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Found 12 Enz. Inhib. hit(s) with Target = 'Amyloid-beta precursor protein [672-711]'
TargetAmyloid-beta precursor protein [672-711](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM250505(US9464103, (6aR,7S,10aS)-10a-(4-chlorobenzenesulfo...)
Affinity DataIC50:  5.40nMpH: 7.0Assay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein [672-711](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM250501(US9464103, (6'S,6aR,7s,10aS)-10a-(4-chlorobenz...)
Affinity DataIC50:  9.5nMpH: 7.0Assay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein [672-711](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50129277(CHEMBL3629739 | US9464103, (6aR,10aS)-10a-(4-chlor...)
Affinity DataIC50:  10.1nMpH: 7.0Assay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAmyloid-beta precursor protein [672-711](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50129269(CHEMBL3629738 | US9464103, (6aR,7S,10aS)-10a-(4-ch...)
Affinity DataIC50:  13.9nMpH: 7.0Assay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAmyloid-beta precursor protein [672-711](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50129272(CHEMBL3629743 | US9464103, (6aR,7S,10aS)-10a-(4-ch...)
Affinity DataIC50:  23.3nMpH: 7.0Assay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAmyloid-beta precursor protein [672-711](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50129278(CHEMBL3629742 | US9464103, (6aR,10aS)-10a-(4-chlor...)
Affinity DataIC50:  26.4nMpH: 7.0Assay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAmyloid-beta precursor protein [672-711](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50129271(CHEMBL3629741 | US9464103, (6aR,10aS)-10a-(4-chlor...)
Affinity DataIC50:  57.7nMpH: 7.0Assay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAmyloid-beta precursor protein [672-711](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50129276(CHEMBL3629737 | US9464103, (6aR,10aS)-10a-(4-chlor...)
Affinity DataIC50:  66.6nMpH: 7.0Assay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAmyloid-beta precursor protein [672-711](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM250504(US9464103, (6'S,6aR,7s,10aS)-1,4-difluoro-6'-methy...)
Affinity DataIC50:  79nMpH: 7.0Assay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein [672-711](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50129270(CHEMBL3629740 | US9464103, (6aR,7S,10aS)-10a-(4-ch...)
Affinity DataIC50:  228nMpH: 7.0Assay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAmyloid-beta precursor protein [672-711](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM250503(US9464103, (6'R,6aR,7r,10aS)-1,4-difluoro-6'-methy...)
Affinity DataIC50:  397nMpH: 7.0Assay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein [672-711](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM250502(US9464103, (6'R,6aR,7r,10aS)-10a-(4-chlorobenz...)
Affinity DataIC50:  421nMpH: 7.0Assay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent