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Found 3086 Enz. Inhib. hit(s) with Target = 'Prostaglandin E synthase'
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM50028856(CHEMBL3342696 | US9216968, 113 | US9732066, 113)
Affinity DataKi:  0.100nM IC50:  0.100nMAssay Description:mPGES-1 microsome fractions were prepared from CHO-K1 cells transiently transfected with plasmid encoding the human mPGES-1cDNA. Microsomes were dilu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM451408(US10710967, Example 2)
Affinity DataIC50:  0.0100nMAssay Description:Microsomes were prepared from COS-1 cells transiently transfected with a plasmid containing human mPGES-1 cDNA, and used as mPGES-1 enzyme. The mPGES...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM451407(US10710967, Example 1)
Affinity DataIC50:  0.0200nMAssay Description:Microsomes were prepared from COS-1 cells transiently transfected with a plasmid containing human mPGES-1 cDNA, and used as mPGES-1 enzyme. The mPGES...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM451438(US10710967, Example 20)
Affinity DataIC50:  0.0600nMAssay Description:Microsomes were prepared from COS-1 cells transiently transfected with a plasmid containing human mPGES-1 cDNA, and used as mPGES-1 enzyme. The mPGES...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM50028856(CHEMBL3342696 | US9216968, 113 | US9732066, 113)
Affinity DataIC50:  0.100nMAssay Description:mPGES-1 microsome fractions were prepared from CHO-K1 cells transiently transfected with plasmid encoding the human mPGES-1cDNA. Microsomes were dilu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM197627(US9216968, 227 | US9732066, 227)
Affinity DataIC50:  0.100nMAssay Description:mPGES-1 microsome fractions were prepared from CHO-K1 cells transiently transfected with plasmid encoding the human mPGES-1cDNA. Microsomes were dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM50532250(CHEMBL4444875)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of human mPGES-1 expressed in CHO-K1 cells using PGH2 as substrate assessed as PGE2 formation preincubated for 20 mins followed by additio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM197590(US9216968, 190 | US9732066, 190)
Affinity DataIC50:  0.100nMAssay Description:mPGES-1 microsome fractions were prepared from CHO-K1 cells transiently transfected with plasmid encoding the human mPGES-1cDNA. Microsomes were dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM50532250(CHEMBL4444875)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of human mPGES-1 expressed in CHO-K1 cells using PGH2 as substrate assessed as PGE2 formation preincubated for 20 mins followed by additio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM197627(US9216968, 227 | US9732066, 227)
Affinity DataIC50:  0.100nMAssay Description:mPGES-1 microsome fractions were prepared from CHO-K1 cells transiently transfected with plasmid encoding the human mPGES-1cDNA. Microsomes were dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM50028856(CHEMBL3342696 | US9216968, 113 | US9732066, 113)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of human recombinant mPGES-1 expressed in CHO cells using PGH2 as substrate incubated for 10 mins prior to substrate addition measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM197590(US9216968, 190 | US9732066, 190)
Affinity DataIC50:  0.100nMAssay Description:mPGES-1 microsome fractions were prepared from CHO-K1 cells transiently transfected with plasmid encoding the human mPGES-1cDNA. Microsomes were dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM451427(US10710967, Example 22)
Affinity DataIC50:  0.110nMAssay Description:Microsomes were prepared from COS-1 cells transiently transfected with a plasmid containing human mPGES-1 cDNA, and used as mPGES-1 enzyme. The mPGES...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM451477(US10710967, Example 74)
Affinity DataIC50:  0.110nMAssay Description:Microsomes were prepared from COS-1 cells transiently transfected with a plasmid containing human mPGES-1 cDNA, and used as mPGES-1 enzyme. The mPGES...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM451447(US10710967, Example 43)
Affinity DataIC50:  0.130nMAssay Description:Microsomes were prepared from COS-1 cells transiently transfected with a plasmid containing human mPGES-1 cDNA, and used as mPGES-1 enzyme. The mPGES...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM451418(US10710967, Example 12)
Affinity DataIC50:  0.180nMAssay Description:Microsomes were prepared from COS-1 cells transiently transfected with a plasmid containing human mPGES-1 cDNA, and used as mPGES-1 enzyme. The mPGES...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM197477(US9216968, 76 | US9732066, 76)
Affinity DataIC50:  0.200nMAssay Description:mPGES-1 microsome fractions were prepared from CHO-K1 cells transiently transfected with plasmid encoding the human mPGES-1cDNA. Microsomes were dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM197540(US9216968, 140 | US9732066, 140)
Affinity DataIC50:  0.200nMAssay Description:mPGES-1 microsome fractions were prepared from CHO-K1 cells transiently transfected with plasmid encoding the human mPGES-1cDNA. Microsomes were dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM197477(US9216968, 76 | US9732066, 76)
Affinity DataIC50:  0.200nMAssay Description:mPGES-1 microsome fractions were prepared from CHO-K1 cells transiently transfected with plasmid encoding the human mPGES-1cDNA. Microsomes were dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM197540(US9216968, 140 | US9732066, 140)
Affinity DataIC50:  0.200nMAssay Description:mPGES-1 microsome fractions were prepared from CHO-K1 cells transiently transfected with plasmid encoding the human mPGES-1cDNA. Microsomes were dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM197576(US9216968, 176 | US9732066, 176)
Affinity DataIC50:  0.300nMAssay Description:mPGES-1 microsome fractions were prepared from CHO-K1 cells transiently transfected with plasmid encoding the human mPGES-1cDNA. Microsomes were dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM197564(US9216968, 164 | US9732066, 164)
Affinity DataIC50:  0.300nMAssay Description:mPGES-1 microsome fractions were prepared from CHO-K1 cells transiently transfected with plasmid encoding the human mPGES-1cDNA. Microsomes were dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM197535(US9216968, 135 | US9732066, 135)
Affinity DataIC50:  0.300nMAssay Description:mPGES-1 microsome fractions were prepared from CHO-K1 cells transiently transfected with plasmid encoding the human mPGES-1cDNA. Microsomes were dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM197576(US9216968, 176 | US9732066, 176)
Affinity DataIC50:  0.300nMAssay Description:mPGES-1 microsome fractions were prepared from CHO-K1 cells transiently transfected with plasmid encoding the human mPGES-1cDNA. Microsomes were dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM197564(US9216968, 164 | US9732066, 164)
Affinity DataIC50:  0.300nMAssay Description:mPGES-1 microsome fractions were prepared from CHO-K1 cells transiently transfected with plasmid encoding the human mPGES-1cDNA. Microsomes were dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM197535(US9216968, 135 | US9732066, 135)
Affinity DataIC50:  0.300nMAssay Description:mPGES-1 microsome fractions were prepared from CHO-K1 cells transiently transfected with plasmid encoding the human mPGES-1cDNA. Microsomes were dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM451429(US10710967, Example 24)
Affinity DataIC50:  0.310nMAssay Description:Microsomes were prepared from COS-1 cells transiently transfected with a plasmid containing human mPGES-1 cDNA, and used as mPGES-1 enzyme. The mPGES...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM197594(US9216968, 194 | US9732066, 194)
Affinity DataIC50:  0.400nMAssay Description:mPGES-1 microsome fractions were prepared from CHO-K1 cells transiently transfected with plasmid encoding the human mPGES-1cDNA. Microsomes were dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM197541(US9216968, 141 | US9732066, 141)
Affinity DataIC50:  0.400nMAssay Description:mPGES-1 microsome fractions were prepared from CHO-K1 cells transiently transfected with plasmid encoding the human mPGES-1cDNA. Microsomes were dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM50302429(2-(9-(2-hydroxy-2-methylpropyl)-6-(isopentyloxy)-1...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of mPGES-1 in IL-1beta-stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 formation incubated for 15 mins using...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM197483(US9216968, 82 | US9732066, 82)
Affinity DataIC50:  0.400nMAssay Description:mPGES-1 microsome fractions were prepared from CHO-K1 cells transiently transfected with plasmid encoding the human mPGES-1cDNA. Microsomes were dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM197542(US9216968, 142 | US9732066, 142)
Affinity DataIC50:  0.400nMAssay Description:mPGES-1 microsome fractions were prepared from CHO-K1 cells transiently transfected with plasmid encoding the human mPGES-1cDNA. Microsomes were dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM197593(US9216968, 193 | US9732066, 193)
Affinity DataIC50:  0.400nMAssay Description:mPGES-1 microsome fractions were prepared from CHO-K1 cells transiently transfected with plasmid encoding the human mPGES-1cDNA. Microsomes were dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM50302429(2-(9-(2-hydroxy-2-methylpropyl)-6-(isopentyloxy)-1...)
Affinity DataIC50:  0.400nMAssay Description:Displacement of [3H]PGH2 from human recombinant PGES1 expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM197594(US9216968, 194 | US9732066, 194)
Affinity DataIC50:  0.400nMAssay Description:mPGES-1 microsome fractions were prepared from CHO-K1 cells transiently transfected with plasmid encoding the human mPGES-1cDNA. Microsomes were dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM197541(US9216968, 141 | US9732066, 141)
Affinity DataIC50:  0.400nMAssay Description:mPGES-1 microsome fractions were prepared from CHO-K1 cells transiently transfected with plasmid encoding the human mPGES-1cDNA. Microsomes were dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM197542(US9216968, 142 | US9732066, 142)
Affinity DataIC50:  0.400nMAssay Description:mPGES-1 microsome fractions were prepared from CHO-K1 cells transiently transfected with plasmid encoding the human mPGES-1cDNA. Microsomes were dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM197593(US9216968, 193 | US9732066, 193)
Affinity DataIC50:  0.400nMAssay Description:mPGES-1 microsome fractions were prepared from CHO-K1 cells transiently transfected with plasmid encoding the human mPGES-1cDNA. Microsomes were dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM197483(US9216968, 82 | US9732066, 82)
Affinity DataIC50:  0.400nMAssay Description:mPGES-1 microsome fractions were prepared from CHO-K1 cells transiently transfected with plasmid encoding the human mPGES-1cDNA. Microsomes were dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM451409(US10710967, Example 3)
Affinity DataIC50:  0.480nMAssay Description:Microsomes were prepared from COS-1 cells transiently transfected with a plasmid containing human mPGES-1 cDNA, and used as mPGES-1 enzyme. The mPGES...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM451413(US10710967, Example 7)
Affinity DataIC50:  0.480nMAssay Description:Microsomes were prepared from COS-1 cells transiently transfected with a plasmid containing human mPGES-1 cDNA, and used as mPGES-1 enzyme. The mPGES...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM197601(US9216968, 201 | US9732066, 201)
Affinity DataIC50:  0.5nMAssay Description:mPGES-1 microsome fractions were prepared from CHO-K1 cells transiently transfected with plasmid encoding the human mPGES-1cDNA. Microsomes were dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM197601(US9216968, 201 | US9732066, 201)
Affinity DataIC50:  0.5nMAssay Description:mPGES-1 microsome fractions were prepared from CHO-K1 cells transiently transfected with plasmid encoding the human mPGES-1cDNA. Microsomes were dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM197486(US9216968, 85 | US9732066, 85)
Affinity DataIC50:  0.5nMAssay Description:mPGES-1 microsome fractions were prepared from CHO-K1 cells transiently transfected with plasmid encoding the human mPGES-1cDNA. Microsomes were dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM197458(US9216968, 57 | US9732066, 57)
Affinity DataIC50:  0.5nMAssay Description:mPGES-1 microsome fractions were prepared from CHO-K1 cells transiently transfected with plasmid encoding the human mPGES-1cDNA. Microsomes were dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM197458(US9216968, 57 | US9732066, 57)
Affinity DataIC50:  0.5nMAssay Description:mPGES-1 microsome fractions were prepared from CHO-K1 cells transiently transfected with plasmid encoding the human mPGES-1cDNA. Microsomes were dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM197486(US9216968, 85 | US9732066, 85)
Affinity DataIC50:  0.5nMAssay Description:mPGES-1 microsome fractions were prepared from CHO-K1 cells transiently transfected with plasmid encoding the human mPGES-1cDNA. Microsomes were dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM50270591(2-(6-chloro-9-(3-hydroxy-3-methylbutyl)-1H-phenant...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM197608(US9216968, 208 | US9732066, 208)
Affinity DataIC50:  0.700nMAssay Description:mPGES-1 microsome fractions were prepared from CHO-K1 cells transiently transfected with plasmid encoding the human mPGES-1cDNA. Microsomes were dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Nippon Shinyaku

US Patent
LigandPNGBDBM197608(US9216968, 208 | US9732066, 208)
Affinity DataIC50:  0.700nMAssay Description:mPGES-1 microsome fractions were prepared from CHO-K1 cells transiently transfected with plasmid encoding the human mPGES-1cDNA. Microsomes were dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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