BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 50003704 CSCC[C@H](NC(=O)CN1c2ccccc2C(=N[C@@H](N(C)C(=O)[C@@H](N)CS)C1=O)c1ccccc1)C(O)=O InChI=1S/C26H31N5O5S2/c1-30(24(33)18(27)15-37)23-25(34)31(14-21(32)28-19(26(35)36)12-13-38-2)20-11-7-6-10-17(20)22(29-23)16-8-4-3-5-9-16/h3-11,18-19,23,37H,12-15,27H2,1-2H3,(H,28,32)(H,35,36)/t18-,19-,23-/m0/s1 SSQIWICZBGRCBC-YDHSSHFGSA-N 50284631 2-(2-{3-[(2-Amino-3-mercapto-propionyl)-methyl-amino]-2-oxo-5-phenyl-2,3-dihydro-benzo[e][1,4]diazepin-1-yl}-acetylamino)-4-methylsulfanyl-butyric acid::CHEMBL418572 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 370 ChEMBL 10.1016/0960-894X(95)00218-I 10.7270/Q27S7NR3 Rawson, TE; Somers, TC; Marsters, JC; Wan, DT; Reynolds, ME; Burdick, DJ TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50284631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50284631&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10460383 104126202 CHEMBL418572 ZINC14277283 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50048092 C[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](COCc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C47H51N9O9/c1-29(42(48)58)52-43(59)39(21-33-23-50-37-15-9-8-14-36(33)37)54-46(62)41(27-64-25-31-10-4-2-5-11-31)55-44(60)38(20-30-16-18-35(57)19-17-30)53-45(61)40(22-34-24-49-28-51-34)56-47(63)65-26-32-12-6-3-7-13-32/h2-19,23-24,28-29,38-41,50,57H,20-22,25-27H2,1H3,(H2,48,58)(H,49,51)(H,52,59)(H,53,61)(H,54,62)(H,55,60)(H,56,63)/t29-,38+,39+,40+,41+/m1/s1 KXDGVOMWEJNZDH-SVOMHHGBSA-N 50408252 CHEMBL2115488 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 35 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50408252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50408252&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10795764 163357276 CHEMBL2115488 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50048094 C[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](COCc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C47H51N9O9/c1-29(42(48)58)52-43(59)39(21-33-23-50-37-15-9-8-14-36(33)37)54-46(62)41(27-64-25-31-10-4-2-5-11-31)55-44(60)38(20-30-16-18-35(57)19-17-30)53-45(61)40(22-34-24-49-28-51-34)56-47(63)65-26-32-12-6-3-7-13-32/h2-19,23-24,28-29,38-41,50,57H,20-22,25-27H2,1H3,(H2,48,58)(H,49,51)(H,52,59)(H,53,61)(H,54,62)(H,55,60)(H,56,63)/t29-,38+,39+,40+,41+/m1/s1 KXDGVOMWEJNZDH-SVOMHHGBSA-N 50408252 CHEMBL2115488 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 35 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50408252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50408252&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10795764 163357276 CHEMBL2115488 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50048096 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](COP(O)(O)=O)NC(=O)[C@@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C47H52N9O12P/c1-29(42(48)57)52-43(58)39(21-33-23-50-37-15-9-8-14-36(33)37)54-46(61)41(27-68-69(63,64)65)55-44(59)38(20-30-16-18-35(19-17-30)66-25-31-10-4-2-5-11-31)53-45(60)40(22-34-24-49-28-51-34)56-47(62)67-26-32-12-6-3-7-13-32/h2-19,23-24,28-29,38-41,50H,20-22,25-27H2,1H3,(H2,48,57)(H,49,51)(H,52,58)(H,53,60)(H,54,61)(H,55,59)(H,56,62)(H2,63,64,65)/t29-,38+,39+,40+,41+/m0/s1 JAHDKNXLWYZKQE-UOPHCCOJSA-N 50055622 CHEMBL386619::[(R)-1-((R)-2-(4-Benzyloxy-phenyl)-1-{(R)-1-[(R)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-2-phosphonooxy-ethylcarbamoyl}-ethylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 240 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055622&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44303070 103952108 CHEMBL386619 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50048097 C[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](COCc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C47H51N9O8/c1-30(42(48)57)52-43(58)39(22-34-24-50-37-20-12-11-19-36(34)37)54-46(61)41(28-63-26-32-15-7-3-8-16-32)55-44(59)38(21-31-13-5-2-6-14-31)53-45(60)40(23-35-25-49-29-51-35)56-47(62)64-27-33-17-9-4-10-18-33/h2-20,24-25,29-30,38-41,50H,21-23,26-28H2,1H3,(H2,48,57)(H,49,51)(H,52,58)(H,53,60)(H,54,61)(H,55,59)(H,56,62)/t30-,38-,39+,40+,41+/m1/s1 CBEUTGQIDBIBGN-QKLHAAGGSA-N 50408253 CHEMBL2115486 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 79 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50408253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50408253&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10748196 163357277 CHEMBL2115486 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50048102 CCOP(=O)(Cc1ccc(CC(NC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)OCc2ccccc2)C(=O)N[C@H](COCc2ccccc2)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)C(N)=O)cc1)OCC InChI=1S/C52H62N9O11P/c1-4-71-73(68,72-5-2)32-38-22-20-35(21-23-38)24-43(58-50(65)45(26-40-28-54-33-56-40)61-52(67)70-30-37-16-10-7-11-17-37)49(64)60-46(31-69-29-36-14-8-6-9-15-36)51(66)59-44(48(63)57-34(3)47(53)62)25-39-27-55-42-19-13-12-18-41(39)42/h6-23,27-28,33-34,43-46,55H,4-5,24-26,29-32H2,1-3H3,(H2,53,62)(H,54,56)(H,57,63)(H,58,65)(H,59,66)(H,60,64)(H,61,67)/t34-,43?,44+,45+,46+/m0/s1 HTSNUDFEIYOHOA-RGNFPRNJSA-N 50055614 (4-{2-{(R)-2-Benzyloxy-1-[(R)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-2-[(R)-2-benzyloxycarbonylamino-3-(1H-imidazol-4-yl)-propionylamino]-ethyl}-benzyl)-phosphonic acid diethyl ester::CHEMBL385848 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 25 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055614&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44303117 103952100 CHEMBL385848 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50048107 C[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](COCc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C47H51N9O9/c1-29(42(48)58)52-43(59)39(21-33-23-50-37-15-9-8-14-36(33)37)54-46(62)41(27-64-25-31-10-4-2-5-11-31)55-44(60)38(20-30-16-18-35(57)19-17-30)53-45(61)40(22-34-24-49-28-51-34)56-47(63)65-26-32-12-6-3-7-13-32/h2-19,23-24,28-29,38-41,50,57H,20-22,25-27H2,1H3,(H2,48,58)(H,49,51)(H,52,59)(H,53,61)(H,54,62)(H,55,60)(H,56,63)/t29-,38+,39+,40+,41+/m1/s1 KXDGVOMWEJNZDH-SVOMHHGBSA-N 50408252 CHEMBL2115488 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 510 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50408252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50408252&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10795764 163357276 CHEMBL2115488 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50048114 C[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](COCc1ccccc1)NC(=O)[C@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C54H57N9O9/c1-35(49(55)64)59-50(65)46(26-40-28-57-44-20-12-11-19-43(40)44)61-53(68)48(33-70-30-37-13-5-2-6-14-37)62-51(66)45(25-36-21-23-42(24-22-36)71-31-38-15-7-3-8-16-38)60-52(67)47(27-41-29-56-34-58-41)63-54(69)72-32-39-17-9-4-10-18-39/h2-24,28-29,34-35,45-48,57H,25-27,30-33H2,1H3,(H2,55,64)(H,56,58)(H,59,65)(H,60,67)(H,61,68)(H,62,66)(H,63,69)/t35-,45+,46+,47+,48+/m1/s1 LMBPTRXCFXWLRW-ZYIGOEBISA-N 50059876 CHEMBL217423::[(S)-1-[(S)-1-{(S)-2-Benzyloxy-1-[(S)-1-((R)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethylcarbamoyl]-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester::[(S)-1-[(S)-1-{(S)-2-Benzyloxy-1-[(S)-1-((R)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethylcarbamoyl]-2-(3H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 1600 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50059876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50059876&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 9919495 103955654 CHEMBL217423 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50048116 C[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](COCc1ccccc1)NC(=O)[C@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C54H57N9O9/c1-35(49(55)64)59-50(65)46(26-40-28-57-44-20-12-11-19-43(40)44)61-53(68)48(33-70-30-37-13-5-2-6-14-37)62-51(66)45(25-36-21-23-42(24-22-36)71-31-38-15-7-3-8-16-38)60-52(67)47(27-41-29-56-34-58-41)63-54(69)72-32-39-17-9-4-10-18-39/h2-24,28-29,34-35,45-48,57H,25-27,30-33H2,1H3,(H2,55,64)(H,56,58)(H,59,65)(H,60,67)(H,61,68)(H,62,66)(H,63,69)/t35-,45+,46+,47+,48+/m1/s1 LMBPTRXCFXWLRW-ZYIGOEBISA-N 50059876 CHEMBL217423::[(S)-1-[(S)-1-{(S)-2-Benzyloxy-1-[(S)-1-((R)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethylcarbamoyl]-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester::[(S)-1-[(S)-1-{(S)-2-Benzyloxy-1-[(S)-1-((R)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethylcarbamoyl]-2-(3H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 76 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50059876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50059876&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 9919495 103955654 CHEMBL217423 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50048117 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](COCc1ccccc1)NC(=O)C(Cc1ccc(CP(O)(O)=O)cc1)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C48H54N9O11P/c1-30(43(49)58)53-44(59)40(21-35-23-51-38-15-9-8-14-37(35)38)55-47(62)42(27-67-25-32-10-4-2-5-11-32)56-45(60)39(20-31-16-18-34(19-17-31)28-69(64,65)66)54-46(61)41(22-36-24-50-29-52-36)57-48(63)68-26-33-12-6-3-7-13-33/h2-19,23-24,29-30,39-42,51H,20-22,25-28H2,1H3,(H2,49,58)(H,50,52)(H,53,59)(H,54,61)(H,55,62)(H,56,60)(H,57,63)(H2,64,65,66)/t30-,39?,40+,41+,42+/m0/s1 WBEAIUIOEMQBNY-HVHGEKNISA-N 50055612 (4-{2-{(R)-2-Benzyloxy-1-[(R)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-2-[(R)-2-benzyloxycarbonylamino-3-(1H-imidazol-4-yl)-propionylamino]-ethyl}-benzyl)-phosphonic acid::CHEMBL64121 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 200 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055612&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44303137 103952098 CHEMBL64121 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50048118 C[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](COCc1ccccc1)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C47H51N9O9/c1-29(42(48)58)52-43(59)39(21-33-23-50-37-15-9-8-14-36(33)37)54-46(62)41(27-64-25-31-10-4-2-5-11-31)55-44(60)38(20-30-16-18-35(57)19-17-30)53-45(61)40(22-34-24-49-28-51-34)56-47(63)65-26-32-12-6-3-7-13-32/h2-19,23-24,28-29,38-41,50,57H,20-22,25-27H2,1H3,(H2,48,58)(H,49,51)(H,52,59)(H,53,61)(H,54,62)(H,55,60)(H,56,63)/t29-,38-,39+,40+,41+/m1/s1 KXDGVOMWEJNZDH-ANFZIGRPSA-N 50408251 CHEMBL2115094 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 170 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50408251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50408251&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10819490 163357275 CHEMBL2115094 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50048119 C[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](COCc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C47H51N9O8/c1-30(42(48)57)52-43(58)39(22-34-24-50-37-20-12-11-19-36(34)37)54-46(61)41(28-63-26-32-15-7-3-8-16-32)55-44(59)38(21-31-13-5-2-6-14-31)53-45(60)40(23-35-25-49-29-51-35)56-47(62)64-27-33-17-9-4-10-18-33/h2-20,24-25,29-30,38-41,50H,21-23,26-28H2,1H3,(H2,48,57)(H,49,51)(H,52,58)(H,53,60)(H,54,61)(H,55,59)(H,56,62)/t30-,38+,39+,40+,41+/m1/s1 CBEUTGQIDBIBGN-ZTJCYAQMSA-N 50408250 CHEMBL2115092 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 9 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50408250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50408250&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10748195 163357274 CHEMBL2115092 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50048120 C[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](COCc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C47H51N9O9/c1-29(42(48)58)52-43(59)39(21-33-23-50-37-15-9-8-14-36(33)37)54-46(62)41(27-64-25-31-10-4-2-5-11-31)55-44(60)38(20-30-16-18-35(57)19-17-30)53-45(61)40(22-34-24-49-28-51-34)56-47(63)65-26-32-12-6-3-7-13-32/h2-19,23-24,28-29,38-41,50,57H,20-22,25-27H2,1H3,(H2,48,58)(H,49,51)(H,52,59)(H,53,61)(H,54,62)(H,55,60)(H,56,63)/t29-,38+,39+,40+,41+/m1/s1 KXDGVOMWEJNZDH-SVOMHHGBSA-N 50408252 CHEMBL2115488 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 102 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50408252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50408252&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10795764 163357276 CHEMBL2115488 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50048121 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](COCc1ccccc1)NC(=O)[C@@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C47H52N9O12P/c1-29(42(48)57)52-43(58)39(21-33-23-50-37-15-9-8-14-36(33)37)54-46(61)41(27-66-25-31-10-4-2-5-11-31)55-44(59)38(20-30-16-18-35(19-17-30)68-69(63,64)65)53-45(60)40(22-34-24-49-28-51-34)56-47(62)67-26-32-12-6-3-7-13-32/h2-19,23-24,28-29,38-41,50H,20-22,25-27H2,1H3,(H2,48,57)(H,49,51)(H,52,58)(H,53,60)(H,54,61)(H,55,59)(H,56,62)(H2,63,64,65)/t29-,38+,39+,40+,41+/m0/s1 DITUKRVCAOAEDB-UOPHCCOJSA-N 50055604 CHEMBL441189::[(R)-1-[(R)-1-{(R)-2-Benzyloxy-1-[(R)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-phosphonooxy-phenyl)-ethylcarbamoyl]-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 13 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055604&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44303045 103952090 CHEMBL441189 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50048122 C[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](COCc1ccccc1)NC(=O)[C@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C54H57N9O9/c1-35(49(55)64)59-50(65)46(26-40-28-57-44-20-12-11-19-43(40)44)61-53(68)48(33-70-30-37-13-5-2-6-14-37)62-51(66)45(25-36-21-23-42(24-22-36)71-31-38-15-7-3-8-16-38)60-52(67)47(27-41-29-56-34-58-41)63-54(69)72-32-39-17-9-4-10-18-39/h2-24,28-29,34-35,45-48,57H,25-27,30-33H2,1H3,(H2,55,64)(H,56,58)(H,59,65)(H,60,67)(H,61,68)(H,62,66)(H,63,69)/t35-,45+,46+,47+,48+/m1/s1 LMBPTRXCFXWLRW-ZYIGOEBISA-N 50059876 CHEMBL217423::[(S)-1-[(S)-1-{(S)-2-Benzyloxy-1-[(S)-1-((R)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethylcarbamoyl]-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester::[(S)-1-[(S)-1-{(S)-2-Benzyloxy-1-[(S)-1-((R)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethylcarbamoyl]-2-(3H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 20 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50059876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50059876&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 9919495 103955654 CHEMBL217423 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50101414 O=C(CN(Cc1ccc(OCc2ccccc2)cc1)C(=O)[C@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)NCCc1ccccc1 InChI=1S/C38H39N5O5/c44-36(40-21-20-29-10-4-1-5-11-29)25-43(24-30-16-18-34(19-17-30)47-26-31-12-6-2-7-13-31)37(45)35(22-33-23-39-28-41-33)42-38(46)48-27-32-14-8-3-9-15-32/h1-19,23,28,35H,20-22,24-27H2,(H,39,41)(H,40,44)(H,42,46)/t35-/m0/s1 JOMJUWAAYRJJBC-DHUJRADRSA-N 50059857 CHEMBL102955::[(S)-1-[(4-Benzyloxy-benzyl)-(phenethylcarbamoyl-methyl)-carbamoyl]-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester::[(S)-1-[(4-Benzyloxy-benzyl)-(phenethylcarbamoyl-methyl)-carbamoyl]-2-(3H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 62 ChEMBL 10.1021/jm970470c 10.7270/Q2V69HQG 9341905 McNamara, DJ; Dobrusin, E; Leonard, DM; Shuler, KR; Kaltenbronn, JS; Quin, J; Bur, S; Thomas, CE; Doherty, AM; Scholten, JD; Zimmerman, KK; Gibbs, BS; Gowan, RC; Latash, MP; Leopold, WR; Przybranowski, SA; Sebolt-Leopold, JS Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50059857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50059857&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 9939360 103955636 CHEMBL102955 ZINC26819208 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50101415 O=C(CN(Cc1ccc(OCc2ccccc2)cc1)C(=O)[C@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)NCC(C#N)c1ccccc1 InChI=1S/C39H38N6O5/c40-21-33(32-14-8-3-9-15-32)22-42-37(46)25-45(24-29-16-18-35(19-17-29)49-26-30-10-4-1-5-11-30)38(47)36(20-34-23-41-28-43-34)44-39(48)50-27-31-12-6-2-7-13-31/h1-19,23,28,33,36H,20,22,24-27H2,(H,41,43)(H,42,46)(H,44,48)/t33?,36-/m0/s1 SMBHALUVUUYXQI-CRGCAJGSSA-N 50060140 CHEMBL115943::[(S)-1-{(4-Benzyloxy-benzyl)-[(2-cyano-2-phenyl-ethylcarbamoyl)-methyl]-carbamoyl}-2-(3H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 2 ChEMBL 10.1021/jm970470c 10.7270/Q2V69HQG 9341905 McNamara, DJ; Dobrusin, E; Leonard, DM; Shuler, KR; Kaltenbronn, JS; Quin, J; Bur, S; Thomas, CE; Doherty, AM; Scholten, JD; Zimmerman, KK; Gibbs, BS; Gowan, RC; Latash, MP; Leopold, WR; Przybranowski, SA; Sebolt-Leopold, JS Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060140&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 11802593 103955912 CHEMBL115943 ZINC26997435 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50101418 O=C(CN(Cc1ccc(OCc2ccccc2)cc1)C(=O)[C@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)NCC1(CCCC1)c1ccccc1 InChI=1S/C42H45N5O5/c48-39(44-30-42(22-10-11-23-42)35-16-8-3-9-17-35)27-47(26-32-18-20-37(21-19-32)51-28-33-12-4-1-5-13-33)40(49)38(24-36-25-43-31-45-36)46-41(50)52-29-34-14-6-2-7-15-34/h1-9,12-21,25,31,38H,10-11,22-24,26-30H2,(H,43,45)(H,44,48)(H,46,50)/t38-/m0/s1 RBPBEGQBSIAIKS-LHEWISCISA-N 50060142 CHEMBL326127::[(S)-1-((4-Benzyloxy-benzyl)-{[(1-phenyl-cyclopentylmethyl)-carbamoyl]-methyl}-carbamoyl)-2-(3H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 17 ChEMBL 10.1021/jm970470c 10.7270/Q2V69HQG 9341905 McNamara, DJ; Dobrusin, E; Leonard, DM; Shuler, KR; Kaltenbronn, JS; Quin, J; Bur, S; Thomas, CE; Doherty, AM; Scholten, JD; Zimmerman, KK; Gibbs, BS; Gowan, RC; Latash, MP; Leopold, WR; Przybranowski, SA; Sebolt-Leopold, JS Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060142&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 11802840 103955914 CHEMBL326127 ZINC03937465 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50101419 O=C(CN(Cc1ccc(OCc2ccccc2)cc1)C(=O)[C@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)NCCOCc1ccccc1 InChI=1S/C39H41N5O6/c45-37(41-20-21-48-26-31-10-4-1-5-11-31)25-44(24-30-16-18-35(19-17-30)49-27-32-12-6-2-7-13-32)38(46)36(22-34-23-40-29-42-34)43-39(47)50-28-33-14-8-3-9-15-33/h1-19,23,29,36H,20-22,24-28H2,(H,40,42)(H,41,45)(H,43,47)/t36-/m0/s1 HSKXGSAIEWWVOI-BHVANESWSA-N 50059879 CHEMBL102492::[(S)-1-{(4-Benzyloxy-benzyl)-[(2-benzyloxy-ethylcarbamoyl)-methyl]-carbamoyl}-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 320 ChEMBL 10.1021/jm970470c 10.7270/Q2V69HQG 9341905 McNamara, DJ; Dobrusin, E; Leonard, DM; Shuler, KR; Kaltenbronn, JS; Quin, J; Bur, S; Thomas, CE; Doherty, AM; Scholten, JD; Zimmerman, KK; Gibbs, BS; Gowan, RC; Latash, MP; Leopold, WR; Przybranowski, SA; Sebolt-Leopold, JS Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50059879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50059879&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 9810043 103955657 CHEMBL102492 ZINC03939700 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50101421 CC(CNC(=O)CN(Cc1ccc(OCc2ccccc2)cc1)C(=O)[C@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)c1ccccc1 InChI=1S/C39H41N5O5/c1-29(33-15-9-4-10-16-33)22-41-37(45)25-44(24-30-17-19-35(20-18-30)48-26-31-11-5-2-6-12-31)38(46)36(21-34-23-40-28-42-34)43-39(47)49-27-32-13-7-3-8-14-32/h2-20,23,28-29,36H,21-22,24-27H2,1H3,(H,40,42)(H,41,45)(H,43,47)/t29?,36-/m0/s1 KLNREZJWLLCYLH-RDFKHQOOSA-N 50060138 CHEMBL324827::[(S)-1-{(4-Benzyloxy-benzyl)-[(2-phenyl-propylcarbamoyl)-methyl]-carbamoyl}-2-(3H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 8 ChEMBL 10.1021/jm970470c 10.7270/Q2V69HQG 9341905 McNamara, DJ; Dobrusin, E; Leonard, DM; Shuler, KR; Kaltenbronn, JS; Quin, J; Bur, S; Thomas, CE; Doherty, AM; Scholten, JD; Zimmerman, KK; Gibbs, BS; Gowan, RC; Latash, MP; Leopold, WR; Przybranowski, SA; Sebolt-Leopold, JS Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060138&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10100867 103955910 CHEMBL324827 ZINC26976370 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50101423 C[C@@H](Cc1ccccc1)NC(=O)CN(Cc1ccc(OCc2ccccc2)cc1)C(=O)[C@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1 InChI=1S/C39H41N5O5/c1-29(21-30-11-5-2-6-12-30)42-37(45)25-44(24-31-17-19-35(20-18-31)48-26-32-13-7-3-8-14-32)38(46)36(22-34-23-40-28-41-34)43-39(47)49-27-33-15-9-4-10-16-33/h2-20,23,28-29,36H,21-22,24-27H2,1H3,(H,40,41)(H,42,45)(H,43,47)/t29-,36-/m0/s1 LHWFFKQEXHJCEB-IVUOSGLUSA-N 50060143 CHEMBL324345::[(S)-1-{(4-Benzyloxy-benzyl)-[((S)-1-methyl-2-phenyl-ethylcarbamoyl)-methyl]-carbamoyl}-2-(3H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 41 ChEMBL 10.1021/jm970470c 10.7270/Q2V69HQG 9341905 McNamara, DJ; Dobrusin, E; Leonard, DM; Shuler, KR; Kaltenbronn, JS; Quin, J; Bur, S; Thomas, CE; Doherty, AM; Scholten, JD; Zimmerman, KK; Gibbs, BS; Gowan, RC; Latash, MP; Leopold, WR; Przybranowski, SA; Sebolt-Leopold, JS Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060143&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10508557 103955915 CHEMBL324345 ZINC27080642 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50101424 C[C@H](CNC(=O)CN(Cc1ccc(OCc2ccccc2)cc1)C(=O)[C@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)c1ccccc1 InChI=1S/C39H41N5O5/c1-29(33-15-9-4-10-16-33)22-41-37(45)25-44(24-30-17-19-35(20-18-30)48-26-31-11-5-2-6-12-31)38(46)36(21-34-23-40-28-42-34)43-39(47)49-27-32-13-7-3-8-14-32/h2-20,23,28-29,36H,21-22,24-27H2,1H3,(H,40,42)(H,41,45)(H,43,47)/t29-,36+/m1/s1 KLNREZJWLLCYLH-ZADIWHOSSA-N 50060145 CHEMBL115669::[(S)-1-{(4-Benzyloxy-benzyl)-[((S)-2-phenyl-propylcarbamoyl)-methyl]-carbamoyl}-2-(3H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 5 ChEMBL 10.1021/jm970470c 10.7270/Q2V69HQG 9341905 McNamara, DJ; Dobrusin, E; Leonard, DM; Shuler, KR; Kaltenbronn, JS; Quin, J; Bur, S; Thomas, CE; Doherty, AM; Scholten, JD; Zimmerman, KK; Gibbs, BS; Gowan, RC; Latash, MP; Leopold, WR; Przybranowski, SA; Sebolt-Leopold, JS Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060145&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10746913 103955917 CHEMBL115669 ZINC26976370 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50101425 O=C(CN(Cc1ccc(OCc2ccccc2)cc1)C(=O)[C@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)NCC1(CCC1)c1ccccc1 InChI=1S/C41H43N5O5/c47-38(43-29-41(21-10-22-41)34-15-8-3-9-16-34)26-46(25-31-17-19-36(20-18-31)50-27-32-11-4-1-5-12-32)39(48)37(23-35-24-42-30-44-35)45-40(49)51-28-33-13-6-2-7-14-33/h1-9,11-20,24,30,37H,10,21-23,25-29H2,(H,42,44)(H,43,47)(H,45,49)/t37-/m0/s1 HNXRTWHXWCHGID-QNGWXLTQSA-N 50060139 CHEMBL326352::[(S)-1-((4-Benzyloxy-benzyl)-{[(1-phenyl-cyclobutylmethyl)-carbamoyl]-methyl}-carbamoyl)-2-(3H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 6 ChEMBL 10.1021/jm970470c 10.7270/Q2V69HQG 9341905 McNamara, DJ; Dobrusin, E; Leonard, DM; Shuler, KR; Kaltenbronn, JS; Quin, J; Bur, S; Thomas, CE; Doherty, AM; Scholten, JD; Zimmerman, KK; Gibbs, BS; Gowan, RC; Latash, MP; Leopold, WR; Przybranowski, SA; Sebolt-Leopold, JS Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060139&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10770859 103955911 CHEMBL326352 ZINC03937452 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50101426 O=C(CN(Cc1ccc(OCc2ccccc2)cc1)C(=O)[C@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)NCC1(CC1)c1ccccc1 InChI=1S/C40H41N5O5/c46-37(42-28-40(20-21-40)33-14-8-3-9-15-33)25-45(24-30-16-18-35(19-17-30)49-26-31-10-4-1-5-11-31)38(47)36(22-34-23-41-29-43-34)44-39(48)50-27-32-12-6-2-7-13-32/h1-19,23,29,36H,20-22,24-28H2,(H,41,43)(H,42,46)(H,44,48)/t36-/m0/s1 WOZVVFKBCBNPBT-BHVANESWSA-N 50060146 CHEMBL407445::[(S)-1-((4-Benzyloxy-benzyl)-{[(1-phenyl-cyclopropylmethyl)-carbamoyl]-methyl}-carbamoyl)-2-(3H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 7.0 ChEMBL 10.1021/jm970470c 10.7270/Q2V69HQG 9341905 McNamara, DJ; Dobrusin, E; Leonard, DM; Shuler, KR; Kaltenbronn, JS; Quin, J; Bur, S; Thomas, CE; Doherty, AM; Scholten, JD; Zimmerman, KK; Gibbs, BS; Gowan, RC; Latash, MP; Leopold, WR; Przybranowski, SA; Sebolt-Leopold, JS Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060146&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10794573 103955918 CHEMBL407445 ZINC03937457 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50101427 CCCC(CNC(=O)CN(Cc1ccc(OCc2ccccc2)cc1)C(=O)[C@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)c1ccccc1 InChI=1S/C41H45N5O5/c1-2-12-35(34-17-10-5-11-18-34)24-43-39(47)27-46(26-31-19-21-37(22-20-31)50-28-32-13-6-3-7-14-32)40(48)38(23-36-25-42-30-44-36)45-41(49)51-29-33-15-8-4-9-16-33/h3-11,13-22,25,30,35,38H,2,12,23-24,26-29H2,1H3,(H,42,44)(H,43,47)(H,45,49)/t35?,38-/m0/s1 HOBCNABKXVPKMF-SHXCFHCCSA-N 50060148 CHEMBL325331::[(S)-1-{(4-Benzyloxy-benzyl)-[(2-phenyl-pentylcarbamoyl)-methyl]-carbamoyl}-2-(3H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 25 ChEMBL 10.1021/jm970470c 10.7270/Q2V69HQG 9341905 McNamara, DJ; Dobrusin, E; Leonard, DM; Shuler, KR; Kaltenbronn, JS; Quin, J; Bur, S; Thomas, CE; Doherty, AM; Scholten, JD; Zimmerman, KK; Gibbs, BS; Gowan, RC; Latash, MP; Leopold, WR; Przybranowski, SA; Sebolt-Leopold, JS Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060148&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10699791 103955920 CHEMBL325331 ZINC26995049 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50101428 CN(CCc1ccccc1)C(=O)CN(Cc1ccc(OCc2ccccc2)cc1)C(=O)[C@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1 InChI=1S/C39H41N5O5/c1-43(22-21-30-11-5-2-6-12-30)37(45)26-44(25-31-17-19-35(20-18-31)48-27-32-13-7-3-8-14-32)38(46)36(23-34-24-40-29-41-34)42-39(47)49-28-33-15-9-4-10-16-33/h2-20,24,29,36H,21-23,25-28H2,1H3,(H,40,41)(H,42,47)/t36-/m0/s1 LPIMFHHFGNPCIE-BHVANESWSA-N 50060147 CHEMBL114495::[(S)-1-{(4-Benzyloxy-benzyl)-[(methyl-phenethyl-carbamoyl)-methyl]-carbamoyl}-2-(3H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 4000 ChEMBL 10.1021/jm970470c 10.7270/Q2V69HQG 9341905 McNamara, DJ; Dobrusin, E; Leonard, DM; Shuler, KR; Kaltenbronn, JS; Quin, J; Bur, S; Thomas, CE; Doherty, AM; Scholten, JD; Zimmerman, KK; Gibbs, BS; Gowan, RC; Latash, MP; Leopold, WR; Przybranowski, SA; Sebolt-Leopold, JS Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060147&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10842065 103955919 CHEMBL114495 ZINC27079762 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50101430 CCC(CNC(=O)CN(Cc1ccc(OCc2ccccc2)cc1)C(=O)[C@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)c1ccccc1 InChI=1S/C40H43N5O5/c1-2-33(34-16-10-5-11-17-34)23-42-38(46)26-45(25-30-18-20-36(21-19-30)49-27-31-12-6-3-7-13-31)39(47)37(22-35-24-41-29-43-35)44-40(48)50-28-32-14-8-4-9-15-32/h3-21,24,29,33,37H,2,22-23,25-28H2,1H3,(H,41,43)(H,42,46)(H,44,48)/t33?,37-/m0/s1 HWLKYGTXYNWEPH-NYZBEGEVSA-N 50060149 CHEMBL112512::[(S)-1-{(4-Benzyloxy-benzyl)-[(2-phenyl-butylcarbamoyl)-methyl]-carbamoyl}-2-(3H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 5 ChEMBL 10.1021/jm970470c 10.7270/Q2V69HQG 9341905 McNamara, DJ; Dobrusin, E; Leonard, DM; Shuler, KR; Kaltenbronn, JS; Quin, J; Bur, S; Thomas, CE; Doherty, AM; Scholten, JD; Zimmerman, KK; Gibbs, BS; Gowan, RC; Latash, MP; Leopold, WR; Przybranowski, SA; Sebolt-Leopold, JS Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060149&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10818236 103955921 CHEMBL112512 ZINC26995061 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50101432 CC(C)(CNC(=O)CN(Cc1ccc(OCc2ccccc2)cc1)C(=O)[C@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)c1ccccc1 InChI=1S/C40H43N5O5/c1-40(2,33-16-10-5-11-17-33)28-42-37(46)25-45(24-30-18-20-35(21-19-30)49-26-31-12-6-3-7-13-31)38(47)36(22-34-23-41-29-43-34)44-39(48)50-27-32-14-8-4-9-15-32/h3-21,23,29,36H,22,24-28H2,1-2H3,(H,41,43)(H,42,46)(H,44,48)/t36-/m0/s1 MYBBTGORNPKHDT-BHVANESWSA-N 50060141 CHEMBL431440::[(S)-1-{(4-Benzyloxy-benzyl)-[(2-methyl-2-phenyl-propylcarbamoyl)-methyl]-carbamoyl}-2-(3H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 4 ChEMBL 10.1021/jm970470c 10.7270/Q2V69HQG 9341905 McNamara, DJ; Dobrusin, E; Leonard, DM; Shuler, KR; Kaltenbronn, JS; Quin, J; Bur, S; Thomas, CE; Doherty, AM; Scholten, JD; Zimmerman, KK; Gibbs, BS; Gowan, RC; Latash, MP; Leopold, WR; Przybranowski, SA; Sebolt-Leopold, JS Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060141&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 9833296 103955913 CHEMBL431440 ZINC03935745 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50101433 C[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](COCc1ccccc1)NC(=O)[C@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C54H57N9O9/c1-35(49(55)64)59-50(65)46(26-40-28-57-44-20-12-11-19-43(40)44)61-53(68)48(33-70-30-37-13-5-2-6-14-37)62-51(66)45(25-36-21-23-42(24-22-36)71-31-38-15-7-3-8-16-38)60-52(67)47(27-41-29-56-34-58-41)63-54(69)72-32-39-17-9-4-10-18-39/h2-24,28-29,34-35,45-48,57H,25-27,30-33H2,1H3,(H2,55,64)(H,56,58)(H,59,65)(H,60,67)(H,61,68)(H,62,66)(H,63,69)/t35-,45+,46+,47+,48+/m1/s1 LMBPTRXCFXWLRW-ZYIGOEBISA-N 50059876 CHEMBL217423::[(S)-1-[(S)-1-{(S)-2-Benzyloxy-1-[(S)-1-((R)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethylcarbamoyl]-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester::[(S)-1-[(S)-1-{(S)-2-Benzyloxy-1-[(S)-1-((R)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethylcarbamoyl]-2-(3H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 76 ChEMBL 10.1021/jm970470c 10.7270/Q2V69HQG 9341905 McNamara, DJ; Dobrusin, E; Leonard, DM; Shuler, KR; Kaltenbronn, JS; Quin, J; Bur, S; Thomas, CE; Doherty, AM; Scholten, JD; Zimmerman, KK; Gibbs, BS; Gowan, RC; Latash, MP; Leopold, WR; Przybranowski, SA; Sebolt-Leopold, JS Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50059876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50059876&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 9919495 103955654 CHEMBL217423 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50101438 CC(C)(Cc1ccccc1)NC(=O)CN(Cc1ccc(OCc2ccccc2)cc1)C(=O)[C@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1 InChI=1S/C40H43N5O5/c1-40(2,23-30-12-6-3-7-13-30)44-37(46)26-45(25-31-18-20-35(21-19-31)49-27-32-14-8-4-9-15-32)38(47)36(22-34-24-41-29-42-34)43-39(48)50-28-33-16-10-5-11-17-33/h3-21,24,29,36H,22-23,25-28H2,1-2H3,(H,41,42)(H,43,48)(H,44,46)/t36-/m0/s1 PMGGRLQMDMDZDE-BHVANESWSA-N 50060151 CHEMBL408134::[(S)-1-{(4-Benzyloxy-benzyl)-[(1,1-dimethyl-2-phenyl-ethylcarbamoyl)-methyl]-carbamoyl}-2-(3H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 270 ChEMBL 10.1021/jm970470c 10.7270/Q2V69HQG 9341905 McNamara, DJ; Dobrusin, E; Leonard, DM; Shuler, KR; Kaltenbronn, JS; Quin, J; Bur, S; Thomas, CE; Doherty, AM; Scholten, JD; Zimmerman, KK; Gibbs, BS; Gowan, RC; Latash, MP; Leopold, WR; Przybranowski, SA; Sebolt-Leopold, JS Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060151&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10604527 103955923 CHEMBL408134 ZINC26982198 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50101441 C[C@@H](CNC(=O)CN(Cc1ccc(OCc2ccccc2)cc1)C(=O)[C@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)c1ccccc1 InChI=1S/C39H41N5O5/c1-29(33-15-9-4-10-16-33)22-41-37(45)25-44(24-30-17-19-35(20-18-30)48-26-31-11-5-2-6-12-31)38(46)36(21-34-23-40-28-42-34)43-39(47)49-27-32-13-7-3-8-14-32/h2-20,23,28-29,36H,21-22,24-27H2,1H3,(H,40,42)(H,41,45)(H,43,47)/t29-,36-/m0/s1 KLNREZJWLLCYLH-IVUOSGLUSA-N 50060150 CHEMBL114281::[(S)-1-{(4-Benzyloxy-benzyl)-[((R)-2-phenyl-propylcarbamoyl)-methyl]-carbamoyl}-2-(3H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 16 ChEMBL 10.1021/jm970470c 10.7270/Q2V69HQG 9341905 McNamara, DJ; Dobrusin, E; Leonard, DM; Shuler, KR; Kaltenbronn, JS; Quin, J; Bur, S; Thomas, CE; Doherty, AM; Scholten, JD; Zimmerman, KK; Gibbs, BS; Gowan, RC; Latash, MP; Leopold, WR; Przybranowski, SA; Sebolt-Leopold, JS Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060150&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10556304 103955922 CHEMBL114281 ZINC26976361 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50101442 CCC(CC)(CNC(=O)CN(Cc1ccc(OCc2ccccc2)cc1)C(=O)[C@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)c1ccccc1 InChI=1S/C42H47N5O5/c1-3-42(4-2,35-18-12-7-13-19-35)30-44-39(48)27-47(26-32-20-22-37(23-21-32)51-28-33-14-8-5-9-15-33)40(49)38(24-36-25-43-31-45-36)46-41(50)52-29-34-16-10-6-11-17-34/h5-23,25,31,38H,3-4,24,26-30H2,1-2H3,(H,43,45)(H,44,48)(H,46,50)/t38-/m0/s1 KESDVVHGRDVTAS-LHEWISCISA-N 50060152 CHEMBL112879::[(S)-1-{(4-Benzyloxy-benzyl)-[(2-ethyl-2-phenyl-butylcarbamoyl)-methyl]-carbamoyl}-2-(3H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 32 ChEMBL 10.1021/jm970470c 10.7270/Q2V69HQG 9341905 McNamara, DJ; Dobrusin, E; Leonard, DM; Shuler, KR; Kaltenbronn, JS; Quin, J; Bur, S; Thomas, CE; Doherty, AM; Scholten, JD; Zimmerman, KK; Gibbs, BS; Gowan, RC; Latash, MP; Leopold, WR; Przybranowski, SA; Sebolt-Leopold, JS Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060152&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10771001 103955924 CHEMBL112879 ZINC26982221 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50101443 C[C@H](Cc1ccccc1)NC(=O)CN(Cc1ccc(OCc2ccccc2)cc1)C(=O)[C@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1 InChI=1S/C39H41N5O5/c1-29(21-30-11-5-2-6-12-30)42-37(45)25-44(24-31-17-19-35(20-18-31)48-26-32-13-7-3-8-14-32)38(46)36(22-34-23-40-28-41-34)43-39(47)49-27-33-15-9-4-10-16-33/h2-20,23,28-29,36H,21-22,24-27H2,1H3,(H,40,41)(H,42,45)(H,43,47)/t29-,36+/m1/s1 LHWFFKQEXHJCEB-ZADIWHOSSA-N 50060144 CHEMBL325073::[(S)-1-{(4-Benzyloxy-benzyl)-[((R)-1-methyl-2-phenyl-ethylcarbamoyl)-methyl]-carbamoyl}-2-(3H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 3 ChEMBL 10.1021/jm970470c 10.7270/Q2V69HQG 9341905 McNamara, DJ; Dobrusin, E; Leonard, DM; Shuler, KR; Kaltenbronn, JS; Quin, J; Bur, S; Thomas, CE; Doherty, AM; Scholten, JD; Zimmerman, KK; Gibbs, BS; Gowan, RC; Latash, MP; Leopold, WR; Przybranowski, SA; Sebolt-Leopold, JS Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060144&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10818103 103955916 CHEMBL325073 ZINC27080193 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50105946 C[C@@H]([C@H](C\C=C\c1nc2ccccc2o1)c1ccc2OCOc2c1)N(Cc1ccc2ccccc2c1)C(=O)[C@H]1OC(O[C@@H]1C([O-])=O)(C([O-])=O)C([O-])=O InChI=1S/C38H32N2O12/c1-21(26(25-15-16-29-30(18-25)49-20-48-29)9-6-12-31-39-27-10-4-5-11-28(27)50-31)40(19-22-13-14-23-7-2-3-8-24(23)17-22)34(41)32-33(35(42)43)52-38(51-32,36(44)45)37(46)47/h2-8,10-18,21,26,32-33H,9,19-20H2,1H3,(H,42,43)(H,44,45)(H,46,47)/p-3/b12-6+/t21-,26-,32-,33-/m0/s1 CXDSZFRIMJUZKT-SXSTWBSRSA-K 50062248 CHEMBL36515::trisodium 5-[2-benzo[d][1,3]dioxol-5-yl-5-benzo[d][1,3]oxazol-2-yl-1-methyl-(1S,2R,4E)-4-pentenyl(2-naphthylmethyl)carbamoyl]-(4S,5S)-1,3-dioxolane-2,2,4-tricarboxylate Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 7.2 ChEMBL 10.1021/jm970540f 10.7270/Q23B5Z82 9457237 Aoyama, T; Satoh, T; Yonemoto, M; Shibata, J; Nonoshita, K; Arai, S; Kawakami, K; Iwasawa, Y; Sano, H; Tanaka, K; Monden, Y; Kodera, T; Arakawa, H; Suzuki-Takahashi, I; Kamei, T; Tomimoto, K Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062248&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 91935499 103957771 CHEMBL36515 ZINC29238366 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50105947 C[C@@H]([C@H](C\C=C\c1nc2ccccc2o1)c1ccc2OCOc2c1)N(Cc1ccc2ccccc2c1)C(=O)[C@@H]1OC(O[C@@H]1C([O-])=O)(C([O-])=O)C([O-])=O InChI=1S/C38H32N2O12/c1-21(26(25-15-16-29-30(18-25)49-20-48-29)9-6-12-31-39-27-10-4-5-11-28(27)50-31)40(19-22-13-14-23-7-2-3-8-24(23)17-22)34(41)32-33(35(42)43)52-38(51-32,36(44)45)37(46)47/h2-8,10-18,21,26,32-33H,9,19-20H2,1H3,(H,42,43)(H,44,45)(H,46,47)/p-3/b12-6+/t21-,26-,32+,33-/m0/s1 CXDSZFRIMJUZKT-OBCHTKLQSA-K 50062249 CHEMBL285434::trisodium 5-[2-benzo[d][1,3]dioxol-5-yl-5-benzo[d][1,3]oxazol-2-yl-1-methyl-(1S,2R,4E)-4-pentenyl(2-naphthylmethyl)carbamoyl]-(4S,5R)-1,3-dioxolane-2,2,4-tricarboxylate Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 5.6 ChEMBL 10.1021/jm970540f 10.7270/Q23B5Z82 9457237 Aoyama, T; Satoh, T; Yonemoto, M; Shibata, J; Nonoshita, K; Arai, S; Kawakami, K; Iwasawa, Y; Sano, H; Tanaka, K; Monden, Y; Kodera, T; Arakawa, H; Suzuki-Takahashi, I; Kamei, T; Tomimoto, K Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062249&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 91935500 103957772 CHEMBL285434 ZINC29248129 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50105948 C[C@H]([C@@H](C\C=C\c1nc2ccccc2o1)c1ccc2OCOc2c1)N(Cc1ccc2ccccc2c1)C(=O)[C@@H]1OC(O[C@@H]1C([O-])=O)(C([O-])=O)C([O-])=O InChI=1S/C38H32N2O12/c1-21(26(25-15-16-29-30(18-25)49-20-48-29)9-6-12-31-39-27-10-4-5-11-28(27)50-31)40(19-22-13-14-23-7-2-3-8-24(23)17-22)34(41)32-33(35(42)43)52-38(51-32,36(44)45)37(46)47/h2-8,10-18,21,26,32-33H,9,19-20H2,1H3,(H,42,43)(H,44,45)(H,46,47)/p-3/b12-6+/t21-,26-,32-,33+/m1/s1 CXDSZFRIMJUZKT-OAFRSSMVSA-K 50062252 CHEMBL36339::trisodium 5-[2-benzo[d][1,3]dioxol-5-yl-5-benzo[d][1,3]oxazol-2-yl-1-methyl-(1R,2S,4E)-4-pentenyl(2-naphthylmethyl)carbamoyl]-(4S,5R)-1,3-dioxolane-2,2,4-tricarboxylate Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 6 ChEMBL 10.1021/jm970540f 10.7270/Q23B5Z82 9457237 Aoyama, T; Satoh, T; Yonemoto, M; Shibata, J; Nonoshita, K; Arai, S; Kawakami, K; Iwasawa, Y; Sano, H; Tanaka, K; Monden, Y; Kodera, T; Arakawa, H; Suzuki-Takahashi, I; Kamei, T; Tomimoto, K Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062252&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 91935503 103957775 CHEMBL36339 ZINC29243435 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50105949 CC(C(Cc1ccc(Cl)cc1)c1ccc(Cl)cc1)N(C)C(=O)CC(CC(O)=O)C(O)=O InChI=1S/C23H25Cl2NO5/c1-14(26(2)21(27)12-17(23(30)31)13-22(28)29)20(16-5-9-19(25)10-6-16)11-15-3-7-18(24)8-4-15/h3-10,14,17,20H,11-13H2,1-2H3,(H,28,29)(H,30,31) MKPPODPKGOWVRL-UHFFFAOYSA-N 50062254 2-({[2,3-Bis-(4-chloro-phenyl)-1-methyl-propyl]-methyl-carbamoyl}-methyl)-succinic acid::CHEMBL284338 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >10000 ChEMBL 10.1021/jm970540f 10.7270/Q23B5Z82 9457237 Aoyama, T; Satoh, T; Yonemoto, M; Shibata, J; Nonoshita, K; Arai, S; Kawakami, K; Iwasawa, Y; Sano, H; Tanaka, K; Monden, Y; Kodera, T; Arakawa, H; Suzuki-Takahashi, I; Kamei, T; Tomimoto, K Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062254 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062254&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10742831 103957777 CHEMBL284338 ZINC13776796 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50105950 CC(C(C\C=C\c1ccc2ccccc2c1)c1ccc(Cl)cc1)N(Cc1ccc2ccccc2c1)C(=O)CC(CC(O)=O)C(O)=O InChI=1S/C39H36ClNO5/c1-26(36(31-17-19-35(40)20-18-31)12-6-7-27-13-15-29-8-2-4-10-32(29)21-27)41(37(42)23-34(39(45)46)24-38(43)44)25-28-14-16-30-9-3-5-11-33(30)22-28/h2-11,13-22,26,34,36H,12,23-25H2,1H3,(H,43,44)(H,45,46)/b7-6+ MJKVUARLHSYAFA-VOTSOKGWSA-N 50062253 2-({[(E)-2-(4-Chloro-phenyl)-1-methyl-5-naphthalen-2-yl-pent-4-enyl]-naphthalen-2-ylmethyl-carbamoyl}-methyl)-succinic acid::CHEMBL35135 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 51 ChEMBL 10.1021/jm970540f 10.7270/Q23B5Z82 9457237 Aoyama, T; Satoh, T; Yonemoto, M; Shibata, J; Nonoshita, K; Arai, S; Kawakami, K; Iwasawa, Y; Sano, H; Tanaka, K; Monden, Y; Kodera, T; Arakawa, H; Suzuki-Takahashi, I; Kamei, T; Tomimoto, K Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062253&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10746627 103957776 CHEMBL35135 ZINC29247368 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50105951 C[C@@H]([C@H](C\C=C\c1nc2ccccc2o1)c1ccc2OCOc2c1)N(Cc1ccc2ccccc2c1)C(=O)[C@@H]1OC(O[C@@H]1C([O-])=O)(C([O-])=O)C([O-])=O InChI=1S/C38H32N2O12/c1-21(26(25-15-16-29-30(18-25)49-20-48-29)9-6-12-31-39-27-10-4-5-11-28(27)50-31)40(19-22-13-14-23-7-2-3-8-24(23)17-22)34(41)32-33(35(42)43)52-38(51-32,36(44)45)37(46)47/h2-8,10-18,21,26,32-33H,9,19-20H2,1H3,(H,42,43)(H,44,45)(H,46,47)/p-3/b12-6+/t21-,26-,32+,33-/m0/s1 CXDSZFRIMJUZKT-OBCHTKLQSA-K 50062249 CHEMBL285434::trisodium 5-[2-benzo[d][1,3]dioxol-5-yl-5-benzo[d][1,3]oxazol-2-yl-1-methyl-(1S,2R,4E)-4-pentenyl(2-naphthylmethyl)carbamoyl]-(4S,5R)-1,3-dioxolane-2,2,4-tricarboxylate Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 5 ChEMBL 10.1021/jm970540f 10.7270/Q23B5Z82 9457237 Aoyama, T; Satoh, T; Yonemoto, M; Shibata, J; Nonoshita, K; Arai, S; Kawakami, K; Iwasawa, Y; Sano, H; Tanaka, K; Monden, Y; Kodera, T; Arakawa, H; Suzuki-Takahashi, I; Kamei, T; Tomimoto, K Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062249&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 91935500 103957772 CHEMBL285434 ZINC29248129 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50105952 CC(C(Cc1ccc(Cl)cc1)c1ccc(Cl)cc1)N(Cc1ccc2ccccc2c1)C(=O)CC(CC(O)=O)C(O)=O InChI=1S/C33H31Cl2NO5/c1-21(30(25-10-14-29(35)15-11-25)17-22-7-12-28(34)13-8-22)36(31(37)18-27(33(40)41)19-32(38)39)20-23-6-9-24-4-2-3-5-26(24)16-23/h2-16,21,27,30H,17-20H2,1H3,(H,38,39)(H,40,41) NXFSKUYLEJMITM-UHFFFAOYSA-N 50062255 2-({[2,3-Bis-(4-chloro-phenyl)-1-methyl-propyl]-naphthalen-2-ylmethyl-carbamoyl}-methyl)-succinic acid::CHEMBL35856 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 3400 ChEMBL 10.1021/jm970540f 10.7270/Q23B5Z82 9457237 Aoyama, T; Satoh, T; Yonemoto, M; Shibata, J; Nonoshita, K; Arai, S; Kawakami, K; Iwasawa, Y; Sano, H; Tanaka, K; Monden, Y; Kodera, T; Arakawa, H; Suzuki-Takahashi, I; Kamei, T; Tomimoto, K Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062255&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44283217 103957778 CHEMBL35856 ZINC29241226 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50105953 C[C@@H]([C@H](C\C=C\c1nc2ccccc2o1)c1ccc2OCOc2c1)N(Cc1ccc2ccccc2c1)C(=O)[C@@H]1OC(O[C@@H]1C([O-])=O)(C([O-])=O)C([O-])=O InChI=1S/C38H32N2O12/c1-21(26(25-15-16-29-30(18-25)49-20-48-29)9-6-12-31-39-27-10-4-5-11-28(27)50-31)40(19-22-13-14-23-7-2-3-8-24(23)17-22)34(41)32-33(35(42)43)52-38(51-32,36(44)45)37(46)47/h2-8,10-18,21,26,32-33H,9,19-20H2,1H3,(H,42,43)(H,44,45)(H,46,47)/p-3/b12-6+/t21-,26-,32+,33-/m0/s1 CXDSZFRIMJUZKT-OBCHTKLQSA-K 50062249 CHEMBL285434::trisodium 5-[2-benzo[d][1,3]dioxol-5-yl-5-benzo[d][1,3]oxazol-2-yl-1-methyl-(1S,2R,4E)-4-pentenyl(2-naphthylmethyl)carbamoyl]-(4S,5R)-1,3-dioxolane-2,2,4-tricarboxylate Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 45 ChEMBL 10.1021/jm970540f 10.7270/Q23B5Z82 9457237 Aoyama, T; Satoh, T; Yonemoto, M; Shibata, J; Nonoshita, K; Arai, S; Kawakami, K; Iwasawa, Y; Sano, H; Tanaka, K; Monden, Y; Kodera, T; Arakawa, H; Suzuki-Takahashi, I; Kamei, T; Tomimoto, K Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062249&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 91935500 103957772 CHEMBL285434 ZINC29248129 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50105954 C[C@H]([C@@H](C\C=C\c1nc2ccccc2o1)c1ccc2OCOc2c1)N(Cc1ccc2ccccc2c1)C(=O)[C@H]1OC(O[C@H]1C([O-])=O)(C([O-])=O)C([O-])=O InChI=1S/C38H32N2O12/c1-21(26(25-15-16-29-30(18-25)49-20-48-29)9-6-12-31-39-27-10-4-5-11-28(27)50-31)40(19-22-13-14-23-7-2-3-8-24(23)17-22)34(41)32-33(35(42)43)52-38(51-32,36(44)45)37(46)47/h2-8,10-18,21,26,32-33H,9,19-20H2,1H3,(H,42,43)(H,44,45)(H,46,47)/p-3/b12-6+/t21-,26-,32+,33-/m1/s1 CXDSZFRIMJUZKT-SQEVKNNPSA-K 50062256 CHEMBL284073::trisodium 5-[2-benzo[d][1,3]dioxol-5-yl-5-benzo[d][1,3]oxazol-2-yl-1-methyl-(1S,2R,4E)-4-pentenyl(2-naphthylmethyl)carbamoyl]-(4R,5R)-1,3-dioxolane-2,2,4-tricarboxylate Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 8 ChEMBL 10.1021/jm970540f 10.7270/Q23B5Z82 9457237 Aoyama, T; Satoh, T; Yonemoto, M; Shibata, J; Nonoshita, K; Arai, S; Kawakami, K; Iwasawa, Y; Sano, H; Tanaka, K; Monden, Y; Kodera, T; Arakawa, H; Suzuki-Takahashi, I; Kamei, T; Tomimoto, K Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062256&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 91935504 103957779 CHEMBL284073 ZINC29248113 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50105955 C[C@@H]([C@H](C\C=C\c1nc2ccccc2o1)c1ccc2OCOc2c1)N(Cc1ccc2ccccc2c1)C(=O)[C@H]1OC(O[C@H]1C([O-])=O)(C([O-])=O)C([O-])=O InChI=1S/C38H32N2O12/c1-21(26(25-15-16-29-30(18-25)49-20-48-29)9-6-12-31-39-27-10-4-5-11-28(27)50-31)40(19-22-13-14-23-7-2-3-8-24(23)17-22)34(41)32-33(35(42)43)52-38(51-32,36(44)45)37(46)47/h2-8,10-18,21,26,32-33H,9,19-20H2,1H3,(H,42,43)(H,44,45)(H,46,47)/p-3/b12-6+/t21-,26-,32-,33+/m0/s1 CXDSZFRIMJUZKT-MDJAPQQWSA-K 50062250 CHEMBL36407::trisodium 5-[2-benzo[d][1,3]dioxol-5-yl-5-benzo[d][1,3]oxazol-2-yl-1-methyl-(1S,2R,4E)-4-pentenyl(2-naphthylmethyl)carbamoyl]-(4R,5S)-1,3-dioxolane-2,2,4-tricarboxylate Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 3.9 ChEMBL 10.1021/jm970540f 10.7270/Q23B5Z82 9457237 Aoyama, T; Satoh, T; Yonemoto, M; Shibata, J; Nonoshita, K; Arai, S; Kawakami, K; Iwasawa, Y; Sano, H; Tanaka, K; Monden, Y; Kodera, T; Arakawa, H; Suzuki-Takahashi, I; Kamei, T; Tomimoto, K Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062250&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 91935501 103957773 CHEMBL36407 ZINC29238357 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50105956 CC(C(C\C=C\c1nc2ccccc2o1)c1ccc(Cl)cc1)N(Cc1ccc2ccccc2c1)C(=O)CC(CC(O)=O)C(O)=O InChI=1S/C36H33ClN2O6/c1-23(30(26-15-17-29(37)18-16-26)9-6-12-33-38-31-10-4-5-11-32(31)45-33)39(34(40)20-28(36(43)44)21-35(41)42)22-24-13-14-25-7-2-3-8-27(25)19-24/h2-8,10-19,23,28,30H,9,20-22H2,1H3,(H,41,42)(H,43,44)/b12-6+ OPDUZLOYSYAFSL-WUXMJOGZSA-N 50062257 2-({[(E)-5-Benzooxazol-2-yl-2-(4-chloro-phenyl)-1-methyl-pent-4-enyl]-naphthalen-2-ylmethyl-carbamoyl}-methyl)-succinic acid::CHEMBL265090 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 28 ChEMBL 10.1021/jm970540f 10.7270/Q23B5Z82 9457237 Aoyama, T; Satoh, T; Yonemoto, M; Shibata, J; Nonoshita, K; Arai, S; Kawakami, K; Iwasawa, Y; Sano, H; Tanaka, K; Monden, Y; Kodera, T; Arakawa, H; Suzuki-Takahashi, I; Kamei, T; Tomimoto, K Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062257&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10817731 103957780 CHEMBL265090 ZINC29249853 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50105957 C[C@@H]([C@H](C\C=C\c1nc2ccccc2o1)c1ccc2OCOc2c1)N(Cc1ccc2ccccc2c1)C(=O)[C@@H]1OC(O[C@@H]1C([O-])=O)(C([O-])=O)C([O-])=O InChI=1S/C38H32N2O12/c1-21(26(25-15-16-29-30(18-25)49-20-48-29)9-6-12-31-39-27-10-4-5-11-28(27)50-31)40(19-22-13-14-23-7-2-3-8-24(23)17-22)34(41)32-33(35(42)43)52-38(51-32,36(44)45)37(46)47/h2-8,10-18,21,26,32-33H,9,19-20H2,1H3,(H,42,43)(H,44,45)(H,46,47)/p-3/b12-6+/t21-,26-,32+,33-/m0/s1 CXDSZFRIMJUZKT-OBCHTKLQSA-K 50062249 CHEMBL285434::trisodium 5-[2-benzo[d][1,3]dioxol-5-yl-5-benzo[d][1,3]oxazol-2-yl-1-methyl-(1S,2R,4E)-4-pentenyl(2-naphthylmethyl)carbamoyl]-(4S,5R)-1,3-dioxolane-2,2,4-tricarboxylate Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 7.2 ChEMBL 10.1021/jm970540f 10.7270/Q23B5Z82 9457237 Aoyama, T; Satoh, T; Yonemoto, M; Shibata, J; Nonoshita, K; Arai, S; Kawakami, K; Iwasawa, Y; Sano, H; Tanaka, K; Monden, Y; Kodera, T; Arakawa, H; Suzuki-Takahashi, I; Kamei, T; Tomimoto, K Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062249&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 91935500 103957772 CHEMBL285434 ZINC29248129 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50105958 C[C@@H]([C@H](C\C=C\c1nc2ccccc2o1)c1ccc2OCOc2c1)N(Cc1ccc2ccccc2c1)C(=O)[C@@H]1OC(O[C@H]1C([O-])=O)(C([O-])=O)C([O-])=O InChI=1S/C38H32N2O12/c1-21(26(25-15-16-29-30(18-25)49-20-48-29)9-6-12-31-39-27-10-4-5-11-28(27)50-31)40(19-22-13-14-23-7-2-3-8-24(23)17-22)34(41)32-33(35(42)43)52-38(51-32,36(44)45)37(46)47/h2-8,10-18,21,26,32-33H,9,19-20H2,1H3,(H,42,43)(H,44,45)(H,46,47)/p-3/b12-6+/t21-,26-,32+,33+/m0/s1 CXDSZFRIMJUZKT-GZHAQUORSA-K 50062251 CHEMBL285263::trisodium 5-[2-benzo[d][1,3]dioxol-5-yl-5-benzo[d][1,3]oxazol-2-yl-1-methyl-(1S,2R,4E)-4-pentenyl(2-naphthylmethyl)carbamoyl]-(4R,5R)-1,3-dioxolane-2,2,4-tricarboxylate Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 3.9 ChEMBL 10.1021/jm970540f 10.7270/Q23B5Z82 9457237 Aoyama, T; Satoh, T; Yonemoto, M; Shibata, J; Nonoshita, K; Arai, S; Kawakami, K; Iwasawa, Y; Sano, H; Tanaka, K; Monden, Y; Kodera, T; Arakawa, H; Suzuki-Takahashi, I; Kamei, T; Tomimoto, K Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062251&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 91935502 103957774 CHEMBL285263 ZINC29248498 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50105959 CC(C(C\C=C\c1nc2ccccc2o1)c1ccc2OCOc2c1)N(Cc1ccc2ccccc2c1)C(=O)CC(CC(O)=O)C(O)=O InChI=1S/C37H34N2O8/c1-23(39(35(40)19-28(37(43)44)20-36(41)42)21-24-13-14-25-7-2-3-8-26(25)17-24)29(27-15-16-32-33(18-27)46-22-45-32)9-6-12-34-38-30-10-4-5-11-31(30)47-34/h2-8,10-18,23,28-29H,9,19-22H2,1H3,(H,41,42)(H,43,44)/b12-6+ FGBJHPNBIPVZKR-WUXMJOGZSA-N 50062258 2-{[((E)-2-Benzo[1,3]dioxol-5-yl-5-benzooxazol-2-yl-1-methyl-pent-4-enyl)-naphthalen-2-ylmethyl-carbamoyl]-methyl}-succinic acid::CHEMBL285058 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 23 ChEMBL 10.1021/jm970540f 10.7270/Q23B5Z82 9457237 Aoyama, T; Satoh, T; Yonemoto, M; Shibata, J; Nonoshita, K; Arai, S; Kawakami, K; Iwasawa, Y; Sano, H; Tanaka, K; Monden, Y; Kodera, T; Arakawa, H; Suzuki-Takahashi, I; Kamei, T; Tomimoto, K Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062258&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10532102 103957781 CHEMBL285058 ZINC29240783 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50180926 Clc1ccc(Sc2cc(Cn3ccnc3)ccc2C#N)c(Cl)c1 InChI=1S/C17H11Cl2N3S/c18-14-3-4-16(15(19)8-14)23-17-7-12(1-2-13(17)9-20)10-22-6-5-21-11-22/h1-8,11H,10H2 JRTOBKVVIBBEQD-UHFFFAOYSA-N 50100300 2-(2,4-Dichloro-phenylsulfanyl)-4-imidazol-1-ylmethyl-benzonitrile::CHEMBL22659 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 96 ChEMBL 10.1016/s0960-894x(01)00162-7 10.7270/Q2FX78RS 11392531 Mactough, SC; Desolms, SJ; Shaw, AW; Abrams, MT; Ciccarone, TM; Davide, JP; Hamilton, KA; Hutchinson, JH; Koblan, KS; Kohl, NE; Lobell, RB; Robinson, RG; Graham, SL Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50100300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50100300&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 9820245 103997087 CHEMBL22659 ZINC00585798 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50145829 CCS(=O)(=O)C[C@H](CC1CCCCC1)NCc1ccc(C(=O)N[C@@H](CCS(C)(=O)=O)C(O)=O)c(c1)-c1ccccc1C InChI=1S/C31H44N2O7S2/c1-4-42(39,40)21-25(18-23-11-6-5-7-12-23)32-20-24-14-15-27(28(19-24)26-13-9-8-10-22(26)2)30(34)33-29(31(35)36)16-17-41(3,37)38/h8-10,13-15,19,23,25,29,32H,4-7,11-12,16-18,20-21H2,1-3H3,(H,33,34)(H,35,36)/t25-,29-/m0/s1 ASWWGQSASVXGDY-SVEHJYQDSA-N 50082894 (S)-2-({5-[((S)-1-Cyclohexylmethyl-2-ethanesulfonyl-ethylamino)-methyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methanesulfonyl-butyric acid::CHEMBL145699 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 1.2 ChEMBL 10.1021/jm990335v 10.7270/Q2WW7GWR 10579847 Henry, KJ; Wasicak, J; Tasker, AS; Cohen, J; Ewing, P; Mitten, M; Larsen, JJ; Kalvin, DM; Swenson, R; Ng, SC; Saeed, B; Cherian, S; Sham, H; Rosenberg, SH Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50082894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50082894&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10793939 103982629 CHEMBL145699 ZINC27527296 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50145830 CSCC[C@H](NC(=O)c1ccc(CN[C@@H](CC2CCCCC2)\C=C\CC(C)C)cc1-c1ccccc1C)C([O-])=O InChI=1S/C34H48N2O3S/c1-24(2)11-10-15-28(21-26-13-6-5-7-14-26)35-23-27-17-18-30(31(22-27)29-16-9-8-12-25(29)3)33(37)36-32(34(38)39)19-20-40-4/h8-10,12,15-18,22,24,26,28,32,35H,5-7,11,13-14,19-21,23H2,1-4H3,(H,36,37)(H,38,39)/p-1/b15-10+/t28-,32+/m1/s1 TZLZIAXUFYAPIG-RVDTUPMASA-M 50082895 2-({5-[(1-Cyclohexylmethyl-5-methyl-hex-2-enylamino)-methyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-Lithiuum butarate::CHEMBL178483 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 0.22 ChEMBL 10.1021/jm990335v 10.7270/Q2WW7GWR 10579847 Henry, KJ; Wasicak, J; Tasker, AS; Cohen, J; Ewing, P; Mitten, M; Larsen, JJ; Kalvin, DM; Swenson, R; Ng, SC; Saeed, B; Cherian, S; Sham, H; Rosenberg, SH Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50082895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50082895&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 91931191 103982630 CHEMBL178483 ZINC28103367 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50145831 CSCC[C@H](NC(=O)c1ccc(CN[C@H](CO)CC2CCCCC2)cc1-c1ccccc1C)C(O)=O InChI=1S/C29H40N2O4S/c1-20-8-6-7-11-24(20)26-17-22(18-30-23(19-32)16-21-9-4-3-5-10-21)12-13-25(26)28(33)31-27(29(34)35)14-15-36-2/h6-8,11-13,17,21,23,27,30,32H,3-5,9-10,14-16,18-19H2,1-2H3,(H,31,33)(H,34,35)/t23-,27-/m0/s1 BQPCQHREHFDITQ-HOFKKMOUSA-N 50082897 (S)-2-({5-[((S)-2-Cyclohexyl-1-hydroxymethyl-ethylamino)-methyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid::CHEMBL344771 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 0.16 ChEMBL 10.1021/jm990335v 10.7270/Q2WW7GWR 10579847 Henry, KJ; Wasicak, J; Tasker, AS; Cohen, J; Ewing, P; Mitten, M; Larsen, JJ; Kalvin, DM; Swenson, R; Ng, SC; Saeed, B; Cherian, S; Sham, H; Rosenberg, SH Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50082897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50082897&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10601855 103982632 CHEMBL344771 ZINC13802291 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50145832 CCSC[C@H](CC1CCCCC1)NCc1ccc(C(=O)N[C@@H](CCS(C)(=O)=O)C(O)=O)c(c1)-c1ccccc1C InChI=1S/C31H44N2O5S2/c1-4-39-21-25(18-23-11-6-5-7-12-23)32-20-24-14-15-27(28(19-24)26-13-9-8-10-22(26)2)30(34)33-29(31(35)36)16-17-40(3,37)38/h8-10,13-15,19,23,25,29,32H,4-7,11-12,16-18,20-21H2,1-3H3,(H,33,34)(H,35,36)/t25-,29-/m0/s1 HTARQEJCWHWALO-SVEHJYQDSA-N 50082898 (S)-2-({5-[((S)-2-Cyclohexyl-1-ethylsulfanylmethyl-ethylamino)-methyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methanesulfonyl-butyric acid::CHEMBL144745 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 1 ChEMBL 10.1021/jm990335v 10.7270/Q2WW7GWR 10579847 Henry, KJ; Wasicak, J; Tasker, AS; Cohen, J; Ewing, P; Mitten, M; Larsen, JJ; Kalvin, DM; Swenson, R; Ng, SC; Saeed, B; Cherian, S; Sham, H; Rosenberg, SH Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50082898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50082898&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10507612 103982633 CHEMBL144745 ZINC27552242 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50145833 CSCC[C@H](NC(=O)c1ccc(CN[C@@H](CO)CC2CCCCC2)cc1-c1ccccc1C)C(O)=O InChI=1S/C29H40N2O4S/c1-20-8-6-7-11-24(20)26-17-22(18-30-23(19-32)16-21-9-4-3-5-10-21)12-13-25(26)28(33)31-27(29(34)35)14-15-36-2/h6-8,11-13,17,21,23,27,30,32H,3-5,9-10,14-16,18-19H2,1-2H3,(H,31,33)(H,34,35)/t23-,27+/m1/s1 BQPCQHREHFDITQ-KCWPFWIISA-N 50082900 (S)-2-({5-[((R)-2-Cyclohexyl-1-hydroxymethyl-ethylamino)-methyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid::CHEMBL145950 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 12 ChEMBL 10.1021/jm990335v 10.7270/Q2WW7GWR 10579847 Henry, KJ; Wasicak, J; Tasker, AS; Cohen, J; Ewing, P; Mitten, M; Larsen, JJ; Kalvin, DM; Swenson, R; Ng, SC; Saeed, B; Cherian, S; Sham, H; Rosenberg, SH Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50082900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50082900&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10720558 103982635 CHEMBL145950 ZINC13802293 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50145834 CSCC[C@H](NC(=O)c1ccc(CN[C@H](C)CC2CCCCC2)cc1-c1ccccc1C)C([O-])=O InChI=1S/C29H40N2O3S/c1-20-9-7-8-12-24(20)26-18-23(19-30-21(2)17-22-10-5-4-6-11-22)13-14-25(26)28(32)31-27(29(33)34)15-16-35-3/h7-9,12-14,18,21-22,27,30H,4-6,10-11,15-17,19H2,1-3H3,(H,31,32)(H,33,34)/p-1/t21-,27+/m1/s1 RNJOVHDQWAMLOR-ZBLYBZFDSA-M 50082901 2-({5-[(2-Cyclohexyl-1-methyl-ethylamino)-methyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-lithium-butarate::CHEMBL369548 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 0.7 ChEMBL 10.1021/jm990335v 10.7270/Q2WW7GWR 10579847 Henry, KJ; Wasicak, J; Tasker, AS; Cohen, J; Ewing, P; Mitten, M; Larsen, JJ; Kalvin, DM; Swenson, R; Ng, SC; Saeed, B; Cherian, S; Sham, H; Rosenberg, SH Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50082901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50082901&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 91931194 103982636 CHEMBL369548 ZINC13802302 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50145835 CSCC[C@H](NC(=O)c1ccc(CN(CCC2CCCCC2)Cc2ccccc2)cc1-c1ccccc1C)C([O-])=O InChI=1S/C35H44N2O3S/c1-26-11-9-10-16-30(26)32-23-29(17-18-31(32)34(38)36-33(35(39)40)20-22-41-2)25-37(24-28-14-7-4-8-15-28)21-19-27-12-5-3-6-13-27/h4,7-11,14-18,23,27,33H,3,5-6,12-13,19-22,24-25H2,1-2H3,(H,36,38)(H,39,40)/p-1/t33-/m0/s1 YSALBQMSZGKSOB-XIFFEERXSA-M 50082902 2-[(5-{[Benzyl-(2-cyclohexyl-ethyl)-amino]-methyl}-2'-methyl-biphenyl-2-carbonyl)-amino]-4-methylsulfanyl-lithium-butarate::CHEMBL178430 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 3.5 ChEMBL 10.1021/jm990335v 10.7270/Q2WW7GWR 10579847 Henry, KJ; Wasicak, J; Tasker, AS; Cohen, J; Ewing, P; Mitten, M; Larsen, JJ; Kalvin, DM; Swenson, R; Ng, SC; Saeed, B; Cherian, S; Sham, H; Rosenberg, SH Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50082902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50082902&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 91931195 103982637 CHEMBL178430 ZINC28106180 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50145836 CSCC[C@H](NC(=O)c1ccc(CN[C@H](CSc2ccccc2)CC2CCCCC2)cc1-c1ccccc1C)C(O)=O InChI=1S/C35H44N2O3S2/c1-25-11-9-10-16-30(25)32-22-27(17-18-31(32)34(38)37-33(35(39)40)19-20-41-2)23-36-28(21-26-12-5-3-6-13-26)24-42-29-14-7-4-8-15-29/h4,7-11,14-18,22,26,28,33,36H,3,5-6,12-13,19-21,23-24H2,1-2H3,(H,37,38)(H,39,40)/t28-,33-/m0/s1 NOYPIEMQQHTPND-UVMMSNCQSA-N 50082904 (S)-2-({5-[((S)-1-Cyclohexylmethyl-2-phenylsulfanyl-ethylamino)-methyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid::CHEMBL144175 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 0.2 ChEMBL 10.1021/jm990335v 10.7270/Q2WW7GWR 10579847 Henry, KJ; Wasicak, J; Tasker, AS; Cohen, J; Ewing, P; Mitten, M; Larsen, JJ; Kalvin, DM; Swenson, R; Ng, SC; Saeed, B; Cherian, S; Sham, H; Rosenberg, SH Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50082904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50082904&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10579545 103982639 CHEMBL144175 ZINC27550352 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50145837 CSCC[C@H](NC(=O)c1ccc(CN(CCC2CCCCC2)C(C)=O)cc1-c1ccccc1C)C([O-])=O InChI=1S/C30H40N2O4S/c1-21-9-7-8-12-25(21)27-19-24(20-32(22(2)33)17-15-23-10-5-4-6-11-23)13-14-26(27)29(34)31-28(30(35)36)16-18-37-3/h7-9,12-14,19,23,28H,4-6,10-11,15-18,20H2,1-3H3,(H,31,34)(H,35,36)/p-1/t28-/m0/s1 CHDWTRUYQSFVEW-NDEPHWFRSA-M 50082906 2-[(5-{[Acetyl-(2-cyclohexyl-ethyl)-amino]-methyl}-2'-methyl-biphenyl-2-carbonyl)-amino]-4-methylsulfanyl-lithium-butarate::CHEMBL177445 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 2.9 ChEMBL 10.1021/jm990335v 10.7270/Q2WW7GWR 10579847 Henry, KJ; Wasicak, J; Tasker, AS; Cohen, J; Ewing, P; Mitten, M; Larsen, JJ; Kalvin, DM; Swenson, R; Ng, SC; Saeed, B; Cherian, S; Sham, H; Rosenberg, SH Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50082906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50082906&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 91931197 103982641 CHEMBL177445 ZINC13802306 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50145838 CSCC[C@H](NC(=O)c1ccc(CN[C@@H](CO)C2CCCCC2)cc1-c1ccccc1C)C(O)=O InChI=1S/C28H38N2O4S/c1-19-8-6-7-11-22(19)24-16-20(17-29-26(18-31)21-9-4-3-5-10-21)12-13-23(24)27(32)30-25(28(33)34)14-15-35-2/h6-8,11-13,16,21,25-26,29,31H,3-5,9-10,14-15,17-18H2,1-2H3,(H,30,32)(H,33,34)/t25-,26-/m0/s1 ZPNGKLKMBATBLI-UIOOFZCWSA-N 50082908 (S)-2-({5-[((R)-1-Cyclohexyl-2-hydroxy-ethylamino)-methyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid::CHEMBL144183 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 10 ChEMBL 10.1021/jm990335v 10.7270/Q2WW7GWR 10579847 Henry, KJ; Wasicak, J; Tasker, AS; Cohen, J; Ewing, P; Mitten, M; Larsen, JJ; Kalvin, DM; Swenson, R; Ng, SC; Saeed, B; Cherian, S; Sham, H; Rosenberg, SH Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50082908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50082908&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 11799507 103982643 CHEMBL144183 ZINC13802298 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50145839 CSCC[C@H](NC(=O)c1ccc(CN(CCC2CCCCC2)C(=O)OC(C)(C)C)cc1-c1ccccc1C)C([O-])=O InChI=1S/C33H46N2O5S/c1-23-11-9-10-14-26(23)28-21-25(15-16-27(28)30(36)34-29(31(37)38)18-20-41-5)22-35(32(39)40-33(2,3)4)19-17-24-12-7-6-8-13-24/h9-11,14-16,21,24,29H,6-8,12-13,17-20,22H2,1-5H3,(H,34,36)(H,37,38)/p-1/t29-/m0/s1 YXSNSWYENOSLMU-LJAQVGFWSA-M 50082909 2-[(5-{[tert-Butoxycarbonyl-(2-cyclohexyl-ethyl)-amino]-methyl}-2'-methyl-biphenyl-2-carbonyl)-amino]-4-methylsulfanyl-lithium-butarate::CHEMBL367324 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 0.17 ChEMBL 10.1021/jm990335v 10.7270/Q2WW7GWR 10579847 Henry, KJ; Wasicak, J; Tasker, AS; Cohen, J; Ewing, P; Mitten, M; Larsen, JJ; Kalvin, DM; Swenson, R; Ng, SC; Saeed, B; Cherian, S; Sham, H; Rosenberg, SH Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50082909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50082909&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 91931199 103982644 CHEMBL367324 ZINC28103355 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50145840 COC[C@H](CC1CCCCC1)NCc1ccc(C(=O)N[C@@H](CCSC)C([O-])=O)c(c1)-c1ccccc1C InChI=1S/C30H42N2O4S/c1-21-9-7-8-12-25(21)27-18-23(19-31-24(20-36-2)17-22-10-5-4-6-11-22)13-14-26(27)29(33)32-28(30(34)35)15-16-37-3/h7-9,12-14,18,22,24,28,31H,4-6,10-11,15-17,19-20H2,1-3H3,(H,32,33)(H,34,35)/p-1/t24-,28-/m0/s1 VOSVCEFFDNSMSR-CUBQBAPOSA-M 50082911 2-({5-[(2-Cyclohexyl-1-methoxymethyl-ethylamino)-methyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-lithium-butarate::CHEMBL368038 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 0.66 ChEMBL 10.1021/jm990335v 10.7270/Q2WW7GWR 10579847 Henry, KJ; Wasicak, J; Tasker, AS; Cohen, J; Ewing, P; Mitten, M; Larsen, JJ; Kalvin, DM; Swenson, R; Ng, SC; Saeed, B; Cherian, S; Sham, H; Rosenberg, SH Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50082911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50082911&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 91931200 103982646 CHEMBL368038 ZINC13802299 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50145841 CCS(=O)(=O)C[C@H](CC1CCCCC1)NCc1ccc(C(=O)N[C@@H](CCSC)C(O)=O)c(c1)-c1ccccc1C InChI=1S/C31H44N2O5S2/c1-4-40(37,38)21-25(18-23-11-6-5-7-12-23)32-20-24-14-15-27(28(19-24)26-13-9-8-10-22(26)2)30(34)33-29(31(35)36)16-17-39-3/h8-10,13-15,19,23,25,29,32H,4-7,11-12,16-18,20-21H2,1-3H3,(H,33,34)(H,35,36)/t25-,29-/m0/s1 FJDXENQMICMEKN-SVEHJYQDSA-N 50082910 (S)-2-({5-[((S)-1-Cyclohexylmethyl-2-ethanesulfonyl-ethylamino)-methyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid::CHEMBL358363 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 0.14 ChEMBL 10.1021/jm990335v 10.7270/Q2WW7GWR 10579847 Henry, KJ; Wasicak, J; Tasker, AS; Cohen, J; Ewing, P; Mitten, M; Larsen, JJ; Kalvin, DM; Swenson, R; Ng, SC; Saeed, B; Cherian, S; Sham, H; Rosenberg, SH Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50082910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50082910&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10651030 103982645 CHEMBL358363 ZINC27552360 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50145842 CSCC[C@H](NC(=O)c1ccc(CN[C@H](CSc2ccccc2C)CC2CCCCC2)cc1-c1ccccc1C)C(O)=O InChI=1S/C36H46N2O3S2/c1-25-11-7-9-15-30(25)32-22-28(17-18-31(32)35(39)38-33(36(40)41)19-20-42-3)23-37-29(21-27-13-5-4-6-14-27)24-43-34-16-10-8-12-26(34)2/h7-12,15-18,22,27,29,33,37H,4-6,13-14,19-21,23-24H2,1-3H3,(H,38,39)(H,40,41)/t29-,33-/m0/s1 ZAHNIEFVTGQWBR-ZQAZVOLISA-N 50082915 (S)-2-({5-[((S)-1-Cyclohexylmethyl-2-o-tolylsulfanyl-ethylamino)-methyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid::CHEMBL342315 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 0.42 ChEMBL 10.1021/jm990335v 10.7270/Q2WW7GWR 10579847 Henry, KJ; Wasicak, J; Tasker, AS; Cohen, J; Ewing, P; Mitten, M; Larsen, JJ; Kalvin, DM; Swenson, R; Ng, SC; Saeed, B; Cherian, S; Sham, H; Rosenberg, SH Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50082915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50082915&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10651501 103982650 CHEMBL342315 ZINC27549663 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50145843 CSCC[C@H](NC(=O)c1ccc(CN(C)CCC2CCCCC2)cc1-c1ccccc1C)C([O-])=O InChI=1S/C29H40N2O3S/c1-21-9-7-8-12-24(21)26-19-23(20-31(2)17-15-22-10-5-4-6-11-22)13-14-25(26)28(32)30-27(29(33)34)16-18-35-3/h7-9,12-14,19,22,27H,4-6,10-11,15-18,20H2,1-3H3,(H,30,32)(H,33,34)/p-1/t27-/m0/s1 DGZFYSHLPNCUEY-MHZLTWQESA-M 50082913 2-[(5-{[(2-Cyclohexyl-ethyl)-methyl-amino]-methyl}-2'-methyl-biphenyl-2-carbonyl)-amino]-4-methylsulfanyl-lithium-butarate::CHEMBL362186 