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Found 97 Enz. Inhib. hit(s) with Target = 'Dual specificity protein phosphatase 2'
TargetDual specificity protein phosphatase 22(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM199180(US9217012, 10)
Affinity DataKi: >1.00E+3nM ΔG°: >-34.2kJ/molepH: 7.0 T: 2°CAssay Description:PTP activity was assayed using p-nitrophenyl phosphate (pNPP) as a substrate in DMG buffer (50 mM DMG, pH 7.0, 1 mM EDTA, 150 mM NaCl, 2 mM DTT, 0.1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein phosphatase 22(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM50168874(3-{5-[1-(4-Fluoro-phenyl)-meth-(Z)-ylidene]-4-oxo-...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of JNK-stimulating phosphatase-1 (JSP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 22(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM50425807(CHEMBL2316902)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of VHX (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 22(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM50425806(CHEMBL2316907)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of VHX (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 22(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM50556732(CHEMBL4750435)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of DUSP22 (unknown origin) pre-incubated for 20 mins followed by fluorescence substrate addition and measured after 120 mins by DiFMUP ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 22(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM50205422(CHEMBL230941 | N3-cyclohexyl-N1-(2,3-di(furan-2-yl...)
Affinity DataIC50:  2.25E+3nMAssay Description:Inhibition of GST-tagged human recombinant JSP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 23(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM50054344(CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...)
Affinity DataIC50:  2.30E+3nMAssay Description:For selectivity studies, the PTPs, including LYP, mPTPA, SHP1-D1C, PTP1B, LMPTP, VHR, Laforin and PTPα-D1D2 were expressed and purified from E. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity protein phosphatase 23(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM50054344(CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of VHZ (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 22(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM50205419(CHEMBL230472 | N3-butyl-N1-(2,3-di(furan-2-yl)quin...)
Affinity DataIC50:  2.35E+3nMAssay Description:Inhibition of GST-tagged human recombinant JSP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 22(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM50205439(CHEMBL230576 | N1-(2,3-di(furan-2-yl)quinoxalin-6-...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of GST-tagged human recombinant JSP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 22(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM50168885(3-{5-[1-(4-Nitro-phenyl)-meth-(Z)-ylidene]-4-oxo-2...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of JNK-stimulating phosphatase-1 (JSP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 22(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM50205438(CHEMBL396800 | N3-butyl-N1-(2,3-di(furan-2-yl)quin...)
Affinity DataIC50:  2.79E+3nMAssay Description:Inhibition of GST-tagged human recombinant JSP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 22(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM50425808(CHEMBL2316906)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of VHX (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 22(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM50205426(CHEMBL230843 | N3-cyclopentyl-N1-(2,3-di(furan-2-y...)
Affinity DataIC50:  3.02E+3nMAssay Description:Inhibition of GST-tagged human recombinant JSP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 23(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM50436358(CHEMBL2396718)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of recombinant VHZ (unknown origin) using pNPP as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 22(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM50168896(4-{5-[1-(4-Fluoro-phenyl)-meth-(Z)-ylidene]-4-oxo-...)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of JNK-stimulating phosphatase-1 (JSP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 22(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM50205428(CHEMBL230471 | N3-butyl-N1-(2,3-di(furan-2-yl)quin...)
Affinity DataIC50:  5.55E+3nMAssay Description:Inhibition of GST-tagged human recombinant JSP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 23(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM50436357(CHEMBL2396719)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of recombinant VHZ (unknown origin) using pNPP as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 22(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM50168876(3-{4-Oxo-5-[1-phenyl-meth-(Z)-ylidene]-2-thioxo-th...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of JNK-stimulating phosphatase-1 (JSP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 22(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM50168876(3-{4-Oxo-5-[1-phenyl-meth-(Z)-ylidene]-2-thioxo-th...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of JNK-stimulating phosphatase-1 (JSP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 22(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM50168893(3-{5-[1-Cyclohexyl-meth-(Z)-ylidene]-4-oxo-2-thiox...)
Affinity DataIC50:  7.30E+3nMAssay Description:Inhibition of JNK-stimulating phosphatase-1 (JSP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 22(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM50205429(CHEMBL425838 | N3-tert-butyl-N1-(2,3-di(furan-2-yl...)
Affinity DataIC50:  8.05E+3nMAssay Description:Inhibition of GST-tagged human recombinant JSP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 22(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM50205427(CHEMBL230681 | N1-(2,3-di(furan-2-yl)quinoxalin-6-...)
Affinity DataIC50:  8.36E+3nMAssay Description:Inhibition of GST-tagged human recombinant JSP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 22(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM50205432(CHEMBL446453 | N-(2,3-di(furan-2-yl)quinoxalin-6-y...)
