNF-alpha-stimulated IkappaBalpha degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175687((4-(4-(5-(3-hydroxy-3-methylbutyl)thiophen-2-yl)py...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of TNF-alpha-stimulated IkappaBalpha degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175686((4-(4-(5-(4-hydroxybutyl)thiophen-2-yl)pyrimidin-2...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of TNF-alpha-stimulated IkappaBalpha degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175694((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)p...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of TNF-alpha-stimulated expression of E-selectin in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175694((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)p...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of TNF-alpha-stimulated expression of ICAM1 in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175694((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)p...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of TNF-alpha-stimulated expression of VCAM1 in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175689((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)p...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of TNF-alpha-stimulated IkappaBalpha degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50484019(CHEMBL1800969)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of IKK in human A549 cells assessed as inhibition of TNF-alpha-induced IkappaB phosphorylation preincubated for 30 mins before TNFalpha ch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50484021(CHEMBL1800965)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of IKK in human A549 cells assessed as inhibition of TNF-alpha-induced IkappaB phosphorylation preincubated for 30 mins before TNFalpha ch...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175692(CHEMBL370166 | N-(2-aminoethyl)-4-(4-(benzo[b]thio...)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibitory activity against IKK complex isolated from HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50484020(CHEMBL1800999)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of IKK in human A549 cells assessed as inhibition of TNF-alpha-induced IkappaB phosphorylation preincubated for 30 mins before TNFalpha ch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50175685(4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)-N...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of TNF-alpha-stimulated IkappaBalpha degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175694((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)p...)
Affinity DataIC50:  8.50E+3nMAssay Description:Inhibitory activity against IKK complex isolated from HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175696(4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)be...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibitory activity against IKK complex isolated from HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175694((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)p...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of TNF-alpha-stimulated IkappaBalpha degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175696(4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)be...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of TNF-alpha-stimulated expression of ICAM1 in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175696(4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)be...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of TNF-alpha-stimulated expression of VCAM1 in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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