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 0.87 ChEMBL 10.1021/jm990335v 10.7270/Q2WW7GWR 10579847 Henry, KJ; Wasicak, J; Tasker, AS; Cohen, J; Ewing, P; Mitten, M; Larsen, JJ; Kalvin, DM; Swenson, R; Ng, SC; Saeed, B; Cherian, S; Sham, H; Rosenberg, SH Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50082913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50082913&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 91931201 103982648 CHEMBL362186 ZINC03982103 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50145844 CSCC[C@H](NC(=O)c1ccc(CN[C@H](CO)C2CCCCC2)cc1-c1ccccc1C)C(O)=O InChI=1S/C28H38N2O4S/c1-19-8-6-7-11-22(19)24-16-20(17-29-26(18-31)21-9-4-3-5-10-21)12-13-23(24)27(32)30-25(28(33)34)14-15-35-2/h6-8,11-13,16,21,25-26,29,31H,3-5,9-10,14-15,17-18H2,1-2H3,(H,30,32)(H,33,34)/t25-,26+/m0/s1 ZPNGKLKMBATBLI-IZZNHLLZSA-N 50082912 (S)-2-({5-[((S)-1-Cyclohexyl-2-hydroxy-ethylamino)-methyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid::CHEMBL424119 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 4 ChEMBL 10.1021/jm990335v 10.7270/Q2WW7GWR 10579847 Henry, KJ; Wasicak, J; Tasker, AS; Cohen, J; Ewing, P; Mitten, M; Larsen, JJ; Kalvin, DM; Swenson, R; Ng, SC; Saeed, B; Cherian, S; Sham, H; Rosenberg, SH Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50082912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50082912&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10672956 103982647 CHEMBL424119 ZINC13802296 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50145845 CCSC[C@H](CC1CCCCC1)NCc1ccc(C(=O)N[C@@H](CCSC)C(O)=O)c(c1)-c1ccccc1C InChI=1S/C31H44N2O3S2/c1-4-38-21-25(18-23-11-6-5-7-12-23)32-20-24-14-15-27(28(19-24)26-13-9-8-10-22(26)2)30(34)33-29(31(35)36)16-17-37-3/h8-10,13-15,19,23,25,29,32H,4-7,11-12,16-18,20-21H2,1-3H3,(H,33,34)(H,35,36)/t25-,29-/m0/s1 SAVLZOMOKUOGAK-SVEHJYQDSA-N 16180 (2S)-2-{[4-({[(2S)-1-cyclohexyl-3-(ethylsulfanyl)propan-2-yl]amino}methyl)-2-(2-methylphenyl)phenyl]formamido}-4-(methylsulfanyl)butanoic acid::A197574::CHEMBL344100::N-({5-[({(1S)-2-cyclohexyl-1-[(ethylsulfanyl)methyl]ethyl}amino)methyl]-2 -methylbiphenyl-2-yl}carbonyl)-L-methionine Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 0.2 ChEMBL 10.1021/jm990335v 10.7270/Q2WW7GWR 10579847 Henry, KJ; Wasicak, J; Tasker, AS; Cohen, J; Ewing, P; Mitten, M; Larsen, JJ; Kalvin, DM; Swenson, R; Ng, SC; Saeed, B; Cherian, S; Sham, H; Rosenberg, SH Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16180&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10721546 46516436 CHEMBL344100 ZINC03982102 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50145846 CSCC[C@H](NC(=O)c1ccc(CNC(CC2CCCCC2)CC2CCCCC2)cc1-c1ccccc1C)C([O-])=O InChI=1S/C35H50N2O3S/c1-25-11-9-10-16-30(25)32-23-28(17-18-31(32)34(38)37-33(35(39)40)19-20-41-2)24-36-29(21-26-12-5-3-6-13-26)22-27-14-7-4-8-15-27/h9-11,16-18,23,26-27,29,33,36H,3-8,12-15,19-22,24H2,1-2H3,(H,37,38)(H,39,40)/p-1/t33-/m0/s1 JTIYQLUWIVESOF-XIFFEERXSA-M 50082914 2-({5-[(2-Cyclohexyl-1-cyclohexylmethyl-ethylamino)-methyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-lithium-butarate::CHEMBL367008 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 0.25 ChEMBL 10.1021/jm990335v 10.7270/Q2WW7GWR 10579847 Henry, KJ; Wasicak, J; Tasker, AS; Cohen, J; Ewing, P; Mitten, M; Larsen, JJ; Kalvin, DM; Swenson, R; Ng, SC; Saeed, B; Cherian, S; Sham, H; Rosenberg, SH Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50082914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50082914&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 91931202 103982649 CHEMBL367008 ZINC28103361 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50145847 CSCC[C@H](NC(=O)c1ccc(CN[C@H](CSC(C)(C)C)CC2CCCCC2)cc1-c1ccccc1C)C(O)=O InChI=1S/C33H48N2O3S2/c1-23-11-9-10-14-27(23)29-20-25(15-16-28(29)31(36)35-30(32(37)38)17-18-39-5)21-34-26(22-40-33(2,3)4)19-24-12-7-6-8-13-24/h9-11,14-16,20,24,26,30,34H,6-8,12-13,17-19,21-22H2,1-5H3,(H,35,36)(H,37,38)/t26-,30-/m0/s1 JAZUJKVLSLQWQJ-YZNIXAGQSA-N 50082905 (S)-2-({5-[((S)-2-tert-Butylsulfanyl-1-cyclohexylmethyl-ethylamino)-methyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid::CHEMBL144536 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 0.6 ChEMBL 10.1021/jm990335v 10.7270/Q2WW7GWR 10579847 Henry, KJ; Wasicak, J; Tasker, AS; Cohen, J; Ewing, P; Mitten, M; Larsen, JJ; Kalvin, DM; Swenson, R; Ng, SC; Saeed, B; Cherian, S; Sham, H; Rosenberg, SH Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50082905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50082905&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10579202 103982640 CHEMBL144536 ZINC27550356 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50145848 CSCC[C@H](NC(=O)c1ccc(CN[C@H](CO)Cc2ccccc2)cc1-c1ccccc1C)C(O)=O InChI=1S/C29H34N2O4S/c1-20-8-6-7-11-24(20)26-17-22(18-30-23(19-32)16-21-9-4-3-5-10-21)12-13-25(26)28(33)31-27(29(34)35)14-15-36-2/h3-13,17,23,27,30,32H,14-16,18-19H2,1-2H3,(H,31,33)(H,34,35)/t23-,27-/m0/s1 GYOPLKVPTMXBCN-HOFKKMOUSA-N 50082916 (S)-2-({5-[((S)-1-Hydroxymethyl-2-phenyl-ethylamino)-methyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid::CHEMBL343435 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 4.6 ChEMBL 10.1021/jm990335v 10.7270/Q2WW7GWR 10579847 Henry, KJ; Wasicak, J; Tasker, AS; Cohen, J; Ewing, P; Mitten, M; Larsen, JJ; Kalvin, DM; Swenson, R; Ng, SC; Saeed, B; Cherian, S; Sham, H; Rosenberg, SH Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50082916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50082916&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10815456 103982651 CHEMBL343435 ZINC13802295 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50145849 CC[C@H](CC1CCCCC1)NCc1ccc(C(=O)N[C@@H](CCSC)C([O-])=O)c(c1)-c1ccccc1C InChI=1S/C30H42N2O3S/c1-4-24(18-22-11-6-5-7-12-22)31-20-23-14-15-26(27(19-23)25-13-9-8-10-21(25)2)29(33)32-28(30(34)35)16-17-36-3/h8-10,13-15,19,22,24,28,31H,4-7,11-12,16-18,20H2,1-3H3,(H,32,33)(H,34,35)/p-1/t24-,28+/m1/s1 VMRPVRUUJIENTF-YWEHKCAJSA-M 50082896 2-({5-[(1-Cyclohexylmethyl-propylamino)-methyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-lithium-butarate::CHEMBL175682 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 0.7 ChEMBL 10.1021/jm990335v 10.7270/Q2WW7GWR 10579847 Henry, KJ; Wasicak, J; Tasker, AS; Cohen, J; Ewing, P; Mitten, M; Larsen, JJ; Kalvin, DM; Swenson, R; Ng, SC; Saeed, B; Cherian, S; Sham, H; Rosenberg, SH Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50082896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50082896&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 91931192 103982631 CHEMBL175682 ZINC13802304 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50145850 CSCC[C@H](NC(=O)c1ccc(CN[C@H](CO)CC2CCCCC2)cc1-c1ccccc1)C(O)=O InChI=1S/C28H38N2O4S/c1-35-15-14-26(28(33)34)30-27(32)24-13-12-21(17-25(24)22-10-6-3-7-11-22)18-29-23(19-31)16-20-8-4-2-5-9-20/h3,6-7,10-13,17,20,23,26,29,31H,2,4-5,8-9,14-16,18-19H2,1H3,(H,30,32)(H,33,34)/t23-,26-/m0/s1 CKBBEIACARVTCH-OZXSUGGESA-N 50082917 (S)-2-({5-[((S)-2-Cyclohexyl-1-hydroxymethyl-ethylamino)-methyl]-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid::CHEMBL145417 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 8 ChEMBL 10.1021/jm990335v 10.7270/Q2WW7GWR 10579847 Henry, KJ; Wasicak, J; Tasker, AS; Cohen, J; Ewing, P; Mitten, M; Larsen, JJ; Kalvin, DM; Swenson, R; Ng, SC; Saeed, B; Cherian, S; Sham, H; Rosenberg, SH Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50082917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50082917&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10481049 103982652 CHEMBL145417 ZINC27549018 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50145851 CSCC[C@H](NC(=O)c1ccc(CN(CCC2CCCCC2)C(=O)c2ccccc2)cc1-c1ccccc1C)C([O-])=O InChI=1S/C35H42N2O4S/c1-25-11-9-10-16-29(25)31-23-27(17-18-30(31)33(38)36-32(35(40)41)20-22-42-2)24-37(21-19-26-12-5-3-6-13-26)34(39)28-14-7-4-8-15-28/h4,7-11,14-18,23,26,32H,3,5-6,12-13,19-22,24H2,1-2H3,(H,36,38)(H,40,41)/p-1/t32-/m0/s1 VRNRWEFFIHKNHV-YTTGMZPUSA-M 50082903 2-[(5-{[Benzoyl-(2-cyclohexyl-ethyl)-amino]-methyl}-2'-methyl-biphenyl-2-carbonyl)-amino]-4-methylsulfanyl-lithium-butarate::CHEMBL177340 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 1.1 ChEMBL 10.1021/jm990335v 10.7270/Q2WW7GWR 10579847 Henry, KJ; Wasicak, J; Tasker, AS; Cohen, J; Ewing, P; Mitten, M; Larsen, JJ; Kalvin, DM; Swenson, R; Ng, SC; Saeed, B; Cherian, S; Sham, H; Rosenberg, SH Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50082903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50082903&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 91931196 103982638 CHEMBL177340 ZINC28103251 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50145852 CCCC[C@H](CC1CCCCC1)NCc1ccc(C(=O)N[C@@H](CCSC)C([O-])=O)c(c1)-c1ccccc1C InChI=1S/C32H46N2O3S/c1-4-5-14-26(20-24-12-7-6-8-13-24)33-22-25-16-17-28(29(21-25)27-15-10-9-11-23(27)2)31(35)34-30(32(36)37)18-19-38-3/h9-11,15-17,21,24,26,30,33H,4-8,12-14,18-20,22H2,1-3H3,(H,34,35)(H,36,37)/p-1/t26-,30+/m1/s1 PODLGFGTHHYSRW-VIZCGCQYSA-M 50082907 2-({5-[(1-Cyclohexylmethyl-pentylamino)-methyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-lithium-butarate::CHEMBL177452 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 0.46 ChEMBL 10.1021/jm990335v 10.7270/Q2WW7GWR 10579847 Henry, KJ; Wasicak, J; Tasker, AS; Cohen, J; Ewing, P; Mitten, M; Larsen, JJ; Kalvin, DM; Swenson, R; Ng, SC; Saeed, B; Cherian, S; Sham, H; Rosenberg, SH Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50082907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50082907&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 91931198 103982642 CHEMBL177452 ZINC13802305 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50145853 CSCC[C@H](NC(=O)c1ccc(CN[C@H](CCCC(C)C)CC2CCCCC2)cc1-c1ccccc1C)C([O-])=O InChI=1S/C34H50N2O3S/c1-24(2)11-10-15-28(21-26-13-6-5-7-14-26)35-23-27-17-18-30(31(22-27)29-16-9-8-12-25(29)3)33(37)36-32(34(38)39)19-20-40-4/h8-9,12,16-18,22,24,26,28,32,35H,5-7,10-11,13-15,19-21,23H2,1-4H3,(H,36,37)(H,38,39)/p-1/t28-,32+/m1/s1 IHZBHSBYOFBKJS-NSJVFKKDSA-M 50082899 2-({5-[(1-Cyclohexylmethyl-5-methyl-hex-2-enylamino)-methyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-lithium-butarate::CHEMBL367456 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 0.28 ChEMBL 10.1021/jm990335v 10.7270/Q2WW7GWR 10579847 Henry, KJ; Wasicak, J; Tasker, AS; Cohen, J; Ewing, P; Mitten, M; Larsen, JJ; Kalvin, DM; Swenson, R; Ng, SC; Saeed, B; Cherian, S; Sham, H; Rosenberg, SH Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50082899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50082899&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 91931193 103982634 CHEMBL367456 ZINC28103752 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50145854 CSCC[C@H](NC(=O)c1ccc(CNCCC2CCCCC2)cc1-c1ccccc1C)C([O-])=O InChI=1S/C28H38N2O3S/c1-20-8-6-7-11-23(20)25-18-22(19-29-16-14-21-9-4-3-5-10-21)12-13-24(25)27(31)30-26(28(32)33)15-17-34-2/h6-8,11-13,18,21,26,29H,3-5,9-10,14-17,19H2,1-2H3,(H,30,31)(H,32,33)/p-1/t26-/m0/s1 AITRSUMFMXLCFQ-SANMLTNESA-M 50082918 2-({5-[(2-Cyclohexyl-ethylamino)-methyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-lithium-butarate::CHEMBL175628 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 0.17 ChEMBL 10.1021/jm990335v 10.7270/Q2WW7GWR 10579847 Henry, KJ; Wasicak, J; Tasker, AS; Cohen, J; Ewing, P; Mitten, M; Larsen, JJ; Kalvin, DM; Swenson, R; Ng, SC; Saeed, B; Cherian, S; Sham, H; Rosenberg, SH Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50082918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50082918&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 91931203 103982653 CHEMBL175628 ZINC13802301 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50145855 CSCC[C@H](NC(=O)c1ccc(CN[C@H](CSC2CCCCC2)CC2CCCCC2)cc1-c1ccccc1C)C(O)=O InChI=1S/C35H50N2O3S2/c1-25-11-9-10-16-30(25)32-22-27(17-18-31(32)34(38)37-33(35(39)40)19-20-41-2)23-36-28(21-26-12-5-3-6-13-26)24-42-29-14-7-4-8-15-29/h9-11,16-18,22,26,28-29,33,36H,3-8,12-15,19-21,23-24H2,1-2H3,(H,37,38)(H,39,40)/t28-,33-/m0/s1 RHBJBAOHXMJAFT-UVMMSNCQSA-N 50082919 (S)-2-({5-[((S)-1-Cyclohexylmethyl-2-cyclohexylsulfanyl-ethylamino)-methyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid::CHEMBL145317 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 0.41 ChEMBL 10.1021/jm990335v 10.7270/Q2WW7GWR 10579847 Henry, KJ; Wasicak, J; Tasker, AS; Cohen, J; Ewing, P; Mitten, M; Larsen, JJ; Kalvin, DM; Swenson, R; Ng, SC; Saeed, B; Cherian, S; Sham, H; Rosenberg, SH Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50082919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50082919&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10555729 103982654 CHEMBL145317 ZINC27527096 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50472032 CSCC[C@@H](NC(=O)CN1c2ccccc2C(=N[C@@H](N(C)C(=O)[C@@H](N)CS)C1=O)c1ccccc1)C(O)=O InChI=1S/C26H31N5O5S2/c1-30(24(33)18(27)15-37)23-25(34)31(14-21(32)28-19(26(35)36)12-13-38-2)20-11-7-6-10-17(20)22(29-23)16-8-4-3-5-9-16/h3-11,18-19,23,37H,12-15,27H2,1-2H3,(H,28,32)(H,35,36)/t18-,19+,23-/m0/s1 SSQIWICZBGRCBC-YYDVJCTNSA-N 50284630 (R)-2-(2-{(S)-3-[((R)-2-Amino-3-mercapto-propionyl)-methyl-amino]-2-oxo-5-phenyl-2,3-dihydro-benzo[e][1,4]diazepin-1-yl}-acetylamino)-4-methylsulfanyl-butyric acid::CHEMBL26816 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 80 ChEMBL 10.1016/0960-894X(95)00218-I 10.7270/Q27S7NR3 Rawson, TE; Somers, TC; Marsters, JC; Wan, DT; Reynolds, ME; Burdick, DJ TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50284630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50284630&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44276058 104126201 CHEMBL26816 ZINC28762777 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50472033 CSCC[C@H](NC(=O)CN1c2ccccc2C(=N[C@@H](N(C)C(=O)[C@@H](N)CS)C1=O)c1ccccc1)C(O)=O InChI=1S/C26H31N5O5S2/c1-30(24(33)18(27)15-37)23-25(34)31(14-21(32)28-19(26(35)36)12-13-38-2)20-11-7-6-10-17(20)22(29-23)16-8-4-3-5-9-16/h3-11,18-19,23,37H,12-15,27H2,1-2H3,(H,28,32)(H,35,36)/t18-,19-,23-/m0/s1 SSQIWICZBGRCBC-YDHSSHFGSA-N 50284631 2-(2-{3-[(2-Amino-3-mercapto-propionyl)-methyl-amino]-2-oxo-5-phenyl-2,3-dihydro-benzo[e][1,4]diazepin-1-yl}-acetylamino)-4-methylsulfanyl-butyric acid::CHEMBL418572 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 2.10 ChEMBL 10.1016/0960-894X(95)00218-I 10.7270/Q27S7NR3 Rawson, TE; Somers, TC; Marsters, JC; Wan, DT; Reynolds, ME; Burdick, DJ TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50284631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50284631&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10460383 104126202 CHEMBL418572 ZINC14277283 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50494011 COCC[C@H]1CN(CCN1C[C@@H](N)CS)C(=O)c1cccc2ccccc12 InChI=1S/C21H29N3O2S/c1-26-12-9-18-14-24(11-10-23(18)13-17(22)15-27)21(25)20-8-4-6-16-5-2-3-7-19(16)20/h2-8,17-18,27H,9-15,22H2,1H3/t17-,18+/m1/s1 GKTZPBPAMFCBNI-MSOLQXFVSA-N 50051823 CHEMBL275378::[(S)-4-((R)-2-Amino-3-mercapto-propyl)-3-(2-methoxy-ethyl)-piperazin-1-yl]-naphthalen-1-yl-methanone Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 500 ChEMBL 10.1021/jm9508090 10.7270/Q2B8576Z 8691462 Williams, TM; Ciccarone, TM; MacTough, SC; Bock, RL; Conner, MW; Davide, JP; Hamilton, K; Koblan, KS; Kohl, NE; Kral, AM; Mosser, SD; Omer, CA; Pompliano, DL; Rands, E; Schaber, MD; Shah, D; Wilson, FR; Gibbs, JB; Graham, SL; Hartman, GD; Oliff, AI; Smith, RL Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50051823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50051823&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 9930166 103948780 CHEMBL275378 ZINC22444690 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50494012 N[C@@H](CS)CN1CCN(C[C@@H]1CCOC1CC1)C(=O)c1cccc2ccccc12 InChI=1S/C23H31N3O2S/c24-18(16-29)14-25-11-12-26(15-19(25)10-13-28-20-8-9-20)23(27)22-7-3-5-17-4-1-2-6-21(17)22/h1-7,18-20,29H,8-16,24H2/t18-,19+/m1/s1 GYHJYVOLUAYUGE-MOPGFXCFSA-N 50051825 CHEMBL27141::[(S)-4-((R)-2-Amino-3-mercapto-propyl)-3-(2-cyclopropoxy-ethyl)-piperazin-1-yl]-naphthalen-1-yl-methanone Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 500 ChEMBL 10.1021/jm9508090 10.7270/Q2B8576Z 8691462 Williams, TM; Ciccarone, TM; MacTough, SC; Bock, RL; Conner, MW; Davide, JP; Hamilton, K; Koblan, KS; Kohl, NE; Kral, AM; Mosser, SD; Omer, CA; Pompliano, DL; Rands, E; Schaber, MD; Shah, D; Wilson, FR; Gibbs, JB; Graham, SL; Hartman, GD; Oliff, AI; Smith, RL Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50051825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50051825&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10319572 103948782 CHEMBL27141 ZINC22444723 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50494013 CCCC[C@H]1CN(CCN1C[C@@H](N)CS)C(=O)c1cccc2ccccc12 InChI=1S/C22H31N3OS/c1-2-3-9-19-15-25(13-12-24(19)14-18(23)16-27)22(26)21-11-6-8-17-7-4-5-10-20(17)21/h4-8,10-11,18-19,27H,2-3,9,12-16,23H2,1H3/t18-,19+/m1/s1 BICXECMCJCNEDG-MOPGFXCFSA-N 50051826 CHEMBL27486::[(S)-4-((R)-2-Amino-3-mercapto-propyl)-3-butyl-piperazin-1-yl]-naphthalen-1-yl-methanone::[4-((R)-2-Amino-3-mercapto-propyl)-3-butyl-piperazin-1-yl]-naphthalen-1-yl-methanone Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 500 ChEMBL 10.1021/jm9508090 10.7270/Q2B8576Z 8691462 Williams, TM; Ciccarone, TM; MacTough, SC; Bock, RL; Conner, MW; Davide, JP; Hamilton, K; Koblan, KS; Kohl, NE; Kral, AM; Mosser, SD; Omer, CA; Pompliano, DL; Rands, E; Schaber, MD; Shah, D; Wilson, FR; Gibbs, JB; Graham, SL; Hartman, GD; Oliff, AI; Smith, RL Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50051826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50051826&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 20638589 103948783 CHEMBL27486 ZINC22938322 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782014 N[C@@H](CS)CNc1ccc(cc1)-c1cccc(c1)C(O)=O InChI=1S/C16H18N2O2S/c17-14(10-21)9-18-15-6-4-11(5-7-15)12-2-1-3-13(8-12)16(19)20/h1-8,14,18,21H,9-10,17H2,(H,19,20)/t14-/m1/s1 GVHAKJDMTSSDKK-CQSZACIVSA-N 50048953 4'-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-3-carboxylic acid::4'-(2-Amino-3-mercapto-propylamino)-biphenyl-3-carboxylic acid 4(FTI-265)::CHEMBL417600 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 50 ChEMBL 10.1021/jm970226l 10.7270/Q26M37HF 9301658 Leonard, DM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048953&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 11779696 103979334 CHEMBL417600 ZINC13471827 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782027 Clc1ccc2c(CCc3cccnc3C2=C2CCN(CC2)C(=O)Cc2ccncc2)c1 InChI=1S/C26H24ClN3O/c27-22-5-6-23-21(17-22)4-3-20-2-1-11-29-26(20)25(23)19-9-14-30(15-10-19)24(31)16-18-7-12-28-13-8-18/h1-2,5-8,11-13,17H,3-4,9-10,14-16H2 KIFXOXSGYMUANJ-UHFFFAOYSA-N 14454 1-(4-pyridylacetyl)-4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine::1-(4-{13-chloro-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaen-2-ylidene}piperidin-1-yl)-2-(pyridin-4-yl)ethan-1-one::CHEMBL289404::SCH 44342 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 250 ChEMBL 10.1021/jm970226l 10.7270/Q26M37HF 9301658 Leonard, DM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14454&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 9845545 46514794 CHEMBL289404 ZINC00600790 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782035 COC(=O)[C@H](CCSC)NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](NC[C@@H](N)CS)C(C)(C)C InChI=1S/C25H40N4O4S2/c1-25(2,3)21(27-13-18(26)15-34)23(31)29-14-17-9-7-6-8-16(17)12-20(29)22(30)28-19(10-11-35-5)24(32)33-4/h6-9,18-21,27,34H,10-15,26H2,1-5H3,(H,28,30)/t18-,19+,20+,21-/m1/s1 VSJRZQRFGNBQRA-IVAOSVALSA-N 50059859 (S)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3,3-dimethyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-methylsulfanyl-butyric acid methyl ester::CHEMBL323507 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 85 ChEMBL 10.1021/jm970226l 10.7270/Q26M37HF 9301658 Leonard, DM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50059859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50059859&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10459485 103955638 CHEMBL323507 ZINC22938249 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782037 COC(=O)C(CCSC)NC(=O)CN1c2ccccc2C(N[C@@H](N(C)C(=O)[C@H](N)CS)C1=O)c1ccccc1 InChI=1S/C27H35N5O5S2/c1-31(25(34)19(28)16-38)24-26(35)32(15-22(33)29-20(13-14-39-3)27(36)37-2)21-12-8-7-11-18(21)23(30-24)17-9-5-4-6-10-17/h4-12,19-20,23-24,30,38H,13-16,28H2,1-3H3,(H,29,33)/t19-,20?,23?,24+/m1/s1 UCPBEFVDPWTBKC-VAUYKUKKSA-N 50059861 2-(2-{(S)-3-[((S)-2-Amino-3-mercapto-propionyl)-methyl-amino]-2-oxo-5-phenyl-2,3,4,5-tetrahydro-benzo[e][1,4]diazepin-1-yl}-acetylamino)-4-methylsulfanyl-butyric acid methyl ester::CHEMBL319904 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 0.85 ChEMBL 10.1021/jm970226l 10.7270/Q26M37HF 9301658 Leonard, DM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50059861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50059861&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44332399 103955640 CHEMBL319904 ZINC26818781 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782052 CC(C)(C)[C@H](NC[C@@H](N)CS)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CCC(N)=O)C(O)=O InChI=1S/C24H37N5O5S/c1-24(2,3)20(27-11-16(25)13-35)22(32)29-12-15-7-5-4-6-14(15)10-18(29)21(31)28-17(23(33)34)8-9-19(26)30/h4-7,16-18,20,27,35H,8-13,25H2,1-3H3,(H2,26,30)(H,28,31)(H,33,34)/t16-,17+,18+,20-/m1/s1 SWMJHZDPPZYMMV-DOADOZAASA-N 50059864 (S)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3,3-dimethyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-carbamoyl-butyric acid::CHEMBL102295 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 2.8 ChEMBL 10.1021/jm970226l 10.7270/Q26M37HF 9301658 Leonard, DM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50059864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50059864&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10006441 103955643 CHEMBL102295 C02716 ZINC22938240 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782056 CCC(OCCCCNCCSS(O)(=O)=O)C1CCCCC1 InChI=1S/C15H31NO4S2/c1-2-15(14-8-4-3-5-9-14)20-12-7-6-10-16-11-13-21-22(17,18)19/h14-16H,2-13H2,1H3,(H,17,18,19) SWIWTGCCJDTXLT-UHFFFAOYSA-N 50059878 CHEMBL103380::Thiosulfuric acid S-{2-[4-(1-cyclohexyl-propoxy)-butylamino]-ethyl} ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 2000 ChEMBL 10.1021/jm970226l 10.7270/Q26M37HF 9301658 Leonard, DM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50059878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50059878&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44332241 103955656 CHEMBL103380 C02885 ZINC26821312 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782057 CSCC[C@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](NCCc1cnc[nH]1)C(C)C)C(O)=O InChI=1S/C25H35N5O4S/c1-16(2)22(27-10-8-19-13-26-15-28-19)24(32)30-14-18-7-5-4-6-17(18)12-21(30)23(31)29-20(25(33)34)9-11-35-3/h4-7,13,15-16,20-22,27H,8-12,14H2,1-3H3,(H,26,28)(H,29,31)(H,33,34)/t20-,21-,22-/m0/s1 RDECPKAPXFKZRQ-FKBYEOEOSA-N 50048399 (S)-2-[((S)-2-{(S)-2-[2-(3H-Imidazol-4-yl)-ethylamino]-3-methyl-butyryl}-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl)-amino]-4-methylsulfanyl-butyric acid::(S)-2-[(2-{(S)-2-[2-(3H-Imidazol-4-yl)-ethylamino]-3-methyl-butyryl}-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl)-amino]-4-methylsulfanyl-butyric acid::CHEMBL90471 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 0.79 ChEMBL 10.1021/jm970226l 10.7270/Q26M37HF 9301658 Leonard, DM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048399&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10413692 103978864 CHEMBL90471 ZINC26651490 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782061 CSCCC(NC(=O)CN1c2ccccc2C(N[C@@H](N(C)C(=O)[C@H](N)CS)C1=O)c1ccccc1)C(O)=O InChI=1S/C26H33N5O5S2/c1-30(24(33)18(27)15-37)23-25(34)31(14-21(32)28-19(26(35)36)12-13-38-2)20-11-7-6-10-17(20)22(29-23)16-8-4-3-5-9-16/h3-11,18-19,22-23,29,37H,12-15,27H2,1-2H3,(H,28,32)(H,35,36)/t18-,19?,22?,23+/m1/s1 KLVDPNOXBOQBQN-PJQBULFCSA-N 50059856 2-(2-{(S)-3-[((S)-2-Amino-3-mercapto-propionyl)-methyl-amino]-2-oxo-5-phenyl-2,3,4,5-tetrahydro-benzo[e][1,4]diazepin-1-yl}-acetylamino)-4-methylsulfanyl-butyric acid::CHEMBL103799 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 0.79 ChEMBL 10.1021/jm970226l 10.7270/Q26M37HF 9301658 Leonard, DM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50059856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50059856&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44332401 103955635 CHEMBL103799 ZINC26819191 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782522 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CS)NC(=O)[C@@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C47H51N9O8S/c1-29(42(48)57)52-43(58)39(21-33-23-50-37-15-9-8-14-36(33)37)54-46(61)41(27-65)55-44(59)38(20-30-16-18-35(19-17-30)63-25-31-10-4-2-5-11-31)53-45(60)40(22-34-24-49-28-51-34)56-47(62)64-26-32-12-6-3-7-13-32/h2-19,23-24,28-29,38-41,50,65H,20-22,25-27H2,1H3,(H2,48,57)(H,49,51)(H,52,58)(H,53,60)(H,54,61)(H,55,59)(H,56,62)/t29-,38+,39+,40+,41+/m0/s1 BBKSTNFGQSGVHX-UOPHCCOJSA-N 50055595 CHEMBL304691::[(R)-1-((R)-2-(4-Benzyloxy-phenyl)-1-{(S)-1-[(R)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-2-mercapto-ethylcarbamoyl}-ethylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 4 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055595&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44303175 103952081 CHEMBL304691 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782523 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](COCc1ccccc1)NC(=O)[C@@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)OCC1c2ccccc2-c2ccccc12)C(N)=O InChI=1S/C61H61N9O9/c1-38(56(62)71)66-57(72)53(29-42-31-64-51-23-13-12-18-45(42)51)68-60(75)55(36-77-33-40-14-4-2-5-15-40)69-58(73)52(28-39-24-26-44(27-25-39)78-34-41-16-6-3-7-17-41)67-59(74)54(30-43-32-63-37-65-43)70-61(76)79-35-50-48-21-10-8-19-46(48)47-20-9-11-22-49(47)50/h2-27,31-32,37-38,50,52-55,64H,28-30,33-36H2,1H3,(H2,62,71)(H,63,65)(H,66,72)(H,67,74)(H,68,75)(H,69,73)(H,70,76)/t38-,52+,53+,54+,55+/m0/s1 XEDIWPAEFVYEGG-LCXKGDCDSA-N 50055596 CHEMBL216183::[(R)-1-[(R)-1-{(R)-2-Benzyloxy-1-[(R)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethylcarbamoyl]-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 1600 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055596&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44302680 103952082 CHEMBL216183 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782524 COC(=O)[C@H](C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](COCc1ccccc1)NC(=O)[C@@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1 InChI=1S/C55H58N8O10/c1-36(54(68)70-2)59-50(64)47(27-41-29-57-45-21-13-12-20-44(41)45)61-53(67)49(34-71-31-38-14-6-3-7-15-38)62-51(65)46(26-37-22-24-43(25-23-37)72-32-39-16-8-4-9-17-39)60-52(66)48(28-42-30-56-35-58-42)63-55(69)73-33-40-18-10-5-11-19-40/h3-25,29-30,35-36,46-49,57H,26-28,31-34H2,1-2H3,(H,56,58)(H,59,64)(H,60,66)(H,61,67)(H,62,65)(H,63,69)/t36-,46+,47+,48+,49+/m0/s1 MBFTYLZHXRVPAZ-RYARECKASA-N 50055594 (S)-2-[(R)-2-{(R)-3-Benzyloxy-2-[(R)-2-[(R)-2-benzyloxycarbonylamino-3-(1H-imidazol-4-yl)-propionylamino]-3-(4-benzyloxy-phenyl)-propionylamino]-propionylamino}-3-(1H-indol-3-yl)-propionylamino]-propionic acid methyl ester::CHEMBL266034 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 48 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055594&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44303060 103952080 CHEMBL266034 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782525 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](COCc1ccccc1)NC(=O)[C@@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)[C@@H](Cc1cnc[nH]1)NC(C)=O)C(N)=O InChI=1S/C48H53N9O8/c1-30(44(49)59)53-45(60)41(22-35-24-51-39-16-10-9-15-38(35)39)56-48(63)43(28-64-26-33-11-5-3-6-12-33)57-46(61)40(55-47(62)42(54-31(2)58)23-36-25-50-29-52-36)21-32-17-19-37(20-18-32)65-27-34-13-7-4-8-14-34/h3-20,24-25,29-30,40-43,51H,21-23,26-28H2,1-2H3,(H2,49,59)(H,50,52)(H,53,60)(H,54,58)(H,55,62)(H,56,63)(H,57,61)/t30-,40+,41+,42+,43+/m0/s1 GPQBIHDBVVCTCX-NAHVTAIFSA-N 50055598 (R)-2-[(R)-2-[(R)-2-Acetylamino-3-(1H-imidazol-4-yl)-propionylamino]-3-(4-benzyloxy-phenyl)-propionylamino]-3-benzyloxy-N-[(R)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethyl]-propionamide::CHEMBL60275 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 10000 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055598&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44303276 103952084 CHEMBL60275 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782526 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](COCc1ccccc1)NC(=O)[C@H](CS)NC(=O)[C@@H](Cc1c[nH]cn1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C41H47N9O8S/c1-25(36(42)51)46-37(52)32(16-28-18-44-31-15-9-8-14-30(28)31)47-39(54)34(22-57-20-26-10-4-2-5-11-26)48-40(55)35(23-59)49-38(53)33(17-29-19-43-24-45-29)50-41(56)58-21-27-12-6-3-7-13-27/h2-15,18-19,24-25,32-35,44,59H,16-17,20-23H2,1H3,(H2,42,51)(H,43,45)(H,46,52)(H,47,54)(H,48,55)(H,49,53)(H,50,56)/t25-,32+,33+,34+,35-/m0/s1 JFMCGTDJGLKGIM-WDIBRZEWSA-N 50055597 CHEMBL2373068::[(R)-1-(1-{(R)-2-Benzyloxy-1-[(R)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-2-mercapto-ethylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 4900 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055597&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 73356375 103952083 CHEMBL2373068 C02248 ZINC95609540 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782529 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](COCc1ccccc1)NC(=O)[C@@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)OC1CCCCC1)C(N)=O InChI=1S/C53H61N9O9/c1-34(48(54)63)58-49(64)45(26-38-28-56-43-20-12-11-19-42(38)43)60-52(67)47(32-69-30-36-13-5-2-6-14-36)61-50(65)44(25-35-21-23-40(24-22-35)70-31-37-15-7-3-8-16-37)59-51(66)46(27-39-29-55-33-57-39)62-53(68)71-41-17-9-4-10-18-41/h2-3,5-8,11-16,19-24,28-29,33-34,41,44-47,56H,4,9-10,17-18,25-27,30-32H2,1H3,(H2,54,63)(H,55,57)(H,58,64)(H,59,66)(H,60,67)(H,61,65)(H,62,68)/t34-,44+,45+,46+,47+/m0/s1 JYOQLTFLRGMGEL-UEIBXURHSA-N 50055602 CHEMBL262091::[(R)-1-[(R)-1-{(R)-2-Benzyloxy-1-[(R)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethylcarbamoyl]-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid cyclohexyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 3800 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055602&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44302898 103952088 CHEMBL262091 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782531 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](COCc1ccccc1)NC(=O)C(CCCCN)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C44H54N10O8/c1-28(39(46)55)50-41(57)36(20-31-22-48-34-17-9-8-16-33(31)34)52-43(59)38(26-61-24-29-12-4-2-5-13-29)53-40(56)35(18-10-11-19-45)51-42(58)37(21-32-23-47-27-49-32)54-44(60)62-25-30-14-6-3-7-15-30/h2-9,12-17,22-23,27-28,35-38,48H,10-11,18-21,24-26,45H2,1H3,(H2,46,55)(H,47,49)(H,50,57)(H,51,58)(H,52,59)(H,53,56)(H,54,60)/t28-,35?,36+,37+,38+/m0/s1 ZAYUTOAVKIDQMC-MJCYBKBBSA-N 50055603 CHEMBL293792::[(R)-1-(5-Amino-1-{(R)-2-benzyloxy-1-[(R)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-pentylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 1900 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055603&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44303044 103952089 CHEMBL293792 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782532 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](COCc1ccccc1)NC(=O)[C@@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C47H52N9O12P/c1-29(42(48)57)52-43(58)39(21-33-23-50-37-15-9-8-14-36(33)37)54-46(61)41(27-66-25-31-10-4-2-5-11-31)55-44(59)38(20-30-16-18-35(19-17-30)68-69(63,64)65)53-45(60)40(22-34-24-49-28-51-34)56-47(62)67-26-32-12-6-3-7-13-32/h2-19,23-24,28-29,38-41,50H,20-22,25-27H2,1H3,(H2,48,57)(H,49,51)(H,52,58)(H,53,60)(H,54,61)(H,55,59)(H,56,62)(H2,63,64,65)/t29-,38+,39+,40+,41+/m0/s1 DITUKRVCAOAEDB-UOPHCCOJSA-N 50055604 CHEMBL441189::[(R)-1-[(R)-1-{(R)-2-Benzyloxy-1-[(R)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-phosphonooxy-phenyl)-ethylcarbamoyl]-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 9 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055604&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44303045 103952090 CHEMBL441189 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782533 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](COCc1ccccc1)NC(=O)[C@@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)C(N)CCCNC(=O)OCc1ccccc1)C(N)=O InChI=1S/C53H60N8O9/c1-35(48(55)62)58-50(64)46(29-40-30-57-44-22-12-11-20-42(40)44)60-52(66)47(34-68-31-37-14-5-2-6-15-37)61-51(65)45(28-36-23-25-41(26-24-36)69-32-38-16-7-3-8-17-38)59-49(63)43(54)21-13-27-56-53(67)70-33-39-18-9-4-10-19-39/h2-12,14-20,22-26,30,35,43,45-47,57H,13,21,27-29,31-34,54H2,1H3,(H2,55,62)(H,56,67)(H,58,64)(H,59,63)(H,60,66)(H,61,65)/t35-,43?,45+,46+,47+/m0/s1 FFXRHDFYXSJDAT-QOKBJXIOSA-N 50055605 CHEMBL263569::{4-Amino-4-[(R)-1-{(R)-2-benzyloxy-1-[(R)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethylcarbamoyl]-butyl}-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 4700 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055605&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44303307 103952091 CHEMBL263569 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782535 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)NC(=O)[C@@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C47H51N9O8/c1-29(42(48)57)52-45(60)40(22-34-24-50-38-16-10-9-15-37(34)38)54-43(58)30(2)53-44(59)39(21-31-17-19-36(20-18-31)63-26-32-11-5-3-6-12-32)55-46(61)41(23-35-25-49-28-51-35)56-47(62)64-27-33-13-7-4-8-14-33/h3-20,24-25,28-30,39-41,50H,21-23,26-27H2,1-2H3,(H2,48,57)(H,49,51)(H,52,60)(H,53,59)(H,54,58)(H,55,61)(H,56,62)/t29-,30?,39+,40+,41+/m0/s1 JDNIRBXGKYLMTP-LUKPKODTSA-N 50055606 CHEMBL61931::[(R)-1-((R)-2-(4-Benzyloxy-phenyl)-1-{1-[(R)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-ethylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 1100 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055606&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44303357 103952092 CHEMBL61931 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782536 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](COCc1ccccc1)NC(=O)[C@@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)C(Cc1ccccc1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C57H59N7O9/c1-38(52(58)65)60-53(66)50(32-44-33-59-47-25-15-14-24-46(44)47)62-56(69)51(37-71-34-41-18-8-3-9-19-41)63-54(67)48(31-40-26-28-45(29-27-40)72-35-42-20-10-4-11-21-42)61-55(68)49(30-39-16-6-2-7-17-39)64-57(70)73-36-43-22-12-5-13-23-43/h2-29,33,38,48-51,59H,30-32,34-37H2,1H3,(H2,58,65)(H,60,66)(H,61,68)(H,62,69)(H,63,67)(H,64,70)/t38-,48+,49?,50+,51+/m0/s1 URGIRRZASVGUIE-LQWILQEJSA-N 50055607 CHEMBL267113::{1-[(R)-1-{(R)-2-Benzyloxy-1-[(R)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >20000 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055607&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44302899 103952093 CHEMBL267113 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782538 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](COCc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@@H](Cc1c[nH]cn1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C41H47N9O8/c1-25(36(42)51)46-38(53)33(17-29-19-44-32-16-10-9-15-31(29)32)48-40(55)35(23-57-21-27-11-5-3-6-12-27)49-37(52)26(2)47-39(54)34(18-30-20-43-24-45-30)50-41(56)58-22-28-13-7-4-8-14-28/h3-16,19-20,24-26,33-35,44H,17-18,21-23H2,1-2H3,(H2,42,51)(H,43,45)(H,46,53)(H,47,54)(H,48,55)(H,49,52)(H,50,56)/t25-,26-,33+,34+,35+/m0/s1 MBWBRCHYFJETKY-XUIBBJDNSA-N 50055609 CHEMBL2373059::[(R)-1-(1-{(R)-2-Benzyloxy-1-[(R)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-ethylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 1000 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055609&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 73351841 103952095 CHEMBL2373059 ZINC95609651 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782539 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](COCc1ccccc1)NC(=O)[C@@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)[C@@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O InChI=1S/C51H56N10O9/c1-31(46(52)63)56-48(65)42(23-35-25-54-39-15-9-8-14-38(35)39)59-51(68)44(29-69-27-33-10-4-2-5-11-33)61-49(66)41(22-32-16-18-37(19-17-32)70-28-34-12-6-3-7-13-34)58-50(67)43(24-36-26-53-30-55-36)60-47(64)40-20-21-45(62)57-40/h2-19,25-26,30-31,40-44,54H,20-24,27-29H2,1H3,(H2,52,63)(H,53,55)(H,56,65)(H,57,62)(H,58,67)(H,59,68)(H,60,64)(H,61,66)/t31-,40-,41+,42+,43+,44+/m0/s1 NZUXNVOJDSDGON-ZFIOXQTISA-N 50055608 5-Oxo-pyrrolidine-2-carboxylic acid [(R)-1-[(R)-1-{(R)-2-benzyloxy-1-[(R)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethylcarbamoyl]-2-(1H-imidazol-4-yl)-ethyl]-amide::CHEMBL2373072 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >20000 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055608&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 73356377 103952094 CHEMBL2373072 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782541 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](COCc1ccccc1)NC(=O)[C@@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)C(CS)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C51H55N7O9S/c1-33(46(52)59)54-47(60)43(26-38-27-53-41-20-12-11-19-40(38)41)56-49(62)44(31-65-28-35-13-5-2-6-14-35)57-48(61)42(25-34-21-23-39(24-22-34)66-29-36-15-7-3-8-16-36)55-50(63)45(32-68)58-51(64)67-30-37-17-9-4-10-18-37/h2-24,27,33,42-45,53,68H,25-26,28-32H2,1H3,(H2,52,59)(H,54,60)(H,55,63)(H,56,62)(H,57,61)(H,58,64)/t33-,42+,43+,44+,45?/m0/s1 YNAOIEVUHZQVNW-DOABRWHOSA-N 50055611 CHEMBL302620::{1-[(R)-1-{(R)-2-Benzyloxy-1-[(R)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethylcarbamoyl]-2-mercapto-ethyl}-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 170 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055611&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44303305 103952097 CHEMBL302620 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782543 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CO)NC(=O)[C@@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C47H51N9O9/c1-29(42(48)58)52-43(59)39(21-33-23-50-37-15-9-8-14-36(33)37)54-46(62)41(25-57)55-44(60)38(20-30-16-18-35(19-17-30)64-26-31-10-4-2-5-11-31)53-45(61)40(22-34-24-49-28-51-34)56-47(63)65-27-32-12-6-3-7-13-32/h2-19,23-24,28-29,38-41,50,57H,20-22,25-27H2,1H3,(H2,48,58)(H,49,51)(H,52,59)(H,53,61)(H,54,62)(H,55,60)(H,56,63)/t29-,38+,39+,40+,41+/m0/s1 MDRPHYCQEJTZQQ-UOPHCCOJSA-N 50055610 CHEMBL57905::[(R)-1-((R)-2-(4-Benzyloxy-phenyl)-1-{(R)-1-[(R)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-2-hydroxy-ethylcarbamoyl}-ethylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 1800 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055610&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44303303 103952096 CHEMBL57905 C06396 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782544 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](COCc1ccccc1)NC(=O)C(Cc1ccc(CP(O)(O)=O)cc1)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C48H54N9O11P/c1-30(43(49)58)53-44(59)40(21-35-23-51-38-15-9-8-14-37(35)38)55-47(62)42(27-67-25-32-10-4-2-5-11-32)56-45(60)39(20-31-16-18-34(19-17-31)28-69(64,65)66)54-46(61)41(22-36-24-50-29-52-36)57-48(63)68-26-33-12-6-3-7-13-33/h2-19,23-24,29-30,39-42,51H,20-22,25-28H2,1H3,(H2,49,58)(H,50,52)(H,53,59)(H,54,61)(H,55,62)(H,56,60)(H,57,63)(H2,64,65,66)/t30-,39?,40+,41+,42+/m0/s1 WBEAIUIOEMQBNY-HVHGEKNISA-N 50055612 (4-{2-{(R)-2-Benzyloxy-1-[(R)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-2-[(R)-2-benzyloxycarbonylamino-3-(1H-imidazol-4-yl)-propionylamino]-ethyl}-benzyl)-phosphonic acid::CHEMBL64121 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 280 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055612&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44303137 103952098 CHEMBL64121 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782546 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](COCc1ccccc1)NC(=O)[C@@H](CCc1ccccc1)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C48H53N9O8/c1-31(43(49)58)53-45(60)40(23-35-25-51-38-20-12-11-19-37(35)38)55-47(62)42(29-64-27-33-15-7-3-8-16-33)56-44(59)39(22-21-32-13-5-2-6-14-32)54-46(61)41(24-36-26-50-30-52-36)57-48(63)65-28-34-17-9-4-10-18-34/h2-20,25-26,30-31,39-42,51H,21-24,27-29H2,1H3,(H2,49,58)(H,50,52)(H,53,60)(H,54,61)(H,55,62)(H,56,59)(H,57,63)/t31-,39+,40+,41+,42+/m0/s1 UOMYCWQQWMTPFI-HXSCCUKKSA-N 50055613 CHEMBL436158::[(R)-1-((R)-1-{(R)-2-Benzyloxy-1-[(R)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-3-phenyl-propylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 18 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055613&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44302955 103952099 CHEMBL436158 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782547 CCOP(=O)(Cc1ccc(CC(NC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)OCc2ccccc2)C(=O)N[C@H](COCc2ccccc2)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)C(N)=O)cc1)OCC InChI=1S/C52H62N9O11P/c1-4-71-73(68,72-5-2)32-38-22-20-35(21-23-38)24-43(58-50(65)45(26-40-28-54-33-56-40)61-52(67)70-30-37-16-10-7-11-17-37)49(64)60-46(31-69-29-36-14-8-6-9-15-36)51(66)59-44(48(63)57-34(3)47(53)62)25-39-27-55-42-19-13-12-18-41(39)42/h6-23,27-28,33-34,43-46,55H,4-5,24-26,29-32H2,1-3H3,(H2,53,62)(H,54,56)(H,57,63)(H,58,65)(H,59,66)(H,60,64)(H,61,67)/t34-,43?,44+,45+,46+/m0/s1 HTSNUDFEIYOHOA-RGNFPRNJSA-N 50055614 (4-{2-{(R)-2-Benzyloxy-1-[(R)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-2-[(R)-2-benzyloxycarbonylamino-3-(1H-imidazol-4-yl)-propionylamino]-ethyl}-benzyl)-phosphonic acid diethyl ester::CHEMBL385848 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 75 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055614&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44303117 103952100 CHEMBL385848 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782549 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)[C@@H](C)OCc1ccccc1)C(N)=O InChI=1S/C55H59N9O9/c1-35(50(56)65)60-51(66)47(27-41-29-58-45-21-13-12-20-44(41)45)62-54(69)49(36(2)71-31-38-14-6-3-7-15-38)64-53(68)46(26-37-22-24-43(25-23-37)72-32-39-16-8-4-9-17-39)61-52(67)48(28-42-30-57-34-59-42)63-55(70)73-33-40-18-10-5-11-19-40/h3-25,29-30,34-36,46-49,58H,26-28,31-33H2,1-2H3,(H2,56,65)(H,57,59)(H,60,66)(H,61,67)(H,62,69)(H,63,70)(H,64,68)/t35-,36+,46+,47+,48+,49+/m0/s1 SWFRBSJZQHCAGA-YDFNRINOSA-N 50369314 CHEMBL1790438 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 15 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50369314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50369314&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 56658816 160848416 CHEMBL1790438 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782550 C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](COCc1ccccc1)NC(=O)[C@@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C54H57N9O9/c1-35(49(55)64)59-50(65)46(26-40-28-57-44-20-12-11-19-43(40)44)61-53(68)48(33-70-30-37-13-5-2-6-14-37)62-51(66)45(25-36-21-23-42(24-22-36)71-31-38-15-7-3-8-16-38)60-52(67)47(27-41-29-56-34-58-41)63-54(69)72-32-39-17-9-4-10-18-39/h2-24,28-29,34-35,45-48,57H,25-27,30-33H2,1H3,(H2,55,64)(H,56,58)(H,59,65)(H,60,67)(H,61,68)(H,62,66)(H,63,69)/t35-,45+,46-,47+,48+/m0/s1 LMBPTRXCFXWLRW-LYFUOYOJSA-N 50055615 CHEMBL427764::[(R)-1-[(R)-1-{(R)-2-Benzyloxy-1-[(S)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethylcarbamoyl]-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 8700 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055615&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44303166 103952101 CHEMBL427764 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782551 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C49H53N9O10/c1-30(44(50)61)54-46(63)41(23-34-25-52-38-15-9-8-14-37(34)38)57-45(62)39(20-21-43(59)60)55-47(64)40(22-31-16-18-36(19-17-31)67-27-32-10-4-2-5-11-32)56-48(65)42(24-35-26-51-29-53-35)58-49(66)68-28-33-12-6-3-7-13-33/h2-19,25-26,29-30,39-42,52H,20-24,27-28H2,1H3,(H2,50,61)(H,51,53)(H,54,63)(H,55,64)(H,56,65)(H,57,62)(H,58,66)(H,59,60)/t30-,39+,40+,41+,42+/m0/s1 VAQAKLWIXSVQRI-VAAOUYGESA-N 50055618 (R)-4-[(R)-2-[(R)-2-Benzyloxycarbonylamino-3-(1H-imidazol-4-yl)-propionylamino]-3-(4-benzyloxy-phenyl)-propionylamino]-4-[(R)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-butyric acid::CHEMBL304712 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 200 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055618&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44303214 103952104 CHEMBL304712 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782552 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](COCc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](Cc1c[nH]cn1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C42H47N9O10/c1-25(37(43)54)47-38(55)32(16-28-19-45-31-15-9-8-14-30(28)31)48-41(58)35(23-60-21-26-10-4-2-5-11-26)50-40(57)34(18-36(52)53)49-39(56)33(17-29-20-44-24-46-29)51-42(59)61-22-27-12-6-3-7-13-27/h2-15,19-20,24-25,32-35,45H,16-18,21-23H2,1H3,(H2,43,54)(H,44,46)(H,47,55)(H,48,58)(H,49,56)(H,50,57)(H,51,59)(H,52,53)/t25-,32+,33+,34-,35+/m0/s1 NOSBFCUVWZSJIM-YEEXTYRUSA-N 50055617 CHEMBL2373058::N-{(R)-2-Benzyloxy-1-[(R)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethyl}-3-[(R)-2-benzyloxycarbonylamino-3-(1H-imidazol-4-yl)-propionylamino]-succinamic acid Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 38 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055617&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 73350326 103952103 CHEMBL2373058 ZINC95536591 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782554 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](COCc1ccccc1)NC(=O)[C@@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C47H52N9O12P/c1-29(42(48)57)52-43(58)39(21-33-23-50-37-15-9-8-14-36(33)37)54-46(61)41(27-66-25-31-10-4-2-5-11-31)55-44(59)38(20-30-16-18-35(19-17-30)68-69(63,64)65)53-45(60)40(22-34-24-49-28-51-34)56-47(62)67-26-32-12-6-3-7-13-32/h2-19,23-24,28-29,38-41,50H,20-22,25-27H2,1H3,(H2,48,57)(H,49,51)(H,52,58)(H,53,60)(H,54,61)(H,55,59)(H,56,62)(H2,63,64,65)/t29-,38+,39+,40+,41+/m0/s1 DITUKRVCAOAEDB-UOPHCCOJSA-N 50055604 CHEMBL441189::[(R)-1-[(R)-1-{(R)-2-Benzyloxy-1-[(R)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-phosphonooxy-phenyl)-ethylcarbamoyl]-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 6 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055604&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44303045 103952090 CHEMBL441189 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782555 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](COCc1ccccc1)NC(=O)[C@@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)[C@H](N)Cc1cnc[nH]1)C(N)=O InChI=1S/C46H51N9O7/c1-29(42(48)56)52-44(58)40(21-33-23-50-38-15-9-8-14-36(33)38)54-46(60)41(27-61-25-31-10-4-2-5-11-31)55-45(59)39(53-43(57)37(47)22-34-24-49-28-51-34)20-30-16-18-35(19-17-30)62-26-32-12-6-3-7-13-32/h2-19,23-24,28-29,37,39-41,50H,20-22,25-27,47H2,1H3,(H2,48,56)(H,49,51)(H,52,58)(H,53,57)(H,54,60)(H,55,59)/t29-,37+,39+,40+,41+/m0/s1 OJYFRCYWJDNJSX-FEVQQQNNSA-N 50055619 (R)-2-Amino-N-[(R)-1-{(R)-2-benzyloxy-1-[(R)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethyl]-3-(1H-imidazol-4-yl)-propionamide::CHEMBL59944 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 4500 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055619&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44303055 103952105 CHEMBL59944 ZINC95537847 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782556 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](COCc1ccccc1)NC(=O)[C@@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C59H60N8O9/c1-38(54(60)68)63-55(69)51(30-43-32-61-48-23-13-11-21-46(43)48)65-58(72)53(37-74-34-40-15-5-2-6-16-40)66-56(70)50(29-39-25-27-45(28-26-39)75-35-41-17-7-3-8-18-41)64-57(71)52(31-44-33-62-49-24-14-12-22-47(44)49)67-59(73)76-36-42-19-9-4-10-20-42/h2-28,32-33,38,50-53,61-62H,29-31,34-37H2,1H3,(H2,60,68)(H,63,69)(H,64,71)(H,65,72)(H,66,70)(H,67,73)/t38-,50+,51+,52?,53+/m0/s1 SJCUTEFQIRNQBY-RTVUYCIZSA-N 50055620 CHEMBL264079::[1-[(R)-1-{(R)-2-Benzyloxy-1-[(R)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethylcarbamoyl]-2-(1H-indol-3-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >20000 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055620&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44303306 103952106 CHEMBL264079 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782557 CCOP(=O)(Cc1ccc(CC(NC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)OCc2ccccc2)C(=O)N[C@H](COCc2ccccc2)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)C(N)=O)cc1)OCC InChI=1S/C52H62N9O11P/c1-4-71-73(68,72-5-2)32-38-22-20-35(21-23-38)24-43(58-50(65)45(26-40-28-54-33-56-40)61-52(67)70-30-37-16-10-7-11-17-37)49(64)60-46(31-69-29-36-14-8-6-9-15-36)51(66)59-44(48(63)57-34(3)47(53)62)25-39-27-55-42-19-13-12-18-41(39)42/h6-23,27-28,33-34,43-46,55H,4-5,24-26,29-32H2,1-3H3,(H2,53,62)(H,54,56)(H,57,63)(H,58,65)(H,59,66)(H,60,64)(H,61,67)/t34-,43?,44+,45+,46+/m0/s1 HTSNUDFEIYOHOA-RGNFPRNJSA-N 50055614 (4-{2-{(R)-2-Benzyloxy-1-[(R)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-2-[(R)-2-benzyloxycarbonylamino-3-(1H-imidazol-4-yl)-propionylamino]-ethyl}-benzyl)-phosphonic acid diethyl ester::CHEMBL385848 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 49 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055614&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44303117 103952100 CHEMBL385848 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782559 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](COCc1ccccc1)NC(=O)C(CCC(N)=O)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C43H50N10O9/c1-26(38(45)55)49-40(57)34(18-29-20-47-32-15-9-8-14-31(29)32)51-42(59)36(24-61-22-27-10-4-2-5-11-27)52-39(56)33(16-17-37(44)54)50-41(58)35(19-30-21-46-25-48-30)53-43(60)62-23-28-12-6-3-7-13-28/h2-15,20-21,25-26,33-36,47H,16-19,22-24H2,1H3,(H2,44,54)(H2,45,55)(H,46,48)(H,49,57)(H,50,58)(H,51,59)(H,52,56)(H,53,60)/t26-,33?,34+,35+,36+/m0/s1 KRGHJSSSYQAZFO-WDUGHZLDSA-N 50055621 CHEMBL294750::[(R)-1-(1-{(R)-2-Benzyloxy-1-[(R)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-3-carbamoyl-propylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 54 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055621&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44303010 103952107 CHEMBL294750 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782561 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](COP(O)(O)=O)NC(=O)[C@@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C47H52N9O12P/c1-29(42(48)57)52-43(58)39(21-33-23-50-37-15-9-8-14-36(33)37)54-46(61)41(27-68-69(63,64)65)55-44(59)38(20-30-16-18-35(19-17-30)66-25-31-10-4-2-5-11-31)53-45(60)40(22-34-24-49-28-51-34)56-47(62)67-26-32-12-6-3-7-13-32/h2-19,23-24,28-29,38-41,50H,20-22,25-27H2,1H3,(H2,48,57)(H,49,51)(H,52,58)(H,53,60)(H,54,61)(H,55,59)(H,56,62)(H2,63,64,65)/t29-,38+,39+,40+,41+/m0/s1 JAHDKNXLWYZKQE-UOPHCCOJSA-N 50055622 CHEMBL386619::[(R)-1-((R)-2-(4-Benzyloxy-phenyl)-1-{(R)-1-[(R)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-2-phosphonooxy-ethylcarbamoyl}-ethylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 660 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055622&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44303070 103952108 CHEMBL386619 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782562 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(Cc1ccccc1)NC(=O)[C@@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C53H55N9O8/c1-34(48(54)63)58-49(64)46(27-39-29-56-43-20-12-11-19-42(39)43)61-51(66)44(25-35-13-5-2-6-14-35)59-50(65)45(26-36-21-23-41(24-22-36)69-31-37-15-7-3-8-16-37)60-52(67)47(28-40-30-55-33-57-40)62-53(68)70-32-38-17-9-4-10-18-38/h2-24,29-30,33-34,44-47,56H,25-28,31-32H2,1H3,(H2,54,63)(H,55,57)(H,58,64)(H,59,65)(H,60,67)(H,61,66)(H,62,68)/t34-,44?,45+,46+,47+/m0/s1 VOXXYIWYNCLYHT-ULVDIYKQSA-N 50055623 CHEMBL262497::[(R)-1-((R)-2-(4-Benzyloxy-phenyl)-1-{1-[(R)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-2-phenyl-ethylcarbamoyl}-ethylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 130 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055623&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44303241 103952109 CHEMBL262497 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782563 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](COCc1ccccc1)NC(=O)[C@@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)OC1CCC1)C(N)=O InChI=1S/C51H57N9O9/c1-32(46(52)61)56-47(62)43(24-36-26-54-41-18-9-8-17-40(36)41)58-50(65)45(30-67-28-34-11-4-2-5-12-34)59-48(63)42(23-33-19-21-38(22-20-33)68-29-35-13-6-3-7-14-35)57-49(64)44(25-37-27-53-31-55-37)60-51(66)69-39-15-10-16-39/h2-9,11-14,17-22,26-27,31-32,39,42-45,54H,10,15-16,23-25,28-30H2,1H3,(H2,52,61)(H,53,55)(H,56,62)(H,57,64)(H,58,65)(H,59,63)(H,60,66)/t32-,42+,43+,44+,45+/m0/s1 LYUWLHBBTRUCKP-VRTZIVOYSA-N 50055625 CHEMBL406794::[(R)-1-[(R)-1-{(R)-2-Benzyloxy-1-[(R)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethylcarbamoyl]-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid cyclobutyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 3200 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055625&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44303329 103952111 CHEMBL406794 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782564 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](COCc1ccccc1)NC(=O)[C@@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C54H57N9O9/c1-35(49(55)64)59-50(65)46(26-40-28-57-44-20-12-11-19-43(40)44)61-53(68)48(33-70-30-37-13-5-2-6-14-37)62-51(66)45(25-36-21-23-42(24-22-36)71-31-38-15-7-3-8-16-38)60-52(67)47(27-41-29-56-34-58-41)63-54(69)72-32-39-17-9-4-10-18-39/h2-24,28-29,34-35,45-48,57H,25-27,30-33H2,1H3,(H2,55,64)(H,56,58)(H,59,65)(H,60,67)(H,61,68)(H,62,66)(H,63,69)/t35-,45+,46+,47-,48+/m0/s1 LMBPTRXCFXWLRW-BQHITMPDSA-N 50055624 CHEMBL428836::[(S)-1-[(R)-1-{(R)-2-Benzyloxy-1-[(R)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethylcarbamoyl]-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 35 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055624&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44303054 103952110 CHEMBL428836 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782565 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](COCc1ccccc1)NC(=O)C(CC1CCCCC1)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C47H57N9O8/c1-30(42(48)57)52-43(58)39(22-34-24-50-37-20-12-11-19-36(34)37)54-46(61)41(28-63-26-32-15-7-3-8-16-32)55-44(59)38(21-31-13-5-2-6-14-31)53-45(60)40(23-35-25-49-29-51-35)56-47(62)64-27-33-17-9-4-10-18-33/h3-4,7-12,15-20,24-25,29-31,38-41,50H,2,5-6,13-14,21-23,26-28H2,1H3,(H2,48,57)(H,49,51)(H,52,58)(H,53,60)(H,54,61)(H,55,59)(H,56,62)/t30-,38?,39+,40+,41+/m0/s1 COANPFLFVMQXSD-GAJOXTLQSA-N 50055629 CHEMBL62202::[(R)-1-(1-{(R)-2-Benzyloxy-1-[(R)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-2-cyclohexyl-ethylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 66 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055629&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44303417 103952115 CHEMBL62202 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782566 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](COCc1ccccc1)NC(=O)[C@@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(O)=O InChI=1S/C54H56N8O10/c1-35(53(67)68)58-49(63)46(26-40-28-56-44-20-12-11-19-43(40)44)60-52(66)48(33-70-30-37-13-5-2-6-14-37)61-50(64)45(25-36-21-23-42(24-22-36)71-31-38-15-7-3-8-16-38)59-51(65)47(27-41-29-55-34-57-41)62-54(69)72-32-39-17-9-4-10-18-39/h2-24,28-29,34-35,45-48,56H,25-27,30-33H2,1H3,(H,55,57)(H,58,63)(H,59,65)(H,60,66)(H,61,64)(H,62,69)(H,67,68)/t35-,45+,46+,47+,48+/m0/s1 TXTNVVSGAKKFIZ-ZQIGARPHSA-N 50055630 (S)-2-[(R)-2-{(R)-3-Benzyloxy-2-[(R)-2-[(R)-2-benzyloxycarbonylamino-3-(1H-imidazol-4-yl)-propionylamino]-3-(4-benzyloxy-phenyl)-propionylamino]-propionylamino}-3-(1H-indol-3-yl)-propionylamino]-propionic acid::CHEMBL413547 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 48 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055630&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44303104 103952116 CHEMBL413547 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782568 CCNC(=O)[C@H](C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](COCc1ccccc1)NC(=O)[C@@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1 InChI=1S/C56H61N9O9/c1-3-58-51(66)37(2)61-52(67)48(28-42-30-59-46-22-14-13-21-45(42)46)63-55(70)50(35-72-32-39-15-7-4-8-16-39)64-53(68)47(27-38-23-25-44(26-24-38)73-33-40-17-9-5-10-18-40)62-54(69)49(29-43-31-57-36-60-43)65-56(71)74-34-41-19-11-6-12-20-41/h4-26,30-31,36-37,47-50,59H,3,27-29,32-35H2,1-2H3,(H,57,60)(H,58,66)(H,61,67)(H,62,69)(H,63,70)(H,64,68)(H,65,71)/t37-,47+,48+,49+,50+/m0/s1 VXQJPJFCAJWFLM-IYBRZSGVSA-N 50055627 CHEMBL268158::[(R)-1-[(R)-1-{(R)-2-Benzyloxy-1-[(R)-1-((S)-1-ethylcarbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethylcarbamoyl]-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 170 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055627&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44302964 103952113 CHEMBL268158 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782569 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](COCc1ccccc1)NC(=O)[C@@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)C(Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C54H57N9O9/c1-35(49(55)64)59-50(65)46(26-40-28-57-44-20-12-11-19-43(40)44)61-53(68)48(33-70-30-37-13-5-2-6-14-37)62-51(66)45(25-36-21-23-42(24-22-36)71-31-38-15-7-3-8-16-38)60-52(67)47(27-41-29-56-34-58-41)63-54(69)72-32-39-17-9-4-10-18-39/h2-24,28-29,34-35,45-48,57H,25-27,30-33H2,1H3,(H2,55,64)(H,56,58)(H,59,65)(H,60,67)(H,61,68)(H,62,66)(H,63,69)/t35-,45+,46+,47?,48+/m0/s1 LMBPTRXCFXWLRW-OIFRRTLPSA-N 50055626 CHEMBL216670::[1-[(R)-1-{(R)-2-Benzyloxy-1-[(R)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethylcarbamoyl]-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 82 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055626&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44303185 103952112 CHEMBL216670 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782571 C[C@H](NC(=O)C(C)NC(=O)[C@@H](COCc1ccccc1)NC(=O)[C@@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C46H52N8O9/c1-30(41(47)55)50-42(56)31(2)51-45(59)40(28-61-25-33-12-6-3-7-13-33)53-43(57)38(22-32-18-20-37(21-19-32)62-26-34-14-8-4-9-15-34)52-44(58)39(23-36-24-48-29-49-36)54-46(60)63-27-35-16-10-5-11-17-35/h3-21,24,29-31,38-40H,22-23,25-28H2,1-2H3,(H2,47,55)(H,48,49)(H,50,56)(H,51,59)(H,52,58)(H,53,57)(H,54,60)/t30-,31?,38+,39+,40+/m0/s1 IQTNKPYACXWWJW-JIIITCOYSA-N 50055628 CHEMBL59117::[(R)-1-[(R)-1-{(R)-2-Benzyloxy-1-[1-((S)-1-carbamoyl-ethylcarbamoyl)-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethylcarbamoyl]-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 250 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055628&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44303361 103952114 CHEMBL59117 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782573 C[C@H](NC(=O)C(Cc1ccccc1)NC(=O)[C@@H](COCc1ccccc1)NC(=O)[C@@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C52H56N8O9/c1-35(47(53)61)56-48(62)43(26-36-14-6-2-7-15-36)58-51(65)46(33-67-30-38-16-8-3-9-17-38)59-49(63)44(27-37-22-24-42(25-23-37)68-31-39-18-10-4-11-19-39)57-50(64)45(28-41-29-54-34-55-41)60-52(66)69-32-40-20-12-5-13-21-40/h2-25,29,34-35,43-46H,26-28,30-33H2,1H3,(H2,53,61)(H,54,55)(H,56,62)(H,57,64)(H,58,65)(H,59,63)(H,60,66)/t35-,43?,44+,45+,46+/m0/s1 XQDVYYQIBMUKAD-VBSBHOTASA-N 50055632 CHEMBL60678::[(R)-1-[(R)-1-{(R)-2-Benzyloxy-1-[1-((S)-1-carbamoyl-ethylcarbamoyl)-2-phenyl-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethylcarbamoyl]-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 2500 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055632&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44303077 103952118 CHEMBL60678 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782574 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CSCc1ccccc1)NC(=O)[C@@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C54H57N9O8S/c1-35(49(55)64)59-50(65)46(26-40-28-57-44-20-12-11-19-43(40)44)61-53(68)48(33-72-32-39-17-9-4-10-18-39)62-51(66)45(25-36-21-23-42(24-22-36)70-30-37-13-5-2-6-14-37)60-52(67)47(27-41-29-56-34-58-41)63-54(69)71-31-38-15-7-3-8-16-38/h2-24,28-29,34-35,45-48,57H,25-27,30-33H2,1H3,(H2,55,64)(H,56,58)(H,59,65)(H,60,67)(H,61,68)(H,62,66)(H,63,69)/t35-,45+,46+,47+,48+/m0/s1 ZZKCOBHEFGMOIZ-ZQIGARPHSA-N 50055631 CHEMBL429183::[(R)-1-((R)-2-(4-Benzyloxy-phenyl)-1-{(S)-2-benzylsulfanyl-1-[(R)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-ethylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 15 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055631&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44303174 103952117 CHEMBL429183 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782576 CC(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](COCc1ccccc1)NC(=O)[C@@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C54H57N9O9/c1-35(49(55)64)59-50(65)46(26-40-28-57-44-20-12-11-19-43(40)44)61-53(68)48(33-70-30-37-13-5-2-6-14-37)62-51(66)45(25-36-21-23-42(24-22-36)71-31-38-15-7-3-8-16-38)60-52(67)47(27-41-29-56-34-58-41)63-54(69)72-32-39-17-9-4-10-18-39/h2-24,28-29,34-35,45-48,57H,25-27,30-33H2,1H3,(H2,55,64)(H,56,58)(H,59,65)(H,60,67)(H,61,68)(H,62,66)(H,63,69)/t35?,45-,46-,47-,48-/m1/s1 LMBPTRXCFXWLRW-SVXMKRRZSA-N 50055633 CHEMBL384416::[(R)-1-[(R)-1-{(R)-2-Benzyloxy-1-[(R)-1-(1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethylcarbamoyl]-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 8.5 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055633&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44303149 103952119 CHEMBL384416 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782578 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](COP(O)(O)=O)NC(=O)[C@@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C47H52N9O12P/c1-29(42(48)57)52-43(58)39(21-33-23-50-37-15-9-8-14-36(33)37)54-46(61)41(27-68-69(63,64)65)55-44(59)38(20-30-16-18-35(19-17-30)66-25-31-10-4-2-5-11-31)53-45(60)40(22-34-24-49-28-51-34)56-47(62)67-26-32-12-6-3-7-13-32/h2-19,23-24,28-29,38-41,50H,20-22,25-27H2,1H3,(H2,48,57)(H,49,51)(H,52,58)(H,53,60)(H,54,61)(H,55,59)(H,56,62)(H2,63,64,65)/t29-,38+,39+,40+,41+/m0/s1 JAHDKNXLWYZKQE-UOPHCCOJSA-N 50055622 CHEMBL386619::[(R)-1-((R)-2-(4-Benzyloxy-phenyl)-1-{(R)-1-[(R)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-2-phosphonooxy-ethylcarbamoyl}-ethylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 360 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055622&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44303070 103952108 CHEMBL386619 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782580 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](COCc1ccccc1)NC(=O)[C@@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C54H57N9O9/c1-35(49(55)64)59-50(65)46(26-40-28-57-44-20-12-11-19-43(40)44)61-53(68)48(33-70-30-37-13-5-2-6-14-37)62-51(66)45(25-36-21-23-42(24-22-36)71-31-38-15-7-3-8-16-38)60-52(67)47(27-41-29-56-34-58-41)63-54(69)72-32-39-17-9-4-10-18-39/h2-24,28-29,34-35,45-48,57H,25-27,30-33H2,1H3,(H2,55,64)(H,56,58)(H,59,65)(H,60,67)(H,61,68)(H,62,66)(H,63,69)/t35-,45+,46+,47+,48-/m0/s1 LMBPTRXCFXWLRW-YNZBLAQASA-N 50055638 CHEMBL268988::[(R)-1-[(R)-1-{(S)-2-Benzyloxy-1-[(R)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethylcarbamoyl]-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 13000 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055638&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44303356 103952124 CHEMBL268988 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782581 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](COCc1ccccc1)NC(=O)[C@@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(=O)NN InChI=1S/C54H58N10O9/c1-35(49(65)64-55)59-50(66)46(26-40-28-57-44-20-12-11-19-43(40)44)61-53(69)48(33-71-30-37-13-5-2-6-14-37)62-51(67)45(25-36-21-23-42(24-22-36)72-31-38-15-7-3-8-16-38)60-52(68)47(27-41-29-56-34-58-41)63-54(70)73-32-39-17-9-4-10-18-39/h2-24,28-29,34-35,45-48,57H,25-27,30-33,55H2,1H3,(H,56,58)(H,59,66)(H,60,68)(H,61,69)(H,62,67)(H,63,70)(H,64,65)/t35-,45+,46+,47+,48+/m0/s1 SQDWFLBOYHMJFI-ZQIGARPHSA-N 50055635 CHEMBL264915::[(R)-1-[(R)-1-{(R)-2-Benzyloxy-1-[(R)-1-((S)-1-hydrazinocarbonyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethylcarbamoyl]-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 64 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055635&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44302982 103952121 CHEMBL264915 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782582 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](COCc1ccccc1)NC(=O)[C@@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)C(C)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C51H55N7O9/c1-33(46(52)59)54-48(61)44(27-39-28-53-42-21-13-12-20-41(39)42)57-50(63)45(32-65-29-36-14-6-3-7-15-36)58-49(62)43(26-35-22-24-40(25-23-35)66-30-37-16-8-4-9-17-37)56-47(60)34(2)55-51(64)67-31-38-18-10-5-11-19-38/h3-25,28,33-34,43-45,53H,26-27,29-32H2,1-2H3,(H2,52,59)(H,54,61)(H,55,64)(H,56,60)(H,57,63)(H,58,62)/t33-,34?,43+,44+,45+/m0/s1 VCSOKUKFDTYTQA-VLZINWJSSA-N 50055637 CHEMBL62100::{1-[(R)-1-{(R)-2-Benzyloxy-1-[(R)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethylcarbamoyl]-ethyl}-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >20000 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055637&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44303184 103952123 CHEMBL62100 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782583 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](COCc1ccccc1)NC(=O)C(Cc1ccc(CP(O)(O)=O)cc1)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C48H54N9O11P/c1-30(43(49)58)53-44(59)40(21-35-23-51-38-15-9-8-14-37(35)38)55-47(62)42(27-67-25-32-10-4-2-5-11-32)56-45(60)39(20-31-16-18-34(19-17-31)28-69(64,65)66)54-46(61)41(22-36-24-50-29-52-36)57-48(63)68-26-33-12-6-3-7-13-33/h2-19,23-24,29-30,39-42,51H,20-22,25-28H2,1H3,(H2,49,58)(H,50,52)(H,53,59)(H,54,61)(H,55,62)(H,56,60)(H,57,63)(H2,64,65,66)/t30-,39?,40+,41+,42+/m0/s1 WBEAIUIOEMQBNY-HVHGEKNISA-N 50055612 (4-{2-{(R)-2-Benzyloxy-1-[(R)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-2-[(R)-2-benzyloxycarbonylamino-3-(1H-imidazol-4-yl)-propionylamino]-ethyl}-benzyl)-phosphonic acid::CHEMBL64121 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 190 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055612&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44303137 103952098 CHEMBL64121 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50782584 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](COCc1ccccc1)NC(=O)C(CCC(O)=O)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C43H49N9O10/c1-26(38(44)55)48-40(57)34(18-29-20-46-32-15-9-8-14-31(29)32)50-42(59)36(24-61-22-27-10-4-2-5-11-27)51-39(56)33(16-17-37(53)54)49-41(58)35(19-30-21-45-25-47-30)52-43(60)62-23-28-12-6-3-7-13-28/h2-15,20-21,25-26,33-36,46H,16-19,22-24H2,1H3,(H2,44,55)(H,45,47)(H,48,57)(H,49,58)(H,50,59)(H,51,56)(H,52,60)(H,53,54)/t26-,33?,34+,35+,36+/m0/s1 AFVPYGFIXOXPDY-WDUGHZLDSA-N 50055636 4-{(R)-2-Benzyloxy-1-[(R)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-4-[(R)-2-benzyloxycarbonylamino-3-(1H-imidazol-4-yl)-propionylamino]-butyric acid::CHEMBL62190 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 18 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055636&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44302978 103952122 CHEMBL62190 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50810083 CC1C(=O)[C@]2(C)C(C)=C[C@@H]3[C@](C)(CC[C@@H]4C(C)(C)[C@H](CC[C@@]34CO)OC(C)=O)[C@]2(C([O-])=O)C1=O InChI=1S/C27H38O7/c1-14-12-18-24(6,27(22(32)33)21(31)15(2)20(30)25(14,27)7)10-8-17-23(4,5)19(34-16(3)29)9-11-26(17,18)13-28/h12,15,17-19,28H,8-11,13H2,1-7H3,(H,32,33)/p-1/t15?,17-,18-,19+,24+,25+,26+,27-/m1/s1 MNZNWHKDKONSRP-WHMREYFHSA-M 50110960 3-Acetoxy-15-hydroxy-10-hydroxymethyl-4,4,8,12,13,16-hexamethyl-17-oxo-1,2,3,4,5,6,7,8,9,10,13,17-dodecahydro-cyclopenta[a]phenanthrene-14-carboxylic acid anion (andrastatin b) Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 47100 ChEMBL 10.1021/jm011075w 10.7270/Q2RV0PDQ 11906287 Pedretti, A; Villa, L; Vistoli, G University of Milan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110960&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 91931899 104005624 29067 ZINC29235966 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50810084 CC(C)CC(=O)C[C@H]1CC(C)=C2C([C@H]3OC(=O)C4(CC56C=C[C@]4(C)C[C@@H]5[C@H]4OC(=O)C(=C)[C@@H]4CC[C@@]6(C)O)C13)C(C)=CC2=O InChI=1S/C37H46O7/c1-18(2)12-23(38)15-22-13-19(3)27-26(39)14-20(4)28(27)31-29(22)37(33(41)44-31)17-36-11-10-34(37,6)16-25(36)30-24(8-9-35(36,7)42)21(5)32(40)43-30/h10-11,14,18,22,24-25,28-31,42H,5,8-9,12-13,15-17H2,1-4,6-7H3/t22-,24+,25-,28?,29?,30+,31-,34-,35-,36?,37?/m1/s1 DXADJEQOLJUISX-LPWWUQPMSA-N 50110961 2'-hydroxy-2',6,9,12'-tetramethyl-6'-methylene-4-(4-methyl-2-oxofuryl)spiro[2,3,3a,4,5,7,9a,9b-octahydroazuleno[4,5-b]furan-3,13'-tetracyclo[10.2.2.01,10.05,9]hexadec-15'-ene]-2,7,7'-trione(arteminolide)::CHEMBL287034 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 360 ChEMBL 10.1021/jm011075w 10.7270/Q2RV0PDQ 11906287 Pedretti, A; Villa, L; Vistoli, G University of Milan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110961&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 73354274 104005625 CHEMBL287034 ZINC43676569 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50810085 CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(=C\C(O)=O)C(O)=O InChI=1S/C20H30O4/c1-15(2)8-5-9-16(3)10-6-11-17(4)12-7-13-18(20(23)24)14-19(21)22/h8,10,12,14H,5-7,9,11,13H2,1-4H3,(H,21,22)(H,23,24)/b16-10+,17-12+,18-14- XNZYMBLMYICBGE-SLSDTJSCSA-N 50110962 2-(4,8,12-Trimethyl-trideca-3,7,11-trienyl)-but-2-enedioic acid (schizostatin E)::2-(4,8,12-Trimethyl-trideca-3,7,11-trienyl)-but-2-enedioic acid (schizostatin Z)::CHEMBL35351 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 300000 ChEMBL 10.1021/jm011075w 10.7270/Q2RV0PDQ 11906287 Pedretti, A; Villa, L; Vistoli, G University of Milan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110962&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10404670 104005626 CHEMBL35351 ZINC14654703 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50810086 COC(=O)C1=CC(CO)=COc2oc3cccc(=O)c3c(O)c12 InChI=1S/C16H12O7/c1-21-15(20)9-5-8(6-17)7-22-16-12(9)14(19)13-10(18)3-2-4-11(13)23-16/h2-5,7,17,19H,6H2,1H3 MLSGFBYSHVHLRJ-UHFFFAOYSA-N 50059880 1-Hydroxy-8-hydroxymethyl-11-oxo-11H-5,6-dioxa-cyclohepta[b]naphthalene-10-carboxylic acid methyl ester::1-Hydroxy-8-hydroxymethyl-11-oxo-11H-5,6-dioxa-cyclohepta[b]naphthalene-10-carboxylic acid methyl ester(fusidienol)::CHEMBL35732 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 300 ChEMBL 10.1021/jm011075w 10.7270/Q2RV0PDQ 11906287 Pedretti, A; Villa, L; Vistoli, G University of Milan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50059880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50059880&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 5492684 103955658 CHEMBL35732 ZINC05605515 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50810087 CC(C)CCCC(C)C1CCC2C3CCC(=O)[C@](C)(C[C@@H](CC(O)=O)C(O)=O)C3CC[C@]12C InChI=1S/C28H46O5/c1-17(2)7-6-8-18(3)21-10-11-22-20-9-12-24(29)28(5,23(20)13-14-27(21,22)4)16-19(26(32)33)15-25(30)31/h17-23H,6-16H2,1-5H3,(H,30,31)(H,32,33)/t18?,19-,20?,21?,22?,23?,27-,28-/m1/s1 DSMMOUACIAORLU-QNVPDBANSA-N 50067843 (S)-2-[(3aR,6R)-3-(1,5-Dimethyl-hexyl)-3a,6-dimethyl-7-oxo-dodecahydro-cyclopenta[a]naphthalen-6-ylmethyl]-succinic acid::2-[3-(1,5-Dimethyl-hexyl)-3a,6-dimethyl-7-oxo-dodecahydro-cyclopenta[a]naphthalen-6-ylmethyl]-succinic acid(Des-B)::CHEMBL35674 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 190 ChEMBL 10.1021/jm011075w 10.7270/Q2RV0PDQ 11906287 Pedretti, A; Villa, L; Vistoli, G University of Milan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067843&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44282288 103962269 CHEMBL35674 ZINC36330309 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50810088 CC[C@H](C)C[C@H](C)\C=C\C(=O)O[C@@H]1[C@@H](O)[C@]2(CCC(=C)[C@@H](OC(C)=O)[C@H](C)Cc3ccccc3)O[C@@]1(C(O)=O)[C@@](O)([C@H](O2)C(O)=O)C(O)=O InChI=1S/C35H46O14/c1-7-19(2)17-20(3)13-14-25(37)47-28-27(38)33(48-29(30(39)40)34(45,31(41)42)35(28,49-33)32(43)44)16-15-21(4)26(46-23(6)36)22(5)18-24-11-9-8-10-12-24/h8-14,19-20,22,26-29,38,45H,4,7,15-18H2,1-3,5-6H3,(H,39,40)(H,41,42)(H,43,44)/b14-13+/t19-,20+,22+,26+,27+,28+,29+,33-,34+,35-/m0/s1 DFKDOZMCHOGOBR-NCSQYGPNSA-N 50051873 (1S,3S,4S,5R,6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-6-phenyl-hexyl)-4,7-dihydroxy-6-((S)-6-methyl-4-methyl-oct-2-enoyloxy)-2,8-dioxa-bicyclo[3.2.1]octane-3,4,5-tricarboxylic acid::(1S,3S,4S,5R,6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-6-phenyl-hexyl)-6-((E)-(4S,6S)-4,6-dimethyl-oct-2-enoyloxy)-4,7-dihydroxy-2,8-dioxa-bicyclo[3.2.1]octane-3,4,5-tricarboxylic acid::7-[3,5-dimethyl-(E)-1-heptenylcarbonyloxy]-2,6-dihydroxy-5-[3-(2-methyl-1-methylcarbonyloxy-3-phenylpropyl)-3-butenyl]-4,8-dioxabicyclo[3.2.1]octane-1,2,3-tricarboxylic acid::CHEMBL280978::Zaragozic Acids A Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 12 ChEMBL 10.1021/jm011075w 10.7270/Q2RV0PDQ 11906287 Pedretti, A; Villa, L; Vistoli, G University of Milan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50051873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50051873&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search ZGA 3VJE,3VJC 6438355 103948803 75170 CHEMBL280978 3057 ZINC34803452 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50810089 CC1C(=O)[C@]2(C)C(C)=C[C@@H]3[C@](C)(CC[C@@H]4C(C)(C)[C@H](CC[C@@]34C=O)OC(C)=O)[C@]2(C([O-])=O)C1=O InChI=1S/C27H36O7/c1-14-12-18-24(6,27(22(32)33)21(31)15(2)20(30)25(14,27)7)10-8-17-23(4,5)19(34-16(3)29)9-11-26(17,18)13-28/h12-13,15,17-19H,8-11H2,1-7H3,(H,32,33)/p-1/t15?,17-,18-,19+,24+,25+,26+,27-/m1/s1 BXQKMPWOGVXXTR-WHMREYFHSA-M 50110964 3-Acetoxy-10-formyl-15-hydroxy-4,4,8,12,13,16-hexamethyl-17-oxo-1,2,3,4,5,6,7,8,9,10,13,17-dodecahydro-cyclopenta[a]phenanthrene-14-carboxylic acid anion(andrastatin a) Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 24900 ChEMBL 10.1021/jm011075w 10.7270/Q2RV0PDQ 11906287 Pedretti, A; Villa, L; Vistoli, G University of Milan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110964&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 91931901 104005628 29067 ZINC29230981 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50810090 CC1C(=O)[C@]2(C)C(C)=C[C@H]3[C@]4(C)CC[C@H](OC(C)=O)C(C)(C)[C@H]4CC[C@]3(C)[C@]2(C([O-])=O)C1=O InChI=1S/C27H38O6/c1-14-13-18-24(6)11-10-19(33-16(3)28)23(4,5)17(24)9-12-25(18,7)27(22(31)32)21(30)15(2)20(29)26(14,27)8/h13,15,17-19H,9-12H2,1-8H3,(H,31,32)/p-1/t15?,17-,18+,19+,24-,25+,26+,27-/m1/s1 YKIUZFVKQDNKDS-FAYXUPNCSA-M 50110965 3-Acetoxy-15-hydroxy-4,4,8,10,12,13,16-heptamethyl-17-oxo-1,2,3,4,5,6,7,8,9,10,13,17-dodecahydro-cyclopenta[a]phenanthrene-14-carboxylic acid anion (andrastatin c) Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 13300 ChEMBL 10.1021/jm011075w 10.7270/Q2RV0PDQ 11906287 Pedretti, A; Villa, L; Vistoli, G University of Milan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110965&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 91931903 104005629 29067 ZINC29236416 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50810091 CC(C)CCCC(C)C1CCC2C3[C@@H](C)CC(=O)[C@](C)(CCC(O)=O)C3CC[C@]12C InChI=1S/C27H46O3/c1-17(2)8-7-9-18(3)20-10-11-21-25-19(4)16-23(28)27(6,15-13-24(29)30)22(25)12-14-26(20,21)5/h17-22,25H,7-16H2,1-6H3,(H,29,30)/t18?,19-,20?,21?,22?,25?,26+,27+/m0/s1 GOSURFASCRNOMA-RSLLPWARSA-N 50067852 3-[(3aR,6R,9S)-3-(1,5-Dimethyl-hexyl)-3a,6,9-trimethyl-7-oxo-dodecahydro-cyclopenta[a]naphthalen-6-yl]-propionic acid::3-[3-(1,5-Dimethyl-hexyl)-3a,6,9-trimethyl-7-oxo-dodecahydro-cyclopenta[a]naphthalen-6-yl]-propionic acid(Des-A)::CHEMBL35344 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 900 ChEMBL 10.1021/jm011075w 10.7270/Q2RV0PDQ 11906287 Pedretti, A; Villa, L; Vistoli, G University of Milan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067852&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44282393 103962278 CHEMBL35344 ZINC36330305 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50799413 [O-][N+](=O)c1cc2C(=O)c3cc(cc(c3-c2c(c1)C(=O)N1CCCCC1)[N+]([O-])=O)[N+]([O-])=O InChI=1S/C19H14N4O8/c24-18-12-6-10(21(26)27)8-14(19(25)20-4-2-1-3-5-20)16(12)17-13(18)7-11(22(28)29)9-15(17)23(30)31/h6-9H,1-5H2 XQGJLHAKPQGERB-UHFFFAOYSA-N 50084823 2,4,7-Trinitro-5-(piperidine-1-carbonyl)-fluoren-9-one::CHEMBL131204 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 96000 ChEMBL 10.1021/jm990408a 10.7270/Q28W3F0K 10669567 Perola, E; Xu, K; Kollmeyer, TM; Kaufmann, SH; Prendergast, FG; Pang, YP Mayo Medical School and Mayo Clinic http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50084823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50084823&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 2775579 103984351 CHEMBL131204 ZINC43379619 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50799414 Oc1ccc(cc1C=C1c2cc(cc(c2-c2c1cc(cc2[N+]([O-])=O)[N+]([O-])=O)[N+]([O-])=O)[N+]([O-])=O)[N+]([O-])=O InChI=1S/C20H9N5O11/c26-18-2-1-10(21(27)28)3-9(18)4-13-14-5-11(22(29)30)7-16(24(33)34)19(14)20-15(13)6-12(23(31)32)8-17(20)25(35)36/h1-8,26H QGPCKPZYOUWFEZ-UHFFFAOYSA-N 50084824 4-Nitro-2-(2,4,5,7-tetranitro-fluoren-9-ylidenemethyl)-phenol::CHEMBL335510 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 100000 ChEMBL 10.1021/jm990408a 10.7270/Q28W3F0K 10669567 Perola, E; Xu, K; Kollmeyer, TM; Kaufmann, SH; Prendergast, FG; Pang, YP Mayo Medical School and Mayo Clinic http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50084824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50084824&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 2775589 103984352 CHEMBL335510 ZINC43888124 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50799415 NC(=O)c1cc(cc2C(=O)c3cc(cc(c3-c12)[N+]([O-])=O)[N+]([O-])=O)[N+]([O-])=O InChI=1S/C14H6N4O8/c15-14(20)9-3-5(16(21)22)1-7-11(9)12-8(13(7)19)2-6(17(23)24)4-10(12)18(25)26/h1-4H,(H2,15,20) FXCNNLGCNUONLQ-UHFFFAOYSA-N 50084826 2,5,7-Trinitro-9-oxo-9H-fluorene-4-carboxylic acid amide::CHEMBL133894 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 80000 ChEMBL 10.1021/jm990408a 10.7270/Q28W3F0K 10669567 Perola, E; Xu, K; Kollmeyer, TM; Kaufmann, SH; Prendergast, FG; Pang, YP Mayo Medical School and Mayo Clinic http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50084826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50084826&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 5157802 103984354 CHEMBL133894 ZINC43379915 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50799416 [O-][N+](=O)c1ccc(NN2C(=O)C3C(C2=O)[C@@]2(Cl)C(Cl)=C(Cl)[C@]3(Cl)C2(Cl)Cl)c(c1)[N+]([O-])=O InChI=1S/C15H6Cl6N4O6/c16-9-10(17)14(19)8-7(13(9,18)15(14,20)21)11(26)23(12(8)27)22-5-2-1-4(24(28)29)3-6(5)25(30)31/h1-3,7-8,22H/t7?,8?,13-,14+ ALWRYSHRLGINAM-BNVVDKPPSA-N 50369776 CHEMBL298301 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 25000 ChEMBL 10.1021/jm990408a 10.7270/Q28W3F0K 10669567 Perola, E; Xu, K; Kollmeyer, TM; Kaufmann, SH; Prendergast, FG; Pang, YP Mayo Medical School and Mayo Clinic http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50369776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50369776&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44292607 160848878 CHEMBL298301 ZINC29414008 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50799417 [O-][N+](=O)c1ccc-2c(c1)C(=O)c1cc(cc(C(=O)NNc3ccc(cc3[N+]([O-])=O)[N+]([O-])=O)c-21)[N+]([O-])=O InChI=1S/C20H10N6O10/c27-19-13-5-9(23(29)30)1-3-12(13)18-14(19)6-11(25(33)34)7-15(18)20(28)22-21-16-4-2-10(24(31)32)8-17(16)26(35)36/h1-8,21H,(H,22,28) WOPGZCXUGQQZCP-UHFFFAOYSA-N 50084827 2,7-Dinitro-9-oxo-9H-fluorene-4-carboxylic acid N'-(2,4-dinitro-phenyl)-hydrazide::CHEMBL132497 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 110000 ChEMBL 10.1021/jm990408a 10.7270/Q28W3F0K 10669567 Perola, E; Xu, K; Kollmeyer, TM; Kaufmann, SH; Prendergast, FG; Pang, YP Mayo Medical School and Mayo Clinic http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50084827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50084827&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 4079363 103984355 CHEMBL132497 ZINC43379767 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50825658 Cn1cnc(c1)S(=O)(=O)N(CC(=O)OC(C)(C)C)C1CN(Cc2cncn2C)c2ccc(cc2C1)C#N InChI=1S/C25H31N7O4S/c1-25(2,3)36-24(33)15-32(37(34,35)23-14-29(4)17-28-23)20-9-19-8-18(10-26)6-7-22(19)31(12-20)13-21-11-27-16-30(21)5/h6-8,11,14,16-17,20H,9,12-13,15H2,1-5H3 NLCBWQRVYLSINY-UHFFFAOYSA-N 13319 BMS-386914::CHEMBL183536::[[6-Cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydroquinolin-3-yl]-(1-methyl-1H-imidazole-4-sulfonyl)amino]-acetic Acid tert-Butyl Ester::tert-butyl 2-({6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl}(1-methyl-1H-imidazole-4-)sulfonamido)acetate::tetrahydroquinoline (THQ)-based inhibitor 4a Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 30 ChEMBL 10.1016/j.bmcl.2005.02.004 10.7270/Q2RB75CJ 15780629 Lombardo, LJ; Camuso, A; Clark, J; Fager, K; Gullo-Brown, J; Hunt, JT; Inigo, I; Kan, D; Koplowitz, B; Lee, F; McGlinchey, K; Qian, L; Ricca, C; Rovnyak, G; Traeger, S; Tokarski, J; Williams, DK; Wu, LI; Zhao, Y; Manne, V; Bhide, RS Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13319&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 11364483 46513727 CHEMBL183536 ZINC09293850 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50825665 CC(=C)CN(C1CN(Cc2cncn2C)c2ccc(cc2C1)C#N)S(C)(=O)=O InChI=1S/C20H25N5O2S/c1-15(2)11-25(28(4,26)27)18-8-17-7-16(9-21)5-6-20(17)24(12-18)13-19-10-22-14-23(19)3/h5-7,10,14,18H,1,8,11-13H2,2-4H3 YRBSHYLIBVCREO-UHFFFAOYSA-N 50164003 CHEMBL183773::N-[6-Cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-N-(2-methyl-allyl)-methanesulfonamide Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 8 ChEMBL 10.1016/j.bmcl.2005.02.004 10.7270/Q2RB75CJ 15780629 Lombardo, LJ; Camuso, A; Clark, J; Fager, K; Gullo-Brown, J; Hunt, JT; Inigo, I; Kan, D; Koplowitz, B; Lee, F; McGlinchey, K; Qian, L; Ricca, C; Rovnyak, G; Traeger, S; Tokarski, J; Williams, DK; Wu, LI; Zhao, Y; Manne, V; Bhide, RS Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50164003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50164003&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44391557 104049906 CHEMBL183773 ZINC28351074 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50825666 CC(=C)CN(C1CN(Cc2cncn2C)c2ccc(cc2C1)C#N)S(=O)(=O)c1ccccn1 InChI=1S/C24H26N6O2S/c1-18(2)14-30(33(31,32)24-6-4-5-9-27-24)21-11-20-10-19(12-25)7-8-23(20)29(15-21)16-22-13-26-17-28(22)3/h4-10,13,17,21H,1,11,14-16H2,2-3H3 PZCCBYWNHZAHAG-UHFFFAOYSA-N 50164009 CHEMBL182813::Pyridine-2-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(2-methyl-allyl)-amide Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 60 ChEMBL 10.1016/j.bmcl.2005.02.004 10.7270/Q2RB75CJ 15780629 Lombardo, LJ; Camuso, A; Clark, J; Fager, K; Gullo-Brown, J; Hunt, JT; Inigo, I; Kan, D; Koplowitz, B; Lee, F; McGlinchey, K; Qian, L; Ricca, C; Rovnyak, G; Traeger, S; Tokarski, J; Williams, DK; Wu, LI; Zhao, Y; Manne, V; Bhide, RS Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50164009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50164009&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44391508 104049912 CHEMBL182813 ZINC28358515 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50825672 Cn1cncc1CN1CC(Cc2cc(ccc12)C#N)N(CC(=O)OC(C)(C)C)S(=O)(=O)c1ccccn1 InChI=1S/C26H30N6O4S/c1-26(2,3)36-25(33)17-32(37(34,35)24-7-5-6-10-29-24)21-12-20-11-19(13-27)8-9-23(20)31(15-21)16-22-14-28-18-30(22)4/h5-11,14,18,21H,12,15-17H2,1-4H3 ZQIKAKSHLZASKW-UHFFFAOYSA-N 50164016 CHEMBL179598::[[6-Cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(pyridine-2-sulfonyl)-amino]-acetic acid tert-butyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 10 ChEMBL 10.1016/j.bmcl.2005.02.004 10.7270/Q2RB75CJ 15780629 Lombardo, LJ; Camuso, A; Clark, J; Fager, K; Gullo-Brown, J; Hunt, JT; Inigo, I; Kan, D; Koplowitz, B; Lee, F; McGlinchey, K; Qian, L; Ricca, C; Rovnyak, G; Traeger, S; Tokarski, J; Williams, DK; Wu, LI; Zhao, Y; Manne, V; Bhide, RS Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50164016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50164016&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 25141073 104049919 CHEMBL179598 ZINC28132486 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50825676 Cn1cncc1CN1CC(Cc2cc(ccc12)C#N)N(Cc1ccccc1)S(=O)(=O)c1cccnc1 InChI=1S/C27H26N6O2S/c1-31-20-30-15-25(31)19-32-18-24(13-23-12-22(14-28)9-10-27(23)32)33(17-21-6-3-2-4-7-21)36(34,35)26-8-5-11-29-16-26/h2-12,15-16,20,24H,13,17-19H2,1H3 FUQQEQIALYIXCF-UHFFFAOYSA-N 50164013 CHEMBL439846::Pyridine-3-sulfonic acid benzyl-[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-amide Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 70 ChEMBL 10.1016/j.bmcl.2005.02.004 10.7270/Q2RB75CJ 15780629 Lombardo, LJ; Camuso, A; Clark, J; Fager, K; Gullo-Brown, J; Hunt, JT; Inigo, I; Kan, D; Koplowitz, B; Lee, F; McGlinchey, K; Qian, L; Ricca, C; Rovnyak, G; Traeger, S; Tokarski, J; Williams, DK; Wu, LI; Zhao, Y; Manne, V; Bhide, RS Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50164013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50164013&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44391540 104049916 CHEMBL439846 ZINC28349539 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50825677 Cn1cncc1CN1CC(Cc2cc(ccc12)C#N)N(CC(=O)OC(C)(C)C)S(=O)(=O)c1cccnc1 InChI=1S/C26H30N6O4S/c1-26(2,3)36-25(33)17-32(37(34,35)23-6-5-9-28-14-23)21-11-20-10-19(12-27)7-8-24(20)31(15-21)16-22-13-29-18-30(22)4/h5-10,13-14,18,21H,11,15-17H2,1-4H3 DAARHFNOAVMALA-UHFFFAOYSA-N 50164004 CHEMBL183590::[[6-Cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(pyridine-3-sulfonyl)-amino]-acetic acid tert-butyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 225 ChEMBL 10.1016/j.bmcl.2005.02.004 10.7270/Q2RB75CJ 15780629 Lombardo, LJ; Camuso, A; Clark, J; Fager, K; Gullo-Brown, J; Hunt, JT; Inigo, I; Kan, D; Koplowitz, B; Lee, F; McGlinchey, K; Qian, L; Ricca, C; Rovnyak, G; Traeger, S; Tokarski, J; Williams, DK; Wu, LI; Zhao, Y; Manne, V; Bhide, RS Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50164004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50164004&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44391520 104049907 CHEMBL183590 ZINC28346025 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50825685 CC(=C)CN(C1CN(Cc2cncn2C)c2ccc(cc2C1)C#N)S(=O)(=O)c1cccnc1 InChI=1S/C24H26N6O2S/c1-18(2)14-30(33(31,32)23-5-4-8-26-13-23)21-10-20-9-19(11-25)6-7-24(20)29(15-21)16-22-12-27-17-28(22)3/h4-9,12-13,17,21H,1,10,14-16H2,2-3H3 NIACYCIOHPNBOW-UHFFFAOYSA-N 50164012 CHEMBL183217::Pyridine-3-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(2-methyl-allyl)-amide Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 100 ChEMBL 10.1016/j.bmcl.2005.02.004 10.7270/Q2RB75CJ 15780629 Lombardo, LJ; Camuso, A; Clark, J; Fager, K; Gullo-Brown, J; Hunt, JT; Inigo, I; Kan, D; Koplowitz, B; Lee, F; McGlinchey, K; Qian, L; Ricca, C; Rovnyak, G; Traeger, S; Tokarski, J; Williams, DK; Wu, LI; Zhao, Y; Manne, V; Bhide, RS Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50164012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50164012&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44391497 104049915 CHEMBL183217 ZINC28355326 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50825687 CC(=C)CN(C1CN(Cc2cncn2C)c2ccc(cc2C1)C#N)S(=O)(=O)c1cn(C)cn1 InChI=1S/C23H27N7O2S/c1-17(2)11-30(33(31,32)23-14-27(3)16-26-23)20-8-19-7-18(9-24)5-6-22(19)29(12-20)13-21-10-25-15-28(21)4/h5-7,10,14-16,20H,1,8,11-13H2,2-4H3 JNJBXYHGNTUTTK-UHFFFAOYSA-N 13320 1-Methyl-1H-imidazole-4-sulfonic Acid [6-Cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydroquinolin-3-yl]-(2-methylallyl)amide::BMS-388891::CHEMBL181102::N-{6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl}-1-methyl-N-(2-methylprop-2-en-1-yl)-1H-imidazole-4-sulfonamide::tetrahydroquinoline (THQ)-based inhibitor 4b Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 50 ChEMBL 10.1016/j.bmcl.2005.02.004 10.7270/Q2RB75CJ 15780629 Lombardo, LJ; Camuso, A; Clark, J; Fager, K; Gullo-Brown, J; Hunt, JT; Inigo, I; Kan, D; Koplowitz, B; Lee, F; McGlinchey, K; Qian, L; Ricca, C; Rovnyak, G; Traeger, S; Tokarski, J; Williams, DK; Wu, LI; Zhao, Y; Manne, V; Bhide, RS Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13320&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 11363291 46513728 CHEMBL181102 ZINC13644627 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50825693 Cn1cncc1CN1CC(Cc2cc(ccc12)C#N)N(Cc1ccsc1)S(=O)(=O)c1ccccn1 InChI=1S/C25H24N6O2S2/c1-29-18-27-13-23(29)16-30-15-22(11-21-10-19(12-26)5-6-24(21)30)31(14-20-7-9-34-17-20)35(32,33)25-4-2-3-8-28-25/h2-10,13,17-18,22H,11,14-16H2,1H3 FPEPZFNRGIPRRN-UHFFFAOYSA-N 50164025 BMS-316810::CHEMBL360330::Pyridine-2-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-thiophen-3-ylmethyl-amide Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 13 ChEMBL 10.1016/j.bmcl.2005.02.004 10.7270/Q2RB75CJ 15780629 Lombardo, LJ; Camuso, A; Clark, J; Fager, K; Gullo-Brown, J; Hunt, JT; Inigo, I; Kan, D; Koplowitz, B; Lee, F; McGlinchey, K; Qian, L; Ricca, C; Rovnyak, G; Traeger, S; Tokarski, J; Williams, DK; Wu, LI; Zhao, Y; Manne, V; Bhide, RS Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50164025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50164025&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 9806149 104049928 CHEMBL360330 ZINC11687584 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 51032278 C[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](COCc1ccccc1)NC(=O)[C@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(N)=O InChI=1S/C54H57N9O9/c1-35(49(55)64)59-50(65)46(26-40-28-57-44-20-12-11-19-43(40)44)61-53(68)48(33-70-30-37-13-5-2-6-14-37)62-51(66)45(25-36-21-23-42(24-22-36)71-31-38-15-7-3-8-16-38)60-52(67)47(27-41-29-56-34-58-41)63-54(69)72-32-39-17-9-4-10-18-39/h2-24,28-29,34-35,45-48,57H,25-27,30-33H2,1H3,(H2,55,64)(H,56,58)(H,59,65)(H,60,67)(H,61,68)(H,62,66)(H,63,69)/t35-,45+,46+,47+,48+/m1/s1 LMBPTRXCFXWLRW-ZYIGOEBISA-N 50059876 CHEMBL217423::[(S)-1-[(S)-1-{(S)-2-Benzyloxy-1-[(S)-1-((R)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethylcarbamoyl]-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester::[(S)-1-[(S)-1-{(S)-2-Benzyloxy-1-[(S)-1-((R)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethylcarbamoyl]-2-(3H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 20 ChEMBL 10.1021/jm960602m 10.7270/Q2JW8FJ4 9003517 Leonard, DM; Shuler, KR; Poulter, CJ; Eaton, SR; Sawyer, TK; Hodges, JC; Su, TZ; Scholten, JD; Gowan, RC; Sebolt-Leopold, JS; Doherty, AM Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50059876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50059876&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 9919495 103955654 CHEMBL217423 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50010943 CC(=C)C1CCC(COc2c(F)c(O)c(c(F)c2F)[N+]([O-])=O)=CC1 InChI=1S/C16H16F3NO4/c1-8(2)10-5-3-9(4-6-10)7-24-16-12(18)11(17)14(20(22)23)15(21)13(16)19/h3,10,21H,1,4-7H2,2H3 XWKMJQGYFTUNQS-UHFFFAOYSA-N 50075440 2,4,5-Trifluoro-3-(4-isopropenyl-cyclohex-1-enylmethoxy)-6-nitro-phenol::CHEMBL156477 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 120000 ChEMBL 10.1016/s0960-894x(99)00043-8 10.7270/Q28P5ZN0 10098677 Barber, AM; Hardcastle, IR; Rowlands, MG; Nutley, BP; Marriott, JH; Jarman, M Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50075440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50075440&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44371606 103968540 CHEMBL156477 ZINC27707808 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50010944 Oc1c(F)c(OCC=C)c(F)c(F)c1[N+]([O-])=O InChI=1S/C9H6F3NO4/c1-2-3-17-9-5(11)4(10)7(13(15)16)8(14)6(9)12/h2,14H,1,3H2 QKWCPFMWMYQZPV-UHFFFAOYSA-N 50075442 3-Allyloxy-2,4,5-trifluoro-6-nitro-phenol::CHEMBL446427 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >200000 ChEMBL 10.1016/s0960-894x(99)00043-8 10.7270/Q28P5ZN0 10098677 Barber, AM; Hardcastle, IR; Rowlands, MG; Nutley, BP; Marriott, JH; Jarman, M Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50075442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50075442&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44371944 103968542 CHEMBL446427 ZINC27713042 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50131001 CC(C)=CCC\C(C)=C\CC\C(C)=C\COc1c(F)c(O)c(c(F)c1F)[N+]([O-])=O InChI=1S/C21H26F3NO4/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-29-21-17(23)16(22)19(25(27)28)20(26)18(21)24/h7,9,11,26H,5-6,8,10,12H2,1-4H3/b14-9+,15-11+ LBMUODAREIABHC-YFVJMOTDSA-N 50075437 2,4,5-Trifluoro-6-nitro-3-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienyloxy)-phenol::CHEMBL154890 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 6300 ChEMBL 10.1016/s0960-894x(99)00043-8 10.7270/Q28P5ZN0 10098677 Barber, AM; Hardcastle, IR; Rowlands, MG; Nutley, BP; Marriott, JH; Jarman, M Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50075437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50075437&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 9932727 103968537 CHEMBL154890 ZINC27655448 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50131002 Oc1c(F)c(OCc2ccccc2)c(F)c(F)c1[N+]([O-])=O InChI=1S/C13H8F3NO4/c14-8-9(15)13(10(16)12(18)11(8)17(19)20)21-6-7-4-2-1-3-5-7/h1-5,18H,6H2 XNWNAJGWAMWNLA-UHFFFAOYSA-N 50075439 3-Benzyloxy-2,4,5-trifluoro-6-nitro-phenol::CHEMBL156976 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >200000 ChEMBL 10.1016/s0960-894x(99)00043-8 10.7270/Q28P5ZN0 10098677 Barber, AM; Hardcastle, IR; Rowlands, MG; Nutley, BP; Marriott, JH; Jarman, M Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50075439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50075439&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44371686 103968539 CHEMBL156976 ZINC27714473 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50131008 Oc1c(F)c(OCc2ccc(cc2)-c2ccccc2)c(F)c(F)c1[N+]([O-])=O InChI=1S/C19H12F3NO4/c20-14-15(21)19(16(22)18(24)17(14)23(25)26)27-10-11-6-8-13(9-7-11)12-4-2-1-3-5-12/h1-9,24H,10H2 PQALVGXQFYKREZ-UHFFFAOYSA-N 50075438 3-(Biphenyl-4-ylmethoxy)-2,4,5-trifluoro-6-nitro-phenol::CHEMBL156501 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 200000 ChEMBL 10.1016/s0960-894x(99)00043-8 10.7270/Q28P5ZN0 10098677 Barber, AM; Hardcastle, IR; Rowlands, MG; Nutley, BP; Marriott, JH; Jarman, M Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50075438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50075438&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44371958 103968538 CHEMBL156501 ZINC27716934 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50131009 Oc1c(F)c(OCc2ccc3ccccc3c2)c(F)c(F)c1[N+]([O-])=O InChI=1S/C17H10F3NO4/c18-12-13(19)17(14(20)16(22)15(12)21(23)24)25-8-9-5-6-10-3-1-2-4-11(10)7-9/h1-7,22H,8H2 KMNWNWUDNUXKEG-UHFFFAOYSA-N 50075441 2,4,5-Trifluoro-3-(naphthalen-2-ylmethoxy)-6-nitro-phenol::CHEMBL423416 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 200000 ChEMBL 10.1016/s0960-894x(99)00043-8 10.7270/Q28P5ZN0 10098677 Barber, AM; Hardcastle, IR; Rowlands, MG; Nutley, BP; Marriott, JH; Jarman, M Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50075441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50075441&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44371673 103968541 CHEMBL423416 ZINC27657734 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50131010 CCCCCCCCCCCCOc1c(F)c(O)c(c(F)c1F)[N+]([O-])=O InChI=1S/C18H26F3NO4/c1-2-3-4-5-6-7-8-9-10-11-12-26-18-14(20)13(19)16(22(24)25)17(23)15(18)21/h23H,2-12H2,1H3 BFKRSGFDWOQSQH-UHFFFAOYSA-N 50075443 3-Dodecyloxy-2,4,5-trifluoro-6-nitro-phenol::CHEMBL346045 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >100000 ChEMBL 10.1016/s0960-894x(99)00043-8 10.7270/Q28P5ZN0 10098677 Barber, AM; Hardcastle, IR; Rowlands, MG; Nutley, BP; Marriott, JH; Jarman, M Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50075443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50075443&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44371684 103968543 CHEMBL346045 ZINC43911299 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50180954 COc1cccc(Oc2cc(Cn3ccnc3)ccc2C#N)c1OC InChI=1S/C19H17N3O3/c1-23-16-4-3-5-17(19(16)24-2)25-18-10-14(6-7-15(18)11-20)12-22-9-8-21-13-22/h3-10,13H,12H2,1-2H3 KISBCVMWQAXCRV-UHFFFAOYSA-N 50100278 2-(2,3-Dimethoxy-phenoxy)-4-imidazol-1-ylmethyl-benzonitrile::CHEMBL24888 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 14 ChEMBL 10.1016/s0960-894x(01)00162-7 10.7270/Q2FX78RS 11392531 Mactough, SC; Desolms, SJ; Shaw, AW; Abrams, MT; Ciccarone, TM; Davide, JP; Hamilton, KA; Hutchinson, JH; Koblan, KS; Kohl, NE; Lobell, RB; Robinson, RG; Graham, SL Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50100278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50100278&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 9862539 103997065 CHEMBL24888 ZINC00023675 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50180971 CCC1(CCCCN(C)C1=O)c1cccc(Oc2cc(Cn3ccnc3)ccc2C#N)c1 InChI=1S/C26H28N4O2/c1-3-26(11-4-5-13-29(2)25(26)31)22-7-6-8-23(16-22)32-24-15-20(9-10-21(24)17-27)18-30-14-12-28-19-30/h6-10,12,14-16,19H,3-5,11,13,18H2,1-2H3 KMNYYAJYASNHCC-UHFFFAOYSA-N 50100279 2-[3-(3-Ethyl-1-methyl-2-oxo-azepan-3-yl)-phenoxy]-4-imidazol-1-ylmethyl-benzonitrile::CHEMBL282499 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 4.9 ChEMBL 10.1016/s0960-894x(01)00162-7 10.7270/Q2FX78RS 11392531 Mactough, SC; Desolms, SJ; Shaw, AW; Abrams, MT; Ciccarone, TM; Davide, JP; Hamilton, KA; Hutchinson, JH; Koblan, KS; Kohl, NE; Lobell, RB; Robinson, RG; Graham, SL Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50100279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50100279&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10320387 103997066 CHEMBL282499 ZINC13523414 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50180979 Clc1ccc(Oc2cc(Cn3ccnc3)ccc2C#N)c(Cl)c1 InChI=1S/C17H11Cl2N3O/c18-14-3-4-16(15(19)8-14)23-17-7-12(1-2-13(17)9-20)10-22-6-5-21-11-22/h1-8,11H,10H2 CKUAWXYQQWMTHM-UHFFFAOYSA-N 50100305 2-(2,4-Dichloro-phenoxy)-4-imidazol-1-ylmethyl-benzonitrile::CHEMBL22319 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 260 ChEMBL 10.1016/s0960-894x(01)00162-7 10.7270/Q2FX78RS 11392531 Mactough, SC; Desolms, SJ; Shaw, AW; Abrams, MT; Ciccarone, TM; Davide, JP; Hamilton, KA; Hutchinson, JH; Koblan, KS; Kohl, NE; Lobell, RB; Robinson, RG; Graham, SL Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50100305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50100305&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 21697057 103997092 CHEMBL22319 ZINC28255003 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50475398 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NCc1cc(ccc1O)C(O)=O)C(C)C)C(O)=O InChI=1S/C27H35N3O7S/c1-16(2)23(28-15-19-14-18(26(34)35)9-10-22(19)31)25(33)30-21(13-17-7-5-4-6-8-17)24(32)29-20(27(36)37)11-12-38-3/h4-10,14,16,20-21,23,28,31H,11-13,15H2,1-3H3,(H,29,32)(H,30,33)(H,34,35)(H,36,37)/t20-,21-,23-/m0/s1 LDTMGJVEXYGWCD-FUDKSRODSA-N 50286178 3-({(S)-1-[(S)-1-((S)-1-Carboxy-3-methylsulfanyl-propylcarbamoyl)-2-phenyl-ethylcarbamoyl]-2-methyl-propylamino}-methyl)-4-hydroxy-benzoic acid; hydrochloride::CHEMBL544562 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 8500 ChEMBL 10.1016/0960-894X(95)00540-3 10.7270/Q2765F95 Kowalczyk, JJ; Ackermann, K; Garcia, AM; Lewis, MD TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50286178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50286178&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44335422 104127749 CHEMBL544562 ZINC26824795 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50475399 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NCc1cc(Br)ccc1O)C(C)C)C(O)=O InChI=1S/C26H34BrN3O5S/c1-16(2)23(28-15-18-14-19(27)9-10-22(18)31)25(33)30-21(13-17-7-5-4-6-8-17)24(32)29-20(26(34)35)11-12-36-3/h4-10,14,16,20-21,23,28,31H,11-13,15H2,1-3H3,(H,29,32)(H,30,33)(H,34,35)/t20-,21-,23-/m0/s1 LTLQCHXZWKMIIT-FUDKSRODSA-N 50286187 (S)-2-{(S)-2-[(S)-2-(5-Bromo-2-hydroxy-benzylamino)-3-methyl-butyrylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid; hydrochloride::CHEMBL542189 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 450 ChEMBL 10.1016/0960-894X(95)00540-3 10.7270/Q2765F95 Kowalczyk, JJ; Ackermann, K; Garcia, AM; Lewis, MD TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50286187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50286187&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10257630 104127758 CHEMBL542189 ZINC26826001 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50475400 COCCOCOc1ccc(cc1CN[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCSC)C(O)=O)C(F)(F)F InChI=1S/C31H42F3N3O7S/c1-20(2)27(35-18-22-17-23(31(32,33)34)10-11-26(22)44-19-43-14-13-42-3)29(39)37-25(16-21-8-6-5-7-9-21)28(38)36-24(30(40)41)12-15-45-4/h5-11,17,20,24-25,27,35H,12-16,18-19H2,1-4H3,(H,36,38)(H,37,39)(H,40,41)/t24-,25-,27-/m0/s1 WPZOZCBQIAHPDO-KLJDGLGGSA-N 50286180 (S)-2-((S)-2-{(S)-2-[2-(2-Methoxy-ethoxymethoxy)-5-trifluoromethyl-benzylamino]-3-methyl-butyrylamino}-3-phenyl-propionylamino)-4-methylsulfanyl-butyric acid; hydrochloride::CHEMBL542199 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 16000 ChEMBL 10.1016/0960-894X(95)00540-3 10.7270/Q2765F95 Kowalczyk, JJ; Ackermann, K; Garcia, AM; Lewis, MD TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50286180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50286180&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44335485 104127751 CHEMBL542199 ZINC26830829 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50475401 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NCc1cc(Cl)ccc1O)C(C)C)C(O)=O InChI=1S/C26H34ClN3O5S/c1-16(2)23(28-15-18-14-19(27)9-10-22(18)31)25(33)30-21(13-17-7-5-4-6-8-17)24(32)29-20(26(34)35)11-12-36-3/h4-10,14,16,20-21,23,28,31H,11-13,15H2,1-3H3,(H,29,32)(H,30,33)(H,34,35)/t20-,21-,23-/m0/s1 LFGFQBDNMGFGPF-FUDKSRODSA-N 50286193 (S)-2-{(S)-2-[(S)-2-(5-Chloro-2-hydroxy-benzylamino)-3-methyl-butyrylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid; hydrochloride::CHEMBL542926 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 500 ChEMBL 10.1016/0960-894X(95)00540-3 10.7270/Q2765F95 Kowalczyk, JJ; Ackermann, K; Garcia, AM; Lewis, MD TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50286193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50286193&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10459807 104127764 CHEMBL542926 ZINC26832747 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50475402 CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(=O)N[C@@H](CCSC)C(O)=O InChI=1S/C19H36N4O5S2/c1-6-11(4)15(18(26)21-13(19(27)28)7-8-30-5)23-17(25)14(10(2)3)22-16(24)12(20)9-29/h10-15,29H,6-9,20H2,1-5H3,(H,21,26)(H,22,24)(H,23,25)(H,27,28)/t11-,12-,13-,14-,15-/m0/s1 WGRDTCQSCXOTES-YTFOTSKYSA-N 50108076 (S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propionylamino)-3-methyl-butyrylamino]-3-methyl-pentanoylamino}-4-methylsulfanyl-butyric acid::2-{1-[1-(1-amino-2-sulfanylethylcarboxamido)-2-methylpropylcarboxamido]-2-methylbutylcarboxamido}-4-methylsulfanylbutanoic acid (Cys-Val-Ile-Met)::CHEMBL55423 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 250 ChEMBL 10.1016/0960-894X(95)00540-3 10.7270/Q2765F95 Kowalczyk, JJ; Ackermann, K; Garcia, AM; Lewis, MD TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50108076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50108076&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44298864 104003298 CHEMBL55423 C01960 ZINC13471826 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50475403 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NCc1ccccc1O)C(C)C)C(O)=O InChI=1S/C26H35N3O5S/c1-17(2)23(27-16-19-11-7-8-12-22(19)30)25(32)29-21(15-18-9-5-4-6-10-18)24(31)28-20(26(33)34)13-14-35-3/h4-12,17,20-21,23,27,30H,13-16H2,1-3H3,(H,28,31)(H,29,32)(H,33,34)/t20-,21-,23-/m0/s1 LERZFYOJPAUEQT-FUDKSRODSA-N 50286199 (S)-2-{(S)-2-[(S)-2-(2-Hydroxy-benzylamino)-3-methyl-butyrylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid; hydrochloride::CHEMBL542198 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 2400 ChEMBL 10.1016/0960-894X(95)00540-3 10.7270/Q2765F95 Kowalczyk, JJ; Ackermann, K; Garcia, AM; Lewis, MD TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50286199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50286199&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44335221 104127770 CHEMBL542198 ZINC26830354 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50475404 COc1ccc(O)c(CN[C@@H](C(C)C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCSC)C(O)=O)c1 InChI=1S/C27H37N3O6S/c1-17(2)24(28-16-19-15-20(36-3)10-11-23(19)31)26(33)30-22(14-18-8-6-5-7-9-18)25(32)29-21(27(34)35)12-13-37-4/h5-11,15,17,21-22,24,28,31H,12-14,16H2,1-4H3,(H,29,32)(H,30,33)(H,34,35)/t21-,22-,24-/m0/s1 JQHVXZWCTZUNIZ-FIXSFTCYSA-N 50286184 (S)-2-{(S)-2-[(S)-2-(2-Hydroxy-5-methoxy-benzylamino)-3-methyl-butyrylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid; hydrochloride::CHEMBL542437 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 3800 ChEMBL 10.1016/0960-894X(95)00540-3 10.7270/Q2765F95 Kowalczyk, JJ; Ackermann, K; Garcia, AM; Lewis, MD TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50286184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50286184&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44335426 104127755 CHEMBL542437 ZINC26824806 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50475405 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NCc1cccc(O)c1)C(C)C)C(O)=O InChI=1S/C26H35N3O5S/c1-17(2)23(27-16-19-10-7-11-20(30)14-19)25(32)29-22(15-18-8-5-4-6-9-18)24(31)28-21(26(33)34)12-13-35-3/h4-11,14,17,21-23,27,30H,12-13,15-16H2,1-3H3,(H,28,31)(H,29,32)(H,33,34)/t21-,22-,23-/m0/s1 HSNJAPHNUSYJGH-VABKMULXSA-N 50286198 (S)-2-{(S)-2-[(S)-2-(3-Hydroxy-benzylamino)-3-methyl-butyrylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid; hydrochloride::CHEMBL538768 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 13000 ChEMBL 10.1016/0960-894X(95)00540-3 10.7270/Q2765F95 Kowalczyk, JJ; Ackermann, K; Garcia, AM; Lewis, MD TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50286198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50286198&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44335235 104127769 CHEMBL538768 ZINC26832821 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50475406 COCCOCOc1ccc(Cl)cc1CN[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCSC)C(O)=O InChI=1S/C30H42ClN3O7S/c1-20(2)27(32-18-22-17-23(31)10-11-26(22)41-19-40-14-13-39-3)29(36)34-25(16-21-8-6-5-7-9-21)28(35)33-24(30(37)38)12-15-42-4/h5-11,17,20,24-25,27,32H,12-16,18-19H2,1-4H3,(H,33,35)(H,34,36)(H,37,38)/t24-,25-,27-/m0/s1 XJKQHTWPPBHIPH-KLJDGLGGSA-N 50286191 (S)-2-((S)-2-{(S)-2-[5-Chloro-2-(2-methoxy-ethoxymethoxy)-benzylamino]-3-methyl-butyrylamino}-3-phenyl-propionylamino)-4-methylsulfanyl-butyric acid; hydrochloride::CHEMBL542197 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 760 ChEMBL 10.1016/0960-894X(95)00540-3 10.7270/Q2765F95 Kowalczyk, JJ; Ackermann, K; Garcia, AM; Lewis, MD TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50286191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50286191&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10031865 104127762 CHEMBL542197 ZINC26832912 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50475407 Cl.Cl.Cl.CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC[C@@H](NCc1cc(Cl)ccc1O)C(C)C)C(O)=O InChI=1S/C26H36ClN3O4S/c1-17(2)23(28-15-19-14-20(27)9-10-24(19)31)16-29-22(13-18-7-5-4-6-8-18)25(32)30-21(26(33)34)11-12-35-3/h4-10,14,17,21-23,28-29,31H,11-13,15-16H2,1-3H3,(H,30,32)(H,33,34)/t21-,22-,23+/m0/s1 HZEHMWRXUWRPDI-RJGXRXQPSA-N 50286185 (S)-2-{(S)-2-[(S)-2-(5-Chloro-2-hydroxy-benzylamino)-3-methyl-butylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid; dihydrochloride::CHEMBL3215527::CHEMBL542691 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 2300 ChEMBL 10.1016/0960-894X(95)00540-3 10.7270/Q2765F95 Kowalczyk, JJ; Ackermann, K; Garcia, AM; Lewis, MD TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50286185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50286185&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 90664273 104127756 CHEMBL3215527CHEMBL542691 ZINC26832490 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50475408 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NCc1c(O)ccc2ccccc12)C(C)C)C(O)=O InChI=1S/C30H37N3O5S/c1-19(2)27(31-18-23-22-12-8-7-11-21(22)13-14-26(23)34)29(36)33-25(17-20-9-5-4-6-10-20)28(35)32-24(30(37)38)15-16-39-3/h4-14,19,24-25,27,31,34H,15-18H2,1-3H3,(H,32,35)(H,33,36)(H,37,38)/t24-,25-,27-/m0/s1 BTWCMQNMYBFGCK-KLJDGLGGSA-N 50286192 (S)-2-((S)-2-{(S)-2-[(2-Hydroxy-naphthalen-1-ylmethyl)-amino]-3-methyl-butyrylamino}-3-phenyl-propionylamino)-4-methylsulfanyl-butyric acid; hydrochloride::CHEMBL555296 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 6300 ChEMBL 10.1016/0960-894X(95)00540-3 10.7270/Q2765F95 Kowalczyk, JJ; Ackermann, K; Garcia, AM; Lewis, MD TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50286192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50286192&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44335478 104127763 CHEMBL555296 ZINC26832602 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50475409 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NCc1ccccc1)C(C)C)C(O)=O InChI=1S/C26H35N3O4S/c1-18(2)23(27-17-20-12-8-5-9-13-20)25(31)29-22(16-19-10-6-4-7-11-19)24(30)28-21(26(32)33)14-15-34-3/h4-13,18,21-23,27H,14-17H2,1-3H3,(H,28,30)(H,29,31)(H,32,33)/t21-,22-,23-/m0/s1 WFSFNLNGSQVRBV-VABKMULXSA-N 50286190 (S)-2-[(S)-2-((S)-2-Benzylamino-3-methyl-butyrylamino)-3-phenyl-propionylamino]-4-methylsulfanyl-butyric acid; hydrochloride::CHEMBL541067 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 21000 ChEMBL 10.1016/0960-894X(95)00540-3 10.7270/Q2765F95 Kowalczyk, JJ; Ackermann, K; Garcia, AM; Lewis, MD TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50286190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50286190&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44335249 104127761 CHEMBL541067 ZINC26831180 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50475410 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(O)=O InChI=1S/C22H34N4O5S2/c1-13(2)18(26-19(27)15(23)12-32)21(29)25-17(11-14-7-5-4-6-8-14)20(28)24-16(22(30)31)9-10-33-3/h4-8,13,15-18,32H,9-12,23H2,1-3H3,(H,24,28)(H,25,29)(H,26,27)(H,30,31)/t15-,16-,17-,18-/m0/s1 PCFMKLVXKKAJSV-XSLAGTTESA-N 13373 (2S)-2-[(2S)-2-[(2S)-2-[(2R)-2-amino-3-sulfanylpropanamido]-3-methylbutanamido]-3-phenylpropanamido]-4-(methylsulfanyl)butanoic acid::CHEMBL289302::CHEMBL553980::CVFM Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 60 ChEMBL 10.1016/0960-894X(95)00540-3 10.7270/Q2765F95 Kowalczyk, JJ; Ackermann, K; Garcia, AM; Lewis, MD TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13373&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 4369208 46513780 CHEMBL553980CHEMBL289302 C01960 ZINC03922430 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50475411 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NCc1cccc(F)c1O)C(C)C)C(O)=O InChI=1S/C26H34FN3O5S/c1-16(2)22(28-15-18-10-7-11-19(27)23(18)31)25(33)30-21(14-17-8-5-4-6-9-17)24(32)29-20(26(34)35)12-13-36-3/h4-11,16,20-22,28,31H,12-15H2,1-3H3,(H,29,32)(H,30,33)(H,34,35)/t20-,21-,22-/m0/s1 LTDNFXHFSYAUGE-FKBYEOEOSA-N 50286195 (S)-2-{(S)-2-[(S)-2-(3-Fluoro-2-hydroxy-benzylamino)-3-methyl-butyrylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid; hydrochloride::CHEMBL553358 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 2500 ChEMBL 10.1016/0960-894X(95)00540-3 10.7270/Q2765F95 Kowalczyk, JJ; Ackermann, K; Garcia, AM; Lewis, MD TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50286195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50286195&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44335476 104127766 CHEMBL553358 ZINC26832598 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50475412 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NCc1cccc(OC\C=C(/C)CC\C=C(/C)CCC=C(C)C)c1O)C(C)C)C(O)=O InChI=1S/C41H59N3O6S/c1-28(2)14-11-15-30(5)16-12-17-31(6)22-24-50-36-21-13-20-33(38(36)45)27-42-37(29(3)4)40(47)44-35(26-32-18-9-8-10-19-32)39(46)43-34(41(48)49)23-25-51-7/h8-10,13-14,16,18-22,29,34-35,37,42,45H,11-12,15,17,23-27H2,1-7H3,(H,43,46)(H,44,47)(H,48,49)/b30-16+,31-22+/t34-,35-,37-/m0/s1 FYEYFOSDWJETPK-OUVQTOMUSA-N 50286179 (S)-2-((S)-2-{(S)-2-[2-Hydroxy-3-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienyloxy)-benzylamino]-3-methyl-butyrylamino}-3-phenyl-propionylamino)-4-methylsulfanyl-butyric acid; hydrochloride::CHEMBL544567 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 70000 ChEMBL 10.1016/0960-894X(95)00540-3 10.7270/Q2765F95 Kowalczyk, JJ; Ackermann, K; Garcia, AM; Lewis, MD TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50286179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50286179&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44335460 104127750 CHEMBL544567 ZINC26826622 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50475413 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NCc1cc(O)ccc1O)C(C)C)C(O)=O InChI=1S/C26H35N3O6S/c1-16(2)23(27-15-18-14-19(30)9-10-22(18)31)25(33)29-21(13-17-7-5-4-6-8-17)24(32)28-20(26(34)35)11-12-36-3/h4-10,14,16,20-21,23,27,30-31H,11-13,15H2,1-3H3,(H,28,32)(H,29,33)(H,34,35)/t20-,21-,23-/m0/s1 MFGYLDFIJCYORJ-FUDKSRODSA-N 50286188 (S)-2-{(S)-2-[(S)-2-(2,5-Dihydroxy-benzylamino)-3-methyl-butyrylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid; hydrochloride::CHEMBL543626 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 24000 ChEMBL 10.1016/0960-894X(95)00540-3 10.7270/Q2765F95 Kowalczyk, JJ; Ackermann, K; Garcia, AM; Lewis, MD TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50286188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50286188&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44335424 104127759 CHEMBL543626 ZINC26824800 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50475414 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NCc1ccc(O)cc1)C(C)C)C(O)=O InChI=1S/C26H35N3O5S/c1-17(2)23(27-16-19-9-11-20(30)12-10-19)25(32)29-22(15-18-7-5-4-6-8-18)24(31)28-21(26(33)34)13-14-35-3/h4-12,17,21-23,27,30H,13-16H2,1-3H3,(H,28,31)(H,29,32)(H,33,34)/t21-,22-,23-/m0/s1 UQRQADCFPLBNTG-VABKMULXSA-N 50286183 (S)-2-{(S)-2-[(S)-2-(4-Hydroxy-benzylamino)-3-methyl-butyrylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid; hydrochloride::CHEMBL545039 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 17000 ChEMBL 10.1016/0960-894X(95)00540-3 10.7270/Q2765F95 Kowalczyk, JJ; Ackermann, K; Garcia, AM; Lewis, MD TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50286183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50286183&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44335224 104127754 CHEMBL545039 ZINC26829489 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50475415 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(c1ncccc1O)c1ncccc1O)C(C)C)C(O)=O InChI=1S/C30H37N5O6S/c1-18(2)24(35-27(25-22(36)11-7-14-31-25)26-23(37)12-8-15-32-26)29(39)34-21(17-19-9-5-4-6-10-19)28(38)33-20(30(40)41)13-16-42-3/h4-12,14-15,18,20-21,24,27,35-37H,13,16-17H2,1-3H3,(H,33,38)(H,34,39)(H,40,41)/t20-,21-,24-/m0/s1 SEGGQCYIUSJDOQ-HFMPRLQTSA-N 50286196 (S)-2-[(S)-2-((S)-2-{[Bis-(3-hydroxy-pyridin-2-yl)-methyl]-amino}-3-methyl-butyrylamino)-3-phenyl-propionylamino]-4-methylsulfanyl-butyric acid; trihydrochloride::CHEMBL540560 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 30000 ChEMBL 10.1016/0960-894X(95)00540-3 10.7270/Q2765F95 Kowalczyk, JJ; Ackermann, K; Garcia, AM; Lewis, MD TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50286196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50286196&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44335191 104127767 CHEMBL540560 ZINC26828821 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50475416 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NCc1cc(ccc1O)C(F)(F)F)C(C)C)C(O)=O InChI=1S/C27H34F3N3O5S/c1-16(2)23(31-15-18-14-19(27(28,29)30)9-10-22(18)34)25(36)33-21(13-17-7-5-4-6-8-17)24(35)32-20(26(37)38)11-12-39-3/h4-10,14,16,20-21,23,31,34H,11-13,15H2,1-3H3,(H,32,35)(H,33,36)(H,37,38)/t20-,21-,23-/m0/s1 IGIPEGPQBIUKSE-FUDKSRODSA-N 50286186 (S)-2-{(S)-2-[(S)-2-(2-Hydroxy-5-trifluoromethyl-benzylamino)-3-methyl-butyrylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid; hydrochloride::CHEMBL544802 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 2100 ChEMBL 10.1016/0960-894X(95)00540-3 10.7270/Q2765F95 Kowalczyk, JJ; Ackermann, K; Garcia, AM; Lewis, MD TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50286186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50286186&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44335195 104127757 CHEMBL544802 ZINC26831913 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50475417 CC(C)[C@H](NCc1cc(F)ccc1O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)=O)C(O)=O InChI=1S/C26H34FN3O6S/c1-16(2)23(28-15-18-14-19(27)9-10-22(18)31)25(33)30-21(13-17-7-5-4-6-8-17)24(32)29-20(26(34)35)11-12-37(3)36/h4-10,14,16,20-21,23,28,31H,11-13,15H2,1-3H3,(H,29,32)(H,30,33)(H,34,35)/t20-,21-,23-,37?/m0/s1 RIRXDBNYHVAVMZ-XHMBWQHOSA-N 50286197 (S)-2-{(S)-2-[(S)-2-(5-Fluoro-2-hydroxy-benzylamino)-3-methyl-butyrylamino]-3-phenyl-propionylamino}-4-methanesulfinyl-butyric acid; hydrochloride::CHEMBL553150 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 1600 ChEMBL 10.1016/0960-894X(95)00540-3 10.7270/Q2765F95 Kowalczyk, JJ; Ackermann, K; Garcia, AM; Lewis, MD TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50286197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50286197&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44335189 104127768 CHEMBL553150 ZINC26828815 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50475418 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NCc1ccccc1S)C(C)C)C(O)=O InChI=1S/C26H35N3O4S2/c1-17(2)23(27-16-19-11-7-8-12-22(19)34)25(31)29-21(15-18-9-5-4-6-10-18)24(30)28-20(26(32)33)13-14-35-3/h4-12,17,20-21,23,27,34H,13-16H2,1-3H3,(H,28,30)(H,29,31)(H,32,33)/t20-,21-,23-/m0/s1 QAWZUSUYERPCES-FUDKSRODSA-N 50286182 (S)-2-{(S)-2-[(S)-2-(2-Mercapto-benzylamino)-3-methyl-butyrylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid; hydrochloride::CHEMBL545739 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 22000 ChEMBL 10.1016/0960-894X(95)00540-3 10.7270/Q2765F95 Kowalczyk, JJ; Ackermann, K; Garcia, AM; Lewis, MD TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50286182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50286182&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44335258 104127753 CHEMBL545739 ZINC26829541 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50475419 CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCSC)C(O)=O InChI=1S/C19H36N4O6S/c1-6-11(4)15(18(27)21-13(19(28)29)7-8-30-5)23-17(26)14(10(2)3)22-16(25)12(20)9-24/h10-15,24H,6-9,20H2,1-5H3,(H,21,27)(H,22,25)(H,23,26)(H,28,29)/t11-,12-,13-,14-,15-/m0/s1 QADCUGMZMGDBPV-YTFOTSKYSA-N 50286181 (S)-2-{(S)-2-[(S)-2-((S)-2-Amino-3-hydroxy-propionylamino)-3-methyl-butyrylamino]-3-methyl-pentanoylamino}-4-methylsulfanyl-butyric acid::CHEMBL105680 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >100000 ChEMBL 10.1016/0960-894X(95)00540-3 10.7270/Q2765F95 Kowalczyk, JJ; Ackermann, K; Garcia, AM; Lewis, MD TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50286181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50286181&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44335323 104127752 CHEMBL105680 C01960 ZINC26833432 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50475420 Cl.Cl.CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NCc1ncccc1O)C(C)C)C(O)=O InChI=1S/C25H34N4O5S/c1-16(2)22(27-15-20-21(30)10-7-12-26-20)24(32)29-19(14-17-8-5-4-6-9-17)23(31)28-18(25(33)34)11-13-35-3/h4-10,12,16,18-19,22,27,30H,11,13-15H2,1-3H3,(H,28,31)(H,29,32)(H,33,34)/t18-,19-,22-/m0/s1 LREMEZRCVHQXOR-IPJJNNNSSA-N 50286194 (S)-2-((S)-2-{(S)-2-[(3-Hydroxy-pyridin-2-ylmethyl)-amino]-3-methyl-butyrylamino}-3-phenyl-propionylamino)-4-methylsulfanyl-butyric acid; dihydrochloride::CHEMBL3216642::CHEMBL541839 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 30000 ChEMBL 10.1016/0960-894X(95)00540-3 10.7270/Q2765F95 Kowalczyk, JJ; Ackermann, K; Garcia, AM; Lewis, MD TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50286194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50286194&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 90664900 104127765 CHEMBL3216642CHEMBL541839 ZINC26827432 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50182979 CN1Cc2cncn2Cc2ccc(C#N)c(Oc3ccc4cccc(N(C)C(=O)C1)c4c3)c2 InChI=1S/C26H23N5O2/c1-29-15-21-13-28-17-31(21)14-18-6-7-20(12-27)25(10-18)33-22-9-8-19-4-3-5-24(23(19)11-22)30(2)26(32)16-29/h3-11,13,17H,14-16H2,1-2H3 ICFXMOZSPFIDAS-UHFFFAOYSA-N 50101909 15,18-dimethyl-17-oxo-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide::CHEMBL53069 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 13 ChEMBL 10.1016/s0960-894x(01)00340-7 10.7270/Q2R210PG 11459639 Beshore, DC; Bell, IM; Dinsmore, CJ; Homnick, CF; Culberson, JC; Robinson, RG; Fernandes, C; Walsh, ES; Abrams, MT; Bhimnathwala, HG; Davide, JP; Ellis-Hutchings, MS; Huber, HA; Koblan, KS; Buser, CA; Kohl, NE; Lobell, RB; Chen, IW; McLoughlin, DA; Olah, TV; Graham, SL; Hartman, GD; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50101909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50101909&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 9932796 103998488 CHEMBL53069 ZINC03923909 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50182980 C[C@H]1N(Cc2ccccc2)Cc2cncn2Cc2ccc(C#N)c(Oc3ccc4cccc(NC1=O)c4c3)c2 InChI=1S/C32H27N5O2/c1-22-32(38)35-30-9-5-8-25-12-13-28(15-29(25)30)39-31-14-24(10-11-26(31)16-33)19-37-21-34-17-27(37)20-36(22)18-23-6-3-2-4-7-23/h2-15,17,21-22H,18-20H2,1H3,(H,35,38)/t22-/m1/s1 USLBJXXUUBLNQX-JOCHJYFZSA-N 50101920 15-benzyl-16-methyl-17-oxo-(16R)-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide::CHEMBL300966 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 240 ChEMBL 10.1016/s0960-894x(01)00340-7 10.7270/Q2R210PG 11459639 Beshore, DC; Bell, IM; Dinsmore, CJ; Homnick, CF; Culberson, JC; Robinson, RG; Fernandes, C; Walsh, ES; Abrams, MT; Bhimnathwala, HG; Davide, JP; Ellis-Hutchings, MS; Huber, HA; Koblan, KS; Buser, CA; Kohl, NE; Lobell, RB; Chen, IW; McLoughlin, DA; Olah, TV; Graham, SL; Hartman, GD; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50101920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50101920&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 22082995 103998499 CHEMBL300966 ZINC29481809 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50182982 CN1c2cccc3ccc(Oc4cc(Cn5cncc5CNCC1=O)ccc4C#N)cc23 InChI=1S/C25H21N5O2/c1-29-23-4-2-3-18-7-8-21(10-22(18)23)32-24-9-17(5-6-19(24)11-26)15-30-16-28-13-20(30)12-27-14-25(29)31/h2-10,13,16,27H,12,14-15H2,1H3 MIUVLTBXZYHORO-UHFFFAOYSA-N 50101913 18-methyl-17-oxo-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide::CHEMBL53183 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 55 ChEMBL 10.1016/s0960-894x(01)00340-7 10.7270/Q2R210PG 11459639 Beshore, DC; Bell, IM; Dinsmore, CJ; Homnick, CF; Culberson, JC; Robinson, RG; Fernandes, C; Walsh, ES; Abrams, MT; Bhimnathwala, HG; Davide, JP; Ellis-Hutchings, MS; Huber, HA; Koblan, KS; Buser, CA; Kohl, NE; Lobell, RB; Chen, IW; McLoughlin, DA; Olah, TV; Graham, SL; Hartman, GD; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50101913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50101913&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 18475821 103998492 CHEMBL53183 ZINC29482920 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50182989 O=C1Nc2cccc3ccc(Oc4cc(Cn5cncc5CN[C@@H]1Cc1cccs1)ccc4C#N)cc23 InChI=1S/C29H23N5O2S/c30-14-21-7-6-19-11-28(21)36-23-9-8-20-3-1-5-26(25(20)12-23)33-29(35)27(13-24-4-2-10-37-24)32-16-22-15-31-18-34(22)17-19/h1-12,15,18,27,32H,13,16-17H2,(H,33,35)/t27-/m1/s1 YUFXAWQITMCWMO-HHHXNRCGSA-N 50101918 17-oxo-16-(2-thienylmethyl)-(16R)-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide::CHEMBL52921 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 43 ChEMBL 10.1016/s0960-894x(01)00340-7 10.7270/Q2R210PG 11459639 Beshore, DC; Bell, IM; Dinsmore, CJ; Homnick, CF; Culberson, JC; Robinson, RG; Fernandes, C; Walsh, ES; Abrams, MT; Bhimnathwala, HG; Davide, JP; Ellis-Hutchings, MS; Huber, HA; Koblan, KS; Buser, CA; Kohl, NE; Lobell, RB; Chen, IW; McLoughlin, DA; Olah, TV; Graham, SL; Hartman, GD; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50101918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50101918&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44297041 103998497 CHEMBL52921 ZINC29486753 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50182993 C[C@H]1N(C)Cc2cncn2Cc2ccc(C#N)c(Oc3ccc4cccc(N(C)C1=O)c4c3)c2 InChI=1S/C27H25N5O2/c1-18-27(33)31(3)25-6-4-5-20-9-10-23(12-24(20)25)34-26-11-19(7-8-21(26)13-28)15-32-17-29-14-22(32)16-30(18)2/h4-12,14,17-18H,15-16H2,1-3H3/t18-/m1/s1 UJRNHAPUICJBGE-GOSISDBHSA-N 50101932 15,16,18-trimethyl-17-oxo-(16R)-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide::CHEMBL418268 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 15 ChEMBL 10.1016/s0960-894x(01)00340-7 10.7270/Q2R210PG 11459639 Beshore, DC; Bell, IM; Dinsmore, CJ; Homnick, CF; Culberson, JC; Robinson, RG; Fernandes, C; Walsh, ES; Abrams, MT; Bhimnathwala, HG; Davide, JP; Ellis-Hutchings, MS; Huber, HA; Koblan, KS; Buser, CA; Kohl, NE; Lobell, RB; Chen, IW; McLoughlin, DA; Olah, TV; Graham, SL; Hartman, GD; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50101932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50101932&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 9803863 103998511 CHEMBL418268 ZINC29486369 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50184660 O=C1Cc2cncn2Cc2ccc(C#N)c(Oc3ccc4cccc(C(=O)NCCN1)c4c3)c2 InChI=1S/C26H21N5O3/c27-13-19-5-4-17-10-24(19)34-21-7-6-18-2-1-3-22(23(18)12-21)26(33)30-9-8-29-25(32)11-20-14-28-16-31(20)15-17/h1-7,10,12,14,16H,8-9,11,15H2,(H,29,32)(H,30,33) XOFBXIHLMNJMOE-UHFFFAOYSA-N 50101910 15,20-dioxo-2-oxa-9,11,16,19-tetraazapentacyclo[19.6.2.13,7.09,13.025,29]triaconta-1(28),3,5,7(30),10,12,21(29),22,24,26-decaen-4-yl cyanide::CHEMBL300206 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 409 ChEMBL 10.1016/s0960-894x(01)00340-7 10.7270/Q2R210PG 11459639 Beshore, DC; Bell, IM; Dinsmore, CJ; Homnick, CF; Culberson, JC; Robinson, RG; Fernandes, C; Walsh, ES; Abrams, MT; Bhimnathwala, HG; Davide, JP; Ellis-Hutchings, MS; Huber, HA; Koblan, KS; Buser, CA; Kohl, NE; Lobell, RB; Chen, IW; McLoughlin, DA; Olah, TV; Graham, SL; Hartman, GD; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50101910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50101910&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 18475867 103998489 CHEMBL300206 ZINC29487999 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50184662 O=C1NCCNCc2cncn2Cc2ccc(C#N)c(Oc3ccc4cccc1c4c3)c2 InChI=1S/C25H21N5O2/c26-12-19-5-4-17-10-24(19)32-21-7-6-18-2-1-3-22(23(18)11-21)25(31)29-9-8-27-13-20-14-28-16-30(20)15-17/h1-7,10-11,14,16,27H,8-9,13,15H2,(H,29,31) LUQBIRLUHCYXQM-UHFFFAOYSA-N 50101912 19-oxo-2-oxa-9,11,15,18-tetraazapentacyclo[18.6.2.13,7.09,13.024,28]nonacosa-1(27),3,5,7(29),10,12,20(28),21,23,25-decaen-4-yl cyanide::CHEMBL54212 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 7.1 ChEMBL 10.1016/s0960-894x(01)00340-7 10.7270/Q2R210PG 11459639 Beshore, DC; Bell, IM; Dinsmore, CJ; Homnick, CF; Culberson, JC; Robinson, RG; Fernandes, C; Walsh, ES; Abrams, MT; Bhimnathwala, HG; Davide, JP; Ellis-Hutchings, MS; Huber, HA; Koblan, KS; Buser, CA; Kohl, NE; Lobell, RB; Chen, IW; McLoughlin, DA; Olah, TV; Graham, SL; Hartman, GD; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50101912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50101912&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 9866971 103998491 CHEMBL54212 ZINC03923910 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50184665 C[C@H]1NCc2cncn2Cc2ccc(C#N)c(Oc3ccc4cccc(N(C)C1=O)c4c3)c2 InChI=1S/C26H23N5O2/c1-17-26(32)30(2)24-5-3-4-19-8-9-22(11-23(19)24)33-25-10-18(6-7-20(25)12-27)15-31-16-28-13-21(31)14-29-17/h3-11,13,16-17,29H,14-15H2,1-2H3/t17-/m1/s1 SGTLQNSIWNWVHS-QGZVFWFLSA-N 50101927 16,18-dimethyl-17-oxo-(16R)-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide::CHEMBL54043 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 17 ChEMBL 10.1016/s0960-894x(01)00340-7 10.7270/Q2R210PG 11459639 Beshore, DC; Bell, IM; Dinsmore, CJ; Homnick, CF; Culberson, JC; Robinson, RG; Fernandes, C; Walsh, ES; Abrams, MT; Bhimnathwala, HG; Davide, JP; Ellis-Hutchings, MS; Huber, HA; Koblan, KS; Buser, CA; Kohl, NE; Lobell, RB; Chen, IW; McLoughlin, DA; Olah, TV; Graham, SL; Hartman, GD; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50101927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50101927&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 22082992 103998506 CHEMBL54043 ZINC29484636 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50184666 O=C1Nc2cccc3ccc(Oc4cc(Cn5cncc5CN[C@@H]1Cc1ccccc1)ccc4C#N)cc23 InChI=1S/C31H25N5O2/c32-16-24-10-9-22-14-30(24)38-26-12-11-23-7-4-8-28(27(23)15-26)35-31(37)29(13-21-5-2-1-3-6-21)34-18-25-17-33-20-36(25)19-22/h1-12,14-15,17,20,29,34H,13,18-19H2,(H,35,37)/t29-/m1/s1 LONOBJYLFFURAI-GDLZYMKVSA-N 50101925 16-benzyl-17-oxo-(16R)-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide::CHEMBL299568 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 17 ChEMBL 10.1016/s0960-894x(01)00340-7 10.7270/Q2R210PG 11459639 Beshore, DC; Bell, IM; Dinsmore, CJ; Homnick, CF; Culberson, JC; Robinson, RG; Fernandes, C; Walsh, ES; Abrams, MT; Bhimnathwala, HG; Davide, JP; Ellis-Hutchings, MS; Huber, HA; Koblan, KS; Buser, CA; Kohl, NE; Lobell, RB; Chen, IW; McLoughlin, DA; Olah, TV; Graham, SL; Hartman, GD; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50101925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50101925&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 9892151 103998504 CHEMBL299568 ZINC37865537 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50184668 CC[C@H]1NCc2cncn2Cc2ccc(C#N)c(Oc3ccc4cccc(NC1=O)c4c3)c2 InChI=1S/C26H23N5O2/c1-2-23-26(32)30-24-5-3-4-18-8-9-21(11-22(18)24)33-25-10-17(6-7-19(25)12-27)15-31-16-28-13-20(31)14-29-23/h3-11,13,16,23,29H,2,14-15H2,1H3,(H,30,32)/t23-/m1/s1 YCUWEXRMZLDWND-HSZRJFAPSA-N 50101923 16-ethyl-17-oxo-(16R)-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide::CHEMBL423303 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 410 ChEMBL 10.1016/s0960-894x(01)00340-7 10.7270/Q2R210PG 11459639 Beshore, DC; Bell, IM; Dinsmore, CJ; Homnick, CF; Culberson, JC; Robinson, RG; Fernandes, C; Walsh, ES; Abrams, MT; Bhimnathwala, HG; Davide, JP; Ellis-Hutchings, MS; Huber, HA; Koblan, KS; Buser, CA; Kohl, NE; Lobell, RB; Chen, IW; McLoughlin, DA; Olah, TV; Graham, SL; Hartman, GD; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50101923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50101923&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44297038 103998502 CHEMBL423303 ZINC29486409 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50184669 O=C1NCCCNCc2cncn2Cc2ccc(C#N)c(Oc3ccc4cccc1c4c3)c2 InChI=1S/C26H23N5O2/c27-13-20-6-5-18-11-25(20)33-22-8-7-19-3-1-4-23(24(19)12-22)26(32)30-10-2-9-28-14-21-15-29-17-31(21)16-18/h1,3-8,11-12,15,17,28H,2,9-10,14,16H2,(H,30,32) AFXXVFSLJYLSOC-UHFFFAOYSA-N 50101917 20-oxo-2-oxa-9,11,15,19-tetraazapentacyclo[19.6.2.13,7.09,13.025,29]triaconta-1(28),3,5,7(30),10,12,21(29),22,24,26-decaen-4-yl cyanide::CHEMBL53037 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 99 ChEMBL 10.1016/s0960-894x(01)00340-7 10.7270/Q2R210PG 11459639 Beshore, DC; Bell, IM; Dinsmore, CJ; Homnick, CF; Culberson, JC; Robinson, RG; Fernandes, C; Walsh, ES; Abrams, MT; Bhimnathwala, HG; Davide, JP; Ellis-Hutchings, MS; Huber, HA; Koblan, KS; Buser, CA; Kohl, NE; Lobell, RB; Chen, IW; McLoughlin, DA; Olah, TV; Graham, SL; Hartman, GD; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50101917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50101917&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44297001 103998496 CHEMBL53037 ZINC29486891 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50184671 CN1Cc2cncn2Cc2ccc(C#N)c(Oc3ccc4cccc(NC(=O)C1)c4c3)c2 InChI=1S/C25H21N5O2/c1-29-14-20-12-27-16-30(20)13-17-5-6-19(11-26)24(9-17)32-21-8-7-18-3-2-4-23(22(18)10-21)28-25(31)15-29/h2-10,12,16H,13-15H2,1H3,(H,28,31) KDJOWKLMGPUQBA-UHFFFAOYSA-N 50101914 15-methyl-17-oxo-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide::CHEMBL301491 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 196 ChEMBL 10.1016/s0960-894x(01)00340-7 10.7270/Q2R210PG 11459639 Beshore, DC; Bell, IM; Dinsmore, CJ; Homnick, CF; Culberson, JC; Robinson, RG; Fernandes, C; Walsh, ES; Abrams, MT; Bhimnathwala, HG; Davide, JP; Ellis-Hutchings, MS; Huber, HA; Koblan, KS; Buser, CA; Kohl, NE; Lobell, RB; Chen, IW; McLoughlin, DA; Olah, TV; Graham, SL; Hartman, GD; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50101914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50101914&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 18475830 103998493 CHEMBL301491 ZINC29488072 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50184672 C[C@H]1N(C)Cc2cncn2Cc2ccc(C#N)c(Oc3ccc4cccc(NC1=O)c4c3)c2 InChI=1S/C26H23N5O2/c1-17-26(32)29-24-5-3-4-19-8-9-22(11-23(19)24)33-25-10-18(6-7-20(25)12-27)14-31-16-28-13-21(31)15-30(17)2/h3-11,13,16-17H,14-15H2,1-2H3,(H,29,32)/t17-/m1/s1 BAQAZCQBLRUMRU-QGZVFWFLSA-N 50101931 15,16-dimethyl-17-oxo-(16R)-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide::CHEMBL54969 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >100 ChEMBL 10.1016/s0960-894x(01)00340-7 10.7270/Q2R210PG 11459639 Beshore, DC; Bell, IM; Dinsmore, CJ; Homnick, CF; Culberson, JC; Robinson, RG; Fernandes, C; Walsh, ES; Abrams, MT; Bhimnathwala, HG; Davide, JP; Ellis-Hutchings, MS; Huber, HA; Koblan, KS; Buser, CA; Kohl, NE; Lobell, RB; Chen, IW; McLoughlin, DA; Olah, TV; Graham, SL; Hartman, GD; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50101931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50101931&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44296947 103998510 CHEMBL54969 ZINC29488708 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50184674 C[C@@H]1NCc2cncn2Cc2ccc(C#N)c(Oc3ccc4cccc(NC1=O)c4c3)c2 InChI=1S/C25H21N5O2/c1-16-25(31)29-23-4-2-3-18-7-8-21(10-22(18)23)32-24-9-17(5-6-19(24)11-26)14-30-15-27-12-20(30)13-28-16/h2-10,12,15-16,28H,13-14H2,1H3,(H,29,31)/t16-/m0/s1 AHPUIZQTTZGXBJ-INIZCTEOSA-N 50101930 16-methyl-17-oxo-(16S)-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide::CHEMBL298337 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 248 ChEMBL 10.1016/s0960-894x(01)00340-7 10.7270/Q2R210PG 11459639 Beshore, DC; Bell, IM; Dinsmore, CJ; Homnick, CF; Culberson, JC; Robinson, RG; Fernandes, C; Walsh, ES; Abrams, MT; Bhimnathwala, HG; Davide, JP; Ellis-Hutchings, MS; Huber, HA; Koblan, KS; Buser, CA; Kohl, NE; Lobell, RB; Chen, IW; McLoughlin, DA; Olah, TV; Graham, SL; Hartman, GD; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50101930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50101930&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 9910183 103998509 CHEMBL298337 ZINC29487696 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50184675 O=C1Nc2cccc3ccc(Oc4cc(Cn5cncc5CN(Cc5ccccc5)[C@@H]1Cc1ccccc1)ccc4C#N)cc23 InChI=1S/C38H31N5O2/c39-21-31-15-14-29-19-37(31)45-33-17-16-30-12-7-13-35(34(30)20-33)41-38(44)36(18-27-8-3-1-4-9-27)42(23-28-10-5-2-6-11-28)25-32-22-40-26-43(32)24-29/h1-17,19-20,22,26,36H,18,23-25H2,(H,41,44)/t36-/m1/s1 QIQWUVXAQGNSCR-PSXMRANNSA-N 50101919 15,16-dibenzyl-17-oxo-(16R)-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide::CHEMBL299621 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 574 ChEMBL 10.1016/s0960-894x(01)00340-7 10.7270/Q2R210PG 11459639 Beshore, DC; Bell, IM; Dinsmore, CJ; Homnick, CF; Culberson, JC; Robinson, RG; Fernandes, C; Walsh, ES; Abrams, MT; Bhimnathwala, HG; Davide, JP; Ellis-Hutchings, MS; Huber, HA; Koblan, KS; Buser, CA; Kohl, NE; Lobell, RB; Chen, IW; McLoughlin, DA; Olah, TV; Graham, SL; Hartman, GD; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50101919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50101919&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 22083000 103998498 CHEMBL299621 ZINC29488408 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50184676 C[C@H]1NC(=O)Cc2cncn2Cc2ccc(C#N)c(Oc3ccc4cccc(NC1=O)c4c3)c2 InChI=1S/C26H21N5O3/c1-16-26(33)30-23-4-2-3-18-7-8-21(11-22(18)23)34-24-9-17(5-6-19(24)12-27)14-31-15-28-13-20(31)10-25(32)29-16/h2-9,11,13,15-16H,10,14H2,1H3,(H,29,32)(H,30,33)/t16-/m1/s1 RZBRPHGLFWWUEG-MRXNPFEDSA-N 50101915 17-methyl-15,18-dioxo-(17R)-2-oxa-9,11,16,19-tetraazapentacyclo[18.6.2.13,7.09,13.024,28]nonacosa-1(27),3,5,7(29),10,12,20(28),21,23,25-decaen-4-yl cyanide::CHEMBL53154 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 258 ChEMBL 10.1016/s0960-894x(01)00340-7 10.7270/Q2R210PG 11459639 Beshore, DC; Bell, IM; Dinsmore, CJ; Homnick, CF; Culberson, JC; Robinson, RG; Fernandes, C; Walsh, ES; Abrams, MT; Bhimnathwala, HG; Davide, JP; Ellis-Hutchings, MS; Huber, HA; Koblan, KS; Buser, CA; Kohl, NE; Lobell, RB; Chen, IW; McLoughlin, DA; Olah, TV; Graham, SL; Hartman, GD; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50101915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50101915&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 22082994 103998494 CHEMBL53154 ZINC29487396 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50184681 CN1c2cccc3ccc(Oc4cc(Cn5cncc5CC(=O)NCC1=O)ccc4C#N)cc23 InChI=1S/C26H21N5O3/c1-30-23-4-2-3-18-7-8-21(11-22(18)23)34-24-9-17(5-6-19(24)12-27)15-31-16-28-13-20(31)10-25(32)29-14-26(30)33/h2-9,11,13,16H,10,14-15H2,1H3,(H,29,32) QJAYXHNDUQQSPN-UHFFFAOYSA-N 50101921 19-methyl-15,18-dioxo-2-oxa-9,11,16,19-tetraazapentacyclo[18.6.2.13,7.09,13.024,28]nonacosa-1(27),3,5,7(29),10,12,20(28),21,23,25-decaen-4-yl cyanide::CHEMBL50857 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 65 ChEMBL 10.1016/s0960-894x(01)00340-7 10.7270/Q2R210PG 11459639 Beshore, DC; Bell, IM; Dinsmore, CJ; Homnick, CF; Culberson, JC; Robinson, RG; Fernandes, C; Walsh, ES; Abrams, MT; Bhimnathwala, HG; Davide, JP; Ellis-Hutchings, MS; Huber, HA; Koblan, KS; Buser, CA; Kohl, NE; Lobell, RB; Chen, IW; McLoughlin, DA; Olah, TV; Graham, SL; Hartman, GD; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50101921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50101921&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44296753 103998500 CHEMBL50857 ZINC29476213 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50184684 CN1Cc2cncn2Cc2ccc(C#N)c(Oc3ccc4cccc(NC(=O)[C@H]1Cc1ccccc1)c4c3)c2 InChI=1S/C32H27N5O2/c1-36-20-26-18-34-21-37(26)19-23-10-11-25(17-33)31(15-23)39-27-13-12-24-8-5-9-29(28(24)16-27)35-32(38)30(36)14-22-6-3-2-4-7-22/h2-13,15-16,18,21,30H,14,19-20H2,1H3,(H,35,38)/t30-/m1/s1 BYAJXJYFHAJINJ-SSEXGKCCSA-N 50101922 16-benzyl-15-methyl-17-oxo-(16R)-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide::CHEMBL53862 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 184 ChEMBL 10.1016/s0960-894x(01)00340-7 10.7270/Q2R210PG 11459639 Beshore, DC; Bell, IM; Dinsmore, CJ; Homnick, CF; Culberson, JC; Robinson, RG; Fernandes, C; Walsh, ES; Abrams, MT; Bhimnathwala, HG; Davide, JP; Ellis-Hutchings, MS; Huber, HA; Koblan, KS; Buser, CA; Kohl, NE; Lobell, RB; Chen, IW; McLoughlin, DA; Olah, TV; Graham, SL; Hartman, GD; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50101922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50101922&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44296940 103998501 CHEMBL53862 ZINC29484232 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50184689 O=C1CNCc2cncn2Cc2ccc(C#N)c(Oc3ccc4cccc(N1)c4c3)c2 InChI=1S/C24H19N5O2/c25-10-18-5-4-16-8-23(18)31-20-7-6-17-2-1-3-22(21(17)9-20)28-24(30)13-26-11-19-12-27-15-29(19)14-16/h1-9,12,15,26H,11,13-14H2,(H,28,30) CYBHYVCTXZJLET-UHFFFAOYSA-N 50101926 17-oxo-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide::CHEMBL52975 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 37 ChEMBL 10.1016/s0960-894x(01)00340-7 10.7270/Q2R210PG 11459639 Beshore, DC; Bell, IM; Dinsmore, CJ; Homnick, CF; Culberson, JC; Robinson, RG; Fernandes, C; Walsh, ES; Abrams, MT; Bhimnathwala, HG; Davide, JP; Ellis-Hutchings, MS; Huber, HA; Koblan, KS; Buser, CA; Kohl, NE; Lobell, RB; Chen, IW; McLoughlin, DA; Olah, TV; Graham, SL; Hartman, GD; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50101926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50101926&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 9844383 103998505 CHEMBL52975 ZINC29488252 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50184690 O=C1CN(Cc2ccccc2)Cc2cncn2Cc2ccc(C#N)c(Oc3ccc4cccc(N1)c4c3)c2 InChI=1S/C31H25N5O2/c32-15-25-10-9-23-13-30(25)38-27-12-11-24-7-4-8-29(28(24)14-27)34-31(37)20-35(17-22-5-2-1-3-6-22)19-26-16-33-21-36(26)18-23/h1-14,16,21H,17-20H2,(H,34,37) AIFZYTDMYQYJMV-UHFFFAOYSA-N 50101924 15-benzyl-17-oxo-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide::CHEMBL298392 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 30 ChEMBL 10.1016/s0960-894x(01)00340-7 10.7270/Q2R210PG 11459639 Beshore, DC; Bell, IM; Dinsmore, CJ; Homnick, CF; Culberson, JC; Robinson, RG; Fernandes, C; Walsh, ES; Abrams, MT; Bhimnathwala, HG; Davide, JP; Ellis-Hutchings, MS; Huber, HA; Koblan, KS; Buser, CA; Kohl, NE; Lobell, RB; Chen, IW; McLoughlin, DA; Olah, TV; Graham, SL; Hartman, GD; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50101924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50101924&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 9848802 103998503 CHEMBL298392 ZINC29485879 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50184692 O=C1Nc2cccc3ccc(Oc4cc(Cn5cncc5CN[C@@H]1Cc1cccnc1)ccc4C#N)cc23 InChI=1S/C30H24N6O2/c31-14-23-7-6-21-12-29(23)38-25-9-8-22-4-1-5-27(26(22)13-25)35-30(37)28(11-20-3-2-10-32-15-20)34-17-24-16-33-19-36(24)18-21/h1-10,12-13,15-16,19,28,34H,11,17-18H2,(H,35,37)/t28-/m1/s1 IDVLFUHLBYSGQS-MUUNZHRXSA-N 50101916 17-oxo-16-(3-pyridylmethyl)-(16R)-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide::CHEMBL52859 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 1310 ChEMBL 10.1016/s0960-894x(01)00340-7 10.7270/Q2R210PG 11459639 Beshore, DC; Bell, IM; Dinsmore, CJ; Homnick, CF; Culberson, JC; Robinson, RG; Fernandes, C; Walsh, ES; Abrams, MT; Bhimnathwala, HG; Davide, JP; Ellis-Hutchings, MS; Huber, HA; Koblan, KS; Buser, CA; Kohl, NE; Lobell, RB; Chen, IW; McLoughlin, DA; Olah, TV; Graham, SL; Hartman, GD; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50101916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50101916&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 22082993 103998495 CHEMBL52859 ZINC29484244 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50184693 C[C@H]1NCc2cncn2Cc2ccc(C#N)c(Oc3ccc4cccc(NC1=O)c4c3)c2 InChI=1S/C25H21N5O2/c1-16-25(31)29-23-4-2-3-18-7-8-21(10-22(18)23)32-24-9-17(5-6-19(24)11-26)14-30-15-27-12-20(30)13-28-16/h2-10,12,15-16,28H,13-14H2,1H3,(H,29,31)/t16-/m1/s1 AHPUIZQTTZGXBJ-MRXNPFEDSA-N 50101911 16-methyl-17-oxo-(16R)-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide::CHEMBL298895 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 23 ChEMBL 10.1016/s0960-894x(01)00340-7 10.7270/Q2R210PG 11459639 Beshore, DC; Bell, IM; Dinsmore, CJ; Homnick, CF; Culberson, JC; Robinson, RG; Fernandes, C; Walsh, ES; Abrams, MT; Bhimnathwala, HG; Davide, JP; Ellis-Hutchings, MS; Huber, HA; Koblan, KS; Buser, CA; Kohl, NE; Lobell, RB; Chen, IW; McLoughlin, DA; Olah, TV; Graham, SL; Hartman, GD; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50101911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50101911&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 9932066 103998490 CHEMBL298895 ZINC29488250 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50184697 O=C1Cc2cncn2Cc2ccc(C#N)c(Oc3ccc4cccc(NC(=O)[C@@H](Cc5ccccc5)N1)c4c3)c2 InChI=1S/C32H25N5O3/c33-17-24-10-9-22-14-30(24)40-26-12-11-23-7-4-8-28(27(23)16-26)36-32(39)29(13-21-5-2-1-3-6-21)35-31(38)15-25-18-34-20-37(25)19-22/h1-12,14,16,18,20,29H,13,15,19H2,(H,35,38)(H,36,39)/t29-/m1/s1 QGCNWBQUPNGUPL-GDLZYMKVSA-N 50101928 17-benzyl-15,18-dioxo-(17R)-2-oxa-9,11,16,19-tetraazapentacyclo[18.6.2.13,7.09,13.024,28]nonacosa-1(27),3,5,7(29),10,12,20(28),21,23,25-decaen-4-yl cyanide::CHEMBL52610 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 310 ChEMBL 10.1016/s0960-894x(01)00340-7 10.7270/Q2R210PG 11459639 Beshore, DC; Bell, IM; Dinsmore, CJ; Homnick, CF; Culberson, JC; Robinson, RG; Fernandes, C; Walsh, ES; Abrams, MT; Bhimnathwala, HG; Davide, JP; Ellis-Hutchings, MS; Huber, HA; Koblan, KS; Buser, CA; Kohl, NE; Lobell, RB; Chen, IW; McLoughlin, DA; Olah, TV; Graham, SL; Hartman, GD; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50101928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50101928&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 15967429 103998507 CHEMBL52610 ZINC29487409 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50184724 O=C1CNC(=O)Cc2cncn2Cc2ccc(C#N)c(Oc3ccc4cccc(N1)c4c3)c2 InChI=1S/C25H19N5O3/c26-11-18-5-4-16-8-23(18)33-20-7-6-17-2-1-3-22(21(17)10-20)29-25(32)13-28-24(31)9-19-12-27-15-30(19)14-16/h1-8,10,12,15H,9,13-14H2,(H,28,31)(H,29,32) DWFPFAQHVZRKBX-UHFFFAOYSA-N 50101908 15,18-dioxo-2-oxa-9,11,16,19-tetraazapentacyclo[18.6.2.13,7.09,13.024,28]nonacosa-1(27),3,5,7(29),10,12,20(28),21,23,25-decaen-4-yl cyanide::CHEMBL53811 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 67 ChEMBL 10.1016/s0960-894x(01)00340-7 10.7270/Q2R210PG 11459639 Beshore, DC; Bell, IM; Dinsmore, CJ; Homnick, CF; Culberson, JC; Robinson, RG; Fernandes, C; Walsh, ES; Abrams, MT; Bhimnathwala, HG; Davide, JP; Ellis-Hutchings, MS; Huber, HA; Koblan, KS; Buser, CA; Kohl, NE; Lobell, RB; Chen, IW; McLoughlin, DA; Olah, TV; Graham, SL; Hartman, GD; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50101908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50101908&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44296772 103998487 CHEMBL53811 ZINC29483847 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50471195 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(O)=O InChI=1S/C23H36N4O5S/c1-4-5-11-17(23(31)32)25-21(29)18(12-15-9-7-6-8-10-15)26-22(30)19(14(2)3)27-20(28)16(24)13-33/h6-10,14,16-19,33H,4-5,11-13,24H2,1-3H3,(H,25,29)(H,26,30)(H,27,28)(H,31,32)/t16-,17-,18-,19-/m0/s1 NHDVOTPEQDOTMB-VJANTYMQSA-N 50058205 (S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propionylamino)-3-methyl-butyrylamino]-3-phenyl-propionylamino}-hexanoic acid::CHEMBL49942 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 950 ChEMBL 10.1016/S0960-894X(01)80257-2 10.7270/Q2N58MB6 Leftheris, K; Kline, T; Natarajan, S; DeVirgilio, MK; Cho, YH; Pluscec, J; Ricca, C; Robinson, S; Seizinger, BR; Manne, V; Meyers, CA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50058205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50058205&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44294959 103954182 CHEMBL49942 C01960 ZINC13762268 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50471199 CSCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(O)=O InChI=1S/C22H34N4O5S2/c1-13(2)18(26-19(27)15(23)12-32)21(29)25-17(11-14-7-5-4-6-8-14)20(28)24-16(22(30)31)9-10-33-3/h4-8,13,15-18,32H,9-12,23H2,1-3H3,(H,24,28)(H,25,29)(H,26,27)(H,30,31)/t15-,16-,17+,18-/m0/s1 PCFMKLVXKKAJSV-FJIDUMEYSA-N 50048965 (S)-2-{(R)-2-[(S)-2-((R)-2-Amino-3-mercapto-propionylamino)-3-methyl-butyrylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid::CHEMBL78855 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 5200 ChEMBL 10.1016/S0960-894X(01)80257-2 10.7270/Q2N58MB6 Leftheris, K; Kline, T; Natarajan, S; DeVirgilio, MK; Cho, YH; Pluscec, J; Ricca, C; Robinson, S; Seizinger, BR; Manne, V; Meyers, CA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048965&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44315577 103979346 CHEMBL78855 C01960 ZINC03922113 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50471203 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCS)C(C)C)C(O)=O InChI=1S/C23H36N4O5S2/c1-14(2)19(27-20(28)16(24)9-11-33)22(30)26-18(13-15-7-5-4-6-8-15)21(29)25-17(23(31)32)10-12-34-3/h4-8,14,16-19,33H,9-13,24H2,1-3H3,(H,25,29)(H,26,30)(H,27,28)(H,31,32)/t16-,17-,18-,19-/m0/s1 DNNUOYRZIKPEOD-VJANTYMQSA-N 50284175 (S)-2-{(S)-2-[(S)-2-((S)-2-Amino-4-mercapto-butyrylamino)-3-methyl-butyrylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid::CHEMBL354044 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 2700 ChEMBL 10.1016/S0960-894X(01)80257-2 10.7270/Q2N58MB6 Leftheris, K; Kline, T; Natarajan, S; DeVirgilio, MK; Cho, YH; Pluscec, J; Ricca, C; Robinson, S; Seizinger, BR; Manne, V; Meyers, CA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50284175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50284175&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44382579 104125832 CHEMBL354044 C01960 ZINC28001571 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50563307 CSCC[C@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@H](NC(=O)[C@H](S)NC(=O)[C@@H](N)CCCCN)C(C)C)C(O)=O InChI=1S/C28H44N6O6S2/c1-16(2)22(32-25(37)26(41)33-23(35)19(30)10-6-7-12-29)27(38)34-15-18-9-5-4-8-17(18)14-21(34)24(36)31-20(28(39)40)11-13-42-3/h4-5,8-9,16,19-22,26,41H,6-7,10-15,29-30H2,1-3H3,(H,31,36)(H,32,37)(H,33,35)(H,39,40)/t19-,20-,21-,22+,26-/m0/s1 AFEXYTZJFRSLAP-NNIVGBBESA-N 50403477 CHEMBL2115025 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 15000 ChEMBL 10.1016/0960-894X(95)00314-J 10.7270/Q2H41RDH Clerc, FF; Guitton, JD; Fromage, N; Lelièvre, Y; Duchesne, M; Tocqué, B; James-Surcouf, E; Commerçon, A; Becquart, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50403477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50403477&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 71461707 163352501 CHEMBL2115025 C01525 ZINC95544063 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50003410 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(O)=O InChI=1S/C24H35N5O5S2/c1-13(2)20(29-21(30)16(25)12-35)23(32)28-19(22(31)27-18(24(33)34)8-9-36-3)10-14-11-26-17-7-5-4-6-15(14)17/h4-7,11,13,16,18-20,26,35H,8-10,12,25H2,1-3H3,(H,27,31)(H,28,32)(H,29,30)(H,33,34)/t16-,18-,19-,20-/m0/s1 DLENGCQIPYCORN-LEAZDLGRSA-N 50083587 (S)-2-[(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propionylamino)-3-methyl-butyrylamino]-3-(1H-indol-3-yl)-propionylamino]-4-methylsulfanyl-butyric acid::2-[1-[1-[1-amino-2-sulfanyl-(1R)-ethylcarboxamido]-2-methyl-(1S)-propylcarboxamido]-2-(1H-3-indolyl)-(1S)-ethylcarboxamido]-4-methylsulfanyl-(2S)-butanoic acid::CHEMBL326131 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 14 ChEMBL 10.1016/S0960-894X(01)80257-2 10.7270/Q2N58MB6 Leftheris, K; Kline, T; Natarajan, S; DeVirgilio, MK; Cho, YH; Pluscec, J; Ricca, C; Robinson, S; Seizinger, BR; Manne, V; Meyers, CA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50083587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50083587&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44340658 103983243 CHEMBL326131 C01960 ZINC26979087 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50471178 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@@H](N)CS)C(O)=O InChI=1S/C20H30N4O5S2/c1-12(22-18(26)14(21)11-30)17(25)24-16(10-13-6-4-3-5-7-13)19(27)23-15(20(28)29)8-9-31-2/h3-7,12,14-16,30H,8-11,21H2,1-2H3,(H,22,26)(H,23,27)(H,24,25)(H,28,29)/t12-,14-,15-,16-/m0/s1 YPNCJPGNWINZII-TUUVXOQKSA-N 50284178 (S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propionylamino)-propionylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid::CHEMBL367733 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 241 ChEMBL 10.1016/S0960-894X(01)80257-2 10.7270/Q2N58MB6 Leftheris, K; Kline, T; Natarajan, S; DeVirgilio, MK; Cho, YH; Pluscec, J; Ricca, C; Robinson, S; Seizinger, BR; Manne, V; Meyers, CA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50284178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50284178&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44382581 104125835 CHEMBL367733 C01960 ZINC27999435 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50471179 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(O)=O InChI=1S/C23H34N4O7S/c1-13(2)19(27-20(30)15(24)12-18(28)29)22(32)26-17(11-14-7-5-4-6-8-14)21(31)25-16(23(33)34)9-10-35-3/h4-8,13,15-17,19H,9-12,24H2,1-3H3,(H,25,31)(H,26,32)(H,27,30)(H,28,29)(H,33,34)/t15-,16-,17-,19-/m0/s1 HQYJMUQRGBSBEM-DWRORGKVSA-N 50284180 (S)-3-Amino-N-{(S)-1-[(S)-1-((S)-1-carboxy-3-methylsulfanyl-propylcarbamoyl)-2-phenyl-ethylcarbamoyl]-2-methyl-propyl}-succinamic acid::CHEMBL172335 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 250000 ChEMBL 10.1016/S0960-894X(01)80257-2 10.7270/Q2N58MB6 Leftheris, K; Kline, T; Natarajan, S; DeVirgilio, MK; Cho, YH; Pluscec, J; Ricca, C; Robinson, S; Seizinger, BR; Manne, V; Meyers, CA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50284180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50284180&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10029331 104125837 CHEMBL172335 C01960 ZINC27991497 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50471180 CSCC[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(O)=O InChI=1S/C23H36N4O5S2/c1-14(2)19(27-20(28)16(24)13-33)22(30)25-17(10-9-15-7-5-4-6-8-15)21(29)26-18(23(31)32)11-12-34-3/h4-8,14,16-19,33H,9-13,24H2,1-3H3,(H,25,30)(H,26,29)(H,27,28)(H,31,32)/t16-,17-,18-,19-/m0/s1 IPYSKETZGLSXSZ-VJANTYMQSA-N 50284177 (S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propionylamino)-3-methyl-butyrylamino]-4-phenyl-butyrylamino}-4-methylsulfanyl-butyric acid::CHEMBL171783 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 120 ChEMBL 10.1016/S0960-894X(01)80257-2 10.7270/Q2N58MB6 Leftheris, K; Kline, T; Natarajan, S; DeVirgilio, MK; Cho, YH; Pluscec, J; Ricca, C; Robinson, S; Seizinger, BR; Manne, V; Meyers, CA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50284177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50284177&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44382587 104125834 CHEMBL171783 C01960 ZINC27991491 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50471181 CSCC[C@H](NC(=S)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(O)=O InChI=1S/C22H34N4O4S3/c1-13(2)18(26-19(27)15(23)12-31)20(28)24-17(11-14-7-5-4-6-8-14)21(32)25-16(22(29)30)9-10-33-3/h4-8,13,15-18,31H,9-12,23H2,1-3H3,(H,24,28)(H,25,32)(H,26,27)(H,29,30)/t15-,16-,17-,18-/m0/s1 FQWLXKORHCUAJF-XSLAGTTESA-N 50058200 (S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propionylamino)-3-methyl-butyrylamino]-3-phenyl-thiopropionylamino}-4-methylsulfanyl-butyric acid::CHEMBL300237 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 17 ChEMBL 10.1016/S0960-894X(01)80257-2 10.7270/Q2N58MB6 Leftheris, K; Kline, T; Natarajan, S; DeVirgilio, MK; Cho, YH; Pluscec, J; Ricca, C; Robinson, S; Seizinger, BR; Manne, V; Meyers, CA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50058200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50058200&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44294608 103954177 CHEMBL300237 ZINC13762266 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50471182 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(O)=O InChI=1S/C23H36N4O5S2/c1-14(2)19(26-20(28)16(24)13-33)22(30)27(3)18(12-15-8-6-5-7-9-15)21(29)25-17(23(31)32)10-11-34-4/h5-9,14,16-19,33H,10-13,24H2,1-4H3,(H,25,29)(H,26,28)(H,31,32)/t16-,17-,18-,19-/m0/s1 PAAMBNNYTPBGMZ-VJANTYMQSA-N 50284173 (S)-2-((S)-2-{[(S)-2-((R)-2-Amino-3-mercapto-propionylamino)-3-methyl-butyryl]-methyl-amino}-3-phenyl-propionylamino)-4-methylsulfanyl-butyric acid::CHEMBL171367 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 360 ChEMBL 10.1016/S0960-894X(01)80257-2 10.7270/Q2N58MB6 Leftheris, K; Kline, T; Natarajan, S; DeVirgilio, MK; Cho, YH; Pluscec, J; Ricca, C; Robinson, S; Seizinger, BR; Manne, V; Meyers, CA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50284173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50284173&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44382673 104125830 CHEMBL171367 ZINC27995346 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50471183 CSCC[C@H](NC[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(O)=O InChI=1S/C22H36N4O4S2/c1-14(2)19(26-20(27)17(23)13-31)21(28)25-16(11-15-7-5-4-6-8-15)12-24-18(22(29)30)9-10-32-3/h4-8,14,16-19,24,31H,9-13,23H2,1-3H3,(H,25,28)(H,26,27)(H,29,30)/t16-,17-,18-,19-/m0/s1 XSKSGFPDLKJTHQ-VJANTYMQSA-N 50058203 (S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propionylamino)-3-methyl-butyrylamino]-3-phenyl-propylamino}-4-methylsulfanyl-butyric acid::CHEMBL52150 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 2220 ChEMBL 10.1016/S0960-894X(01)80257-2 10.7270/Q2N58MB6 Leftheris, K; Kline, T; Natarajan, S; DeVirgilio, MK; Cho, YH; Pluscec, J; Ricca, C; Robinson, S; Seizinger, BR; Manne, V; Meyers, CA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50058203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50058203&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44294615 103954180 CHEMBL52150 ZINC13762272 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50471184 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC[C@@H](N)CS)C(C)C)C(O)=O InChI=1S/C22H36N4O4S2/c1-14(2)19(24-12-16(23)13-31)21(28)26-18(11-15-7-5-4-6-8-15)20(27)25-17(22(29)30)9-10-32-3/h4-8,14,16-19,24,31H,9-13,23H2,1-3H3,(H,25,27)(H,26,28)(H,29,30)/t16-,17+,18+,19+/m1/s1 IPWZNXBFUVGZPW-XWSJACJDSA-N 50284165 (S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methyl-butyrylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid::CHEMBL327674 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 12 ChEMBL 10.1016/S0960-894X(01)80257-2 10.7270/Q2N58MB6 Leftheris, K; Kline, T; Natarajan, S; DeVirgilio, MK; Cho, YH; Pluscec, J; Ricca, C; Robinson, S; Seizinger, BR; Manne, V; Meyers, CA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50284165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50284165&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44324009 104125822 CHEMBL327674 ZINC26654069 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50471185 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)C[C@H](N)CS)C(C)C)C(O)=O InChI=1S/C23H36N4O5S2/c1-14(2)20(27-19(28)12-16(24)13-33)22(30)26-18(11-15-7-5-4-6-8-15)21(29)25-17(23(31)32)9-10-34-3/h4-8,14,16-18,20,33H,9-13,24H2,1-3H3,(H,25,29)(H,26,30)(H,27,28)(H,31,32)/t16-,17-,18-,20-/m0/s1 BRWFDVXNCLCBHT-JPLJXNOCSA-N 50284170 (S)-2-{(S)-2-[(S)-2-((S)-3-Amino-4-mercapto-butyrylamino)-3-methyl-butyrylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid::CHEMBL352408 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 1800 ChEMBL 10.1016/S0960-894X(01)80257-2 10.7270/Q2N58MB6 Leftheris, K; Kline, T; Natarajan, S; DeVirgilio, MK; Cho, YH; Pluscec, J; Ricca, C; Robinson, S; Seizinger, BR; Manne, V; Meyers, CA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50284170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50284170&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44382597 104125827 CHEMBL352408 ZINC27996617 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50471186 CSCC[C@H](N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(O)=O InChI=1S/C23H36N4O5S2/c1-14(2)19(26-20(28)16(24)13-33)21(29)25-17(12-15-8-6-5-7-9-15)22(30)27(3)18(23(31)32)10-11-34-4/h5-9,14,16-19,33H,10-13,24H2,1-4H3,(H,25,29)(H,26,28)(H,31,32)/t16-,17-,18-,19-/m0/s1 FHFMIOIAZJSODA-VJANTYMQSA-N 50058206 (S)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propionylamino)-3-methyl-butyrylamino]-3-phenyl-propionyl}-methyl-amino)-4-methylsulfanyl-butyric acid::CHEMBL48470 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 1400 ChEMBL 10.1016/S0960-894X(01)80257-2 10.7270/Q2N58MB6 Leftheris, K; Kline, T; Natarajan, S; DeVirgilio, MK; Cho, YH; Pluscec, J; Ricca, C; Robinson, S; Seizinger, BR; Manne, V; Meyers, CA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50058206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50058206&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44294666 103954183 CHEMBL48470 ZINC13762270 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50471187 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCC(O)=O)C(C)C)C(O)=O InChI=1S/C24H36N4O7S/c1-14(2)20(28-21(31)16(25)9-10-19(29)30)23(33)27-18(13-15-7-5-4-6-8-15)22(32)26-17(24(34)35)11-12-36-3/h4-8,14,16-18,20H,9-13,25H2,1-3H3,(H,26,32)(H,27,33)(H,28,31)(H,29,30)(H,34,35)/t16-,17-,18-,20-/m0/s1 PMVIYSNELPLCIY-JPLJXNOCSA-N 50284179 (S)-2-{(S)-2-[(S)-2-((S)-2-Amino-4-carboxy-butyrylamino)-3-methyl-butyrylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid::CHEMBL354880 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 120000 ChEMBL 10.1016/S0960-894X(01)80257-2 10.7270/Q2N58MB6 Leftheris, K; Kline, T; Natarajan, S; DeVirgilio, MK; Cho, YH; Pluscec, J; Ricca, C; Robinson, S; Seizinger, BR; Manne, V; Meyers, CA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50284179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50284179&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44382535 104125836 CHEMBL354880 C01960 ZINC27989006 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50471188 CSCC[C@H](NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(O)=O InChI=1S/C26H36N4O5S2/c1-15(2)22(30-23(31)19(27)14-36)25(33)29-21(24(32)28-20(26(34)35)10-11-37-3)13-16-8-9-17-6-4-5-7-18(17)12-16/h4-9,12,15,19-22,36H,10-11,13-14,27H2,1-3H3,(H,28,32)(H,29,33)(H,30,31)(H,34,35)/t19-,20-,21-,22-/m0/s1 HZPSWNVHTKOMLQ-CMOCDZPBSA-N 50284172 (S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propionylamino)-3-methyl-butyrylamino]-3-naphthalen-2-yl-propionylamino}-4-methylsulfanyl-butyric acid::CHEMBL353715 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 12 ChEMBL 10.1016/S0960-894X(01)80257-2 10.7270/Q2N58MB6 Leftheris, K; Kline, T; Natarajan, S; DeVirgilio, MK; Cho, YH; Pluscec, J; Ricca, C; Robinson, S; Seizinger, BR; Manne, V; Meyers, CA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50284172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50284172&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44382767 104125829 CHEMBL353715 C01960 ZINC28004647 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50471189 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)C(C)(C)NC(=O)[C@@H](N)CS)C(O)=O InChI=1S/C21H32N4O5S2/c1-21(2,25-17(26)14(22)12-31)20(30)24-16(11-13-7-5-4-6-8-13)18(27)23-15(19(28)29)9-10-32-3/h4-8,14-16,31H,9-12,22H2,1-3H3,(H,23,27)(H,24,30)(H,25,26)(H,28,29)/t14-,15-,16-/m0/s1 AYVGZFZCSQHKPP-JYJNAYRXSA-N 50284166 (S)-2-{(S)-2-[2-((R)-2-Amino-3-mercapto-propionylamino)-2-methyl-propionylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid::CHEMBL426931 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 400 ChEMBL 10.1016/S0960-894X(01)80257-2 10.7270/Q2N58MB6 Leftheris, K; Kline, T; Natarajan, S; DeVirgilio, MK; Cho, YH; Pluscec, J; Ricca, C; Robinson, S; Seizinger, BR; Manne, V; Meyers, CA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50284166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50284166&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44382688 104125823 CHEMBL426931 ZINC27996049 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50471190 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(O)=O InChI=1S/C22H34N4O5S2/c1-13(2)18(26-19(27)15(23)12-32)21(29)25-17(11-14-7-5-4-6-8-14)20(28)24-16(22(30)31)9-10-33-3/h4-8,13,15-18,32H,9-12,23H2,1-3H3,(H,24,28)(H,25,29)(H,26,27)(H,30,31)/t15-,16-,17-,18-/m0/s1 PCFMKLVXKKAJSV-XSLAGTTESA-N 13373 (2S)-2-[(2S)-2-[(2S)-2-[(2R)-2-amino-3-sulfanylpropanamido]-3-methylbutanamido]-3-phenylpropanamido]-4-(methylsulfanyl)butanoic acid::CHEMBL289302::CHEMBL553980::CVFM Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 37 ChEMBL 10.1016/S0960-894X(01)80257-2 10.7270/Q2N58MB6 Leftheris, K; Kline, T; Natarajan, S; DeVirgilio, MK; Cho, YH; Pluscec, J; Ricca, C; Robinson, S; Seizinger, BR; Manne, V; Meyers, CA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13373&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 4369208 46513780 CHEMBL553980CHEMBL289302 C01960 ZINC03922430 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50471191 CN[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCSC)C(O)=O InChI=1S/C23H36N4O5S2/c1-14(2)19(27-21(29)18(13-33)24-3)22(30)26-17(12-15-8-6-5-7-9-15)20(28)25-16(23(31)32)10-11-34-4/h5-9,14,16-19,24,33H,10-13H2,1-4H3,(H,25,28)(H,26,30)(H,27,29)(H,31,32)/t16-,17-,18-,19-/m0/s1 VVHALEBVTPLGHL-VJANTYMQSA-N 50284171 (S)-2-{(S)-2-[(S)-2-((R)-3-Mercapto-2-methylamino-propionylamino)-3-methyl-butyrylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid::CHEMBL169799 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 420 ChEMBL 10.1016/S0960-894X(01)80257-2 10.7270/Q2N58MB6 Leftheris, K; Kline, T; Natarajan, S; DeVirgilio, MK; Cho, YH; Pluscec, J; Ricca, C; Robinson, S; Seizinger, BR; Manne, V; Meyers, CA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50284171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50284171&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44382677 104125828 CHEMBL169799 ZINC27988427 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50471192 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H](N)CS)C(O)=O InChI=1S/C23H36N4O5S2/c1-14(2)19(27(3)22(30)16(24)13-33)21(29)26-18(12-15-8-6-5-7-9-15)20(28)25-17(23(31)32)10-11-34-4/h5-9,14,16-19,33H,10-13,24H2,1-4H3,(H,25,28)(H,26,29)(H,31,32)/t16-,17-,18-,19-/m0/s1 NIKLJFUBMPMVBM-VJANTYMQSA-N 50284168 (S)-2-((S)-2-{(S)-2-[((R)-2-Amino-3-mercapto-propionyl)-methyl-amino]-3-methyl-butyrylamino}-3-phenyl-propionylamino)-4-methylsulfanyl-butyric acid::CHEMBL169988 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 250 ChEMBL 10.1016/S0960-894X(01)80257-2 10.7270/Q2N58MB6 Leftheris, K; Kline, T; Natarajan, S; DeVirgilio, MK; Cho, YH; Pluscec, J; Ricca, C; Robinson, S; Seizinger, BR; Manne, V; Meyers, CA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50284168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50284168&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44382719 104125825 CHEMBL169988 ZINC27990836 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50471193 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)C1(CCCCC1)NC(=O)[C@@H](N)CS)C(O)=O InChI=1S/C24H36N4O5S2/c1-35-13-10-18(22(31)32)26-21(30)19(14-16-8-4-2-5-9-16)27-23(33)24(11-6-3-7-12-24)28-20(29)17(25)15-34/h2,4-5,8-9,17-19,34H,3,6-7,10-15,25H2,1H3,(H,26,30)(H,27,33)(H,28,29)(H,31,32)/t17-,18-,19-/m0/s1 MBIOMPBSGKYFRP-FHWLQOOXSA-N 50284182 (S)-2-((S)-2-{[1-((R)-2-Amino-3-mercapto-propionylamino)-cyclohexanecarbonyl]-amino}-3-phenyl-propionylamino)-4-methylsulfanyl-butyric acid::CHEMBL171168 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 1200 ChEMBL 10.1016/S0960-894X(01)80257-2 10.7270/Q2N58MB6 Leftheris, K; Kline, T; Natarajan, S; DeVirgilio, MK; Cho, YH; Pluscec, J; Ricca, C; Robinson, S; Seizinger, BR; Manne, V; Meyers, CA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50284182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50284182&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44382638 104125839 CHEMBL171168 ZINC27992815 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50471194 CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)c1ccccc1)C(O)=O InChI=1S/C21H32N4O5S2/c1-12(2)16(24-18(26)14(22)11-31)19(27)25-17(13-7-5-4-6-8-13)20(28)23-15(21(29)30)9-10-32-3/h4-8,12,14-17,31H,9-11,22H2,1-3H3,(H,23,28)(H,24,26)(H,25,27)(H,29,30)/t14-,15-,16-,17-/m0/s1 PJXYUCZKQRKVTN-QAETUUGQSA-N 50284181 (S)-2-{2-[(S)-2-((R)-2-Amino-3-mercapto-propionylamino)-3-methyl-butyrylamino]-2-phenyl-acetylamino}-4-methylsulfanyl-butyric acid::CHEMBL2371610 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 696 ChEMBL 10.1016/S0960-894X(01)80257-2 10.7270/Q2N58MB6 Leftheris, K; Kline, T; Natarajan, S; DeVirgilio, MK; Cho, YH; Pluscec, J; Ricca, C; Robinson, S; Seizinger, BR; Manne, V; Meyers, CA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50284181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50284181&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 73354679 104125838 CHEMBL2371610 C01960 ZINC27997067 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50471196 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1cnc[nH]1)C(C)C)C(O)=O InChI=1S/C25H36N6O5S/c1-15(2)21(31-22(32)18(26)12-17-13-27-14-28-17)24(34)30-20(11-16-7-5-4-6-8-16)23(33)29-19(25(35)36)9-10-37-3/h4-8,13-15,18-21H,9-12,26H2,1-3H3,(H,27,28)(H,29,33)(H,30,34)(H,31,32)(H,35,36)/t18-,19-,20-,21-/m0/s1 MLUMSZGAWGBYFW-TUFLPTIASA-N 50048397 (S)-2-((S)-2-{(S)-2-[(S)-2-Amino-3-(3H-imidazol-4-yl)-propionylamino]-3-methyl-butyrylamino}-3-phenyl-propionylamino)-4-methylsulfanyl-butyric acid::CHEMBL333870 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 6800 ChEMBL 10.1016/S0960-894X(01)80257-2 10.7270/Q2N58MB6 Leftheris, K; Kline, T; Natarajan, S; DeVirgilio, MK; Cho, YH; Pluscec, J; Ricca, C; Robinson, S; Seizinger, BR; Manne, V; Meyers, CA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048397&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44345485 103978862 CHEMBL333870 C01960 ZINC27183337 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50471197 CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC[C@@H](N)CS)C(C)C)C(C)C)C(O)=O InChI=1S/C18H36N4O4S2/c1-10(2)14(20-8-12(19)9-27)16(23)22-15(11(3)4)17(24)21-13(18(25)26)6-7-28-5/h10-15,20,27H,6-9,19H2,1-5H3,(H,21,24)(H,22,23)(H,25,26)/t12-,13+,14+,15+/m1/s1 TWJSJIXCCAKENP-QPSCCSFWSA-N 50284176 (S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methyl-butyrylamino]-3-methyl-butyrylamino}-4-methylsulfanyl-butyric acid::CHEMBL353040 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 29 ChEMBL 10.1016/S0960-894X(01)80257-2 10.7270/Q2N58MB6 Leftheris, K; Kline, T; Natarajan, S; DeVirgilio, MK; Cho, YH; Pluscec, J; Ricca, C; Robinson, S; Seizinger, BR; Manne, V; Meyers, CA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50284176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50284176&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44382815 104125833 CHEMBL353040 ZINC28000701 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50471200 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(O)=O InChI=1S/C22H36N4O4S2/c1-14(2)19(26-20(27)16(23)13-31)12-24-18(11-15-7-5-4-6-8-15)21(28)25-17(22(29)30)9-10-32-3/h4-8,14,16-19,24,31H,9-13,23H2,1-3H3,(H,25,28)(H,26,27)(H,29,30)/t16-,17-,18-,19+/m0/s1 WBYSFZWJSLRVJP-CADBVGFASA-N 50284174 (S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propionylamino)-3-methyl-butylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid::CHEMBL171250 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 126 ChEMBL 10.1016/S0960-894X(01)80257-2 10.7270/Q2N58MB6 Leftheris, K; Kline, T; Natarajan, S; DeVirgilio, MK; Cho, YH; Pluscec, J; Ricca, C; Robinson, S; Seizinger, BR; Manne, V; Meyers, CA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50284174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50284174&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44382814 104125831 CHEMBL171250 ZINC53275915 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50471201 CC(C)[C@H](NC(=O)[C@@H](N)CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O InChI=1S/C26H34N4O5S/c1-16(2)22(30-23(31)19(27)15-36)25(33)28-20(13-17-9-5-3-6-10-17)24(32)29-21(26(34)35)14-18-11-7-4-8-12-18/h3-12,16,19-22,36H,13-15,27H2,1-2H3,(H,28,33)(H,29,32)(H,30,31)(H,34,35)/t19-,20-,21-,22-/m0/s1 FSXQTOKSDQZKJQ-CMOCDZPBSA-N 50284167 (S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propionylamino)-3-methyl-butyrylamino]-3-phenyl-propionylamino}-3-phenyl-propionic acid::CHEMBL352414 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 400 ChEMBL 10.1016/S0960-894X(01)80257-2 10.7270/Q2N58MB6 Leftheris, K; Kline, T; Natarajan, S; DeVirgilio, MK; Cho, YH; Pluscec, J; Ricca, C; Robinson, S; Seizinger, BR; Manne, V; Meyers, CA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50284167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50284167&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44382816 104125824 CHEMBL352414 C01960 ZINC28000705 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50471202 CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(C)C)C(O)=O InChI=1S/C18H34N4O5S2/c1-9(2)13(16(24)20-12(18(26)27)6-7-29-5)22-17(25)14(10(3)4)21-15(23)11(19)8-28/h9-14,28H,6-8,19H2,1-5H3,(H,20,24)(H,21,23)(H,22,25)(H,26,27)/t11-,12-,13-,14-/m0/s1 JEBJIPQVWIPQAG-XUXIUFHCSA-N 50284169 (S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propionylamino)-3-methyl-butyrylamino]-3-methyl-butyrylamino}-4-methylsulfanyl-butyric acid::CHEMBL354194 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 68 ChEMBL 10.1016/S0960-894X(01)80257-2 10.7270/Q2N58MB6 Leftheris, K; Kline, T; Natarajan, S; DeVirgilio, MK; Cho, YH; Pluscec, J; Ricca, C; Robinson, S; Seizinger, BR; Manne, V; Meyers, CA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50284169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50284169&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44382494 104125826 CHEMBL354194 C01960 ZINC27991934 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50471204 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCS)C(C)C)C(O)=O InChI=1S/C23H36N4O5S2/c1-14(2)19(27-20(28)16(24)9-11-33)22(30)26-18(13-15-7-5-4-6-8-15)21(29)25-17(23(31)32)10-12-34-3/h4-8,14,16-19,33H,9-13,24H2,1-3H3,(H,25,29)(H,26,30)(H,27,28)(H,31,32)/t16-,17-,18-,19-/m0/s1 DNNUOYRZIKPEOD-VJANTYMQSA-N 50284175 (S)-2-{(S)-2-[(S)-2-((S)-2-Amino-4-mercapto-butyrylamino)-3-methyl-butyrylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid::CHEMBL354044 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 2700 ChEMBL 10.1016/S0960-894X(01)80257-2 10.7270/Q2N58MB6 Leftheris, K; Kline, T; Natarajan, S; DeVirgilio, MK; Cho, YH; Pluscec, J; Ricca, C; Robinson, S; Seizinger, BR; Manne, V; Meyers, CA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50284175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50284175&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44382579 104125832 CHEMBL354044 C01960 ZINC28001571 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50003875 CSCC[C@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](S)NC(=O)[C@H](N)CCCCN)C(O)=O InChI=1S/C29H46N6O6S2/c1-17(2)23(34(3)28(39)26(42)33-24(36)20(31)11-7-8-13-30)27(38)35-16-19-10-6-5-9-18(19)15-22(35)25(37)32-21(29(40)41)12-14-43-4/h5-6,9-10,17,20-23,26,42H,7-8,11-16,30-31H2,1-4H3,(H,32,37)(H,33,36)(H,40,41)/t20-,21+,22+,23+,26+/m1/s1 HRBYLFMJMRLSCD-SQSAXNKISA-N 50284949 (S)-2-{[(S)-2-((S)-2-{[(S)-2-((R)-2,6-Diamino-hexanoylamino)-2-mercapto-acetyl]-methyl-amino}-3-methyl-butyryl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl]-amino}-4-methylsulfanyl-butyric acid::CHEMBL299956 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 5 ChEMBL 10.1016/0960-894X(95)00314-J 10.7270/Q2H41RDH Clerc, FF; Guitton, JD; Fromage, N; Lelièvre, Y; Duchesne, M; Tocqué, B; James-Surcouf, E; Commerçon, A; Becquart, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50284949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50284949&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44295357 104126520 CHEMBL299956 C01525 ZINC29478166 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50003876 CSCC[C@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@H](NC(=O)[C@H](CS)NC(=O)[C@@H](N)CCCCN)C(C)C)C(O)=O InChI=1S/C29H46N6O6S2/c1-17(2)24(34-26(37)22(16-42)33-25(36)20(31)10-6-7-12-30)28(39)35-15-19-9-5-4-8-18(19)14-23(35)27(38)32-21(29(40)41)11-13-43-3/h4-5,8-9,17,20-24,42H,6-7,10-16,30-31H2,1-3H3,(H,32,38)(H,33,36)(H,34,37)(H,40,41)/t20-,21-,22-,23-,24+/m0/s1 VWVKWGUXIOOQGM-QCCYXRBGSA-N 50213274 CHEMBL3350314 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 100000 ChEMBL 10.1016/0960-894X(95)00314-J 10.7270/Q2H41RDH Clerc, FF; Guitton, JD; Fromage, N; Lelièvre, Y; Duchesne, M; Tocqué, B; James-Surcouf, E; Commerçon, A; Becquart, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50213274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50213274&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 118718834 376070886 CHEMBL3350314 C02248 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50003877 CSCC[C@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@H](NC(=O)[C@H](CS)NC(=O)[C@@H](N)CCCCN)C(C)C)C(O)=O InChI=1S/C29H46N6O6S2/c1-17(2)24(34-26(37)22(16-42)33-25(36)20(31)10-6-7-12-30)28(39)35-15-19-9-5-4-8-18(19)14-23(35)27(38)32-21(29(40)41)11-13-43-3/h4-5,8-9,17,20-24,42H,6-7,10-16,30-31H2,1-3H3,(H,32,38)(H,33,36)(H,34,37)(H,40,41)/t20-,21-,22-,23-,24+/m0/s1 VWVKWGUXIOOQGM-QCCYXRBGSA-N 50213274 CHEMBL3350314 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 100000 ChEMBL 10.1016/0960-894X(95)00314-J 10.7270/Q2H41RDH Clerc, FF; Guitton, JD; Fromage, N; Lelièvre, Y; Duchesne, M; Tocqué, B; James-Surcouf, E; Commerçon, A; Becquart, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50213274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50213274&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 118718834 376070886 CHEMBL3350314 C02248 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50003878 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](S)NC(=O)[C@H](N)CCCCN)C(C)C)C(O)=O InChI=1S/C27H44N6O6S2/c1-16(2)21(32-25(37)26(40)33-22(34)18(29)11-7-8-13-28)24(36)31-20(15-17-9-5-4-6-10-17)23(35)30-19(27(38)39)12-14-41-3/h4-6,9-10,16,18-21,26,40H,7-8,11-15,28-29H2,1-3H3,(H,30,35)(H,31,36)(H,32,37)(H,33,34)(H,38,39)/t18-,19+,20+,21+,26+/m1/s1 DFNOKXHMHRDRNE-QDKCGITRSA-N 50284952 (S)-2-((S)-2-{(S)-2-[(S)-2-((R)-2,6-Diamino-hexanoylamino)-2-mercapto-acetylamino]-3-methyl-butyrylamino}-3-phenyl-propionylamino)-4-methylsulfanyl-butyric acid::CHEMBL51436 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 1000 ChEMBL 10.1016/0960-894X(95)00314-J 10.7270/Q2H41RDH Clerc, FF; Guitton, JD; Fromage, N; Lelièvre, Y; Duchesne, M; Tocqué, B; James-Surcouf, E; Commerçon, A; Becquart, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50284952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50284952&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44295358 104126523 CHEMBL51436 C01525 ZINC29478171 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50472683 CSCC[C@H](NC(=O)[C@H]1Cc2ccccc2CN1C(=O)[C@H]1CCCN1C(=O)[C@H](CS)NC(=O)[C@@H](N)CCCCN)C(O)=O InChI=1S/C29H44N6O6S2/c1-43-14-11-21(29(40)41)32-26(37)24-15-18-7-2-3-8-19(18)16-35(24)28(39)23-10-6-13-34(23)27(38)22(17-42)33-25(36)20(31)9-4-5-12-30/h2-3,7-8,20-24,42H,4-6,9-17,30-31H2,1H3,(H,32,37)(H,33,36)(H,40,41)/t20-,21-,22-,23+,24+/m0/s1 PFIVQTSXMHRTGN-ZROJVYTPSA-N 50213273 CHEMBL3350692 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 100000 ChEMBL 10.1016/0960-894X(95)00314-J 10.7270/Q2H41RDH Clerc, FF; Guitton, JD; Fromage, N; Lelièvre, Y; Duchesne, M; Tocqué, B; James-Surcouf, E; Commerçon, A; Becquart, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50213273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50213273&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 118719085 376070885 CHEMBL3350692 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50472686 CSCC[C@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](NC(=O)[C@H](S)NC(=O)[C@@H](N)CCCCN)C(C)C)C(O)=O InChI=1S/C28H44N6O6S2/c1-16(2)22(32-25(37)26(41)33-23(35)19(30)10-6-7-12-29)27(38)34-15-18-9-5-4-8-17(18)14-21(34)24(36)31-20(28(39)40)11-13-42-3/h4-5,8-9,16,19-22,26,41H,6-7,10-15,29-30H2,1-3H3,(H,31,36)(H,32,37)(H,33,35)(H,39,40)/t19-,20-,21-,22-,26-/m0/s1 AFEXYTZJFRSLAP-KAWFJRQCSA-N 50403479 CHEMBL2115457 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 20 ChEMBL 10.1016/0960-894X(95)00314-J 10.7270/Q2H41RDH Clerc, FF; Guitton, JD; Fromage, N; Lelièvre, Y; Duchesne, M; Tocqué, B; James-Surcouf, E; Commerçon, A; Becquart, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50403479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50403479&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 71458143 163352503 CHEMBL2115457 C01525 ZINC95557639 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50472689 CSCC[C@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H]1CCCN1C(=O)[C@H](S)NC(=O)[C@@H](N)CCCCN)C(O)=O InChI=1S/C28H42N6O6S2/c1-42-14-11-20(28(39)40)31-24(36)22-15-17-7-2-3-8-18(17)16-34(22)26(37)21-10-6-13-33(21)27(38)25(41)32-23(35)19(30)9-4-5-12-29/h2-3,7-8,19-22,25,41H,4-6,9-16,29-30H2,1H3,(H,31,36)(H,32,35)(H,39,40)/t19-,20-,21-,22-,25-/m0/s1 NLYDHALMGUSTFD-XHVFSLISSA-N 50403478 CHEMBL2115458 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 2000 ChEMBL 10.1016/0960-894X(95)00314-J 10.7270/Q2H41RDH Clerc, FF; Guitton, JD; Fromage, N; Lelièvre, Y; Duchesne, M; Tocqué, B; James-Surcouf, E; Commerçon, A; Becquart, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50403478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50403478&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 71461731 163352502 CHEMBL2115458 C01525 ZINC95557640 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50472690 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(O)=O InChI=1S/C22H34N4O5S2/c1-13(2)18(26-19(27)15(23)12-32)21(29)25-17(11-14-7-5-4-6-8-14)20(28)24-16(22(30)31)9-10-33-3/h4-8,13,15-18,32H,9-12,23H2,1-3H3,(H,24,28)(H,25,29)(H,26,27)(H,30,31)/t15-,16-,17-,18-/m0/s1 PCFMKLVXKKAJSV-XSLAGTTESA-N 13373 (2S)-2-[(2S)-2-[(2S)-2-[(2R)-2-amino-3-sulfanylpropanamido]-3-methylbutanamido]-3-phenylpropanamido]-4-(methylsulfanyl)butanoic acid::CHEMBL289302::CHEMBL553980::CVFM Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 25000 ChEMBL 10.1016/0960-894X(95)00314-J 10.7270/Q2H41RDH Clerc, FF; Guitton, JD; Fromage, N; Lelièvre, Y; Duchesne, M; Tocqué, B; James-Surcouf, E; Commerçon, A; Becquart, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13373&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 4369208 46513780 CHEMBL553980CHEMBL289302 C01960 ZINC03922430 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50472691 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](S)NC(=O)[C@H](N)CCCCN)C(O)=O InChI=1S/C28H46N6O6S2/c1-17(2)22(34(3)27(38)26(41)33-23(35)19(30)12-8-9-14-29)25(37)32-21(16-18-10-6-5-7-11-18)24(36)31-20(28(39)40)13-15-42-4/h5-7,10-11,17,19-22,26,41H,8-9,12-16,29-30H2,1-4H3,(H,31,36)(H,32,37)(H,33,35)(H,39,40)/t19-,20+,21+,22+,26+/m1/s1 JCTKMPHTQNNOEU-RZFRIWOHSA-N 50284953 (S)-2-[(S)-2-((S)-2-{[(S)-2-((R)-2,6-Diamino-hexanoylamino)-2-mercapto-acetyl]-methyl-amino}-3-methyl-butyrylamino)-3-phenyl-propionylamino]-4-methylsulfanyl-butyric acid::CHEMBL50624 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 1000 ChEMBL 10.1016/0960-894X(95)00314-J 10.7270/Q2H41RDH Clerc, FF; Guitton, JD; Fromage, N; Lelièvre, Y; Duchesne, M; Tocqué, B; James-Surcouf, E; Commerçon, A; Becquart, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50284953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50284953&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44295245 104126524 CHEMBL50624 C01525 ZINC29478653 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50472692 CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](S)NC(=O)[C@H](N)CCCCN)C(C)(C)C)c1ccccc1)C(O)=O InChI=1S/C27H44N6O6S2/c1-27(2,3)20(32-24(37)25(40)33-21(34)17(29)12-8-9-14-28)23(36)31-19(16-10-6-5-7-11-16)22(35)30-18(26(38)39)13-15-41-4/h5-7,10-11,17-20,25,40H,8-9,12-15,28-29H2,1-4H3,(H,30,35)(H,31,36)(H,32,37)(H,33,34)(H,38,39)/t17-,18+,19+,20-,25+/m1/s1 JHRIEOQKOXMHHX-RLTOQUHHSA-N 50284950 (S)-2-((S)-2-{(S)-2-[(S)-2-((R)-2,6-Diamino-hexanoylamino)-2-mercapto-acetylamino]-3,3-dimethyl-butyrylamino}-2-phenyl-acetylamino)-4-methylsulfanyl-butyric acid::CHEMBL433279 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 1000 ChEMBL 10.1016/0960-894X(95)00314-J 10.7270/Q2H41RDH Clerc, FF; Guitton, JD; Fromage, N; Lelièvre, Y; Duchesne, M; Tocqué, B; James-Surcouf, E; Commerçon, A; Becquart, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50284950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50284950&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44295316 104126521 CHEMBL433279 C01525 ZINC29472661 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50472694 CSCC[C@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](NC(=O)[C@H](S)NC(=O)[C@H](N)CCCCN)C(C)(C)C)C(O)=O InChI=1S/C29H46N6O6S2/c1-29(2,3)22(33-25(38)26(42)34-23(36)19(31)11-7-8-13-30)27(39)35-16-18-10-6-5-9-17(18)15-21(35)24(37)32-20(28(40)41)12-14-43-4/h5-6,9-10,19-22,26,42H,7-8,11-16,30-31H2,1-4H3,(H,32,37)(H,33,38)(H,34,36)(H,40,41)/t19-,20+,21+,22-,26+/m1/s1 TZGPBIZTBHUSEI-XMLSHEPFSA-N 50284951 (S)-2-[((S)-2-{(S)-2-[(S)-2-((R)-2,6-Diamino-hexanoylamino)-2-mercapto-acetylamino]-3,3-dimethyl-butyryl}-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl)-amino]-4-methylsulfanyl-butyric acid::CHEMBL48182 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 40 ChEMBL 10.1016/0960-894X(95)00314-J 10.7270/Q2H41RDH Clerc, FF; Guitton, JD; Fromage, N; Lelièvre, Y; Duchesne, M; Tocqué, B; James-Surcouf, E; Commerçon, A; Becquart, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50284951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50284951&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44295386 104126522 CHEMBL48182 C01525 ZINC29469540 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50563308 CSCC[C@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@H](NC(=O)[C@H](S)NC(=O)[C@@H](N)CCCCN)C(C)C)C(O)=O InChI=1S/C28H44N6O6S2/c1-16(2)22(32-25(37)26(41)33-23(35)19(30)10-6-7-12-29)27(38)34-15-18-9-5-4-8-17(18)14-21(34)24(36)31-20(28(39)40)11-13-42-3/h4-5,8-9,16,19-22,26,41H,6-7,10-15,29-30H2,1-3H3,(H,31,36)(H,32,37)(H,33,35)(H,39,40)/t19-,20-,21-,22+,26-/m0/s1 AFEXYTZJFRSLAP-NNIVGBBESA-N 50403477 CHEMBL2115025 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 15000 ChEMBL 10.1016/0960-894X(95)00314-J 10.7270/Q2H41RDH Clerc, FF; Guitton, JD; Fromage, N; Lelièvre, Y; Duchesne, M; Tocqué, B; James-Surcouf, E; Commerçon, A; Becquart, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50403477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50403477&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 71461707 163352501 CHEMBL2115025 C01525 ZINC95544063 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 50563309 CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](S)NC(=O)[C@H](N)CCCCN)c1ccccc1)C(O)=O InChI=1S/C27H44N6O6S2/c1-16(2)21(33(3)26(37)25(40)32-22(34)18(29)12-8-9-14-28)24(36)31-20(17-10-6-5-7-11-17)23(35)30-19(27(38)39)13-15-41-4/h5-7,10-11,16,18-21,25,40H,8-9,12-15,28-29H2,1-4H3,(H,30,35)(H,31,36)(H,32,34)(H,38,39)/t18-,19+,20+,21+,25+/m1/s1 WYRYVFKNAKYOEK-PHGOAHNDSA-N 50284948 (S)-2-[(S)-2-((S)-2-{[(S)-2-((R)-2,6-Diamino-hexanoylamino)-2-mercapto-acetyl]-methyl-amino}-3-methyl-butyrylamino)-2-phenyl-acetylamino]-4-methylsulfanyl-butyric acid::CHEMBL297242 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 1000 ChEMBL 10.1016/0960-894X(95)00314-J 10.7270/Q2H41RDH Clerc, FF; Guitton, JD; Fromage, N; Lelièvre, Y; Duchesne, M; Tocqué, B; James-Surcouf, E; Commerçon, A; Becquart, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50284948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50284948&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44295246 104126519 CHEMBL297242 C01525 ZINC29478656 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 51111211 NC(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1 InChI=1S/C27H31Br2ClN4O2/c28-20-12-19-2-1-18-13-21(30)14-22(29)24(18)25(26(19)32-15-20)17-5-9-33(10-6-17)23(35)11-16-3-7-34(8-4-16)27(31)36/h12-17,25H,1-11H2,(H2,31,36)/t25-/m1/s1 DHMTURDWPRKSOA-RUZDIDTESA-N 14459 (+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(R)-yl)-1-piperidin-yl]-2-oxo-ethyl]-1-piperidinecarboxamide::4-(2-{4-[(2R)-6,15-dibromo-13-chloro-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaen-2-yl]piperidin-1-yl}-2-oxoethyl)piperidine-1-carboxamide::CHEMBL298734::Lonafarnib::SCH 66336::Sarasar Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 1.9 ChEMBL 10.1021/acs.jmedchem.6b01817 10.7270/Q2542R5N 28505447 Buuh, ZY; Lyu, Z; Wang, RE Temple University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14459&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 336 1O5M 148195 46514799 CHEMBL298734 ZINC03950115 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 51229975 Cc1cc2ncn(CC(C(O)=O)P(O)(O)=O)c2cc1C InChI=1S/C12H15N2O5P/c1-7-3-9-10(4-8(7)2)14(6-13-9)5-11(12(15)16)20(17,18)19/h3-4,6,11H,5H2,1-2H3,(H,15,16)(H2,17,18,19) KLWGAEZHEYXBGT-UHFFFAOYSA-N 50504714 CHEMBL4460301 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >1000000 ChEMBL 10.1016/j.bmcl.2019.126757 10.7270/Q2JM2DW5 31699606 Bhuiyan, NH; Varney, ML; Wiemer, DF; Holstein, SA University of Iowa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504714&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 155528021 440713299 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 51229988 Cc1cc2ncn(CC(P(O)(O)=O)P(O)(O)=O)c2cc1C InChI=1S/C11H16N2O6P2/c1-7-3-9-10(4-8(7)2)13(6-12-9)5-11(20(14,15)16)21(17,18)19/h3-4,6,11H,5H2,1-2H3,(H2,14,15,16)(H2,17,18,19) LHHSPWONSLWNQK-UHFFFAOYSA-N 50504720 CHEMBL4529809 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >1000000 ChEMBL 10.1016/j.bmcl.2019.126757 10.7270/Q2JM2DW5 31699606 Bhuiyan, NH; Varney, ML; Wiemer, DF; Holstein, SA University of Iowa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504720&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 155545691 440713305 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 51229989 OP(O)(=O)C(Cn1cnc2ccccc12)P(O)(O)=O InChI=1S/C9H12N2O6P2/c12-18(13,14)9(19(15,16)17)5-11-6-10-7-3-1-2-4-8(7)11/h1-4,6,9H,5H2,(H2,12,13,14)(H2,15,16,17) ISSICOMKRRPVPD-UHFFFAOYSA-N 50273716 CHEMBL457423::[2-(Benzoimidazol-1-yl)ethyl]-bisphosphonic acid Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 830000 ChEMBL 10.1016/j.bmcl.2019.126757 10.7270/Q2JM2DW5 31699606 Bhuiyan, NH; Varney, ML; Wiemer, DF; Holstein, SA University of Iowa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50273716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50273716&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 5277505 104117728 CHEMBL457423 ZINC33818248 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 51229990 CC(Cn1cnc2ccccc12)(C(O)=O)P(O)(O)=O InChI=1S/C11H13N2O5P/c1-11(10(14)15,19(16,17)18)6-13-7-12-8-4-2-3-5-9(8)13/h2-5,7H,6H2,1H3,(H,14,15)(H2,16,17,18) QUDUQQDLBUPHAQ-UHFFFAOYSA-N 50504715 CHEMBL4514446 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >1000000 ChEMBL 10.1016/j.bmcl.2019.126757 10.7270/Q2JM2DW5 31699606 Bhuiyan, NH; Varney, ML; Wiemer, DF; Holstein, SA University of Iowa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504715&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 155539327 440713300 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 51229991 OC(=O)C(Cn1cnc2ccccc12)P(O)(O)=O InChI=1S/C10H11N2O5P/c13-10(14)9(18(15,16)17)5-12-6-11-7-3-1-2-4-8(7)12/h1-4,6,9H,5H2,(H,13,14)(H2,15,16,17) LQZXULNZTSCOBJ-UHFFFAOYSA-N 50504719 CHEMBL4438314 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 125000 ChEMBL 10.1016/j.bmcl.2019.126757 10.7270/Q2JM2DW5 31699606 Bhuiyan, NH; Varney, ML; Wiemer, DF; Holstein, SA University of Iowa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504719 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504719&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 155512943 440713304 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 51230004 OP(O)(=O)C(Cn1cnc2cc(F)c(F)cc12)P(O)(O)=O InChI=1S/C9H10F2N2O6P2/c10-5-1-7-8(2-6(5)11)13(4-12-7)3-9(20(14,15)16)21(17,18)19/h1-2,4,9H,3H2,(H2,14,15,16)(H2,17,18,19) TUOARNRROAEGKV-UHFFFAOYSA-N 50504717 CHEMBL4459281 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 340000 ChEMBL 10.1016/j.bmcl.2019.126757 10.7270/Q2JM2DW5 31699606 Bhuiyan, NH; Varney, ML; Wiemer, DF; Holstein, SA University of Iowa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504717&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 155526409 440713302 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 51230010 OC(=O)C(Cn1cnc2cc(F)c(F)cc12)P(O)(O)=O InChI=1S/C10H9F2N2O5P/c11-5-1-7-8(2-6(5)12)14(4-13-7)3-9(10(15)16)20(17,18)19/h1-2,4,9H,3H2,(H,15,16)(H2,17,18,19) XWMOZTADYNUFHE-UHFFFAOYSA-N 50504718 CHEMBL4564870 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 450000 ChEMBL 10.1016/j.bmcl.2019.126757 10.7270/Q2JM2DW5 31699606 Bhuiyan, NH; Varney, ML; Wiemer, DF; Holstein, SA University of Iowa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504718&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 155560088 440713303 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293 51230017 CC(Cn1cnc2ccccc12)(P(O)(O)=O)P(O)(O)=O InChI=1S/C10H14N2O6P2/c1-10(19(13,14)15,20(16,17)18)6-12-7-11-8-4-2-3-5-9(8)12/h2-5,7H,6H2,1H3,(H2,13,14,15)(H2,16,17,18) MRVZYYYNUNGBNW-UHFFFAOYSA-N 50504716 CHEMBL4589567 Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >1000000 ChEMBL 10.1016/j.bmcl.2019.126757 10.7270/Q2JM2DW5 31699606 Bhuiyan, NH; Varney, ML; Wiemer, DF; Holstein, SA University of Iowa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000075&target=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504716&enzyme=Protein+farnesyltransferase+subunit+beta%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 155568571 440713301 2 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N94,1N95,1N9A,1NI1,1NL4,1O1R,1O1S,1O1T,1O5M,1QBQ,1SA5,1TN7,1TN8,1X81,2BED,2R2L,2ZIR,2ZIS,3DPY,3E30,3E32,3E33,3E34,3EU5,3KSL,3KSQ,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,7RN5,7RNI,8E9E Protein farnesyltransferase subunit beta FNTB_RAT Q02293