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Found 264 Enz. Inhib. hit(s) with Target = 'Legumain'
TargetLegumain(Homo sapiens (Human))
Emory Chemical Biology Discovery Center Emory University School Of Medicine Atlanta

Curated by ChEMBL
LigandPNGBDBM50240928(CHEMBL4067280)
Affinity DataKi:  105nMAssay Description:Competitive inhibition of AEP (unknown origin) using varying levels of Z-AAN-AMC substrate after 10 mins by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Homo sapiens (Human))
Emory Chemical Biology Discovery Center Emory University School Of Medicine Atlanta

Curated by ChEMBL
LigandPNGBDBM50510337(CHEMBL4545652)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of recombinant human legumain using Z-Ala-Ala-Asn-AMC as substrate measured for every 2 mins for 60 mins by fluorescence-based microplate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLegumain(Ixodes ricinus)
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50378274(CHEMBL573437)
Affinity DataIC50:  0.140nMAssay Description:Inhibition of Ixodes ricinus asparaginyl endopeptidasesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Ixodes ricinus)
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50378260(CHEMBL577594)
Affinity DataIC50:  0.230nMAssay Description:Inhibition of Ixodes ricinus asparaginyl endopeptidasesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Homo sapiens (Human))
Emory Chemical Biology Discovery Center Emory University School Of Medicine Atlanta

Curated by ChEMBL
LigandPNGBDBM50510318(CHEMBL4438891)
Affinity DataIC50:  0.260nMAssay Description:Inhibition of recombinant human legumain using Z-Ala-Ala-Asn-AMC as substrate measured for every 2 mins for 60 mins by fluorescence-based microplate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLegumain(Ixodes ricinus)
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50378275(CHEMBL582897)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of Ixodes ricinus asparaginyl endopeptidasesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Ixodes ricinus)
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50378276(CHEMBL582898)
Affinity DataIC50:  0.370nMAssay Description:Inhibition of Ixodes ricinus asparaginyl endopeptidasesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Homo sapiens (Human))
Emory Chemical Biology Discovery Center Emory University School Of Medicine Atlanta

Curated by ChEMBL
LigandPNGBDBM50510331(CHEMBL4556228)
Affinity DataIC50:  0.470nMAssay Description:Inhibition of recombinant human legumain using Z-Ala-Ala-Asn-AMC as substrate measured for every 2 mins for 60 mins by fluorescence-based microplate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLegumain(Ixodes ricinus)
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50378280(CHEMBL576557)
Affinity DataIC50:  0.520nMAssay Description:Inhibition of Ixodes ricinus asparaginyl endopeptidasesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Homo sapiens (Human))
Emory Chemical Biology Discovery Center Emory University School Of Medicine Atlanta

Curated by ChEMBL
LigandPNGBDBM50015362(CHEMBL3264590)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of recombinant human legumain using Z-Ala-Ala-Asn-AMC fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Ixodes ricinus)
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM22116(aza-peptide Michael acceptor, 7b | benzyl (2E)-3-{...)
Affinity DataIC50: <1nMT: 2°CAssay Description:AE activity in the induction medium was measured with the substrate Cbz-Ala-Ala-Asn-AMC. In a black 96-well microtiter plate, aza-peptidyl inhibitors...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Ixodes ricinus)
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM22125(aza-peptide Michael acceptor, 5i | benzyl N-[(1S)-...)
Affinity DataIC50: <1nMT: 2°CAssay Description:AE activity in the induction medium was measured with the substrate Cbz-Ala-Ala-Asn-AMC. In a black 96-well microtiter plate, aza-peptidyl inhibitors...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Ixodes ricinus)
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM22128(aza-peptide Michael acceptor, 5l | benzyl N-[(1S)-...)
Affinity DataIC50: <1nMT: 2°CAssay Description:AE activity in the induction medium was measured with the substrate Cbz-Ala-Ala-Asn-AMC. In a black 96-well microtiter plate, aza-peptidyl inhibitors...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Homo sapiens (Human))
Emory Chemical Biology Discovery Center Emory University School Of Medicine Atlanta

Curated by ChEMBL
LigandPNGBDBM50510316(CHEMBL4549828)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of recombinant human legumain using Z-Ala-Ala-Asn-AMC as substrate measured for every 2 mins for 60 mins by fluorescence-based microplate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLegumain(Homo sapiens (Human))
Emory Chemical Biology Discovery Center Emory University School Of Medicine Atlanta

