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Found 5 Enz. Inhib. hit(s) with Target = 'Cytochrome P450 3A7'
TargetCytochrome P450 3A7(Homo sapiens)
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50318484(2-((1R,6R)-6-Isopropenyl-3-methyl-cyclohex-2-enyl)...)
Affinity DataKi:  1.23E+4nMAssay Description:Mixed type inhibition of human recombinant CYP3A7 expressed in baculovirus-infected insect cells using diltiazem as substrate incubated for 30 mins f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A7(Homo sapiens)
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50584760(CHEMBL2068968)
Affinity DataIC50:  1.08E+4nMAssay Description:Time dependent inhibition of recombinant human CYP3A7 incubated for 30 mins in presence of NADPH generating system by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A7 [T409R](Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50088503(CHEMBL3527048)
Affinity DataIC50:  3.30E+4nMAssay Description:Reversible inhibition of midazolam 1'-hydroxylase activity of human recombinant CYP3A7 harboring human P450 oxidoreductase and b5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A7(Homo sapiens)
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50584760(CHEMBL2068968)
Affinity DataIC50:  6.48E+4nMAssay Description:Time dependent inhibition of recombinant human CYP3A7 using midazolam as substrate preincubated for 30 mins in presence of NADPH generating system fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A7(Homo sapiens)
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50584761(BUFALIN | Bufalin | CHEBI:517248)
Affinity DataIC50: >1.00E+5nMAssay Description:Time dependent inhibition of recombinant human CYP3A7 incubated for 30 mins in presence of NADPH generating system by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed