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Found 678 Enz. Inhib. hit(s) with Target = 'Anoctamin-1'
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50503445(CHEMBL4445544 | US11274074, Example 1 [Chemical Fo...)
Affinity DataIC50:  21nMAssay Description:Inhibition of YFP-fused ANO1 (unknown origin) expressed in FRT cells after 20 mins by fluorescence quenching methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50503445(CHEMBL4445544 | US11274074, Example 1 [Chemical Fo...)
Affinity DataIC50:  21nMAssay Description:The method for inhibiting the expression of ANO1 (TMEM16A) of the present disclosure includes a step of inhibiting the expression of ANO1 (TMEM16A) i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50503445(CHEMBL4445544 | US11274074, Example 1 [Chemical Fo...)
Affinity DataIC50:  22nMAssay Description:Inhibition of ANO1 (unknown origin) expressed in FRT cells assessed as reduction in ATP-induced chloride current after 20 mins by electrophysiologica...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50594075(CHEMBL5186789)
Affinity DataIC50:  24nMAssay Description:Inhibition of YFP tagged ANO1 (unknown origin) expressed in FRT cells incubated for 24 hrs by fluorescence plate reader assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Affinity DataIC50:  28nMAssay Description:Inhibition of YFP tagged ANO1 (unknown origin) expressed in FRT cells incubated for 24 hrs by fluorescence plate reader assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50594073(CHEMBL5206041)
Affinity DataIC50:  29nMAssay Description:Inhibition of YFP tagged ANO1 (unknown origin) expressed in FRT cells incubated for 24 hrs by fluorescence plate reader assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50239459(CHEMBL4074929)
Affinity DataIC50:  30nMAssay Description:Inhibition of ANO1 channel (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50239459(CHEMBL4074929)
Affinity DataIC50:  30nMAssay Description:In vitro inhibition of [3H]norepinephrine uptake in rat brain synaptosomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50239459(CHEMBL4074929)
Affinity DataIC50:  30nMAssay Description:Inhibition of YFP tagged ANO1 (unknown origin) expressed in FRT cells incubated for 24 hrs by fluorescence plate reader assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAnoctamin-1(Mus musculus)
Korea University

Curated by ChEMBL
LigandPNGBDBM50239465(CHEMBL4080525 | US11274074, Control [Ani9])
Affinity DataIC50:  30nMAssay Description:Inhibition of GFP-fused mouse ANO1 channel expressed in HEK293A cells assessed as inhibition of ATP-induced channel current amplitude at membrane pot...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Mus musculus)
Korea University

Curated by ChEMBL
LigandPNGBDBM50239459(CHEMBL4074929)
Affinity DataIC50:  50nMAssay Description:Inhibition of GFP-fused mouse ANO1 channel expressed in HEK293A cells assessed as inhibition of ATP-induced channel current amplitude at membrane pot...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50239465(CHEMBL4080525 | US11274074, Control [Ani9])
Affinity DataIC50:  60nMAssay Description:Inhibition of human ANO1 channel expressed in HEK293 cells incubated for 10 mins by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50239465(CHEMBL4080525 | US11274074, Control [Ani9])
Affinity DataIC50:  77nMAssay Description:Inhibition of ANO1 (unknown origin) expressed in FRT cells assessed as reduction in ATP-induced chloride current after 20 mins by electrophysiologica...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50239465(CHEMBL4080525 | US11274074, Control [Ani9])
Affinity DataIC50:  77nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells assessed as reduction of ATP-induced in chloride conductance preincubated for 20 mins followed by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50239465(CHEMBL4080525 | US11274074, Control [Ani9])
Affinity DataIC50:  77nMAssay Description:Inhibition of human ANO1 expressed in FRT cells assessed as inhibition of ATP-induced channel current treated 20 mins prior to ATP challenge and meas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50239467(CHEMBL4086165)
Affinity DataIC50:  80nMAssay Description:Inhibition of TMEM16A (unknown origin) expressed in Xenopus laevis oocytes at -60 mV holding potential by voltage-clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50239459(CHEMBL4074929)
Affinity DataIC50:  83nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50239465(CHEMBL4080525 | US11274074, Control [Ani9])
Affinity DataIC50:  97nMAssay Description:The method for inhibiting the expression of ANO1 (TMEM16A) of the present disclosure includes a step of inhibiting the expression of ANO1 (TMEM16A) i...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50239465(CHEMBL4080525 | US11274074, Control [Ani9])
Affinity DataIC50:  97nMAssay Description:Inhibition of YFP-fused ANO1 (unknown origin) expressed in FRT cells after 20 mins by fluorescence quenching methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50239465(CHEMBL4080525 | US11274074, Control [Ani9])
Affinity DataIC50:  110nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells assessed as reduction of ATP-induced in chloride conductance preincubated for 5 mins followed by A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50239433(CHEMBL3134585)
Affinity DataIC50:  130nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells assessed as reduction of ATP-induced in chloride conductance preincubated for 5 mins followed by A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50239428(CHEMBL4104024)
Affinity DataIC50:  150nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50239446(CHEMBL4069503)
Affinity DataIC50:  170nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50239457(CHEMBL4071143)
Affinity DataIC50:  180nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50503455(CHEMBL4448175 | US11274074, Example 5 [Chemical Fo...)