Curated by ChEMBL
LigandPNGBDBM50510339(CHEMBL4547118)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of recombinant human legumain using Z-Ala-Ala-Asn-AMC as substrate measured for every 2 mins for 60 mins by fluorescence-based microplate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLegumain(Ixodes ricinus)
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50378246(CHEMBL584155)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of Ixodes ricinus asparaginyl endopeptidasesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Ixodes ricinus)
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM22124(aza-peptide Michael acceptor, 5h | benzyl N-[(1S)-...)
Affinity DataIC50:  1.80nMT: 2°CAssay Description:AE activity in the induction medium was measured with the substrate Cbz-Ala-Ala-Asn-AMC. In a black 96-well microtiter plate, aza-peptidyl inhibitors...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Ixodes ricinus)
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50378258(CHEMBL573249)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of Ixodes ricinus asparaginyl endopeptidasesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Ixodes ricinus)
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50378268(CHEMBL573433)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of Ixodes ricinus asparaginyl endopeptidasesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Ixodes ricinus)
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM22145(Biotinylated Michael acceptor, 12 | ethyl (2E)-4-[...)
Affinity DataIC50:  2.80nMT: 2°CAssay Description:AE activity in the induction medium was measured with the substrate Cbz-Ala-Ala-Asn-AMC. In a black 96-well microtiter plate, aza-peptidyl inhibitors...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLegumain(Homo sapiens (Human))
Emory Chemical Biology Discovery Center Emory University School Of Medicine Atlanta

Curated by ChEMBL
LigandPNGBDBM50015361(CHEMBL3264589)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of recombinant human legumain using Z-Ala-Ala-Asn-AMC fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Ixodes ricinus)
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50378263(CHEMBL573672)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of Ixodes ricinus asparaginyl endopeptidasesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Homo sapiens (Human))
Emory Chemical Biology Discovery Center Emory University School Of Medicine Atlanta

Curated by ChEMBL
LigandPNGBDBM50510329(CHEMBL4474978)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of recombinant human legumain using Z-Ala-Ala-Asn-AMC as substrate measured for every 2 mins for 60 mins by fluorescence-based microplate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Ixodes ricinus)
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50378267(CHEMBL573161)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of Ixodes ricinus asparaginyl endopeptidasesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Ixodes ricinus)
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM22139(aza-peptide Michael acceptor, 5s | benzyl N-[(1S)-...)
Affinity DataIC50:  4nMT: 2°CAssay Description:AE activity in the induction medium was measured with the substrate Cbz-Ala-Ala-Asn-AMC. In a black 96-well microtiter plate, aza-peptidyl inhibitors...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Mus musculus)
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50364367(CHEMBL1950283)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of mouse recombinant legumain using Cbz-Ala-Ala-Asn-AMC as substrate measured every 30 secs for 2.5 hrs by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Ixodes ricinus)
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM22142(aza-peptide Michael acceptor, 5v | benzyl N-[(1S)-...)
Affinity DataIC50:  4.5nMT: 2°CAssay Description:AE activity in the induction medium was measured with the substrate Cbz-Ala-Ala-Asn-AMC. In a black 96-well microtiter plate, aza-peptidyl inhibitors...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Ixodes ricinus)
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM22114(aza-peptide Michael acceptor, 7a | ethyl (2E)-4-[(...)
Affinity DataIC50:  4.5nMT: 2°CAssay Description:AE activity in the induction medium was measured with the substrate Cbz-Ala-Ala-Asn-AMC. In a black 96-well microtiter plate, aza-peptidyl inhibitors...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Ixodes ricinus)
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50378273(CHEMBL583115)
Affinity DataIC50:  5nMAssay Description:Inhibition of Ixodes ricinus asparaginyl endopeptidasesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Homo sapiens (Human))
Emory Chemical Biology Discovery Center Emory University School Of Medicine Atlanta

Curated by ChEMBL
LigandPNGBDBM50499753(CHEMBL3741471)
Affinity DataIC50:  5nMAssay Description:Inhibition of recombinant human legumain using Z-Ala-Ala-Asn-MCA substrate measured every 2 mins for 60 mins by microplate reader analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLegumain(Homo sapiens (Human))
Emory Chemical Biology Discovery Center Emory University School Of Medicine Atlanta

Curated by ChEMBL
LigandPNGBDBM50015348(CHEMBL3264578)
Affinity DataIC50:  5nMAssay Description:Inhibition of recombinant human legumain using Z-Ala-Ala-Asn-AMC fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Ixodes ricinus)
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM22126(aza-peptide Michael acceptor, 5j | benzyl N-[(1S)-...)
Affinity DataIC50:  5.5nMT: 2°CAssay Description:AE activity in the induction medium was measured with the substrate Cbz-Ala-Ala-Asn-AMC. In a black 96-well microtiter plate, aza-peptidyl inhibitors...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Homo sapiens (Human))
Emory Chemical Biology Discovery Center Emory University School Of Medicine Atlanta