Affinity DataIC50:  8.39E+3nMAssay Description:Inhibition of GST-tagged human recombinant JSP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50488935(CHEMBL2299386)
Affinity DataIC50:  8.90E+3nMAssay Description:inhibition of Homo sapiens (human) recombinant DUSP26 catalytic domain (61 to 211 amino acid residues) overexpressed in Escherichia coli BL21 (DE3) a...More data for this Ligand-Target Pair
In DepthDetails Article
TargetDual specificity protein phosphatase 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50360601(CHEMBL1933349 | MK-0893)
Affinity DataIC50:  9.20E+3nMAssay Description:Antagonist activity at human PAC1 expressed in mouse HIN 3T3 cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 22(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM50168894((4-{4-Oxo-5-[1-phenyl-meth-(Z)-ylidene]-2-thioxo-t...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of JNK-stimulating phosphatase-1 (JSP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 23(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM50607111(CHEMBL5218807)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of VHZ (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity protein phosphatase 22(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM231167(US9340574, 7)
Affinity DataIC50: >1.00E+4nMpH: 7.0Assay Description:PTP activity was assayed using p-nitrophenyl phosphate (pNPP) as a substrate in 3,3-dimethylglutarate buffer (50 mM 3,3-dimethylglutarate, pH 7.0, 1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein phosphatase 22(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM50168886(4-{4-Oxo-5-[1-phenyl-meth-(Z)-ylidene]-2-thioxo-th...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of JNK-stimulating phosphatase-1 (JSP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 23(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM50087856(CHEMBL3426913)
Affinity DataIC50:  1.14E+4nMpH: 7.0Assay Description:Inhibition of VHZ (unknown origin) using pNPP as substrate at pH 7 at 25 degC by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 22(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM50205425(CHEMBL230842 | N1-(2,3-di(furan-2-yl)quinoxalin-6-...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of GST-tagged human recombinant JSP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50488945(CHEMBL2299387)
Affinity DataIC50:  1.25E+4nMAssay Description:inhibition of Homo sapiens (human) recombinant DUSP26 catalytic domain (61 to 211 amino acid residues) overexpressed in Escherichia coli BL21 (DE3) a...More data for this Ligand-Target Pair
In DepthDetails Article
TargetDual specificity protein phosphatase 22(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM50168877(2-Hydroxy-5-{4-oxo-5-[1-phenyl-meth-(Z)-ylidene]-2...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of JNK-stimulating phosphatase-1 (JSP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 22(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM50168882(2-Hydroxy-4-{4-oxo-5-[1-phenyl-meth-(Z)-ylidene]-2...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of JNK-stimulating phosphatase-1 (JSP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 22(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM50168875(3-{4-Oxo-2-thioxo-5-[1-p-tolyl-meth-(Z)-ylidene]-t...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of JNK-stimulating phosphatase-1 (JSP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50087879(CHEMBL472004 | NSC-87877)
Affinity DataIC50:  1.67E+4nMAssay Description:Inhibition of DUSP26 (unknown origin)-mediated p38 dephosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50488942(CHEMBL2299388)
Affinity DataIC50:  1.70E+4nMAssay Description:inhibition of Homo sapiens (human) recombinant DUSP26 catalytic domain (61 to 211 amino acid residues) overexpressed in Escherichia coli BL21 (DE3) a...More data for this Ligand-Target Pair
In DepthDetails Article
TargetDual specificity protein phosphatase 22(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM50168881(4-{4-Oxo-5-[1-phenyl-meth-(Z)-ylidene]-2-thioxo-th...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of JNK-stimulating phosphatase-1 (JSP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50488938(CHEMBL2296000)
Affinity DataIC50:  1.98E+4nMAssay Description:inhibition of Homo sapiens (human) recombinant DUSP26 catalytic domain (61 to 211 amino acid residues) overexpressed in Escherichia coli BL21 (DE3) a...More data for this Ligand-Target Pair
In DepthDetails Article
TargetDual specificity protein phosphatase 22(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM50168883((4-{4-Oxo-5-[1-phenyl-meth-(Z)-ylidene]-2-thioxo-t...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of JNK-stimulating phosphatase-1 (JSP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 22(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM50168878((3-{4-Oxo-5-[1-phenyl-meth-(Z)-ylidene]-2-thioxo-t...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of JNK-stimulating phosphatase-1 (JSP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50488946(CHEMBL2295992)
Affinity DataIC50:  2.23E+4nMAssay Description:inhibition of Homo sapiens (human) recombinant DUSP26 catalytic domain (61 to 211 amino acid residues) overexpressed in Escherichia coli BL21 (DE3) a...More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50488947(CHEMBL2295993)
Affinity DataIC50:  2.51E+4nMAssay Description:inhibition of Homo sapiens (human) recombinant DUSP26 catalytic domain (61 to 211 amino acid residues) overexpressed in Escherichia coli BL21 (DE3) a...More data for this Ligand-Target Pair
In DepthDetails Article
TargetDual specificity protein phosphatase 22(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM50168897(3-{5-[1-(4-Methoxy-phenyl)-meth-(Z)-ylidene]-4-oxo...)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition of JNK-stimulating phosphatase-1 (JSP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 22(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM82577((4-fluoro-1,3-benzothiazol-2-yl)-[5-(4-methoxyphen...)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition of recombinant VHX (unknown origin) using OMFP as substrate after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50488941(CHEMBL2295994)
Affinity DataIC50:  2.63E+4nMAssay Description:inhibition of Homo sapiens (human) recombinant DUSP26 catalytic domain (61 to 211 amino acid residues) overexpressed in Escherichia coli BL21 (DE3) a...More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50488937(CHEMBL2296001)
Affinity DataIC50:  2.69E+4nMAssay Description:inhibition of Homo sapiens (human) recombinant DUSP26 catalytic domain (61 to 211 amino acid residues) overexpressed in Escherichia coli BL21 (DE3) a...More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50488940(CHEMBL2295995)
Affinity DataIC50:  3.02E+4nMAssay Description:inhibition of Homo sapiens (human) recombinant DUSP26 catalytic domain (61 to 211 amino acid residues) overexpressed in Escherichia coli BL21 (DE3) a...More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50488939(CHEMBL2295996)
Affinity DataIC50:  3.66E+4nMAssay Description:inhibition of Homo sapiens (human) recombinant DUSP26 catalytic domain (61 to 211 amino acid residues) overexpressed in Escherichia coli BL21 (DE3) a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
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