Affinity DataIC50:  210nMAssay Description:The method for inhibiting the expression of ANO1 (TMEM16A) of the present disclosure includes a step of inhibiting the expression of ANO1 (TMEM16A) i...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50503455(CHEMBL4448175 | US11274074, Example 5 [Chemical Fo...)
Affinity DataIC50:  210nMAssay Description:Inhibition of YFP-fused ANO1 (unknown origin) expressed in FRT cells after 20 mins by fluorescence quenching methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50239447(CHEMBL4090522)
Affinity DataIC50:  220nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50239470(CHEMBL4095338)
Affinity DataIC50:  230nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50239457(CHEMBL4071143)
Affinity DataIC50:  230nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells assessed as reduction of ATP-induced in chloride conductance preincubated for 5 mins followed by A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50239461(CHEMBL4074900)
Affinity DataIC50:  230nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50239426(CHEMBL1444023)
Affinity DataIC50:  260nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells assessed as reduction of ATP-induced in chloride conductance preincubated for 5 mins followed by A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50594059(CHEMBL5186589)
Affinity DataIC50:  270nMAssay Description:Inhibition of YFP tagged ANO1 (unknown origin) expressed in FRT cells incubated for 24 hrs by fluorescence plate reader assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50503439(CHEMBL4515829 | US11274074, Example 6 [Chemical Fo...)
Affinity DataIC50:  300nMAssay Description:The method for inhibiting the expression of ANO1 (TMEM16A) of the present disclosure includes a step of inhibiting the expression of ANO1 (TMEM16A) i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50239433(CHEMBL3134585)
Affinity DataIC50:  300nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50503439(CHEMBL4515829 | US11274074, Example 6 [Chemical Fo...)
Affinity DataIC50:  300nMAssay Description:Inhibition of YFP-fused ANO1 (unknown origin) expressed in FRT cells after 20 mins by fluorescence quenching methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50239438(CHEMBL4099581)
Affinity DataIC50:  320nMAssay Description:Inhibition of [3H]spiperone binding to Dopamine receptor D2 from rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50239469(CHEMBL4091961)
Affinity DataIC50:  370nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50239475(CHEMBL4082703)
Affinity DataIC50:  370nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50239458(CHEMBL4095365)
Affinity DataIC50:  380nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50239426(CHEMBL1444023)
Affinity DataIC50:  420nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50075050(Alinia | Nitazoxanide | PH-5776)
Affinity DataIC50:  424nMAssay Description:Inhibition of YFP tagged ANO1 (unknown origin) expressed in FRT cells incubated for 24 hrs by fluorescence plate reader assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50239463(CHEMBL4087641)
Affinity DataIC50:  450nMAssay Description:In vitro inhibition of [3H]dopamine uptake in rat brain synaptosomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50239448(CHEMBL4080209)
Affinity DataIC50:  490nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50239428(CHEMBL4104024)
Affinity DataIC50:  600nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells assessed as reduction of ATP-induced in chloride conductance preincubated for 5 mins followed by A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50239464(CHEMBL4085154)
Affinity DataIC50:  600nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50239439(CHEMBL4083154)
Affinity DataIC50:  660nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50239430(CHEMBL4096263)
Affinity DataIC50:  700nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50239464(CHEMBL4085154)
Affinity DataIC50:  730nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells assessed as reduction of ATP-induced in chloride conductance preincubated for 5 mins followed by A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50594049(CHEMBL5185767)
Affinity DataIC50:  790nMAssay Description:Inhibition of YFP tagged ANO1 (unknown origin) expressed in FRT cells incubated for 24 hrs by fluorescence plate reader assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAnoctamin-1(Homo sapiens (Human))
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50239462(CHEMBL4066286)
Affinity DataIC50:  840nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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