Curated by ChEMBL
LigandPNGBDBM50510333(CHEMBL4472825)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of recombinant human legumain using Z-Ala-Ala-Asn-AMC as substrate measured for every 2 mins for 60 mins by fluorescence-based microplate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLegumain(Ixodes ricinus)
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM22138(aza-peptide Michael acceptor, 5r | benzyl N-[(1S)-...)
Affinity DataIC50:  6nMT: 2°CAssay Description:AE activity in the induction medium was measured with the substrate Cbz-Ala-Ala-Asn-AMC. In a black 96-well microtiter plate, aza-peptidyl inhibitors...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Homo sapiens (Human))
Emory Chemical Biology Discovery Center Emory University School Of Medicine Atlanta

Curated by ChEMBL
LigandPNGBDBM50499738(CHEMBL3740153)
Affinity DataIC50:  6nMAssay Description:Inhibition of recombinant human legumain using Z-Ala-Ala-Asn-MCA substrate measured every 2 mins for 60 mins by microplate reader analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLegumain(Homo sapiens (Human))
Emory Chemical Biology Discovery Center Emory University School Of Medicine Atlanta

Curated by ChEMBL
LigandPNGBDBM50499733(CHEMBL3740378)
Affinity DataIC50:  6nMAssay Description:Inhibition of recombinant human legumain using Z-Ala-Ala-Asn-MCA substrate measured every 2 mins for 60 mins by microplate reader analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLegumain(Ixodes ricinus)
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50378287(CHEMBL584154)
Affinity DataIC50:  6nMAssay Description:Inhibition of Ixodes ricinus asparaginyl endopeptidasesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Mus musculus)
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50364353(CHEMBL1950109)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of mouse recombinant legumain using Cbz-Ala-Ala-Asn-AMC as substrate measured every 30 secs for 2.5 hrs by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Homo sapiens (Human))
Emory Chemical Biology Discovery Center Emory University School Of Medicine Atlanta

Curated by ChEMBL
LigandPNGBDBM50510320(CHEMBL4452627)
Affinity DataIC50:  7.10nMAssay Description:Inhibition of recombinant human legumain using Z-Ala-Ala-Asn-AMC as substrate measured for every 2 mins for 60 mins by fluorescence-based microplate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLegumain(Ixodes ricinus)
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50378270(CHEMBL573435)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of Ixodes ricinus asparaginyl endopeptidasesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Homo sapiens (Human))
Emory Chemical Biology Discovery Center Emory University School Of Medicine Atlanta

Curated by ChEMBL
LigandPNGBDBM50015363(CHEMBL3264591)
Affinity DataIC50:  7.80nMAssay Description:Inhibition of recombinant human legumain using Z-Ala-Ala-Asn-AMC fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Ixodes ricinus)
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM22137(aza-peptide Michael acceptor, 5q | benzyl N-[(1S)-...)
Affinity DataIC50:  8nMT: 2°CAssay Description:AE activity in the induction medium was measured with the substrate Cbz-Ala-Ala-Asn-AMC. In a black 96-well microtiter plate, aza-peptidyl inhibitors...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Ixodes ricinus)
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50378259(CHEMBL572824)
Affinity DataIC50:  8nMAssay Description:Inhibition of Ixodes ricinus asparaginyl endopeptidasesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Mus musculus)
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50364366(CHEMBL1950282)
Affinity DataIC50:  8.10nMAssay Description:Inhibition of mouse recombinant legumain using Cbz-Ala-Ala-Asn-AMC as substrate measured every 30 secs for 2.5 hrs by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Mus musculus)
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM228618(BDBM50364365 | US9345789, LI-2)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of mouse recombinant legumain using Cbz-Ala-Ala-Asn-AMC as substrate measured every 30 secs for 2.5 hrs by fluorimetryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLegumain(Ixodes ricinus)
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50378264(CHEMBL577371)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of Ixodes ricinus asparaginyl endopeptidasesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Ixodes ricinus)
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50378286(CHEMBL573670)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of Ixodes ricinus asparaginyl endopeptidasesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Ixodes ricinus)
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50378269(CHEMBL574673)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of Ixodes ricinus asparaginyl endopeptidasesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Mus musculus)
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50364368(CHEMBL1950284)
Affinity DataIC50:  8.60nMAssay Description:Inhibition of mouse recombinant legumain using Cbz-Ala-Ala-Asn-AMC as substrate measured every 30 secs for 2.5 hrs by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Homo sapiens (Human))
Emory Chemical Biology Discovery Center Emory University School Of Medicine Atlanta

Curated by ChEMBL
LigandPNGBDBM50015353(CHEMBL3264583)
Affinity DataIC50:  9nMAssay Description:Inhibition of recombinant human legumain using Z-Ala-Ala-Asn-AMC fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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